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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCD3
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3
Alias:
EC 3.1.4.11; Phospholipase C delta 3; PLC delta3
Type:
Membrane, Cytoplasm protein; Enzyme, phospholipid phospholipase
Mass (Da):
89258
Number AA:
789
UniProt ID:
Q8N3E9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004435
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0016042
GO:0006629
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
A
A
P
V
A
L
P
S
P
P
T
P
S
D
G
Site 2
T37
V
A
L
P
S
P
P
T
P
S
D
G
G
T
K
Site 3
S39
L
P
S
P
P
T
P
S
D
G
G
T
K
R
P
Site 4
T43
P
T
P
S
D
G
G
T
K
R
P
G
L
R
A
Site 5
S69
V
R
A
M
L
R
G
S
R
L
R
K
I
R
S
Site 6
S76
S
R
L
R
K
I
R
S
R
T
W
H
K
E
R
Site 7
T78
L
R
K
I
R
S
R
T
W
H
K
E
R
L
Y
Site 8
Y85
T
W
H
K
E
R
L
Y
R
L
Q
E
D
G
L
Site 9
S93
R
L
Q
E
D
G
L
S
V
W
F
Q
R
R
I
Site 10
S105
R
R
I
P
R
A
P
S
Q
H
I
F
F
V
Q
Site 11
S123
A
V
R
E
G
H
Q
S
E
G
L
R
R
F
G
Site 12
T168
Q
R
W
V
R
G
L
T
K
L
R
A
R
L
D
Site 13
S178
R
A
R
L
D
A
M
S
Q
R
E
R
L
D
H
Site 14
Y190
L
D
H
W
I
H
S
Y
L
H
R
A
D
S
N
Site 15
S196
S
Y
L
H
R
A
D
S
N
Q
D
S
K
M
S
Site 16
S200
R
A
D
S
N
Q
D
S
K
M
S
F
K
E
I
Site 17
S203
S
N
Q
D
S
K
M
S
F
K
E
I
K
S
L
Site 18
Y222
N
V
D
M
N
D
M
Y
A
Y
L
L
F
K
E
Site 19
Y224
D
M
N
D
M
Y
A
Y
L
L
F
K
E
C
D
Site 20
S233
L
F
K
E
C
D
H
S
N
N
D
R
L
E
G
Site 21
S271
S
G
E
D
R
V
L
S
A
P
E
L
L
E
F
Site 22
T288
D
Q
G
E
E
G
A
T
L
A
R
A
Q
Q
L
Site 23
T304
Q
T
Y
E
L
N
E
T
A
K
Q
H
E
L
M
Site 24
T331
E
G
A
A
L
D
N
T
H
T
C
V
F
Q
D
Site 25
Y346
M
N
Q
P
L
A
H
Y
F
I
S
S
S
H
N
Site 26
S349
P
L
A
H
Y
F
I
S
S
S
H
N
T
Y
L
Site 27
T354
F
I
S
S
S
H
N
T
Y
L
T
D
S
Q
I
Site 28
Y355
I
S
S
S
H
N
T
Y
L
T
D
S
Q
I
G
Site 29
T357
S
S
H
N
T
Y
L
T
D
S
Q
I
G
G
P
Site 30
S359
H
N
T
Y
L
T
D
S
Q
I
G
G
P
S
S
Site 31
S366
S
Q
I
G
G
P
S
S
T
E
A
Y
V
R
A
Site 32
Y370
G
P
S
S
T
E
A
Y
V
R
A
F
A
Q
G
Site 33
Y396
P
G
G
E
P
V
I
Y
H
G
H
T
L
T
S
Site 34
S461
L
V
T
Q
A
L
D
S
P
N
P
E
E
L
P
Site 35
S469
P
N
P
E
E
L
P
S
P
E
Q
L
K
G
R
Site 36
S489
K
K
L
P
A
A
R
S
E
D
G
R
A
L
S
Site 37
S496
S
E
D
G
R
A
L
S
D
R
E
E
E
E
E
Site 38
S525
R
R
L
A
K
Q
I
S
P
E
L
S
A
L
A
Site 39
T542
C
H
A
T
R
L
R
T
L
H
P
A
P
N
A
Site 40
S557
P
Q
P
C
Q
V
S
S
L
S
E
R
K
A
K
Site 41
S559
P
C
Q
V
S
S
L
S
E
R
K
A
K
K
L
Site 42
S573
L
I
R
E
A
G
N
S
F
V
R
H
N
A
R
Site 43
T583
R
H
N
A
R
Q
L
T
R
V
Y
P
L
G
L
Site 44
Y586
A
R
Q
L
T
R
V
Y
P
L
G
L
R
M
N
Site 45
S594
P
L
G
L
R
M
N
S
A
N
Y
S
P
Q
E
Site 46
S598
R
M
N
S
A
N
Y
S
P
Q
E
M
W
N
S
Site 47
Y619
L
N
F
Q
T
P
G
Y
E
M
D
L
N
A
G
Site 48
S648
A
C
L
R
Q
P
D
S
T
F
D
P
E
Y
P
Site 49
T649
C
L
R
Q
P
D
S
T
F
D
P
E
Y
P
G
Site 50
Y654
D
S
T
F
D
P
E
Y
P
G
P
P
R
T
T
Site 51
T660
E
Y
P
G
P
P
R
T
T
L
S
I
Q
V
L
Site 52
T661
Y
P
G
P
P
R
T
T
L
S
I
Q
V
L
T
Site 53
S663
G
P
P
R
T
T
L
S
I
Q
V
L
T
A
Q
Site 54
S682
L
N
A
E
K
P
H
S
I
V
D
P
L
V
R
Site 55
T704
A
D
C
A
R
Q
E
T
D
Y
V
L
N
N
G
Site 56
Y706
C
A
R
Q
E
T
D
Y
V
L
N
N
G
F
N
Site 57
Y739
V
R
F
V
V
E
D
Y
D
A
T
S
P
N
D
Site 58
S743
V
E
D
Y
D
A
T
S
P
N
D
F
V
G
Q
Site 59
S756
G
Q
F
T
L
P
L
S
S
L
K
Q
G
Y
R
Site 60
S769
Y
R
H
I
H
L
L
S
K
D
G
A
S
L
S
Site 61
S776
S
K
D
G
A
S
L
S
P
A
T
L
F
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation