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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RGNEF
Full Name:
Rho-guanine nucleotide exchange factor
Alias:
P190RhoGEF
Type:
Mass (Da):
191892
Number AA:
1705
UniProt ID:
Q8N1W1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005089
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007242
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
L
Y
G
Q
M
M
I
Y
A
K
F
D
K
N
V
Site 2
Y33
L
P
E
D
A
E
F
Y
F
T
Y
D
G
S
H
Site 3
T35
E
D
A
E
F
Y
F
T
Y
D
G
S
H
Q
R
Site 4
Y36
D
A
E
F
Y
F
T
Y
D
G
S
H
Q
R
H
Site 5
S57
I
E
D
N
V
L
Q
S
S
V
P
G
H
G
L
Site 6
S58
E
D
N
V
L
Q
S
S
V
P
G
H
G
L
Q
Site 7
T83
S
E
G
Y
S
P
V
T
M
G
S
G
S
V
T
Site 8
S86
Y
S
P
V
T
M
G
S
G
S
V
T
Y
V
D
Site 9
Y91
M
G
S
G
S
V
T
Y
V
D
N
M
A
C
R
Site 10
T105
R
L
A
R
L
L
V
T
Q
A
N
R
L
T
A
Site 11
T111
V
T
Q
A
N
R
L
T
A
C
S
H
Q
T
L
Site 12
S114
A
N
R
L
T
A
C
S
H
Q
T
L
L
T
P
Site 13
S156
W
T
V
L
G
S
S
S
L
E
V
S
S
H
R
Site 14
S160
G
S
S
S
L
E
V
S
S
H
R
E
S
L
L
Site 15
S161
S
S
S
L
E
V
S
S
H
R
E
S
L
L
H
Site 16
S165
E
V
S
S
H
R
E
S
L
L
H
L
A
M
R
Site 17
T201
L
P
N
E
E
G
A
T
P
L
D
L
A
L
R
Site 18
T219
S
K
L
V
E
D
V
T
N
F
Q
G
R
W
S
Site 19
S226
T
N
F
Q
G
R
W
S
P
S
F
S
R
V
Q
Site 20
S228
F
Q
G
R
W
S
P
S
F
S
R
V
Q
L
S
Site 21
S230
G
R
W
S
P
S
F
S
R
V
Q
L
S
E
E
Site 22
S235
S
F
S
R
V
Q
L
S
E
E
A
S
L
H
Y
Site 23
S239
V
Q
L
S
E
E
A
S
L
H
Y
I
H
S
S
Site 24
Y242
S
E
E
A
S
L
H
Y
I
H
S
S
E
T
L
Site 25
S245
A
S
L
H
Y
I
H
S
S
E
T
L
T
L
T
Site 26
T250
I
H
S
S
E
T
L
T
L
T
L
N
H
T
A
Site 27
T252
S
S
E
T
L
T
L
T
L
N
H
T
A
E
H
Site 28
Y271
D
I
K
L
F
R
K
Y
F
W
D
R
A
F
L
Site 29
T292
E
A
R
P
E
E
R
T
A
M
P
S
S
G
A
Site 30
S296
E
E
R
T
A
M
P
S
S
G
A
E
T
E
E
Site 31
S297
E
R
T
A
M
P
S
S
G
A
E
T
E
E
E
Site 32
T301
M
P
S
S
G
A
E
T
E
E
E
I
K
N
S
Site 33
S308
T
E
E
E
I
K
N
S
V
S
S
R
S
A
A
Site 34
S310
E
E
I
K
N
S
V
S
S
R
S
A
A
E
K
Site 35
S325
E
D
I
K
R
V
K
S
L
V
V
Q
H
N
E
Site 36
S338
N
E
H
E
D
Q
H
S
L
D
L
D
R
S
F
Site 37
S344
H
S
L
D
L
D
R
S
F
D
I
L
K
K
S
Site 38
S351
S
F
D
I
L
K
K
S
K
P
P
S
T
L
L
Site 39
S355
L
K
K
S
K
P
P
S
T
L
L
A
A
G
R
Site 40
T356
K
K
S
K
P
P
S
T
L
L
A
A
G
R
L
Site 41
T399
N
I
E
G
I
T
A
T
T
S
P
E
S
R
G
Site 42
S401
E
G
I
T
A
T
T
S
P
E
S
R
G
C
T
Site 43
S404
T
A
T
T
S
P
E
S
R
G
C
T
L
W
P
Site 44
T408
S
P
E
S
R
G
C
T
L
W
P
Q
S
S
K
Site 45
S413
G
C
T
L
W
P
Q
S
S
K
H
T
L
P
T
Site 46
S414
C
T
L
W
P
Q
S
S
K
H
T
L
P
T
E
Site 47
T417
W
P
Q
S
S
K
H
T
L
P
T
E
T
S
P
Site 48
T420
S
S
K
H
T
L
P
T
E
T
S
P
S
V
Y
Site 49
S423
H
T
L
P
T
E
T
S
P
S
V
Y
P
L
S
Site 50
S425
L
P
T
E
T
S
P
S
V
Y
P
L
S
E
N
Site 51
Y427
T
E
T
S
P
S
V
Y
P
L
S
E
N
V
E
Site 52
S430
S
P
S
V
Y
P
L
S
E
N
V
E
G
T
A
Site 53
S444
A
H
T
E
A
Q
Q
S
F
M
S
P
S
S
S
Site 54
S447
E
A
Q
Q
S
F
M
S
P
S
S
S
C
A
S
Site 55
S449
Q
Q
S
F
M
S
P
S
S
S
C
A
S
N
L
Site 56
S450
Q
S
F
M
S
P
S
S
S
C
A
S
N
L
N
Site 57
S451
S
F
M
S
P
S
S
S
C
A
S
N
L
N
L
Site 58
S454
S
P
S
S
S
C
A
S
N
L
N
L
S
F
G
Site 59
S470
H
G
F
E
K
E
Q
S
H
L
K
K
R
S
S
Site 60
S477
S
H
L
K
K
R
S
S
S
L
D
A
L
D
A
Site 61
S478
H
L
K
K
R
S
S
S
L
D
A
L
D
A
D
Site 62
S486
L
D
A
L
D
A
D
S
E
G
E
G
H
S
E
Site 63
S492
D
S
E
G
E
G
H
S
E
P
S
H
I
C
Y
Site 64
S495
G
E
G
H
S
E
P
S
H
I
C
Y
T
P
G
Site 65
Y499
S
E
P
S
H
I
C
Y
T
P
G
S
Q
S
S
Site 66
T500
E
P
S
H
I
C
Y
T
P
G
S
Q
S
S
S
Site 67
S503
H
I
C
Y
T
P
G
S
Q
S
S
S
R
T
G
Site 68
S505
C
Y
T
P
G
S
Q
S
S
S
R
T
G
I
P
Site 69
S506
Y
T
P
G
S
Q
S
S
S
R
T
G
I
P
S
Site 70
S507
T
P
G
S
Q
S
S
S
R
T
G
I
P
S
G
Site 71
T509
G
S
Q
S
S
S
R
T
G
I
P
S
G
D
E
Site 72
S513
S
S
R
T
G
I
P
S
G
D
E
L
D
S
F
Site 73
S519
P
S
G
D
E
L
D
S
F
E
T
N
T
E
P
Site 74
S531
T
E
P
D
F
N
I
S
R
A
E
S
L
P
L
Site 75
S535
F
N
I
S
R
A
E
S
L
P
L
S
S
N
L
Site 76
S539
R
A
E
S
L
P
L
S
S
N
L
Q
S
K
E
Site 77
S540
A
E
S
L
P
L
S
S
N
L
Q
S
K
E
S
Site 78
S544
P
L
S
S
N
L
Q
S
K
E
S
L
L
S
G
Site 79
S547
S
N
L
Q
S
K
E
S
L
L
S
G
V
R
S
Site 80
S550
Q
S
K
E
S
L
L
S
G
V
R
S
R
S
Y
Site 81
S554
S
L
L
S
G
V
R
S
R
S
Y
S
C
S
S
Site 82
S556
L
S
G
V
R
S
R
S
Y
S
C
S
S
P
K
Site 83
Y557
S
G
V
R
S
R
S
Y
S
C
S
S
P
K
I
Site 84
S558
G
V
R
S
R
S
Y
S
C
S
S
P
K
I
S
Site 85
S560
R
S
R
S
Y
S
C
S
S
P
K
I
S
L
G
Site 86
S561
S
R
S
Y
S
C
S
S
P
K
I
S
L
G
K
Site 87
S565
S
C
S
S
P
K
I
S
L
G
K
T
R
L
V
Site 88
T569
P
K
I
S
L
G
K
T
R
L
V
R
E
L
T
Site 89
T576
T
R
L
V
R
E
L
T
V
C
S
S
S
E
E
Site 90
S580
R
E
L
T
V
C
S
S
S
E
E
Q
R
A
Y
Site 91
S581
E
L
T
V
C
S
S
S
E
E
Q
R
A
Y
S
Site 92
Y587
S
S
E
E
Q
R
A
Y
S
L
S
E
P
P
R
Site 93
S588
S
E
E
Q
R
A
Y
S
L
S
E
P
P
R
E
Site 94
S590
E
Q
R
A
Y
S
L
S
E
P
P
R
E
N
R
Site 95
Y606
Q
E
E
E
W
D
K
Y
I
I
P
A
K
S
E
Site 96
S612
K
Y
I
I
P
A
K
S
E
S
E
K
Y
K
V
Site 97
S614
I
I
P
A
K
S
E
S
E
K
Y
K
V
S
R
Site 98
Y617
A
K
S
E
S
E
K
Y
K
V
S
R
T
F
S
Site 99
S620
E
S
E
K
Y
K
V
S
R
T
F
S
F
L
M
Site 100
T622
E
K
Y
K
V
S
R
T
F
S
F
L
M
N
R
Site 101
S624
Y
K
V
S
R
T
F
S
F
L
M
N
R
M
T
Site 102
T631
S
F
L
M
N
R
M
T
S
P
R
N
K
S
K
Site 103
S632
F
L
M
N
R
M
T
S
P
R
N
K
S
K
T
Site 104
S637
M
T
S
P
R
N
K
S
K
T
K
S
K
D
A
Site 105
T639
S
P
R
N
K
S
K
T
K
S
K
D
A
K
D
Site 106
S641
R
N
K
S
K
T
K
S
K
D
A
K
D
K
E
Site 107
T659
R
H
Q
F
A
P
G
T
F
S
G
V
L
Q
C
Site 108
S678
K
T
L
L
G
K
E
S
L
Q
C
S
D
C
N
Site 109
S682
G
K
E
S
L
Q
C
S
D
C
N
A
N
V
H
Site 110
T700
K
D
A
A
P
A
C
T
K
K
F
Q
E
K
Y
Site 111
Y707
T
K
K
F
Q
E
K
Y
N
K
N
K
P
Q
T
Site 112
T714
Y
N
K
N
K
P
Q
T
I
L
G
N
S
S
F
Site 113
S720
Q
T
I
L
G
N
S
S
F
R
D
I
P
Q
P
Site 114
S730
D
I
P
Q
P
G
L
S
L
H
P
S
S
S
V
Site 115
T743
S
V
P
V
G
L
P
T
G
R
R
E
T
V
G
Site 116
T748
L
P
T
G
R
R
E
T
V
G
Q
V
H
P
L
Site 117
S756
V
G
Q
V
H
P
L
S
R
S
V
P
G
T
T
Site 118
S758
Q
V
H
P
L
S
R
S
V
P
G
T
T
L
E
Site 119
T762
L
S
R
S
V
P
G
T
T
L
E
S
F
R
R
Site 120
T763
S
R
S
V
P
G
T
T
L
E
S
F
R
R
S
Site 121
S766
V
P
G
T
T
L
E
S
F
R
R
S
A
T
S
Site 122
S770
T
L
E
S
F
R
R
S
A
T
S
L
E
S
E
Site 123
T772
E
S
F
R
R
S
A
T
S
L
E
S
E
S
D
Site 124
S773
S
F
R
R
S
A
T
S
L
E
S
E
S
D
H
Site 125
S776
R
S
A
T
S
L
E
S
E
S
D
H
N
S
C
Site 126
S778
A
T
S
L
E
S
E
S
D
H
N
S
C
R
S
Site 127
S782
E
S
E
S
D
H
N
S
C
R
S
R
S
H
S
Site 128
S785
S
D
H
N
S
C
R
S
R
S
H
S
D
E
L
Site 129
S787
H
N
S
C
R
S
R
S
H
S
D
E
L
L
Q
Site 130
S789
S
C
R
S
R
S
H
S
D
E
L
L
Q
S
M
Site 131
S795
H
S
D
E
L
L
Q
S
M
G
S
S
P
S
T
Site 132
S798
E
L
L
Q
S
M
G
S
S
P
S
T
E
S
F
Site 133
S799
L
L
Q
S
M
G
S
S
P
S
T
E
S
F
I
Site 134
S801
Q
S
M
G
S
S
P
S
T
E
S
F
I
M
E
Site 135
T802
S
M
G
S
S
P
S
T
E
S
F
I
M
E
D
Site 136
S804
G
S
S
P
S
T
E
S
F
I
M
E
D
V
V
Site 137
S814
M
E
D
V
V
D
S
S
L
W
S
D
L
S
S
Site 138
S817
V
V
D
S
S
L
W
S
D
L
S
S
D
A
Q
Site 139
S820
S
S
L
W
S
D
L
S
S
D
A
Q
E
F
E
Site 140
S821
S
L
W
S
D
L
S
S
D
A
Q
E
F
E
A
Site 141
S832
E
F
E
A
E
S
W
S
L
V
V
D
P
S
F
Site 142
S838
W
S
L
V
V
D
P
S
F
C
N
R
Q
E
K
Site 143
S888
E
E
L
Q
L
D
H
S
T
V
D
K
I
F
P
Site 144
T889
E
L
Q
L
D
H
S
T
V
D
K
I
F
P
C
Site 145
S918
M
K
E
R
R
Q
E
S
C
A
G
S
D
R
N
Site 146
S922
R
Q
E
S
C
A
G
S
D
R
N
F
V
I
D
Site 147
S940
D
I
L
V
Q
Q
F
S
E
E
N
A
S
K
M
Site 148
S945
Q
F
S
E
E
N
A
S
K
M
K
K
I
Y
G
Site 149
Y951
A
S
K
M
K
K
I
Y
G
E
F
C
C
H
H
Site 150
S983
N
F
I
K
L
R
N
S
N
L
L
A
R
R
R
Site 151
Y1006
V
T
Q
R
I
T
K
Y
P
V
L
V
E
R
I
Site 152
T1017
V
E
R
I
L
Q
Y
T
K
E
R
T
E
E
H
Site 153
Y1048
V
D
L
K
V
N
E
Y
E
K
N
Q
K
W
L
Site 154
Y1066
N
K
I
E
N
K
T
Y
T
K
L
K
N
G
H
Site 155
S1082
F
R
K
Q
A
L
M
S
E
E
R
T
L
L
Y
Site 156
Y1089
S
E
E
R
T
L
L
Y
D
G
L
V
Y
W
K
Site 157
T1097
D
G
L
V
Y
W
K
T
A
T
G
R
F
K
D
Site 158
Y1124
L
Q
E
K
D
Q
K
Y
I
F
A
A
V
D
Q
Site 159
S1137
D
Q
K
P
S
V
I
S
L
Q
K
L
I
A
R
Site 160
S1157
E
R
G
M
F
L
I
S
A
S
S
A
G
P
E
Site 161
Y1166
S
S
A
G
P
E
M
Y
E
I
H
T
N
S
K
Site 162
S1189
R
I
Q
Q
A
V
E
S
C
P
E
E
K
G
G
Site 163
S1199
E
E
K
G
G
R
T
S
E
S
D
E
D
K
R
Site 164
S1201
K
G
G
R
T
S
E
S
D
E
D
K
R
K
A
Site 165
Y1232
Q
D
Q
Q
I
C
A
Y
L
E
E
K
L
H
I
Site 166
Y1240
L
E
E
K
L
H
I
Y
A
E
L
G
E
L
S
Site 167
S1247
Y
A
E
L
G
E
L
S
G
F
E
D
V
H
L
Site 168
S1297
A
S
Q
M
G
A
V
S
Q
S
C
E
D
S
C
Site 169
S1299
Q
M
G
A
V
S
Q
S
C
E
D
S
C
G
D
Site 170
S1303
V
S
Q
S
C
E
D
S
C
G
D
S
V
L
A
Site 171
S1307
C
E
D
S
C
G
D
S
V
L
A
D
T
L
S
Site 172
T1312
G
D
S
V
L
A
D
T
L
S
S
H
D
V
P
Site 173
S1314
S
V
L
A
D
T
L
S
S
H
D
V
P
G
S
Site 174
S1315
V
L
A
D
T
L
S
S
H
D
V
P
G
S
P
Site 175
S1321
S
S
H
D
V
P
G
S
P
T
A
S
L
V
T
Site 176
S1325
V
P
G
S
P
T
A
S
L
V
T
G
G
R
E
Site 177
S1337
G
R
E
G
R
G
C
S
D
V
D
P
G
I
Q
Site 178
S1367
E
C
R
N
F
P
G
S
S
Q
S
E
I
I
Q
Site 179
S1368
C
R
N
F
P
G
S
S
Q
S
E
I
I
Q
A
Site 180
S1370
N
F
P
G
S
S
Q
S
E
I
I
Q
A
I
Q
Site 181
T1391
Y
S
L
Q
A
A
L
T
I
Q
D
S
H
I
E
Site 182
S1411
L
Q
Q
Q
E
G
L
S
L
G
H
S
I
L
R
Site 183
S1427
G
P
L
Q
D
Q
K
S
R
D
A
D
R
Q
H
Site 184
S1470
R
A
Q
A
T
R
E
S
W
L
Q
E
R
E
R
Site 185
S1481
E
R
E
R
E
C
Q
S
Q
E
E
L
L
L
R
Site 186
Y1500
L
D
L
Q
L
Q
E
Y
Q
H
S
L
E
R
L
Site 187
S1503
Q
L
Q
E
Y
Q
H
S
L
E
R
L
R
E
G
Site 188
S1526
A
R
M
R
A
Q
Q
S
L
L
G
H
W
K
H
Site 189
S1538
W
K
H
G
R
Q
R
S
L
P
A
V
L
L
P
Site 190
S1556
E
V
M
E
L
N
R
S
E
S
L
C
H
E
N
Site 191
S1558
M
E
L
N
R
S
E
S
L
C
H
E
N
S
F
Site 192
S1564
E
S
L
C
H
E
N
S
F
F
I
N
E
A
L
Site 193
S1575
N
E
A
L
V
Q
M
S
F
N
T
F
N
K
L
Site 194
T1578
L
V
Q
M
S
F
N
T
F
N
K
L
N
P
S
Site 195
S1585
T
F
N
K
L
N
P
S
V
I
H
Q
D
A
T
Site 196
T1592
S
V
I
H
Q
D
A
T
Y
P
T
T
Q
S
H
Site 197
Y1593
V
I
H
Q
D
A
T
Y
P
T
T
Q
S
H
S
Site 198
T1596
Q
D
A
T
Y
P
T
T
Q
S
H
S
D
L
V
Site 199
S1598
A
T
Y
P
T
T
Q
S
H
S
D
L
V
R
T
Site 200
S1600
Y
P
T
T
Q
S
H
S
D
L
V
R
T
S
E
Site 201
S1606
H
S
D
L
V
R
T
S
E
H
Q
V
D
L
K
Site 202
S1617
V
D
L
K
V
D
P
S
Q
P
S
N
V
S
H
Site 203
S1620
K
V
D
P
S
Q
P
S
N
V
S
H
K
L
W
Site 204
S1623
P
S
Q
P
S
N
V
S
H
K
L
W
T
A
A
Site 205
T1628
N
V
S
H
K
L
W
T
A
A
G
S
G
H
Q
Site 206
S1642
Q
I
L
P
F
H
E
S
S
K
D
S
C
K
N
Site 207
S1643
I
L
P
F
H
E
S
S
K
D
S
C
K
N
D
Site 208
S1646
F
H
E
S
S
K
D
S
C
K
N
D
L
D
T
Site 209
T1653
S
C
K
N
D
L
D
T
S
H
T
E
S
P
T
Site 210
S1654
C
K
N
D
L
D
T
S
H
T
E
S
P
T
P
Site 211
T1656
N
D
L
D
T
S
H
T
E
S
P
T
P
H
D
Site 212
S1658
L
D
T
S
H
T
E
S
P
T
P
H
D
S
N
Site 213
T1660
T
S
H
T
E
S
P
T
P
H
D
S
N
S
H
Site 214
S1664
E
S
P
T
P
H
D
S
N
S
H
R
P
Q
L
Site 215
S1666
P
T
P
H
D
S
N
S
H
R
P
Q
L
Q
A
Site 216
T1676
P
Q
L
Q
A
F
I
T
E
A
K
L
N
L
P
Site 217
T1688
N
L
P
T
R
T
M
T
R
Q
D
G
E
T
G
Site 218
T1694
M
T
R
Q
D
G
E
T
G
D
G
A
K
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation