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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP18
Full Name:
Rho GTPase-activating protein 18
Alias:
BA307O14.2; MacGAP; RHG18; Rho GTPase activating protein 18; Rho-type GTPase-activating protein 18
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
74947
Number AA:
663
UniProt ID:
Q8N392
International Prot ID:
IPI00296353
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
S
S
Q
G
V
V
L
T
A
Y
H
P
S
G
K
Site 2
Y15
Q
G
V
V
L
T
A
Y
H
P
S
G
K
D
Q
Site 3
S37
K
A
G
E
E
A
T
S
S
R
R
Y
G
Q
Y
Site 4
S38
A
G
E
E
A
T
S
S
R
R
Y
G
Q
Y
T
Site 5
Y41
E
A
T
S
S
R
R
Y
G
Q
Y
T
M
N
Q
Site 6
Y44
S
S
R
R
Y
G
Q
Y
T
M
N
Q
E
S
T
Site 7
T45
S
R
R
Y
G
Q
Y
T
M
N
Q
E
S
T
T
Site 8
S64
E
K
P
P
F
D
R
S
I
S
Q
D
S
L
D
Site 9
S66
P
P
F
D
R
S
I
S
Q
D
S
L
D
E
L
Site 10
S69
D
R
S
I
S
Q
D
S
L
D
E
L
S
M
E
Site 11
S74
Q
D
S
L
D
E
L
S
M
E
D
Y
W
I
E
Site 12
Y78
D
E
L
S
M
E
D
Y
W
I
E
L
E
N
I
Site 13
S88
E
L
E
N
I
K
K
S
S
E
N
S
Q
E
D
Site 14
S92
I
K
K
S
S
E
N
S
Q
E
D
Q
E
V
V
Site 15
S120
W
L
K
E
A
G
L
S
N
L
F
G
E
S
A
Site 16
T154
A
V
Q
K
R
V
E
T
V
S
Q
T
L
R
K
Site 17
S156
Q
K
R
V
E
T
V
S
Q
T
L
R
K
K
N
Site 18
T158
R
V
E
T
V
S
Q
T
L
R
K
K
N
K
Q
Site 19
Y166
L
R
K
K
N
K
Q
Y
Q
I
P
D
V
R
D
Site 20
S181
I
F
A
Q
Q
R
E
S
K
E
T
A
P
G
G
Site 21
T184
Q
Q
R
E
S
K
E
T
A
P
G
G
T
E
S
Site 22
S191
T
A
P
G
G
T
E
S
Q
S
L
R
T
N
E
Site 23
S193
P
G
G
T
E
S
Q
S
L
R
T
N
E
N
K
Site 24
Y201
L
R
T
N
E
N
K
Y
Q
G
R
D
D
E
A
Site 25
S209
Q
G
R
D
D
E
A
S
N
L
V
G
E
E
K
Site 26
T223
K
L
I
P
P
E
E
T
P
A
P
E
T
D
I
Site 27
S235
T
D
I
N
L
E
V
S
F
A
E
Q
A
L
N
Site 28
S254
S
K
E
K
I
Q
K
S
K
G
D
D
A
T
L
Site 29
T260
K
S
K
G
D
D
A
T
L
P
S
F
R
L
P
Site 30
S263
G
D
D
A
T
L
P
S
F
R
L
P
K
D
K
Site 31
T271
F
R
L
P
K
D
K
T
G
T
T
R
I
G
D
Site 32
T316
Q
K
A
V
K
I
K
T
K
D
S
G
L
F
C
Site 33
Y385
Q
E
L
E
A
K
F
Y
E
G
T
F
N
W
E
Site 34
T388
E
A
K
F
Y
E
G
T
F
N
W
E
S
V
K
Site 35
T453
L
P
D
A
N
R
D
T
L
K
A
L
L
E
F
Site 36
S497
H
A
L
G
L
K
S
S
E
Q
R
E
F
V
M
Site 37
Y557
K
L
L
K
K
M
A
Y
D
R
E
K
Y
E
K
Site 38
Y562
M
A
Y
D
R
E
K
Y
E
K
Q
D
K
S
T
Site 39
S568
K
Y
E
K
Q
D
K
S
T
N
D
A
D
V
P
Site 40
S587
R
V
Q
A
P
H
L
S
K
V
S
M
A
I
Q
Site 41
S610
D
V
L
A
R
F
L
S
Q
E
S
G
V
A
Q
Site 42
Y627
K
K
G
E
V
F
L
Y
E
I
G
G
N
I
G
Site 43
Y643
R
C
L
D
D
D
T
Y
M
K
D
L
Y
Q
L
Site 44
Y648
D
T
Y
M
K
D
L
Y
Q
L
N
P
N
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation