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Updated November 2019
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Protein Info
Short Name:
ASCC3
Full Name:
Activating signal cointegrator 1 complex subunit 3
Alias:
ASC-1 complex subunit p200; ASC1p200; DJ121G13.4; DJ467N11.1; HELC1; HELIC1; Helicase, ATP binding 1; RNA helicase family; RNAH; Trip4 complex subunit p200
Type:
EC 3.6.1.-; Transcription, coactivator/corepressor; Helicase
Mass (Da):
251460
Number AA:
2202
UniProt ID:
Q8N3C0
International Prot ID:
IPI00430472
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005737
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
R
L
T
G
A
L
R
S
F
S
N
V
T
K
Q
Site 2
S14
T
G
A
L
R
S
F
S
N
V
T
K
Q
D
N
Site 3
Y22
N
V
T
K
Q
D
N
Y
N
E
E
V
A
D
L
Site 4
S61
L
N
E
K
L
E
K
S
K
M
Q
S
I
N
E
Site 5
S65
L
E
K
S
K
M
Q
S
I
N
E
D
L
K
D
Site 6
S106
M
T
F
H
L
K
D
S
V
G
H
K
E
T
K
Site 7
T128
P
F
P
S
S
S
A
T
A
A
C
N
A
T
N
Site 8
S139
N
A
T
N
R
I
I
S
H
F
S
Q
D
D
L
Site 9
S142
N
R
I
I
S
H
F
S
Q
D
D
L
T
A
L
Site 10
T147
H
F
S
Q
D
D
L
T
A
L
V
Q
M
T
E
Site 11
S170
F
G
K
N
L
A
F
S
F
D
M
H
D
L
D
Site 12
T191
I
N
G
E
T
Q
K
T
I
S
L
D
Y
K
K
Site 13
Y196
Q
K
T
I
S
L
D
Y
K
K
F
L
N
E
H
Site 14
T209
E
H
L
Q
E
A
C
T
P
E
L
K
P
V
E
Site 15
T218
E
L
K
P
V
E
K
T
N
G
S
F
L
W
C
Site 16
S221
P
V
E
K
T
N
G
S
F
L
W
C
E
V
E
Site 17
Y230
L
W
C
E
V
E
K
Y
L
N
S
T
L
K
E
Site 18
S260
D
M
L
A
S
I
K
S
G
D
E
L
Q
D
E
Site 19
T289
K
L
L
Q
N
R
I
T
I
V
D
R
F
L
N
Site 20
S297
I
V
D
R
F
L
N
S
S
N
D
H
R
F
Q
Site 21
S298
V
D
R
F
L
N
S
S
N
D
H
R
F
Q
A
Site 22
Y322
G
E
N
A
K
P
N
Y
G
C
Q
V
T
I
Q
Site 23
S385
Q
A
L
L
N
A
R
S
V
P
I
L
S
R
Q
Site 24
S390
A
R
S
V
P
I
L
S
R
Q
R
D
A
D
V
Site 25
Y402
A
D
V
E
K
I
H
Y
P
H
V
Y
D
S
Q
Site 26
Y406
K
I
H
Y
P
H
V
Y
D
S
Q
A
E
A
M
Site 27
Y438
Q
R
E
N
N
K
L
Y
E
E
V
R
I
P
Y
Site 28
Y445
Y
E
E
V
R
I
P
Y
S
E
P
M
P
L
S
Site 29
S446
E
E
V
R
I
P
Y
S
E
P
M
P
L
S
F
Site 30
S452
Y
S
E
P
M
P
L
S
F
E
E
K
P
V
Y
Site 31
Y459
S
F
E
E
K
P
V
Y
I
Q
D
L
D
E
I
Site 32
S482
K
R
L
N
R
I
Q
S
I
V
F
E
T
A
Y
Site 33
Y489
S
I
V
F
E
T
A
Y
N
T
N
E
N
M
L
Site 34
T547
K
A
L
A
A
E
M
T
D
Y
F
S
R
R
L
Site 35
Y549
L
A
A
E
M
T
D
Y
F
S
R
R
L
E
P
Site 36
S551
A
E
M
T
D
Y
F
S
R
R
L
E
P
L
G
Site 37
S571
L
T
G
D
M
Q
L
S
K
S
E
I
L
R
T
Site 38
S573
G
D
M
Q
L
S
K
S
E
I
L
R
T
Q
M
Site 39
T578
S
K
S
E
I
L
R
T
Q
M
L
V
T
T
P
Site 40
T584
R
T
Q
M
L
V
T
T
P
E
K
W
D
V
V
Site 41
T592
P
E
K
W
D
V
V
T
R
K
S
V
G
D
V
Site 42
S595
W
D
V
V
T
R
K
S
V
G
D
V
A
L
S
Site 43
S626
D
R
G
P
V
L
E
S
I
V
A
R
T
L
R
Site 44
S637
R
T
L
R
Q
V
E
S
T
Q
S
M
I
R
I
Site 45
T638
T
L
R
Q
V
E
S
T
Q
S
M
I
R
I
L
Site 46
S640
R
Q
V
E
S
T
Q
S
M
I
R
I
L
G
L
Site 47
T659
P
N
Y
L
D
V
A
T
F
L
H
V
N
P
Y
Site 48
Y705
N
N
M
D
E
V
C
Y
E
N
V
L
K
Q
V
Site 49
Y756
F
P
T
Q
G
H
D
Y
V
L
A
E
K
Q
V
Site 50
Y831
I
I
K
G
T
Q
I
Y
A
A
K
R
G
S
F
Site 51
T868
F
G
E
G
I
I
I
T
T
H
D
K
L
S
H
Site 52
T869
G
E
G
I
I
I
T
T
H
D
K
L
S
H
Y
Site 53
S874
I
T
T
H
D
K
L
S
H
Y
L
T
L
L
T
Site 54
Y876
T
H
D
K
L
S
H
Y
L
T
L
L
T
Q
R
Site 55
T878
D
K
L
S
H
Y
L
T
L
L
T
Q
R
N
P
Site 56
T881
S
H
Y
L
T
L
L
T
Q
R
N
P
I
E
S
Site 57
S888
T
Q
R
N
P
I
E
S
Q
F
L
E
S
L
A
Site 58
S893
I
E
S
Q
F
L
E
S
L
A
D
N
L
N
A
Site 59
Y919
E
A
V
K
W
I
S
Y
T
Y
L
Y
V
R
M
Site 60
Y921
V
K
W
I
S
Y
T
Y
L
Y
V
R
M
R
A
Site 61
Y923
W
I
S
Y
T
Y
L
Y
V
R
M
R
A
N
P
Site 62
Y940
Y
G
I
S
H
K
A
Y
Q
I
D
P
T
L
R
Site 63
T945
K
A
Y
Q
I
D
P
T
L
R
K
H
R
E
Q
Site 64
T973
M
I
R
F
E
E
R
T
G
Y
F
S
S
T
D
Site 65
Y975
R
F
E
E
R
T
G
Y
F
S
S
T
D
L
G
Site 66
S977
E
E
R
T
G
Y
F
S
S
T
D
L
G
R
T
Site 67
S978
E
R
T
G
Y
F
S
S
T
D
L
G
R
T
A
Site 68
T979
R
T
G
Y
F
S
S
T
D
L
G
R
T
A
S
Site 69
Y988
L
G
R
T
A
S
H
Y
Y
I
K
Y
N
T
I
Site 70
Y992
A
S
H
Y
Y
I
K
Y
N
T
I
E
T
F
N
Site 71
T997
I
K
Y
N
T
I
E
T
F
N
E
L
F
D
A
Site 72
S1016
G
D
I
F
A
I
V
S
K
A
E
E
F
D
Q
Site 73
T1036
E
E
I
E
E
L
D
T
L
L
S
N
F
C
E
Site 74
S1039
E
E
L
D
T
L
L
S
N
F
C
E
L
S
T
Site 75
S1045
L
S
N
F
C
E
L
S
T
P
G
G
V
E
N
Site 76
T1046
S
N
F
C
E
L
S
T
P
G
G
V
E
N
S
Site 77
S1053
T
P
G
G
V
E
N
S
Y
G
K
I
N
I
L
Site 78
Y1054
P
G
G
V
E
N
S
Y
G
K
I
N
I
L
L
Site 79
Y1064
I
N
I
L
L
Q
T
Y
I
S
R
G
E
M
D
Site 80
S1072
I
S
R
G
E
M
D
S
F
S
L
I
S
D
S
Site 81
S1074
R
G
E
M
D
S
F
S
L
I
S
D
S
A
Y
Site 82
Y1081
S
L
I
S
D
S
A
Y
V
A
Q
N
A
A
R
Site 83
T1104
A
L
R
K
R
W
P
T
M
T
Y
R
L
L
N
Site 84
T1106
R
K
R
W
P
T
M
T
Y
R
L
L
N
L
S
Site 85
S1113
T
Y
R
L
L
N
L
S
K
V
I
D
K
R
L
Site 86
S1125
K
R
L
W
G
W
A
S
P
L
R
Q
F
S
I
Site 87
S1131
A
S
P
L
R
Q
F
S
I
L
P
P
H
I
L
Site 88
T1147
R
L
E
E
K
K
L
T
V
D
K
L
K
D
M
Site 89
S1187
P
S
V
M
M
E
A
S
I
Q
P
I
T
R
T
Site 90
Y1233
D
P
T
N
D
H
I
Y
H
S
E
Y
F
L
A
Site 91
Y1237
D
H
I
Y
H
S
E
Y
F
L
A
L
K
K
Q
Site 92
Y1268
E
P
L
P
S
Q
Y
Y
I
R
A
V
S
D
R
Site 93
S1273
Q
Y
Y
I
R
A
V
S
D
R
W
L
G
A
E
Site 94
T1300
P
E
R
H
P
P
H
T
E
L
L
D
L
Q
P
Site 95
Y1322
C
K
A
Y
E
A
L
Y
N
F
S
H
F
N
P
Site 96
Y1370
I
F
R
V
F
N
K
Y
P
T
S
K
A
V
Y
Site 97
T1408
G
K
K
V
I
E
L
T
G
D
V
T
P
D
M
Site 98
S1417
D
V
T
P
D
M
K
S
I
A
K
A
D
L
I
Site 99
T1427
K
A
D
L
I
V
T
T
P
E
K
W
D
G
V
Site 100
Y1443
R
S
W
Q
N
R
N
Y
V
Q
Q
V
T
I
L
Site 101
S1477
V
S
R
T
N
F
I
S
S
H
T
E
K
P
V
Site 102
S1478
S
R
T
N
F
I
S
S
H
T
E
K
P
V
R
Site 103
T1480
T
N
F
I
S
S
H
T
E
K
P
V
R
I
V
Site 104
S1490
P
V
R
I
V
G
L
S
T
A
L
A
N
A
R
Site 105
S1516
G
L
F
N
F
R
P
S
V
R
P
V
P
L
E
Site 106
Y1534
Q
G
F
P
G
Q
H
Y
C
P
R
M
A
S
M
Site 107
S1551
P
A
F
Q
A
I
R
S
H
S
P
A
K
P
V
Site 108
S1553
F
Q
A
I
R
S
H
S
P
A
K
P
V
L
I
Site 109
S1563
K
P
V
L
I
F
V
S
S
R
R
Q
T
R
L
Site 110
S1564
P
V
L
I
F
V
S
S
R
R
Q
T
R
L
T
Site 111
T1568
F
V
S
S
R
R
Q
T
R
L
T
A
L
E
L
Site 112
T1571
S
R
R
Q
T
R
L
T
A
L
E
L
I
A
F
Site 113
T1602
E
M
E
N
I
I
A
T
V
R
D
S
N
L
K
Site 114
T1630
L
H
E
R
D
R
K
T
V
E
E
L
F
V
N
Site 115
Y1667
V
I
I
K
G
T
E
Y
Y
D
G
K
T
R
R
Site 116
T1672
T
E
Y
Y
D
G
K
T
R
R
Y
V
D
F
P
Site 117
Y1675
Y
D
G
K
T
R
R
Y
V
D
F
P
I
T
D
Site 118
Y1713
H
D
I
K
K
D
F
Y
K
K
F
L
Y
E
P
Site 119
Y1718
D
F
Y
K
K
F
L
Y
E
P
F
P
V
E
S
Site 120
S1746
I
A
G
G
T
I
T
S
K
Q
D
A
L
D
Y
Site 121
Y1753
S
K
Q
D
A
L
D
Y
I
T
W
T
Y
F
F
Site 122
S1768
R
R
L
I
M
N
P
S
Y
Y
N
L
G
D
V
Site 123
Y1769
R
L
I
M
N
P
S
Y
Y
N
L
G
D
V
S
Site 124
Y1770
L
I
M
N
P
S
Y
Y
N
L
G
D
V
S
H
Site 125
S1779
L
G
D
V
S
H
D
S
V
N
K
F
L
S
H
Site 126
S1785
D
S
V
N
K
F
L
S
H
L
I
E
K
S
L
Site 127
S1809
E
I
G
E
D
N
R
S
I
E
P
L
T
Y
G
Site 128
T1814
N
R
S
I
E
P
L
T
Y
G
R
I
A
S
Y
Site 129
Y1815
R
S
I
E
P
L
T
Y
G
R
I
A
S
Y
Y
Site 130
Y1822
Y
G
R
I
A
S
Y
Y
Y
L
K
H
Q
T
V
Site 131
Y1823
G
R
I
A
S
Y
Y
Y
L
K
H
Q
T
V
K
Site 132
S1841
D
R
L
K
P
E
C
S
T
E
E
L
L
S
I
Site 133
S1847
C
S
T
E
E
L
L
S
I
L
S
D
A
E
E
Site 134
S1850
E
E
L
L
S
I
L
S
D
A
E
E
Y
T
D
Site 135
T1856
L
S
D
A
E
E
Y
T
D
L
P
V
R
H
N
Site 136
S1879
A
K
C
L
P
I
E
S
N
P
H
S
F
D
S
Site 137
S1883
P
I
E
S
N
P
H
S
F
D
S
P
H
T
K
Site 138
S1886
S
N
P
H
S
F
D
S
P
H
T
K
A
H
L
Site 139
Y1909
A
M
L
P
C
P
D
Y
D
T
D
T
K
T
V
Site 140
T1911
L
P
C
P
D
Y
D
T
D
T
K
T
V
L
D
Site 141
T1913
C
P
D
Y
D
T
D
T
K
T
V
L
D
Q
A
Site 142
T1915
D
Y
D
T
D
T
K
T
V
L
D
Q
A
L
R
Site 143
S1959
Q
G
R
W
L
K
D
S
S
L
L
T
L
P
N
Site 144
S1960
G
R
W
L
K
D
S
S
L
L
T
L
P
N
I
Site 145
T1963
L
K
D
S
S
L
L
T
L
P
N
I
E
N
H
Site 146
T1991
G
P
H
A
R
G
R
T
S
I
E
S
L
P
E
Site 147
S1992
P
H
A
R
G
R
T
S
I
E
S
L
P
E
L
Site 148
S1995
R
G
R
T
S
I
E
S
L
P
E
L
I
H
A
Site 149
S2011
G
G
K
D
H
V
F
S
S
M
V
E
S
E
L
Site 150
S2012
G
K
D
H
V
F
S
S
M
V
E
S
E
L
H
Site 151
T2023
S
E
L
H
A
A
K
T
K
Q
A
W
N
F
L
Site 152
S2057
V
E
G
H
N
E
L
S
V
S
T
L
T
A
D
Site 153
S2059
G
H
N
E
L
S
V
S
T
L
T
A
D
K
R
Site 154
Y2080
K
L
H
A
D
Q
E
Y
V
L
Q
V
S
L
Q
Site 155
S2085
Q
E
Y
V
L
Q
V
S
L
Q
R
V
H
F
G
Site 156
S2100
F
H
K
G
K
P
E
S
C
A
V
T
P
R
F
Site 157
T2104
K
P
E
S
C
A
V
T
P
R
F
P
K
S
K
Site 158
S2110
V
T
P
R
F
P
K
S
K
D
E
G
W
F
L
Site 159
Y2135
I
A
L
K
R
V
G
Y
I
R
N
H
H
V
A
Site 160
S2143
I
R
N
H
H
V
A
S
L
S
F
Y
T
P
E
Site 161
S2145
N
H
H
V
A
S
L
S
F
Y
T
P
E
I
P
Site 162
Y2147
H
V
A
S
L
S
F
Y
T
P
E
I
P
G
R
Site 163
T2148
V
A
S
L
S
F
Y
T
P
E
I
P
G
R
Y
Site 164
Y2157
E
I
P
G
R
Y
I
Y
T
L
Y
F
M
S
D
Site 165
Y2166
L
Y
F
M
S
D
C
Y
L
G
L
D
Q
Q
Y
Site 166
Y2173
Y
L
G
L
D
Q
Q
Y
D
I
Y
L
N
V
T
Site 167
Y2176
L
D
Q
Q
Y
D
I
Y
L
N
V
T
Q
A
S
Site 168
S2185
N
V
T
Q
A
S
L
S
A
Q
V
N
T
K
V
Site 169
S2195
V
N
T
K
V
S
D
S
L
T
D
L
A
L
K
Site 170
T2197
T
K
V
S
D
S
L
T
D
L
A
L
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation