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Updated November 2019
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Protein Info
Short Name:
UNC80
Full Name:
Protein unc-80 homolog
Alias:
Type:
Mass (Da):
363390
Number AA:
3258
UniProt ID:
Q8N2C7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
V
K
R
K
S
S
E
G
Q
E
Q
D
Site 2
S7
_
M
V
K
R
K
S
S
E
G
Q
E
Q
D
G
Site 3
T24
G
I
P
L
P
I
Q
T
F
L
W
R
Q
T
S
Site 4
T30
Q
T
F
L
W
R
Q
T
S
A
F
L
R
P
K
Site 5
S31
T
F
L
W
R
Q
T
S
A
F
L
R
P
K
L
Site 6
Y42
R
P
K
L
G
K
Q
Y
E
A
S
C
V
S
F
Site 7
S45
L
G
K
Q
Y
E
A
S
C
V
S
F
E
R
V
Site 8
S48
Q
Y
E
A
S
C
V
S
F
E
R
V
L
V
E
Site 9
S62
E
N
K
L
H
G
L
S
P
A
L
S
E
A
I
Site 10
S94
H
C
T
A
T
L
L
S
N
R
N
K
L
G
H
Site 11
T135
N
N
E
R
F
G
G
T
D
R
G
S
S
W
G
Site 12
S139
F
G
G
T
D
R
G
S
S
W
G
G
S
S
S
Site 13
S140
G
G
T
D
R
G
S
S
W
G
G
S
S
S
A
Site 14
S144
R
G
S
S
W
G
G
S
S
S
A
F
I
H
Q
Site 15
S145
G
S
S
W
G
G
S
S
S
A
F
I
H
Q
V
Site 16
S146
S
S
W
G
G
S
S
S
A
F
I
H
Q
V
E
Site 17
S157
H
Q
V
E
N
Q
G
S
P
G
Q
P
C
Q
S
Site 18
S165
P
G
Q
P
C
Q
S
S
S
N
D
E
E
E
N
Site 19
S166
G
Q
P
C
Q
S
S
S
N
D
E
E
E
N
N
Site 20
S202
L
V
H
R
I
K
E
S
D
L
T
F
R
L
A
Site 21
T205
R
I
K
E
S
D
L
T
F
R
L
A
S
G
L
Site 22
S227
E
H
R
Q
P
G
V
S
G
F
T
A
L
V
K
Site 23
T241
K
P
I
R
N
I
I
T
A
K
R
S
S
P
I
Site 24
S246
I
I
T
A
K
R
S
S
P
I
N
S
Q
S
R
Site 25
S250
K
R
S
S
P
I
N
S
Q
S
R
T
C
E
S
Site 26
S252
S
S
P
I
N
S
Q
S
R
T
C
E
S
P
N
Site 27
T254
P
I
N
S
Q
S
R
T
C
E
S
P
N
Q
D
Site 28
S257
S
Q
S
R
T
C
E
S
P
N
Q
D
A
R
H
Site 29
S277
V
V
C
E
T
F
Q
S
D
S
I
S
P
K
A
Site 30
S279
C
E
T
F
Q
S
D
S
I
S
P
K
A
T
I
Site 31
S281
T
F
Q
S
D
S
I
S
P
K
A
T
I
S
G
Site 32
T285
D
S
I
S
P
K
A
T
I
S
G
C
H
R
G
Site 33
S287
I
S
P
K
A
T
I
S
G
C
H
R
G
N
S
Site 34
S294
S
G
C
H
R
G
N
S
F
D
G
S
L
S
S
Site 35
S298
R
G
N
S
F
D
G
S
L
S
S
Q
T
S
Q
Site 36
S300
N
S
F
D
G
S
L
S
S
Q
T
S
Q
E
R
Site 37
S301
S
F
D
G
S
L
S
S
Q
T
S
Q
E
R
G
Site 38
S304
G
S
L
S
S
Q
T
S
Q
E
R
G
P
S
H
Site 39
S310
T
S
Q
E
R
G
P
S
H
S
R
A
S
L
V
Site 40
S312
Q
E
R
G
P
S
H
S
R
A
S
L
V
I
P
Site 41
S315
G
P
S
H
S
R
A
S
L
V
I
P
P
C
Q
Site 42
Y326
P
P
C
Q
R
S
R
Y
A
T
Y
F
D
V
A
Site 43
T328
C
Q
R
S
R
Y
A
T
Y
F
D
V
A
V
L
Site 44
Y329
Q
R
S
R
Y
A
T
Y
F
D
V
A
V
L
R
Site 45
Y355
T
Q
W
S
L
M
Y
Y
L
Q
R
L
R
H
M
Site 46
S383
P
L
L
P
R
P
R
S
S
S
M
V
A
A
A
Site 47
S384
L
L
P
R
P
R
S
S
S
M
V
A
A
A
P
Site 48
S385
L
P
R
P
R
S
S
S
M
V
A
A
A
P
S
Site 49
T399
S
L
V
N
T
H
K
T
Q
D
L
T
M
K
C
Site 50
T403
T
H
K
T
Q
D
L
T
M
K
C
N
E
E
E
Site 51
S412
K
C
N
E
E
E
K
S
L
S
S
E
A
F
S
Site 52
S414
N
E
E
E
K
S
L
S
S
E
A
F
S
K
V
Site 53
S415
E
E
E
K
S
L
S
S
E
A
F
S
K
V
S
Site 54
S422
S
E
A
F
S
K
V
S
L
T
N
L
R
R
S
Site 55
T424
A
F
S
K
V
S
L
T
N
L
R
R
S
A
V
Site 56
S429
S
L
T
N
L
R
R
S
A
V
P
D
L
S
S
Site 57
S435
R
S
A
V
P
D
L
S
S
D
L
G
M
N
I
Site 58
S448
N
I
F
K
K
F
K
S
R
K
E
D
R
E
R
Site 59
S458
E
D
R
E
R
K
G
S
I
P
F
H
H
T
G
Site 60
T464
G
S
I
P
F
H
H
T
G
K
R
R
P
R
R
Site 61
S486
H
E
D
H
L
D
V
S
P
T
R
S
T
F
S
Site 62
T488
D
H
L
D
V
S
P
T
R
S
T
F
S
F
G
Site 63
S490
L
D
V
S
P
T
R
S
T
F
S
F
G
S
F
Site 64
T491
D
V
S
P
T
R
S
T
F
S
F
G
S
F
S
Site 65
S493
S
P
T
R
S
T
F
S
F
G
S
F
S
G
L
Site 66
S496
R
S
T
F
S
F
G
S
F
S
G
L
G
E
D
Site 67
S498
T
F
S
F
G
S
F
S
G
L
G
E
D
R
R
Site 68
T521
T
T
I
L
G
K
L
T
R
R
G
S
S
D
A
Site 69
S525
G
K
L
T
R
R
G
S
S
D
A
A
T
E
M
Site 70
S526
K
L
T
R
R
G
S
S
D
A
A
T
E
M
E
Site 71
T530
R
G
S
S
D
A
A
T
E
M
E
S
L
S
A
Site 72
S534
D
A
A
T
E
M
E
S
L
S
A
R
H
S
H
Site 73
S536
A
T
E
M
E
S
L
S
A
R
H
S
H
S
H
Site 74
S540
E
S
L
S
A
R
H
S
H
S
H
H
T
L
V
Site 75
S542
L
S
A
R
H
S
H
S
H
H
T
L
V
S
D
Site 76
T545
R
H
S
H
S
H
H
T
L
V
S
D
L
P
D
Site 77
S548
H
S
H
H
T
L
V
S
D
L
P
D
P
S
N
Site 78
S554
V
S
D
L
P
D
P
S
N
S
H
G
E
N
T
Site 79
S556
D
L
P
D
P
S
N
S
H
G
E
N
T
V
K
Site 80
T561
S
N
S
H
G
E
N
T
V
K
E
V
R
S
Q
Site 81
S567
N
T
V
K
E
V
R
S
Q
I
S
T
I
T
V
Site 82
T573
R
S
Q
I
S
T
I
T
V
A
T
F
N
T
T
Site 83
Y588
L
A
S
F
N
V
G
Y
A
D
F
F
N
E
H
Site 84
S621
A
C
A
N
L
P
R
S
L
T
D
S
C
I
N
Site 85
T623
A
N
L
P
R
S
L
T
D
S
C
I
N
Y
S
Site 86
S625
L
P
R
S
L
T
D
S
C
I
N
Y
S
Y
L
Site 87
Y629
L
T
D
S
C
I
N
Y
S
Y
L
E
D
T
E
Site 88
Y631
D
S
C
I
N
Y
S
Y
L
E
D
T
E
H
I
Site 89
T635
N
Y
S
Y
L
E
D
T
E
H
I
D
G
T
N
Site 90
S654
K
N
G
M
L
D
L
S
V
V
L
K
A
V
Y
Site 91
S699
V
E
K
N
R
K
K
S
E
N
K
E
N
E
T
Site 92
S712
E
T
L
E
K
R
P
S
E
G
A
F
Q
F
K
Site 93
S724
Q
F
K
G
V
S
G
S
S
T
C
G
F
G
G
Site 94
S725
F
K
G
V
S
G
S
S
T
C
G
F
G
G
P
Site 95
T726
K
G
V
S
G
S
S
T
C
G
F
G
G
P
A
Site 96
Y768
G
G
G
G
G
G
P
Y
E
K
N
D
K
N
Q
Site 97
S780
K
N
Q
E
K
D
E
S
T
P
V
S
N
H
R
Site 98
T781
N
Q
E
K
D
E
S
T
P
V
S
N
H
R
L
Site 99
S784
K
D
E
S
T
P
V
S
N
H
R
L
A
L
T
Site 100
T791
S
N
H
R
L
A
L
T
M
L
I
K
I
V
K
Site 101
S799
M
L
I
K
I
V
K
S
L
G
C
A
Y
G
C
Site 102
Y804
V
K
S
L
G
C
A
Y
G
C
G
E
G
H
R
Site 103
S814
G
E
G
H
R
G
L
S
G
D
R
L
R
H
Q
Site 104
Y849
F
R
Q
T
M
R
D
Y
V
N
K
D
S
L
N
Site 105
S854
R
D
Y
V
N
K
D
S
L
N
N
V
V
D
F
Site 106
T874
G
F
C
M
E
P
V
T
D
N
K
A
G
F
G
Site 107
T886
G
F
G
N
N
F
T
T
V
D
N
K
S
T
A
Site 108
S891
F
T
T
V
D
N
K
S
T
A
Q
N
V
E
G
Site 109
S914
S
L
I
T
R
C
A
S
T
T
H
E
L
H
S
Site 110
T916
I
T
R
C
A
S
T
T
H
E
L
H
S
P
E
Site 111
S921
S
T
T
H
E
L
H
S
P
E
N
L
G
L
Y
Site 112
Y928
S
P
E
N
L
G
L
Y
C
D
I
R
Q
L
V
Site 113
S979
Q
E
S
K
P
A
G
S
K
R
S
E
A
G
S
Site 114
S986
S
K
R
S
E
A
G
S
I
V
D
K
G
Q
V
Site 115
S1002
S
A
P
E
E
C
R
S
F
M
S
G
R
P
S
Site 116
S1005
E
E
C
R
S
F
M
S
G
R
P
S
Q
T
P
Site 117
S1009
S
F
M
S
G
R
P
S
Q
T
P
E
H
D
E
Site 118
T1011
M
S
G
R
P
S
Q
T
P
E
H
D
E
Q
M
Site 119
S1035
F
W
R
K
M
F
K
S
Q
S
A
A
S
D
T
Site 120
S1037
R
K
M
F
K
S
Q
S
A
A
S
D
T
S
S
Site 121
S1040
F
K
S
Q
S
A
A
S
D
T
S
S
Q
S
E
Site 122
T1042
S
Q
S
A
A
S
D
T
S
S
Q
S
E
Q
D
Site 123
S1044
S
A
A
S
D
T
S
S
Q
S
E
Q
D
T
S
Site 124
S1046
A
S
D
T
S
S
Q
S
E
Q
D
T
S
E
C
Site 125
T1050
S
S
Q
S
E
Q
D
T
S
E
C
T
T
A
H
Site 126
S1051
S
Q
S
E
Q
D
T
S
E
C
T
T
A
H
S
Site 127
T1055
Q
D
T
S
E
C
T
T
A
H
S
G
T
T
S
Site 128
S1058
S
E
C
T
T
A
H
S
G
T
T
S
D
R
R
Site 129
S1062
T
A
H
S
G
T
T
S
D
R
R
A
R
S
R
Site 130
S1068
T
S
D
R
R
A
R
S
R
S
R
R
I
S
L
Site 131
S1070
D
R
R
A
R
S
R
S
R
R
I
S
L
R
K
Site 132
S1074
R
S
R
S
R
R
I
S
L
R
K
K
L
K
L
Site 133
S1093
R
N
W
L
K
R
S
S
L
S
G
L
A
D
G
Site 134
S1114
I
S
S
V
D
R
L
S
F
I
R
Q
S
S
K
Site 135
S1119
R
L
S
F
I
R
Q
S
S
K
V
K
F
T
S
Site 136
S1120
L
S
F
I
R
Q
S
S
K
V
K
F
T
S
A
Site 137
S1126
S
S
K
V
K
F
T
S
A
V
K
L
S
E
G
Site 138
S1131
F
T
S
A
V
K
L
S
E
G
G
P
G
S
G
Site 139
S1137
L
S
E
G
G
P
G
S
G
M
E
N
G
R
D
Site 140
S1157
F
K
R
L
G
C
H
S
F
D
D
H
L
S
P
Site 141
S1163
H
S
F
D
D
H
L
S
P
N
Q
D
G
G
K
Site 142
S1171
P
N
Q
D
G
G
K
S
K
N
V
V
N
L
G
Site 143
T1249
K
G
H
H
V
N
I
T
K
K
G
L
S
R
G
Site 144
S1254
N
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G
Q
Q
N
L
Site 296
S3073
Q
L
R
R
P
L
L
S
R
Q
K
T
Q
T
E
Site 297
T3077
P
L
L
S
R
Q
K
T
Q
T
E
P
R
N
R
Site 298
T3079
L
S
R
Q
K
T
Q
T
E
P
R
N
R
Q
G
Site 299
S3090
N
R
Q
G
A
R
L
S
T
T
R
R
S
I
Q
Site 300
T3091
R
Q
G
A
R
L
S
T
T
R
R
S
I
Q
P
Site 301
T3092
Q
G
A
R
L
S
T
T
R
R
S
I
Q
P
K
Site 302
S3095
R
L
S
T
T
R
R
S
I
Q
P
K
T
K
P
Site 303
T3100
R
R
S
I
Q
P
K
T
K
P
S
A
D
Q
K
Site 304
S3109
P
S
A
D
Q
K
R
S
V
T
F
I
E
A
Q
Site 305
T3111
A
D
Q
K
R
S
V
T
F
I
E
A
Q
P
E
Site 306
T3130
P
T
D
A
L
P
A
T
G
Q
L
Q
G
C
S
Site 307
S3137
T
G
Q
L
Q
G
C
S
P
A
P
S
R
K
P
Site 308
S3141
Q
G
C
S
P
A
P
S
R
K
P
E
A
M
D
Site 309
S3165
I
V
V
A
D
L
H
S
V
S
P
K
Q
S
E
Site 310
S3167
V
A
D
L
H
S
V
S
P
K
Q
S
E
N
F
Site 311
S3171
H
S
V
S
P
K
Q
S
E
N
F
P
T
E
E
Site 312
T3176
K
Q
S
E
N
F
P
T
E
E
G
E
K
E
E
Site 313
T3185
E
G
E
K
E
E
D
T
E
A
Q
G
A
T
A
Site 314
S3194
A
Q
G
A
T
A
H
S
P
L
S
A
Q
L
S
Site 315
S3197
A
T
A
H
S
P
L
S
A
Q
L
S
D
P
D
Site 316
S3201
S
P
L
S
A
Q
L
S
D
P
D
D
F
T
G
Site 317
T3207
L
S
D
P
D
D
F
T
G
L
E
T
S
S
L
Site 318
S3213
F
T
G
L
E
T
S
S
L
L
Q
H
G
D
T
Site 319
T3220
S
L
L
Q
H
G
D
T
V
L
H
I
S
E
E
Site 320
S3236
G
M
E
N
P
L
L
S
S
Q
F
T
F
T
P
Site 321
S3237
M
E
N
P
L
L
S
S
Q
F
T
F
T
P
T
Site 322
T3242
L
S
S
Q
F
T
F
T
P
T
E
L
G
K
T
Site 323
T3249
T
P
T
E
L
G
K
T
D
A
V
L
D
E
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation