KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LNX2
Full Name:
Ligand of Numb protein X 2
Alias:
Ligand of numb protein X 2; Ligand of numb-protein X 2; MGC46315; Numb-binding protein 2; PDZ domain-containing RING finger 1; PDZRN1
Type:
Mass (Da):
76000
Number AA:
UniProt ID:
Q8N448
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
T
T
S
D
E
M
V
S
V
E
Q
T
S
S
S
Site 2
T14
E
M
V
S
V
E
Q
T
S
S
S
S
L
N
P
Site 3
S16
V
S
V
E
Q
T
S
S
S
S
L
N
P
L
C
Site 4
S17
S
V
E
Q
T
S
S
S
S
L
N
P
L
C
F
Site 5
S18
V
E
Q
T
S
S
S
S
L
N
P
L
C
F
E
Site 6
Y38
W
T
R
E
N
H
L
Y
N
Y
Q
N
E
V
D
Site 7
Y40
R
E
N
H
L
Y
N
Y
Q
N
E
V
D
D
D
Site 8
S99
H
F
K
L
C
K
K
S
S
I
L
V
H
K
L
Site 9
S141
K
N
R
C
P
G
A
S
H
R
R
V
A
L
E
Site 10
T152
V
A
L
E
R
R
K
T
S
R
T
Q
A
E
I
Site 11
S153
A
L
E
R
R
K
T
S
R
T
Q
A
E
I
E
Site 12
T155
E
R
R
K
T
S
R
T
Q
A
E
I
E
N
E
Site 13
T166
I
E
N
E
N
G
P
T
L
L
D
P
A
G
T
Site 14
T173
T
L
L
D
P
A
G
T
L
S
P
E
A
D
C
Site 15
T193
V
P
V
E
R
H
L
T
S
A
S
L
S
T
W
Site 16
S194
P
V
E
R
H
L
T
S
A
S
L
S
T
W
S
Site 17
S196
E
R
H
L
T
S
A
S
L
S
T
W
S
E
E
Site 18
S198
H
L
T
S
A
S
L
S
T
W
S
E
E
P
G
Site 19
S201
S
A
S
L
S
T
W
S
E
E
P
G
L
D
N
Site 20
T220
E
S
A
G
A
D
T
T
Q
Q
P
L
S
L
P
Site 21
S225
D
T
T
Q
Q
P
L
S
L
P
E
G
E
I
T
Site 22
T232
S
L
P
E
G
E
I
T
T
I
E
I
H
R
S
Site 23
S239
T
T
I
E
I
H
R
S
N
P
Y
I
Q
L
G
Site 24
Y242
E
I
H
R
S
N
P
Y
I
Q
L
G
I
S
I
Site 25
Y289
Q
I
L
Q
V
N
N
Y
N
I
S
N
V
S
H
Site 26
Y298
I
S
N
V
S
H
N
Y
A
R
A
V
L
S
Q
Site 27
S304
N
Y
A
R
A
V
L
S
Q
P
C
N
T
L
H
Site 28
T313
P
C
N
T
L
H
L
T
V
L
R
E
R
R
F
Site 29
S328
G
N
R
A
H
N
H
S
D
S
N
S
P
R
E
Site 30
S330
R
A
H
N
H
S
D
S
N
S
P
R
E
E
I
Site 31
S332
H
N
H
S
D
S
N
S
P
R
E
E
I
F
Q
Site 32
S347
V
A
L
H
K
R
D
S
G
E
Q
L
G
I
K
Site 33
T359
G
I
K
L
V
R
R
T
D
E
P
G
V
F
I
Site 34
S382
A
A
Q
D
G
R
L
S
S
N
D
R
V
L
A
Site 35
S383
A
Q
D
G
R
L
S
S
N
D
R
V
L
A
I
Site 36
Y397
I
N
G
H
D
L
K
Y
G
T
P
E
L
A
A
Site 37
T399
G
H
D
L
K
Y
G
T
P
E
L
A
A
Q
I
Site 38
T417
S
G
E
R
V
N
L
T
I
A
R
P
G
K
P
Site 39
T429
G
K
P
Q
P
G
N
T
I
R
E
A
G
N
H
Site 40
S437
I
R
E
A
G
N
H
S
S
S
S
Q
H
H
T
Site 41
S438
R
E
A
G
N
H
S
S
S
S
Q
H
H
T
P
Site 42
S439
E
A
G
N
H
S
S
S
S
Q
H
H
T
P
P
Site 43
S440
A
G
N
H
S
S
S
S
Q
H
H
T
P
P
P
Site 44
T444
S
S
S
S
Q
H
H
T
P
P
P
Y
Y
S
R
Site 45
Y448
Q
H
H
T
P
P
P
Y
Y
S
R
P
S
S
H
Site 46
Y449
H
H
T
P
P
P
Y
Y
S
R
P
S
S
H
K
Site 47
S450
H
T
P
P
P
Y
Y
S
R
P
S
S
H
K
D
Site 48
S453
P
P
Y
Y
S
R
P
S
S
H
K
D
L
T
Q
Site 49
S454
P
Y
Y
S
R
P
S
S
H
K
D
L
T
Q
C
Site 50
T459
P
S
S
H
K
D
L
T
Q
C
V
T
C
Q
E
Site 51
T470
T
C
Q
E
K
H
I
T
V
K
K
E
P
H
E
Site 52
S478
V
K
K
E
P
H
E
S
L
G
M
T
V
A
G
Site 53
T482
P
H
E
S
L
G
M
T
V
A
G
G
R
G
S
Site 54
S489
T
V
A
G
G
R
G
S
K
S
G
E
L
P
I
Site 55
S491
A
G
G
R
G
S
K
S
G
E
L
P
I
F
V
Site 56
T528
N
I
N
G
I
D
L
T
N
L
S
H
S
E
A
Site 57
S533
D
L
T
N
L
S
H
S
E
A
V
A
M
L
K
Site 58
S570
Q
N
A
E
E
Q
P
S
T
F
S
E
N
E
Y
Site 59
T571
N
A
E
E
Q
P
S
T
F
S
E
N
E
Y
D
Site 60
Y577
S
T
F
S
E
N
E
Y
D
A
S
W
S
P
S
Site 61
S580
S
E
N
E
Y
D
A
S
W
S
P
S
W
V
M
Site 62
S606
H
D
I
V
L
R
R
S
Y
L
G
S
W
G
F
Site 63
Y607
D
I
V
L
R
R
S
Y
L
G
S
W
G
F
S
Site 64
S614
Y
L
G
S
W
G
F
S
I
V
G
G
Y
E
E
Site 65
T624
G
G
Y
E
E
N
H
T
N
Q
P
F
F
I
K
Site 66
T637
I
K
T
I
V
L
G
T
P
A
Y
Y
D
G
R
Site 67
Y641
V
L
G
T
P
A
Y
Y
D
G
R
L
K
C
G
Site 68
T681
Q
R
N
K
V
T
L
T
V
I
C
W
P
G
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation