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Updated November 2019
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Protein Info
Short Name:
RUSC2
Full Name:
Iporin
Alias:
Interacting protein of Rab1; KIAA0375; RUN and SH3 domain containing 2; RUN and SH3 domain-containing protein 2
Type:
Adaptor/scaffold
Mass (Da):
161195
Number AA:
1516
UniProt ID:
Q8N2Y8
International Prot ID:
IPI00444656
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
G
A
G
G
G
G
G
S
T
R
P
N
P
F
C
Site 2
T53
C
P
P
E
L
G
I
T
Q
P
D
Q
D
L
G
Site 3
S64
Q
D
L
G
Q
A
D
S
L
L
F
S
S
L
H
Site 4
S68
Q
A
D
S
L
L
F
S
S
L
H
S
A
P
G
Site 5
S80
A
P
G
G
T
A
R
S
I
D
S
T
K
S
R
Site 6
S83
G
T
A
R
S
I
D
S
T
K
S
R
S
R
D
Site 7
T84
T
A
R
S
I
D
S
T
K
S
R
S
R
D
G
Site 8
S86
R
S
I
D
S
T
K
S
R
S
R
D
G
R
G
Site 9
S88
I
D
S
T
K
S
R
S
R
D
G
R
G
P
G
Site 10
Y118
E
P
G
L
G
D
L
Y
D
D
S
I
G
D
S
Site 11
S121
L
G
D
L
Y
D
D
S
I
G
D
S
A
T
Q
Site 12
S125
Y
D
D
S
I
G
D
S
A
T
Q
Q
S
F
H
Site 13
T127
D
S
I
G
D
S
A
T
Q
Q
S
F
H
L
H
Site 14
S130
G
D
S
A
T
Q
Q
S
F
H
L
H
G
T
G
Site 15
S144
G
Q
P
N
F
H
L
S
S
F
Q
L
P
P
S
Site 16
S145
Q
P
N
F
H
L
S
S
F
Q
L
P
P
S
G
Site 17
S151
S
S
F
Q
L
P
P
S
G
P
R
V
G
R
P
Site 18
T161
R
V
G
R
P
W
G
T
T
R
S
R
A
G
V
Site 19
T162
V
G
R
P
W
G
T
T
R
S
R
A
G
V
V
Site 20
S164
R
P
W
G
T
T
R
S
R
A
G
V
V
E
G
Site 21
T179
Q
E
Q
E
P
V
M
T
L
D
T
Q
Q
C
G
Site 22
T182
E
P
V
M
T
L
D
T
Q
Q
C
G
T
S
H
Site 23
S211
E
C
G
G
P
G
G
S
G
S
G
G
G
A
S
Site 24
S213
G
G
P
G
G
S
G
S
G
G
G
A
S
D
T
Site 25
S218
S
G
S
G
G
G
A
S
D
T
S
G
F
S
F
Site 26
T220
S
G
G
G
A
S
D
T
S
G
F
S
F
D
Q
Site 27
S221
G
G
G
A
S
D
T
S
G
F
S
F
D
Q
E
Site 28
S224
A
S
D
T
S
G
F
S
F
D
Q
E
W
K
L
Site 29
S232
F
D
Q
E
W
K
L
S
S
D
E
S
P
R
N
Site 30
S233
D
Q
E
W
K
L
S
S
D
E
S
P
R
N
P
Site 31
S236
W
K
L
S
S
D
E
S
P
R
N
P
G
C
S
Site 32
S243
S
P
R
N
P
G
C
S
G
S
G
D
Q
H
C
Site 33
S253
G
D
Q
H
C
R
C
S
S
T
S
S
Q
S
E
Site 34
S254
D
Q
H
C
R
C
S
S
T
S
S
Q
S
E
A
Site 35
T255
Q
H
C
R
C
S
S
T
S
S
Q
S
E
A
A
Site 36
S256
H
C
R
C
S
S
T
S
S
Q
S
E
A
A
D
Site 37
S257
C
R
C
S
S
T
S
S
Q
S
E
A
A
D
Q
Site 38
S259
C
S
S
T
S
S
Q
S
E
A
A
D
Q
S
M
Site 39
S265
Q
S
E
A
A
D
Q
S
M
G
Y
V
S
D
S
Site 40
Y268
A
A
D
Q
S
M
G
Y
V
S
D
S
S
C
N
Site 41
S270
D
Q
S
M
G
Y
V
S
D
S
S
C
N
S
S
Site 42
S272
S
M
G
Y
V
S
D
S
S
C
N
S
S
D
G
Site 43
S273
M
G
Y
V
S
D
S
S
C
N
S
S
D
G
V
Site 44
S276
V
S
D
S
S
C
N
S
S
D
G
V
L
V
T
Site 45
S277
S
D
S
S
C
N
S
S
D
G
V
L
V
T
F
Site 46
T283
S
S
D
G
V
L
V
T
F
S
T
L
Y
N
K
Site 47
Y288
L
V
T
F
S
T
L
Y
N
K
M
H
G
T
P
Site 48
T294
L
Y
N
K
M
H
G
T
P
R
A
N
L
N
S
Site 49
S301
T
P
R
A
N
L
N
S
A
P
Q
S
C
S
D
Site 50
S305
N
L
N
S
A
P
Q
S
C
S
D
S
S
F
C
Site 51
S307
N
S
A
P
Q
S
C
S
D
S
S
F
C
S
H
Site 52
S309
A
P
Q
S
C
S
D
S
S
F
C
S
H
S
D
Site 53
S310
P
Q
S
C
S
D
S
S
F
C
S
H
S
D
P
Site 54
S313
C
S
D
S
S
F
C
S
H
S
D
P
G
A
F
Site 55
S315
D
S
S
F
C
S
H
S
D
P
G
A
F
Y
L
Site 56
Y321
H
S
D
P
G
A
F
Y
L
D
L
Q
P
S
P
Site 57
S327
F
Y
L
D
L
Q
P
S
P
F
E
S
K
M
S
Site 58
S331
L
Q
P
S
P
F
E
S
K
M
S
Y
E
S
H
Site 59
S334
S
P
F
E
S
K
M
S
Y
E
S
H
H
P
E
Site 60
Y335
P
F
E
S
K
M
S
Y
E
S
H
H
P
E
S
Site 61
S337
E
S
K
M
S
Y
E
S
H
H
P
E
S
G
G
Site 62
S342
Y
E
S
H
H
P
E
S
G
G
R
E
G
G
Y
Site 63
Y349
S
G
G
R
E
G
G
Y
G
C
P
H
A
S
S
Site 64
S356
Y
G
C
P
H
A
S
S
P
E
L
D
A
N
C
Site 65
T401
Q
N
Y
Y
K
L
V
T
C
D
L
S
S
Q
S
Site 66
S405
K
L
V
T
C
D
L
S
S
Q
S
S
P
S
P
Site 67
S406
L
V
T
C
D
L
S
S
Q
S
S
P
S
P
A
Site 68
S408
T
C
D
L
S
S
Q
S
S
P
S
P
A
G
S
Site 69
S409
C
D
L
S
S
Q
S
S
P
S
P
A
G
S
S
Site 70
S411
L
S
S
Q
S
S
P
S
P
A
G
S
S
I
T
Site 71
S415
S
S
P
S
P
A
G
S
S
I
T
S
C
S
E
Site 72
S416
S
P
S
P
A
G
S
S
I
T
S
C
S
E
E
Site 73
S419
P
A
G
S
S
I
T
S
C
S
E
E
H
T
K
Site 74
S421
G
S
S
I
T
S
C
S
E
E
H
T
K
I
S
Site 75
T425
T
S
C
S
E
E
H
T
K
I
S
P
P
P
G
Site 76
S428
S
E
E
H
T
K
I
S
P
P
P
G
P
G
P
Site 77
S440
P
G
P
D
P
G
P
S
Q
P
S
E
Y
Y
L
Site 78
Y446
P
S
Q
P
S
E
Y
Y
L
F
Q
K
P
E
V
Site 79
S463
E
E
Q
E
A
V
S
S
S
T
Q
A
A
A
A
Site 80
Y481
T
V
L
E
G
Q
V
Y
T
N
T
S
P
P
N
Site 81
T484
E
G
Q
V
Y
T
N
T
S
P
P
N
L
S
T
Site 82
S485
G
Q
V
Y
T
N
T
S
P
P
N
L
S
T
G
Site 83
S490
N
T
S
P
P
N
L
S
T
G
R
Q
R
S
R
Site 84
T491
T
S
P
P
N
L
S
T
G
R
Q
R
S
R
S
Site 85
S496
L
S
T
G
R
Q
R
S
R
S
Y
D
R
S
L
Site 86
S498
T
G
R
Q
R
S
R
S
Y
D
R
S
L
Q
R
Site 87
Y499
G
R
Q
R
S
R
S
Y
D
R
S
L
Q
R
S
Site 88
S502
R
S
R
S
Y
D
R
S
L
Q
R
S
P
P
V
Site 89
S506
Y
D
R
S
L
Q
R
S
P
P
V
R
L
G
S
Site 90
S513
S
P
P
V
R
L
G
S
L
E
R
M
L
S
C
Site 91
S519
G
S
L
E
R
M
L
S
C
P
V
R
L
S
E
Site 92
S536
A
A
M
A
G
P
G
S
P
P
R
R
V
T
S
Site 93
T542
G
S
P
P
R
R
V
T
S
F
A
E
L
A
K
Site 94
S543
S
P
P
R
R
V
T
S
F
A
E
L
A
K
G
Site 95
T554
L
A
K
G
R
K
K
T
G
G
S
G
S
P
P
Site 96
S557
G
R
K
K
T
G
G
S
G
S
P
P
L
R
V
Site 97
S559
K
K
T
G
G
S
G
S
P
P
L
R
V
S
V
Site 98
S565
G
S
P
P
L
R
V
S
V
G
D
S
S
Q
E
Site 99
S569
L
R
V
S
V
G
D
S
S
Q
E
F
S
P
I
Site 100
S570
R
V
S
V
G
D
S
S
Q
E
F
S
P
I
Q
Site 101
S574
G
D
S
S
Q
E
F
S
P
I
Q
E
A
Q
Q
Site 102
T591
G
A
P
L
D
E
G
T
C
C
S
H
S
L
P
Site 103
S594
L
D
E
G
T
C
C
S
H
S
L
P
P
M
P
Site 104
S596
E
G
T
C
C
S
H
S
L
P
P
M
P
L
G
Site 105
S614
D
L
L
G
P
D
P
S
P
P
W
S
T
Q
V
Site 106
S618
P
D
P
S
P
P
W
S
T
Q
V
C
Q
G
P
Site 107
S627
Q
V
C
Q
G
P
H
S
S
E
M
P
P
A
G
Site 108
S628
V
C
Q
G
P
H
S
S
E
M
P
P
A
G
L
Site 109
T638
P
P
A
G
L
R
A
T
G
Q
G
P
L
A
Q
Site 110
S656
P
G
P
A
L
P
G
S
P
A
N
S
H
T
Q
Site 111
S660
L
P
G
S
P
A
N
S
H
T
Q
R
D
A
R
Site 112
T662
G
S
P
A
N
S
H
T
Q
R
D
A
R
A
R
Site 113
S677
A
D
G
G
G
T
E
S
R
P
V
L
R
Y
S
Site 114
S684
S
R
P
V
L
R
Y
S
K
E
Q
R
P
T
T
Site 115
T690
Y
S
K
E
Q
R
P
T
T
L
P
I
Q
P
F
Site 116
T691
S
K
E
Q
R
P
T
T
L
P
I
Q
P
F
V
Site 117
S715
A
K
A
R
A
L
H
S
L
S
Q
L
Y
S
L
Site 118
S717
A
R
A
L
H
S
L
S
Q
L
Y
S
L
S
G
Site 119
Y720
L
H
S
L
S
Q
L
Y
S
L
S
G
C
S
R
Site 120
S721
H
S
L
S
Q
L
Y
S
L
S
G
C
S
R
T
Site 121
S723
L
S
Q
L
Y
S
L
S
G
C
S
R
T
Q
Q
Site 122
T728
S
L
S
G
C
S
R
T
Q
Q
P
A
P
L
A
Site 123
S747
Q
V
S
V
P
A
P
S
G
E
P
Q
A
S
T
Site 124
S753
P
S
G
E
P
Q
A
S
T
P
R
A
T
G
R
Site 125
T754
S
G
E
P
Q
A
S
T
P
R
A
T
G
R
G
Site 126
T758
Q
A
S
T
P
R
A
T
G
R
G
A
R
K
A
Site 127
S767
R
G
A
R
K
A
G
S
E
P
E
T
S
R
P
Site 128
T771
K
A
G
S
E
P
E
T
S
R
P
S
P
L
G
Site 129
S772
A
G
S
E
P
E
T
S
R
P
S
P
L
G
S
Site 130
S775
E
P
E
T
S
R
P
S
P
L
G
S
Y
S
P
Site 131
S779
S
R
P
S
P
L
G
S
Y
S
P
I
R
S
V
Site 132
S781
P
S
P
L
G
S
Y
S
P
I
R
S
V
G
P
Site 133
S785
G
S
Y
S
P
I
R
S
V
G
P
F
G
P
S
Site 134
S792
S
V
G
P
F
G
P
S
T
D
S
S
A
S
T
Site 135
T793
V
G
P
F
G
P
S
T
D
S
S
A
S
T
S
Site 136
S795
P
F
G
P
S
T
D
S
S
A
S
T
S
C
S
Site 137
S796
F
G
P
S
T
D
S
S
A
S
T
S
C
S
P
Site 138
S798
P
S
T
D
S
S
A
S
T
S
C
S
P
P
P
Site 139
T799
S
T
D
S
S
A
S
T
S
C
S
P
P
P
E
Site 140
S800
T
D
S
S
A
S
T
S
C
S
P
P
P
E
Q
Site 141
S802
S
S
A
S
T
S
C
S
P
P
P
E
Q
P
T
Site 142
T809
S
P
P
P
E
Q
P
T
A
T
E
S
L
P
P
Site 143
T811
P
P
E
Q
P
T
A
T
E
S
L
P
P
W
S
Site 144
S813
E
Q
P
T
A
T
E
S
L
P
P
W
S
H
S
Site 145
S818
T
E
S
L
P
P
W
S
H
S
C
P
S
A
V
Site 146
S820
S
L
P
P
W
S
H
S
C
P
S
A
V
R
P
Site 147
S823
P
W
S
H
S
C
P
S
A
V
R
P
A
T
S
Site 148
T829
P
S
A
V
R
P
A
T
S
Q
Q
P
Q
K
E
Site 149
S830
S
A
V
R
P
A
T
S
Q
Q
P
Q
K
E
D
Site 150
T842
K
E
D
Q
K
I
L
T
L
T
E
Y
R
L
H
Site 151
T844
D
Q
K
I
L
T
L
T
E
Y
R
L
H
G
T
Site 152
Y846
K
I
L
T
L
T
E
Y
R
L
H
G
T
G
S
Site 153
S853
Y
R
L
H
G
T
G
S
L
P
P
L
G
S
W
Site 154
S859
G
S
L
P
P
L
G
S
W
R
S
G
L
S
R
Site 155
S862
P
P
L
G
S
W
R
S
G
L
S
R
A
E
S
Site 156
S865
G
S
W
R
S
G
L
S
R
A
E
S
L
A
R
Site 157
S869
S
G
L
S
R
A
E
S
L
A
R
G
G
G
E
Site 158
S878
A
R
G
G
G
E
G
S
M
A
T
R
P
S
N
Site 159
S884
G
S
M
A
T
R
P
S
N
A
N
H
L
S
P
Site 160
S890
P
S
N
A
N
H
L
S
P
Q
A
L
K
W
R
Site 161
Y899
Q
A
L
K
W
R
E
Y
R
R
K
N
P
L
G
Site 162
S911
P
L
G
P
P
G
L
S
G
S
L
D
R
R
S
Site 163
S913
G
P
P
G
L
S
G
S
L
D
R
R
S
Q
E
Site 164
S918
S
G
S
L
D
R
R
S
Q
E
A
R
L
A
R
Site 165
T957
A
V
K
P
L
P
L
T
C
P
D
F
Q
D
P
Site 166
S966
P
D
F
Q
D
P
F
S
L
T
E
K
P
P
A
Site 167
T968
F
Q
D
P
F
S
L
T
E
K
P
P
A
E
F
Site 168
S978
P
P
A
E
F
C
L
S
P
D
G
S
S
E
A
Site 169
S987
D
G
S
S
E
A
I
S
I
D
L
L
Q
K
K
Site 170
T1013
L
I
V
A
H
F
G
T
S
R
D
P
G
V
K
Site 171
S1014
I
V
A
H
F
G
T
S
R
D
P
G
V
K
A
Site 172
S1026
V
K
A
K
L
G
N
S
S
V
S
P
N
V
G
Site 173
S1027
K
A
K
L
G
N
S
S
V
S
P
N
V
G
H
Site 174
S1029
K
L
G
N
S
S
V
S
P
N
V
G
H
L
V
Site 175
S1070
Q
R
K
N
M
P
W
S
V
V
E
A
S
T
Q
Site 176
S1075
P
W
S
V
V
E
A
S
T
Q
L
G
P
S
T
Site 177
T1082
S
T
Q
L
G
P
S
T
K
V
L
H
G
L
Y
Site 178
Y1089
T
K
V
L
H
G
L
Y
N
K
V
S
Q
F
P
Site 179
S1093
H
G
L
Y
N
K
V
S
Q
F
P
E
L
T
S
Site 180
Y1136
E
D
I
I
Q
T
H
Y
Q
P
W
G
F
L
S
Site 181
S1195
H
K
E
L
L
R
V
S
Q
D
L
L
L
S
A
Site 182
T1247
E
E
E
E
E
E
E
T
E
E
V
A
E
A
A
Site 183
S1257
V
A
E
A
A
G
G
S
G
R
A
R
W
A
R
Site 184
Y1272
G
G
Q
A
G
W
W
Y
Q
L
M
Q
S
S
Q
Site 185
Y1281
L
M
Q
S
S
Q
V
Y
I
D
G
S
I
E
G
Site 186
S1285
S
Q
V
Y
I
D
G
S
I
E
G
S
R
F
P
Site 187
S1289
I
D
G
S
I
E
G
S
R
F
P
R
G
S
S
Site 188
S1295
G
S
R
F
P
R
G
S
S
N
S
S
S
E
K
Site 189
S1296
S
R
F
P
R
G
S
S
N
S
S
S
E
K
K
Site 190
S1298
F
P
R
G
S
S
N
S
S
S
E
K
K
K
G
Site 191
S1299
P
R
G
S
S
N
S
S
S
E
K
K
K
G
A
Site 192
S1300
R
G
S
S
N
S
S
S
E
K
K
K
G
A
G
Site 193
S1331
G
A
E
A
C
P
A
S
E
E
A
L
G
R
E
Site 194
S1347
G
W
P
F
W
M
G
S
P
P
D
S
V
L
A
Site 195
S1351
W
M
G
S
P
P
D
S
V
L
A
E
L
R
R
Site 196
S1359
V
L
A
E
L
R
R
S
R
E
R
E
G
P
A
Site 197
S1368
E
R
E
G
P
A
A
S
P
A
E
N
E
E
G
Site 198
S1377
A
E
N
E
E
G
A
S
E
P
S
P
G
G
I
Site 199
S1380
E
E
G
A
S
E
P
S
P
G
G
I
K
W
G
Site 200
T1402
A
Q
R
E
A
R
P
T
N
R
L
P
S
D
W
Site 201
S1407
R
P
T
N
R
L
P
S
D
W
L
S
L
D
K
Site 202
S1411
R
L
P
S
D
W
L
S
L
D
K
S
M
F
Q
Site 203
S1415
D
W
L
S
L
D
K
S
M
F
Q
L
V
A
Q
Site 204
S1426
L
V
A
Q
T
V
G
S
R
R
E
P
E
P
K
Site 205
S1435
R
E
P
E
P
K
E
S
L
Q
E
P
H
S
P
Site 206
S1441
E
S
L
Q
E
P
H
S
P
A
L
P
S
S
P
Site 207
S1446
P
H
S
P
A
L
P
S
S
P
P
C
E
V
Q
Site 208
S1447
H
S
P
A
L
P
S
S
P
P
C
E
V
Q
A
Site 209
S1467
A
T
G
P
G
Q
L
S
F
H
K
G
D
I
L
Site 210
S1488
G
G
D
W
L
R
C
S
R
G
P
D
S
G
L
Site 211
S1493
R
C
S
R
G
P
D
S
G
L
V
P
L
A
Y
Site 212
T1504
P
L
A
Y
V
T
L
T
P
T
P
S
P
T
P
Site 213
T1506
A
Y
V
T
L
T
P
T
P
S
P
T
P
G
S
Site 214
S1508
V
T
L
T
P
T
P
S
P
T
P
G
S
S
Q
Site 215
T1510
L
T
P
T
P
S
P
T
P
G
S
S
Q
N
_
Site 216
S1513
T
P
S
P
T
P
G
S
S
Q
N
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation