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Updated November 2019
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Protein Info
Short Name:
EHBP1L1
Full Name:
EH domain-binding protein 1-like protein 1
Alias:
DKFZp762C186; EH domain binding protein 1-like 1; EH1L1; FLJ35431; TANGERIN
Type:
Vesicle protein
Mass (Da):
161854
Number AA:
1523
UniProt ID:
Q8N3D4
International Prot ID:
IPI00296421
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T45
D
K
L
V
V
V
W
T
R
R
N
R
R
I
C
Site 2
S53
R
R
N
R
R
I
C
S
K
A
H
S
W
Q
P
Site 3
Y66
Q
P
G
I
Q
N
P
Y
R
G
T
V
V
W
M
Site 4
S81
V
P
E
N
V
D
I
S
V
T
L
Y
R
D
P
Site 5
T83
E
N
V
D
I
S
V
T
L
Y
R
D
P
H
V
Site 6
Y85
V
D
I
S
V
T
L
Y
R
D
P
H
V
D
Q
Site 7
Y93
R
D
P
H
V
D
Q
Y
E
A
K
E
W
T
F
Site 8
T99
Q
Y
E
A
K
E
W
T
F
I
I
E
N
E
S
Site 9
T115
G
Q
R
K
V
L
A
T
A
E
V
D
L
A
R
Site 10
S141
R
L
R
L
K
P
K
S
V
K
V
V
Q
A
E
Site 11
T164
L
L
R
E
G
R
A
T
D
D
D
M
Q
S
L
Site 12
S170
A
T
D
D
D
M
Q
S
L
A
S
L
M
S
V
Site 13
S173
D
D
M
Q
S
L
A
S
L
M
S
V
K
P
S
Site 14
S176
Q
S
L
A
S
L
M
S
V
K
P
S
D
V
G
Site 15
S180
S
L
M
S
V
K
P
S
D
V
G
N
L
D
D
Site 16
S191
N
L
D
D
F
A
E
S
D
E
D
E
A
H
G
Site 17
S214
R
V
P
Q
P
D
P
S
R
E
L
K
T
L
C
Site 18
T219
D
P
S
R
E
L
K
T
L
C
E
E
E
E
E
Site 19
S237
R
P
Q
Q
A
V
A
S
P
S
N
A
E
D
T
Site 20
S245
P
S
N
A
E
D
T
S
P
A
P
V
S
A
P
Site 21
S250
D
T
S
P
A
P
V
S
A
P
A
P
P
A
R
Site 22
S259
P
A
P
P
A
R
T
S
R
G
Q
G
S
E
R
Site 23
S264
R
T
S
R
G
Q
G
S
E
R
A
N
E
A
G
Site 24
T284
E
A
P
R
P
P
E
T
S
P
E
M
R
S
S
Site 25
S285
A
P
R
P
P
E
T
S
P
E
M
R
S
S
R
Site 26
S290
E
T
S
P
E
M
R
S
S
R
Q
P
A
Q
D
Site 27
S291
T
S
P
E
M
R
S
S
R
Q
P
A
Q
D
T
Site 28
T301
P
A
Q
D
T
A
P
T
P
A
P
R
L
R
K
Site 29
S310
A
P
R
L
R
K
G
S
D
A
L
R
P
P
V
Site 30
S337
A
P
P
A
G
L
G
S
A
R
E
T
Q
A
Q
Site 31
T341
G
L
G
S
A
R
E
T
Q
A
Q
A
C
P
Q
Site 32
S361
H
G
A
R
L
G
P
S
I
E
D
K
G
S
G
Site 33
S367
P
S
I
E
D
K
G
S
G
D
P
F
G
R
Q
Site 34
T383
L
K
A
E
E
M
D
T
E
D
R
P
E
A
S
Site 35
S390
T
E
D
R
P
E
A
S
G
V
D
T
E
P
R
Site 36
T394
P
E
A
S
G
V
D
T
E
P
R
S
G
G
R
Site 37
S398
G
V
D
T
E
P
R
S
G
G
R
E
A
N
T
Site 38
T405
S
G
G
R
E
A
N
T
K
R
S
G
V
R
A
Site 39
S418
R
A
G
E
A
E
E
S
S
A
V
C
Q
V
D
Site 40
T437
S
K
V
R
H
V
D
T
K
G
P
E
A
T
G
Site 41
T443
D
T
K
G
P
E
A
T
G
V
M
P
E
A
R
Site 42
T454
P
E
A
R
C
R
G
T
P
E
A
P
P
R
G
Site 43
S462
P
E
A
P
P
R
G
S
Q
G
R
L
G
V
R
Site 44
T470
Q
G
R
L
G
V
R
T
R
D
E
A
P
S
G
Site 45
S476
R
T
R
D
E
A
P
S
G
L
S
L
P
P
A
Site 46
S479
D
E
A
P
S
G
L
S
L
P
P
A
E
P
A
Site 47
S528
T
G
L
E
Q
G
P
S
V
G
A
I
S
T
R
Site 48
S533
G
P
S
V
G
A
I
S
T
R
P
Q
V
S
S
Site 49
T534
P
S
V
G
A
I
S
T
R
P
Q
V
S
S
W
Site 50
S540
S
T
R
P
Q
V
S
S
W
Q
G
A
L
L
S
Site 51
S554
S
T
A
Q
G
A
I
S
R
G
L
G
G
W
E
Site 52
S567
W
E
A
E
A
G
G
S
G
D
L
E
T
E
T
Site 53
T572
G
G
S
G
D
L
E
T
E
T
E
V
V
G
L
Site 54
T574
S
G
D
L
E
T
E
T
E
V
V
G
L
E
V
Site 55
T584
V
G
L
E
V
L
G
T
Q
E
K
E
V
E
G
Site 56
S592
Q
E
K
E
V
E
G
S
G
F
P
E
T
R
T
Site 57
T599
S
G
F
P
E
T
R
T
L
E
I
E
I
L
G
Site 58
S615
L
E
K
E
A
A
R
S
R
V
L
E
S
E
V
Site 59
S620
A
R
S
R
V
L
E
S
E
V
A
G
T
A
Q
Site 60
T625
L
E
S
E
V
A
G
T
A
Q
C
E
G
L
E
Site 61
T633
A
Q
C
E
G
L
E
T
Q
E
T
E
V
G
V
Site 62
T636
E
G
L
E
T
Q
E
T
E
V
G
V
I
E
T
Site 63
T643
T
E
V
G
V
I
E
T
P
G
T
E
T
E
V
Site 64
T653
T
E
T
E
V
L
G
T
Q
K
T
E
A
G
G
Site 65
T656
E
V
L
G
T
Q
K
T
E
A
G
G
S
G
V
Site 66
T693
G
P
L
K
I
E
D
T
I
Q
S
E
M
L
G
Site 67
S696
K
I
E
D
T
I
Q
S
E
M
L
G
T
Q
E
Site 68
T701
I
Q
S
E
M
L
G
T
Q
E
T
E
V
E
A
Site 69
S709
Q
E
T
E
V
E
A
S
R
V
P
E
S
E
A
Site 70
S714
E
A
S
R
V
P
E
S
E
A
E
G
T
E
A
Site 71
T719
P
E
S
E
A
E
G
T
E
A
K
I
L
G
T
Site 72
T730
I
L
G
T
Q
E
I
T
A
R
D
S
G
V
R
Site 73
S734
Q
E
I
T
A
R
D
S
G
V
R
E
I
E
A
Site 74
S781
L
G
T
Q
E
I
A
S
R
D
S
G
V
P
G
Site 75
S784
Q
E
I
A
S
R
D
S
G
V
P
G
L
E
A
Site 76
T794
P
G
L
E
A
D
T
T
G
I
Q
V
K
E
V
Site 77
S804
Q
V
K
E
V
G
G
S
E
V
P
E
I
A
T
Site 78
T821
A
E
T
E
I
L
G
T
Q
E
I
A
S
R
S
Site 79
S826
L
G
T
Q
E
I
A
S
R
S
S
G
V
P
G
Site 80
S829
Q
E
I
A
S
R
S
S
G
V
P
G
L
E
S
Site 81
S836
S
G
V
P
G
L
E
S
E
V
A
G
A
Q
E
Site 82
S849
Q
E
T
E
V
G
G
S
G
I
S
G
P
E
A
Site 83
T866
A
E
A
R
V
L
M
T
R
K
T
E
I
I
V
Site 84
T869
R
V
L
M
T
R
K
T
E
I
I
V
P
E
A
Site 85
S884
E
K
E
E
A
Q
T
S
G
V
Q
E
A
E
T
Site 86
T891
S
G
V
Q
E
A
E
T
R
V
G
S
A
L
K
Site 87
S895
E
A
E
T
R
V
G
S
A
L
K
Y
E
A
L
Site 88
Y899
R
V
G
S
A
L
K
Y
E
A
L
R
A
P
V
Site 89
T907
E
A
L
R
A
P
V
T
Q
P
R
V
L
G
S
Site 90
S914
T
Q
P
R
V
L
G
S
Q
E
A
K
A
E
I
Site 91
S922
Q
E
A
K
A
E
I
S
G
V
Q
G
S
E
T
Site 92
S927
E
I
S
G
V
Q
G
S
E
T
Q
V
L
R
V
Site 93
T929
S
G
V
Q
G
S
E
T
Q
V
L
R
V
Q
E
Site 94
S945
E
A
G
V
W
G
M
S
E
G
K
S
G
A
W
Site 95
S949
W
G
M
S
E
G
K
S
G
A
W
G
A
Q
E
Site 96
S964
A
E
M
K
V
L
E
S
P
E
N
K
S
G
T
Site 97
S993
K
G
K
E
A
E
G
S
L
T
E
A
S
L
P
Site 98
T995
K
E
A
E
G
S
L
T
E
A
S
L
P
E
A
Site 99
S998
E
G
S
L
T
E
A
S
L
P
E
A
Q
V
A
Site 100
S1016
G
A
G
A
P
R
A
S
S
P
E
K
A
E
E
Site 101
S1017
A
G
A
P
R
A
S
S
P
E
K
A
E
E
D
Site 102
S1030
E
D
R
R
L
P
G
S
Q
A
P
P
A
L
V
Site 103
S1038
Q
A
P
P
A
L
V
S
S
S
Q
S
L
L
E
Site 104
S1042
A
L
V
S
S
S
Q
S
L
L
E
W
C
Q
E
Site 105
T1063
G
V
R
I
T
N
F
T
T
S
W
R
N
G
L
Site 106
Y1080
C
A
I
L
H
R
F
Y
P
D
K
I
D
Y
A
Site 107
Y1086
F
Y
P
D
K
I
D
Y
A
S
L
D
P
L
N
Site 108
S1088
P
D
K
I
D
Y
A
S
L
D
P
L
N
I
K
Site 109
S1123
P
A
D
M
V
L
L
S
V
P
D
K
L
I
V
Site 110
T1159
E
G
G
G
G
A
G
T
Y
R
V
G
S
A
Q
Site 111
Y1160
G
G
G
G
A
G
T
Y
R
V
G
S
A
Q
P
Site 112
S1164
A
G
T
Y
R
V
G
S
A
Q
P
S
P
P
D
Site 113
S1168
R
V
G
S
A
Q
P
S
P
P
D
D
L
D
A
Site 114
S1218
N
A
V
A
G
R
A
S
K
D
G
G
A
E
A
Site 115
S1229
G
A
E
A
P
R
E
S
R
P
A
E
V
P
A
Site 116
S1257
G
V
R
L
R
R
P
S
V
N
G
E
P
G
S
Site 117
S1264
S
V
N
G
E
P
G
S
V
P
P
P
R
A
H
Site 118
S1273
P
P
P
R
A
H
G
S
F
S
H
V
R
D
A
Site 119
S1275
P
R
A
H
G
S
F
S
H
V
R
D
A
D
L
Site 120
S1288
D
L
L
K
K
R
R
S
R
L
R
N
S
S
S
Site 121
S1293
R
R
S
R
L
R
N
S
S
S
F
S
M
D
D
Site 122
S1294
R
S
R
L
R
N
S
S
S
F
S
M
D
D
P
Site 123
S1295
S
R
L
R
N
S
S
S
F
S
M
D
D
P
D
Site 124
S1297
L
R
N
S
S
S
F
S
M
D
D
P
D
A
G
Site 125
S1319
E
G
Q
A
P
D
P
S
P
A
P
G
P
P
T
Site 126
T1326
S
P
A
P
G
P
P
T
A
A
D
S
Q
Q
P
Site 127
S1330
G
P
P
T
A
A
D
S
Q
Q
P
P
G
G
S
Site 128
S1338
Q
Q
P
P
G
G
S
S
P
S
E
E
P
P
P
Site 129
S1340
P
P
G
G
S
S
P
S
E
E
P
P
P
S
P
Site 130
S1346
P
S
E
E
P
P
P
S
P
G
E
E
A
G
L
Site 131
S1360
L
Q
R
F
Q
D
T
S
Q
Y
V
C
A
E
L
Site 132
Y1362
R
F
Q
D
T
S
Q
Y
V
C
A
E
L
Q
A
Site 133
S1390
E
V
E
M
Q
L
R
S
L
M
E
S
G
A
N
Site 134
S1394
Q
L
R
S
L
M
E
S
G
A
N
K
L
Q
E
Site 135
S1442
E
R
R
F
E
L
L
S
R
E
L
R
A
M
L
Site 136
S1473
L
L
L
E
E
L
V
S
L
V
N
Q
R
D
E
Site 137
S1511
E
Q
R
R
R
K
L
S
R
Q
L
S
R
R
E
Site 138
S1515
E
Q
R
R
R
K
L
S
R
Q
L
S
R
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation