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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARP8
Full Name:
Poly [ADP-ribose] polymerase 8
Alias:
EC 2.4.2.30; FLJ21308; MGC42864; Poly (ADP-ribose) polymerase family, member 8
Type:
Mass (Da):
95871
Number AA:
854
UniProt ID:
Q8N3A8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0003950
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
G
M
C
S
R
Q
E
R
I
Q
K
Site 2
S35
L
F
A
D
F
R
Y
S
D
S
T
F
T
F
T
Site 3
S37
A
D
F
R
Y
S
D
S
T
F
T
F
T
Y
V
Site 4
T38
D
F
R
Y
S
D
S
T
F
T
F
T
Y
V
G
Site 5
T40
R
Y
S
D
S
T
F
T
F
T
Y
V
G
G
P
Site 6
T42
S
D
S
T
F
T
F
T
Y
V
G
G
P
R
S
Site 7
Y43
D
S
T
F
T
F
T
Y
V
G
G
P
R
S
V
Site 8
S49
T
Y
V
G
G
P
R
S
V
S
Y
S
V
H
V
Site 9
S51
V
G
G
P
R
S
V
S
Y
S
V
H
V
S
E
Site 10
Y52
G
G
P
R
S
V
S
Y
S
V
H
V
S
E
D
Site 11
S53
G
P
R
S
V
S
Y
S
V
H
V
S
E
D
Y
Site 12
S57
V
S
Y
S
V
H
V
S
E
D
Y
P
D
N
T
Site 13
Y60
S
V
H
V
S
E
D
Y
P
D
N
T
Y
V
S
Site 14
T64
S
E
D
Y
P
D
N
T
Y
V
S
S
S
E
N
Site 15
Y65
E
D
Y
P
D
N
T
Y
V
S
S
S
E
N
D
Site 16
S69
D
N
T
Y
V
S
S
S
E
N
D
E
D
V
L
Site 17
T91
V
I
F
H
R
I
A
T
E
L
R
K
T
N
D
Site 18
T96
I
A
T
E
L
R
K
T
N
D
I
N
C
C
L
Site 19
S104
N
D
I
N
C
C
L
S
I
K
S
K
L
Q
K
Site 20
S107
N
C
C
L
S
I
K
S
K
L
Q
K
E
N
G
Site 21
S121
G
E
E
S
R
Q
N
S
T
V
E
E
D
S
E
Site 22
T122
E
E
S
R
Q
N
S
T
V
E
E
D
S
E
G
Site 23
S127
N
S
T
V
E
E
D
S
E
G
D
N
D
S
E
Site 24
S133
D
S
E
G
D
N
D
S
E
E
F
Y
Y
G
G
Site 25
Y137
D
N
D
S
E
E
F
Y
Y
G
G
Q
V
N
Y
Site 26
Y138
N
D
S
E
E
F
Y
Y
G
G
Q
V
N
Y
D
Site 27
S159
P
Q
L
E
A
D
L
S
A
V
R
E
I
Y
G
Site 28
Y175
H
A
V
S
L
R
E
Y
G
A
I
D
D
V
D
Site 29
Y219
L
H
C
S
L
T
Q
Y
L
N
G
P
V
P
T
Site 30
T226
Y
L
N
G
P
V
P
T
V
D
V
F
Q
I
S
Site 31
T234
V
D
V
F
Q
I
S
T
K
E
R
F
G
L
G
Site 32
S278
L
S
E
K
K
V
K
S
P
L
H
L
F
S
T
Site 33
S284
K
S
P
L
H
L
F
S
T
L
R
R
S
P
S
Site 34
T285
S
P
L
H
L
F
S
T
L
R
R
S
P
S
Y
Site 35
S289
L
F
S
T
L
R
R
S
P
S
Y
P
P
P
G
Site 36
S291
S
T
L
R
R
S
P
S
Y
P
P
P
G
C
G
Site 37
Y292
T
L
R
R
S
P
S
Y
P
P
P
G
C
G
K
Site 38
S300
P
P
P
G
C
G
K
S
K
S
K
L
K
S
E
Site 39
S302
P
G
C
G
K
S
K
S
K
L
K
S
E
Q
D
Site 40
S306
K
S
K
S
K
L
K
S
E
Q
D
G
I
S
K
Site 41
S312
K
S
E
Q
D
G
I
S
K
T
H
K
L
L
R
Site 42
T321
T
H
K
L
L
R
R
T
C
S
S
T
V
K
T
Site 43
S323
K
L
L
R
R
T
C
S
S
T
V
K
T
D
D
Site 44
S324
L
L
R
R
T
C
S
S
T
V
K
T
D
D
V
Site 45
T325
L
R
R
T
C
S
S
T
V
K
T
D
D
V
C
Site 46
T328
T
C
S
S
T
V
K
T
D
D
V
C
V
T
K
Site 47
S336
D
D
V
C
V
T
K
S
H
R
T
F
G
R
S
Site 48
T339
C
V
T
K
S
H
R
T
F
G
R
S
L
S
S
Site 49
S343
S
H
R
T
F
G
R
S
L
S
S
D
P
R
A
Site 50
S345
R
T
F
G
R
S
L
S
S
D
P
R
A
E
Q
Site 51
S346
T
F
G
R
S
L
S
S
D
P
R
A
E
Q
A
Site 52
T355
P
R
A
E
Q
A
M
T
A
I
K
S
H
K
L
Site 53
S359
Q
A
M
T
A
I
K
S
H
K
L
L
N
R
P
Site 54
S373
P
C
P
A
A
V
K
S
E
E
C
L
T
L
K
Site 55
T378
V
K
S
E
E
C
L
T
L
K
S
H
R
L
L
Site 56
S381
E
E
C
L
T
L
K
S
H
R
L
L
T
R
S
Site 57
T386
L
K
S
H
R
L
L
T
R
S
C
S
G
D
P
Site 58
S388
S
H
R
L
L
T
R
S
C
S
G
D
P
R
C
Site 59
S390
R
L
L
T
R
S
C
S
G
D
P
R
C
E
H
Site 60
T399
D
P
R
C
E
H
N
T
N
L
K
P
H
K
L
Site 61
S408
L
K
P
H
K
L
L
S
R
S
Y
S
S
N
L
Site 62
S410
P
H
K
L
L
S
R
S
Y
S
S
N
L
R
M
Site 63
S412
K
L
L
S
R
S
Y
S
S
N
L
R
M
E
E
Site 64
Y421
N
L
R
M
E
E
L
Y
G
L
K
N
H
K
L
Site 65
S430
L
K
N
H
K
L
L
S
K
S
Y
S
S
A
P
Site 66
S432
N
H
K
L
L
S
K
S
Y
S
S
A
P
K
S
Site 67
S434
K
L
L
S
K
S
Y
S
S
A
P
K
S
S
K
Site 68
S435
L
L
S
K
S
Y
S
S
A
P
K
S
S
K
T
Site 69
S439
S
Y
S
S
A
P
K
S
S
K
T
E
L
F
K
Site 70
S456
N
A
E
G
R
R
L
S
L
T
S
G
L
I
G
Site 71
S470
G
I
L
T
P
S
S
S
S
S
S
Q
L
A
P
Site 72
S472
L
T
P
S
S
S
S
S
S
Q
L
A
P
N
G
Site 73
S473
T
P
S
S
S
S
S
S
Q
L
A
P
N
G
A
Site 74
T527
N
G
P
M
L
R
P
T
V
C
E
R
E
L
C
Site 75
S567
L
L
V
S
M
C
R
S
A
L
E
S
P
R
K
Site 76
S583
V
I
F
E
P
Y
P
S
V
V
D
P
N
D
P
Site 77
Y602
F
N
P
R
K
K
N
Y
D
R
V
M
K
A
L
Site 78
S611
R
V
M
K
A
L
D
S
I
T
S
I
R
E
M
Site 79
S614
K
A
L
D
S
I
T
S
I
R
E
M
T
Q
A
Site 80
T619
I
T
S
I
R
E
M
T
Q
A
P
Y
L
E
I
Site 81
Y623
R
E
M
T
Q
A
P
Y
L
E
I
K
K
Q
M
Site 82
S650
W
V
I
S
S
N
R
S
H
I
V
K
L
P
V
Site 83
T666
R
Q
L
K
F
M
H
T
P
H
Q
F
L
L
L
Site 84
S674
P
H
Q
F
L
L
L
S
S
P
P
A
K
E
S
Site 85
S675
H
Q
F
L
L
L
S
S
P
P
A
K
E
S
N
Site 86
S681
S
S
P
P
A
K
E
S
N
F
R
A
A
K
K
Site 87
S692
A
A
K
K
L
F
G
S
T
F
A
F
H
G
S
Site 88
T693
A
K
K
L
F
G
S
T
F
A
F
H
G
S
H
Site 89
S740
L
S
P
M
S
S
I
S
F
G
Y
S
G
M
N
Site 90
S744
S
S
I
S
F
G
Y
S
G
M
N
K
K
Q
K
Site 91
S760
S
A
K
D
E
P
A
S
S
S
K
S
S
N
T
Site 92
S761
A
K
D
E
P
A
S
S
S
K
S
S
N
T
S
Site 93
S762
K
D
E
P
A
S
S
S
K
S
S
N
T
S
Q
Site 94
S764
E
P
A
S
S
S
K
S
S
N
T
S
Q
S
Q
Site 95
S765
P
A
S
S
S
K
S
S
N
T
S
Q
S
Q
K
Site 96
T767
S
S
S
K
S
S
N
T
S
Q
S
Q
K
K
G
Site 97
S768
S
S
K
S
S
N
T
S
Q
S
Q
K
K
G
Q
Site 98
S770
K
S
S
N
T
S
Q
S
Q
K
K
G
Q
Q
S
Site 99
S777
S
Q
K
K
G
Q
Q
S
Q
F
L
Q
S
R
N
Site 100
S797
L
C
E
V
I
T
S
S
D
L
H
K
H
G
E
Site 101
Y822
C
T
R
F
F
F
V
Y
E
D
G
Q
V
G
D
Site 102
T834
V
G
D
A
N
I
N
T
Q
E
G
G
I
H
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation