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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRT78
Full Name:
Keratin, type II cytoskeletal 78
Alias:
Cytokeratin-78;Keratin-5b;Keratin-78;Type-II keratin Kb40
Type:
Mass (Da):
56866
Number AA:
520
UniProt ID:
Q8N1N4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
C
R
A
Q
R
G
F
S
A
R
S
A
C
S
A
Site 2
S16
Q
R
G
F
S
A
R
S
A
C
S
A
R
S
R
Site 3
S19
F
S
A
R
S
A
C
S
A
R
S
R
G
R
S
Site 4
S22
R
S
A
C
S
A
R
S
R
G
R
S
R
G
G
Site 5
S26
S
A
R
S
R
G
R
S
R
G
G
F
S
S
R
Site 6
S31
G
R
S
R
G
G
F
S
S
R
G
G
F
S
S
Site 7
S32
R
S
R
G
G
F
S
S
R
G
G
F
S
S
R
Site 8
S37
F
S
S
R
G
G
F
S
S
R
S
L
N
S
F
Site 9
S38
S
S
R
G
G
F
S
S
R
S
L
N
S
F
G
Site 10
S40
R
G
G
F
S
S
R
S
L
N
S
F
G
G
C
Site 11
S43
F
S
S
R
S
L
N
S
F
G
G
C
L
E
G
Site 12
S51
F
G
G
C
L
E
G
S
R
G
S
T
W
G
S
Site 13
S54
C
L
E
G
S
R
G
S
T
W
G
S
G
G
R
Site 14
T55
L
E
G
S
R
G
S
T
W
G
S
G
G
R
L
Site 15
S58
S
R
G
S
T
W
G
S
G
G
R
L
G
V
R
Site 16
S70
G
V
R
F
G
E
W
S
G
G
P
G
L
S
L
Site 17
T94
T
I
N
Q
N
L
L
T
P
L
K
I
E
I
D
Site 18
S124
T
L
N
N
Q
F
A
S
F
I
D
K
V
R
F
Site 19
S152
L
L
Q
Q
Q
G
L
S
G
S
Q
Q
G
L
E
Site 20
S154
Q
Q
Q
G
L
S
G
S
Q
Q
G
L
E
P
V
Site 21
S199
D
Q
E
E
E
Y
K
S
K
Y
E
E
E
A
H
Site 22
Y201
E
E
E
Y
K
S
K
Y
E
E
E
A
H
R
R
Site 23
T210
E
E
A
H
R
R
A
T
L
E
N
D
F
V
V
Site 24
S228
D
V
D
G
V
F
L
S
K
M
E
L
E
G
K
Site 25
Y242
K
L
E
A
L
R
E
Y
L
Y
F
L
K
H
L
Site 26
Y244
E
A
L
R
E
Y
L
Y
F
L
K
H
L
N
E
Site 27
T259
E
E
L
G
Q
L
Q
T
Q
A
S
D
T
S
V
Site 28
S262
G
Q
L
Q
T
Q
A
S
D
T
S
V
V
L
S
Site 29
T264
L
Q
T
Q
A
S
D
T
S
V
V
L
S
M
D
Site 30
S265
Q
T
Q
A
S
D
T
S
V
V
L
S
M
D
N
Site 31
S269
S
D
T
S
V
V
L
S
M
D
N
N
R
Y
L
Site 32
Y275
L
S
M
D
N
N
R
Y
L
D
F
S
S
I
I
Site 33
S279
N
N
R
Y
L
D
F
S
S
I
I
T
E
V
R
Site 34
T283
L
D
F
S
S
I
I
T
E
V
R
A
R
Y
E
Site 35
Y289
I
T
E
V
R
A
R
Y
E
E
I
A
R
S
S
Site 36
S295
R
Y
E
E
I
A
R
S
S
K
A
E
A
E
A
Site 37
S296
Y
E
E
I
A
R
S
S
K
A
E
A
E
A
L
Site 38
Y304
K
A
E
A
E
A
L
Y
Q
T
K
V
Y
Q
E
Site 39
T306
E
A
E
A
L
Y
Q
T
K
Y
Q
E
L
Q
V
Site 40
Y308
E
A
L
Y
Q
T
K
Y
Q
E
L
Q
V
S
A
Site 41
S314
K
Y
Q
E
L
Q
V
S
A
Q
L
H
G
D
R
Site 42
T325
H
G
D
R
M
Q
E
T
K
V
Q
I
S
Q
L
Site 43
S341
Q
E
I
Q
R
L
Q
S
Q
T
E
N
L
K
K
Site 44
T343
I
Q
R
L
Q
S
Q
T
E
N
L
K
K
Q
N
Site 45
Y396
L
A
R
L
L
C
E
Y
Q
E
L
T
S
T
K
Site 46
S401
C
E
Y
Q
E
L
T
S
T
K
L
S
L
D
V
Site 47
T402
E
Y
Q
E
L
T
S
T
K
L
S
L
D
V
E
Site 48
T412
S
L
D
V
E
I
A
T
Y
R
R
L
L
E
G
Site 49
Y413
L
D
V
E
I
A
T
Y
R
R
L
L
E
G
E
Site 50
S425
E
G
E
E
C
R
M
S
G
E
C
T
S
Q
V
Site 51
T429
C
R
M
S
G
E
C
T
S
Q
V
T
I
S
S
Site 52
S430
R
M
S
G
E
C
T
S
Q
V
T
I
S
S
V
Site 53
S459
G
S
T
C
G
L
G
S
G
K
G
S
P
G
S
Site 54
S463
G
L
G
S
G
K
G
S
P
G
S
C
C
T
S
Site 55
S466
S
G
K
G
S
P
G
S
C
C
T
S
I
V
T
Site 56
S470
S
P
G
S
C
C
T
S
I
V
T
G
G
S
N
Site 57
S490
G
K
D
P
V
L
D
S
C
S
V
S
G
S
S
Site 58
S492
D
P
V
L
D
S
C
S
V
S
G
S
S
A
G
Site 59
S496
D
S
C
S
V
S
G
S
S
A
G
S
S
C
H
Site 60
S497
S
C
S
V
S
G
S
S
A
G
S
S
C
H
T
Site 61
S500
V
S
G
S
S
A
G
S
S
C
H
T
I
L
K
Site 62
S501
S
G
S
S
A
G
S
S
C
H
T
I
L
K
K
Site 63
T504
S
A
G
S
S
C
H
T
I
L
K
K
T
V
E
Site 64
T509
C
H
T
I
L
K
K
T
V
E
S
S
L
K
T
Site 65
S513
L
K
K
T
V
E
S
S
L
K
T
S
I
T
Y
Site 66
T516
T
V
E
S
S
L
K
T
S
I
T
Y
_
_
_
Site 67
S517
V
E
S
S
L
K
T
S
I
T
Y
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation