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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VWDE
Full Name:
von Willebrand factor D and EGF domain-containing protein
Alias:
Type:
Mass (Da):
176880
Number AA:
1590
UniProt ID:
Q8N2E2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
W
G
E
A
Q
E
C
S
P
G
G
H
Q
F
L
Site 2
S33
G
G
H
Q
F
L
R
S
P
Y
R
S
V
R
F
Site 3
Y35
H
Q
F
L
R
S
P
Y
R
S
V
R
F
D
S
Site 4
S37
F
L
R
S
P
Y
R
S
V
R
F
D
S
W
H
Site 5
S42
Y
R
S
V
R
F
D
S
W
H
L
Q
Q
S
A
Site 6
Y64
H
S
L
S
P
G
W
Y
R
F
L
I
L
D
R
Site 7
S94
T
Q
A
P
I
W
L
S
L
R
D
S
E
T
L
Site 8
S98
I
W
L
S
L
R
D
S
E
T
L
P
S
P
G
Site 9
T100
L
S
L
R
D
S
E
T
L
P
S
P
G
E
I
Site 10
S103
R
D
S
E
T
L
P
S
P
G
E
I
K
Q
L
Site 11
T111
P
G
E
I
K
Q
L
T
A
C
A
T
W
Q
F
Site 12
Y144
N
C
G
N
F
S
V
Y
L
L
Q
P
T
Q
G
Site 13
Y155
P
T
Q
G
C
M
G
Y
C
A
E
A
I
S
D
Site 14
S161
G
Y
C
A
E
A
I
S
D
A
R
L
H
P
C
Site 15
S170
A
R
L
H
P
C
G
S
D
E
T
E
T
G
G
Site 16
T173
H
P
C
G
S
D
E
T
E
T
G
G
D
C
V
Site 17
S211
S
R
L
F
C
R
C
S
F
D
V
P
A
T
K
Site 18
T217
C
S
F
D
V
P
A
T
K
N
S
V
G
F
H
Site 19
S228
V
G
F
H
I
A
W
S
R
L
S
S
Q
E
V
Site 20
S231
H
I
A
W
S
R
L
S
S
Q
E
V
K
E
E
Site 21
S232
I
A
W
S
R
L
S
S
Q
E
V
K
E
E
L
Site 22
T244
E
E
L
T
Q
E
T
T
V
Q
A
F
S
L
L
Site 23
S280
L
E
N
P
H
V
Q
S
V
A
I
E
S
Q
E
Site 24
S299
I
K
L
Q
P
E
L
S
T
I
S
E
D
G
K
Site 25
S302
Q
P
E
L
S
T
I
S
E
D
G
K
E
Y
Y
Site 26
Y308
I
S
E
D
G
K
E
Y
Y
L
R
I
E
S
T
Site 27
Y309
S
E
D
G
K
E
Y
Y
L
R
I
E
S
T
V
Site 28
S333
L
D
Q
E
C
K
I
S
L
K
L
K
T
I
D
Site 29
S391
S
R
D
G
D
R
V
S
N
I
V
V
Q
P
I
Site 30
Y408
E
D
F
L
W
N
N
Y
I
P
D
S
I
Q
I
Site 31
Y424
V
K
D
V
P
T
A
Y
C
Y
T
F
T
D
P
Site 32
Y426
D
V
P
T
A
Y
C
Y
T
F
T
D
P
H
I
Site 33
T435
F
T
D
P
H
I
I
T
F
D
G
R
V
Y
D
Site 34
Y441
I
T
F
D
G
R
V
Y
D
N
F
K
T
G
T
Site 35
T448
Y
D
N
F
K
T
G
T
F
V
L
Y
K
S
M
Site 36
Y452
K
T
G
T
F
V
L
Y
K
S
M
S
R
D
F
Site 37
S454
G
T
F
V
L
Y
K
S
M
S
R
D
F
E
V
Site 38
S502
C
N
G
Q
L
R
E
S
Q
P
Y
L
F
I
K
Site 39
Y505
Q
L
R
E
S
Q
P
Y
L
F
I
K
S
Q
D
Site 40
S510
Q
P
Y
L
F
I
K
S
Q
D
V
T
R
N
I
Site 41
T514
F
I
K
S
Q
D
V
T
R
N
I
K
I
S
E
Site 42
S520
V
T
R
N
I
K
I
S
E
S
Y
L
G
R
K
Site 43
T529
S
Y
L
G
R
K
V
T
I
W
F
S
S
G
A
Site 44
S548
D
L
G
E
W
G
M
S
L
T
I
R
A
P
S
Site 45
T550
G
E
W
G
M
S
L
T
I
R
A
P
S
V
D
Site 46
S555
S
L
T
I
R
A
P
S
V
D
Y
R
N
T
L
Site 47
Y558
I
R
A
P
S
V
D
Y
R
N
T
L
G
L
C
Site 48
T561
P
S
V
D
Y
R
N
T
L
G
L
C
G
T
F
Site 49
T567
N
T
L
G
L
C
G
T
F
D
E
N
P
E
N
Site 50
T609
P
G
K
S
M
F
D
T
L
P
V
S
M
T
S
Site 51
S613
M
F
D
T
L
P
V
S
M
T
S
P
G
K
P
Site 52
T615
D
T
L
P
V
S
M
T
S
P
G
K
P
S
Y
Site 53
S616
T
L
P
V
S
M
T
S
P
G
K
P
S
Y
C
Site 54
S621
M
T
S
P
G
K
P
S
Y
C
S
C
S
L
D
Site 55
Y622
T
S
P
G
K
P
S
Y
C
S
C
S
L
D
T
Site 56
S624
P
G
K
P
S
Y
C
S
C
S
L
D
T
A
A
Site 57
S626
K
P
S
Y
C
S
C
S
L
D
T
A
A
Y
P
Site 58
Y632
C
S
L
D
T
A
A
Y
P
S
S
E
D
L
D
Site 59
S635
D
T
A
A
Y
P
S
S
E
D
L
D
S
V
S
Site 60
S640
P
S
S
E
D
L
D
S
V
S
R
S
E
I
A
Site 61
S642
S
E
D
L
D
S
V
S
R
S
E
I
A
L
G
Site 62
S644
D
L
D
S
V
S
R
S
E
I
A
L
G
C
K
Site 63
S657
C
K
D
L
N
H
V
S
L
S
S
L
I
P
E
Site 64
T668
L
I
P
E
L
D
V
T
S
E
Y
I
N
S
D
Site 65
S669
I
P
E
L
D
V
T
S
E
Y
I
N
S
D
T
Site 66
Y671
E
L
D
V
T
S
E
Y
I
N
S
D
T
L
V
Site 67
S674
V
T
S
E
Y
I
N
S
D
T
L
V
R
E
I
Site 68
T676
S
E
Y
I
N
S
D
T
L
V
R
E
I
N
K
Site 69
S686
R
E
I
N
K
H
T
S
P
E
E
Y
N
L
N
Site 70
Y690
K
H
T
S
P
E
E
Y
N
L
N
L
F
L
Q
Site 71
S722
P
G
N
E
K
E
D
S
L
Q
Y
L
A
N
K
Site 72
Y725
E
K
E
D
S
L
Q
Y
L
A
N
K
K
Y
T
Site 73
Y731
Q
Y
L
A
N
K
K
Y
T
Q
G
R
G
S
H
Site 74
T732
Y
L
A
N
K
K
Y
T
Q
G
R
G
S
H
S
Site 75
S737
K
Y
T
Q
G
R
G
S
H
S
Q
E
M
R
Y
Site 76
S739
T
Q
G
R
G
S
H
S
Q
E
M
R
Y
N
R
Site 77
Y744
S
H
S
Q
E
M
R
Y
N
R
Q
N
R
W
K
Site 78
S766
P
P
L
F
A
F
P
S
L
S
Q
T
D
L
E
Site 79
T770
A
F
P
S
L
S
Q
T
D
L
E
E
L
T
Y
Site 80
Y777
T
D
L
E
E
L
T
Y
F
F
P
E
D
H
A
Site 81
S794
V
Q
Q
E
F
F
P
S
W
P
T
P
S
G
L
Site 82
T797
E
F
F
P
S
W
P
T
P
S
G
L
T
E
Y
Site 83
S799
F
P
S
W
P
T
P
S
G
L
T
E
Y
S
T
Site 84
T806
S
G
L
T
E
Y
S
T
L
T
L
C
Q
E
T
Site 85
Y872
R
I
V
E
E
G
K
Y
N
T
E
E
Y
G
T
Site 86
S880
N
T
E
E
Y
G
T
S
I
E
D
I
L
S
V
Site 87
S912
C
A
C
S
P
S
F
S
S
Y
D
C
S
D
S
Site 88
S913
A
C
S
P
S
F
S
S
Y
D
C
S
D
S
Y
Site 89
Y914
C
S
P
S
F
S
S
Y
D
C
S
D
S
Y
D
Site 90
S917
S
F
S
S
Y
D
C
S
D
S
Y
D
K
A
P
Site 91
S919
S
S
Y
D
C
S
D
S
Y
D
K
A
P
E
I
Site 92
Y920
S
Y
D
C
S
D
S
Y
D
K
A
P
E
I
T
Site 93
Y967
C
E
V
T
N
L
Q
Y
N
S
S
E
W
M
P
Site 94
Y979
W
M
P
G
E
P
I
Y
T
Q
T
V
F
H
N
Site 95
T980
M
P
G
E
P
I
Y
T
Q
T
V
F
H
N
S
Site 96
T982
G
E
P
I
Y
T
Q
T
V
F
H
N
S
R
A
Site 97
T1003
T
D
V
Q
Q
F
D
T
M
D
L
V
G
G
K
Site 98
S1020
G
K
W
Q
L
K
V
S
N
D
G
Y
K
F
S
Site 99
Y1024
L
K
V
S
N
D
G
Y
K
F
S
N
P
K
I
Site 100
Y1035
N
P
K
I
M
V
I
Y
D
G
A
C
Q
V
C
Site 101
Y1045
A
C
Q
V
C
G
L
Y
K
N
D
S
C
T
I
Site 102
Y1064
C
I
I
D
G
L
C
Y
V
E
G
D
K
N
P
Site 103
S1073
E
G
D
K
N
P
T
S
P
C
L
I
C
R
P
Site 104
T1086
R
P
K
I
S
R
F
T
W
S
F
L
E
N
N
Site 105
S1088
K
I
S
R
F
T
W
S
F
L
E
N
N
Q
P
Site 106
T1107
A
L
Q
D
K
L
Q
T
F
Y
G
E
N
F
E
Site 107
Y1109
Q
D
K
L
Q
T
F
Y
G
E
N
F
E
Y
Q
Site 108
Y1115
F
Y
G
E
N
F
E
Y
Q
F
V
A
F
D
P
Site 109
S1125
V
A
F
D
P
E
G
S
D
I
H
F
T
L
D
Site 110
T1130
E
G
S
D
I
H
F
T
L
D
S
G
P
E
G
Site 111
S1133
D
I
H
F
T
L
D
S
G
P
E
G
A
S
V
Site 112
S1139
D
S
G
P
E
G
A
S
V
S
S
A
G
L
F
Site 113
T1150
A
G
L
F
M
W
K
T
D
L
L
T
T
Q
Q
Site 114
T1154
M
W
K
T
D
L
L
T
T
Q
Q
I
T
V
R
Site 115
T1173
C
D
A
E
T
R
V
T
I
E
V
T
V
K
S
Site 116
S1191
L
N
G
G
S
C
V
S
D
R
N
F
S
P
G
Site 117
S1196
C
V
S
D
R
N
F
S
P
G
S
G
V
Y
L
Site 118
S1224
V
D
I
S
G
C
Q
S
N
P
C
G
L
G
S
Site 119
S1231
S
N
P
C
G
L
G
S
Y
I
S
G
F
H
S
Site 120
Y1232
N
P
C
G
L
G
S
Y
I
S
G
F
H
S
Y
Site 121
Y1239
Y
I
S
G
F
H
S
Y
S
C
D
C
P
P
E
Site 122
S1240
I
S
G
F
H
S
Y
S
C
D
C
P
P
E
L
Site 123
T1261
V
N
Q
F
T
T
Q
T
V
V
L
T
R
S
D
Site 124
S1270
V
L
T
R
S
D
K
S
V
N
K
E
E
D
D
Site 125
T1290
R
K
R
H
V
K
P
T
S
G
N
A
F
T
I
Site 126
S1291
K
R
H
V
K
P
T
S
G
N
A
F
T
I
C
Site 127
T1296
P
T
S
G
N
A
F
T
I
C
K
Y
P
C
G
Site 128
Y1300
N
A
F
T
I
C
K
Y
P
C
G
K
S
R
E
Site 129
Y1320
I
C
K
C
K
P
G
Y
I
G
S
N
C
Q
T
Site 130
Y1480
V
C
V
C
R
E
G
Y
T
G
R
R
F
Q
K
Site 131
T1481
C
V
C
R
E
G
Y
T
G
R
R
F
Q
K
S
Site 132
S1504
G
G
K
C
V
G
P
S
T
C
S
C
P
S
G
Site 133
T1505
G
K
C
V
G
P
S
T
C
S
C
P
S
G
W
Site 134
S1507
C
V
G
P
S
T
C
S
C
P
S
G
W
S
G
Site 135
S1510
P
S
T
C
S
C
P
S
G
W
S
G
K
R
C
Site 136
T1519
W
S
G
K
R
C
N
T
P
I
C
L
Q
K
C
Site 137
Y1576
V
C
S
C
R
T
E
Y
S
G
V
K
C
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation