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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL34
Full Name:
Kelch-like protein 34
Alias:
Type:
Mass (Da):
70612
Number AA:
644
UniProt ID:
Q8N239
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T32
E
G
F
L
C
D
V
T
L
E
T
E
G
S
E
Site 2
S38
V
T
L
E
T
E
G
S
E
F
P
A
H
R
S
Site 3
S45
S
E
F
P
A
H
R
S
L
L
A
C
S
S
D
Site 4
S60
Y
F
R
A
L
F
K
S
H
T
Q
E
S
R
A
Site 5
T62
R
A
L
F
K
S
H
T
Q
E
S
R
A
R
V
Site 6
S65
F
K
S
H
T
Q
E
S
R
A
R
V
I
H
L
Site 7
S95
Y
T
A
W
L
S
L
S
M
D
T
V
E
D
T
Site 8
T98
W
L
S
L
S
M
D
T
V
E
D
T
L
E
A
Site 9
T102
S
M
D
T
V
E
D
T
L
E
A
A
S
Y
L
Site 10
T209
A
W
L
R
Q
E
P
T
T
E
R
L
A
H
C
Site 11
T210
W
L
R
Q
E
P
T
T
E
R
L
A
H
C
T
Site 12
Y237
A
D
V
L
R
R
V
Y
S
G
S
G
L
V
L
Site 13
Y258
L
I
I
Q
A
L
N
Y
H
T
T
P
S
R
Q
Site 14
T261
Q
A
L
N
Y
H
T
T
P
S
R
Q
P
L
M
Site 15
T273
P
L
M
Q
G
E
Q
T
S
I
R
S
P
Q
T
Site 16
S274
L
M
Q
G
E
Q
T
S
I
R
S
P
Q
T
R
Site 17
S277
G
E
Q
T
S
I
R
S
P
Q
T
R
I
L
L
Site 18
T333
E
E
E
E
W
E
L
T
Q
N
V
V
A
F
D
Site 19
Y342
N
V
V
A
F
D
V
Y
N
H
R
W
R
S
L
Site 20
S348
V
Y
N
H
R
W
R
S
L
T
Q
L
P
T
P
Site 21
T350
N
H
R
W
R
S
L
T
Q
L
P
T
P
L
L
Site 22
T354
R
S
L
T
Q
L
P
T
P
L
L
G
H
S
V
Site 23
S377
V
L
G
G
E
S
P
S
G
S
A
S
S
P
L
Site 24
S379
G
G
E
S
P
S
G
S
A
S
S
P
L
A
D
Site 25
S381
E
S
P
S
G
S
A
S
S
P
L
A
D
D
S
Site 26
S382
S
P
S
G
S
A
S
S
P
L
A
D
D
S
R
Site 27
S388
S
S
P
L
A
D
D
S
R
V
V
T
A
Q
V
Site 28
T392
A
D
D
S
R
V
V
T
A
Q
V
H
R
Y
D
Site 29
Y398
V
T
A
Q
V
H
R
Y
D
P
R
F
H
A
W
Site 30
T406
D
P
R
F
H
A
W
T
E
V
P
A
M
R
E
Site 31
Y446
V
L
A
S
V
E
M
Y
D
L
R
R
D
R
W
Site 32
T454
D
L
R
R
D
R
W
T
A
A
G
A
L
P
R
Site 33
Y477
V
G
D
R
G
V
V
Y
I
S
G
G
K
A
G
Site 34
S479
D
R
G
V
V
Y
I
S
G
G
K
A
G
R
G
Site 35
S491
G
R
G
E
G
G
A
S
S
L
R
D
L
Y
V
Site 36
S492
R
G
E
G
G
A
S
S
L
R
D
L
Y
V
L
Site 37
Y497
A
S
S
L
R
D
L
Y
V
L
G
P
E
E
Q
Site 38
S507
G
P
E
E
Q
V
W
S
K
K
A
P
M
G
T
Site 39
T514
S
K
K
A
P
M
G
T
A
R
F
G
H
H
M
Site 40
S539
L
G
R
Y
E
P
F
S
E
I
E
R
Y
D
P
Site 41
Y544
P
F
S
E
I
E
R
Y
D
P
G
A
D
Q
W
Site 42
T552
D
P
G
A
D
Q
W
T
R
L
R
P
L
P
Y
Site 43
Y559
T
R
L
R
P
L
P
Y
D
R
F
C
Y
G
L
Site 44
S584
G
G
L
K
W
R
D
S
R
Q
V
P
T
R
N
Site 45
Y595
P
T
R
N
V
V
G
Y
D
L
D
L
D
R
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation