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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TXNDC3
Full Name:
Thioredoxin domain-containing protein 3
Alias:
NM23-H8;Spermatid-specific thioredoxin-2
Type:
Mass (Da):
67270
Number AA:
588
UniProt ID:
Q8N427
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
K
R
E
V
Q
L
Q
T
V
I
N
N
Q
S
L
Site 2
T74
A
E
A
D
N
I
V
T
L
Q
P
F
R
D
K
Site 3
Y130
G
E
M
A
R
P
Q
Y
P
E
I
P
L
V
D
Site 4
S138
P
E
I
P
L
V
D
S
D
S
E
V
S
E
E
Site 5
S140
I
P
L
V
D
S
D
S
E
V
S
E
E
S
P
Site 6
S146
D
S
E
V
S
E
E
S
P
C
E
S
V
Q
E
Site 7
S150
S
E
E
S
P
C
E
S
V
Q
E
L
Y
S
I
Site 8
T190
I
I
E
A
E
H
K
T
V
L
T
E
E
Q
V
Site 9
Y201
E
E
Q
V
V
N
F
Y
S
R
I
A
D
Q
C
Site 10
S228
L
S
Y
I
L
V
V
S
Q
G
S
K
H
N
P
Site 11
S237
G
S
K
H
N
P
P
S
E
E
T
E
P
Q
T
Site 12
T246
E
T
E
P
Q
T
D
T
E
P
N
E
R
S
E
Site 13
T263
P
E
V
E
A
Q
V
T
P
G
M
M
K
N
K
Site 14
S273
M
M
K
N
K
Q
D
S
L
Q
E
Y
L
E
R
Site 15
Y277
K
Q
D
S
L
Q
E
Y
L
E
R
Q
H
L
A
Site 16
S312
P
D
F
K
K
M
K
S
M
K
L
E
K
T
L
Site 17
T318
K
S
M
K
L
E
K
T
L
A
L
L
R
P
N
Site 18
S354
E
Q
R
Q
V
V
L
S
E
K
E
A
Q
A
L
Site 19
Y370
K
E
Y
E
N
E
D
Y
F
N
K
L
I
E
N
Site 20
T379
N
K
L
I
E
N
M
T
S
G
P
S
L
A
L
Site 21
Y396
L
R
D
N
G
L
Q
Y
W
K
Q
L
L
G
P
Site 22
T405
K
Q
L
L
G
P
R
T
V
E
E
A
I
E
Y
Site 23
Y432
S
L
P
V
N
Q
L
Y
G
S
D
S
L
E
T
Site 24
S434
P
V
N
Q
L
Y
G
S
D
S
L
E
T
A
E
Site 25
S436
N
Q
L
Y
G
S
D
S
L
E
T
A
E
R
E
Site 26
S463
L
I
K
P
H
A
T
S
E
Q
R
E
Q
I
L
Site 27
T481
K
E
A
G
F
D
L
T
Q
V
K
K
M
F
L
Site 28
T489
Q
V
K
K
M
F
L
T
P
E
Q
I
E
K
I
Site 29
Y497
P
E
Q
I
E
K
I
Y
P
K
V
T
G
K
D
Site 30
Y506
K
V
T
G
K
D
F
Y
K
D
L
L
E
M
L
Site 31
T539
W
R
R
L
M
G
P
T
D
P
E
E
A
K
L
Site 32
S548
P
E
E
A
K
L
L
S
P
D
S
I
R
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation