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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALS2CR8
Full Name:
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
Alias:
AL2S8; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8; Calcium-response factor; CARF; FLJ21579; NYD-SP24; Testis development protein NYD-SP24
Type:
Transcription factor
Mass (Da):
80698
Number AA:
725
UniProt ID:
Q8N187
International Prot ID:
IPI00295701
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
N
D
G
E
E
S
K
T
S
A
Q
V
F
E
H
Site 2
S21
D
G
E
E
S
K
T
S
A
Q
V
F
E
H
L
Site 3
S33
E
H
L
I
C
M
D
S
R
D
S
S
F
G
Q
Site 4
S36
I
C
M
D
S
R
D
S
S
F
G
Q
N
D
S
Site 5
S37
C
M
D
S
R
D
S
S
F
G
Q
N
D
S
P
Site 6
S43
S
S
F
G
Q
N
D
S
P
T
V
L
P
I
T
Site 7
T45
F
G
Q
N
D
S
P
T
V
L
P
I
T
T
R
Site 8
T50
S
P
T
V
L
P
I
T
T
R
E
A
N
N
S
Site 9
S57
T
T
R
E
A
N
N
S
L
I
S
Q
N
I
P
Site 10
S60
E
A
N
N
S
L
I
S
Q
N
I
P
G
P
L
Site 11
T68
Q
N
I
P
G
P
L
T
Q
T
Q
T
L
S
A
Site 12
T72
G
P
L
T
Q
T
Q
T
L
S
A
E
Q
F
H
Site 13
S74
L
T
Q
T
Q
T
L
S
A
E
Q
F
H
L
V
Site 14
Y90
Q
N
G
Q
A
I
Q
Y
E
L
Q
S
L
G
E
Site 15
S94
A
I
Q
Y
E
L
Q
S
L
G
E
S
N
A
Q
Site 16
S140
G
Q
L
V
D
V
N
S
P
R
D
V
P
E
E
Site 17
S150
D
V
P
E
E
K
P
S
N
R
N
L
P
T
V
Site 18
T156
P
S
N
R
N
L
P
T
V
R
V
D
T
L
A
Site 19
T161
L
P
T
V
R
V
D
T
L
A
D
N
T
S
N
Site 20
T166
V
D
T
L
A
D
N
T
S
N
Y
I
L
H
P
Site 21
S167
D
T
L
A
D
N
T
S
N
Y
I
L
H
P
Q
Site 22
T175
N
Y
I
L
H
P
Q
T
S
F
P
L
P
K
K
Site 23
S176
Y
I
L
H
P
Q
T
S
F
P
L
P
K
K
S
Site 24
S183
S
F
P
L
P
K
K
S
V
T
G
M
L
E
E
Site 25
S201
G
P
L
Q
P
L
S
S
N
T
P
I
W
A
C
Site 26
S212
I
W
A
C
R
L
R
S
C
E
K
I
G
D
S
Site 27
S219
S
C
E
K
I
G
D
S
Y
R
G
Y
C
V
S
Site 28
Y220
C
E
K
I
G
D
S
Y
R
G
Y
C
V
S
E
Site 29
Y223
I
G
D
S
Y
R
G
Y
C
V
S
E
T
E
L
Site 30
S226
S
Y
R
G
Y
C
V
S
E
T
E
L
E
S
V
Site 31
T228
R
G
Y
C
V
S
E
T
E
L
E
S
V
L
T
Site 32
S232
V
S
E
T
E
L
E
S
V
L
T
F
H
K
Q
Site 33
T235
T
E
L
E
S
V
L
T
F
H
K
Q
Q
T
Q
Site 34
T241
L
T
F
H
K
Q
Q
T
Q
S
V
W
G
T
R
Site 35
T247
Q
T
Q
S
V
W
G
T
R
Q
S
P
S
P
A
Site 36
S250
S
V
W
G
T
R
Q
S
P
S
P
A
K
P
A
Site 37
S252
W
G
T
R
Q
S
P
S
P
A
K
P
A
T
R
Site 38
T258
P
S
P
A
K
P
A
T
R
L
M
W
K
S
Q
Site 39
Y266
R
L
M
W
K
S
Q
Y
V
P
Y
D
G
I
P
Site 40
Y288
A
V
V
M
E
C
Q
Y
G
P
R
R
K
G
F
Site 41
S301
G
F
Q
L
K
K
V
S
E
Q
E
S
R
S
C
Site 42
S305
K
K
V
S
E
Q
E
S
R
S
C
Q
L
Y
K
Site 43
Y311
E
S
R
S
C
Q
L
Y
K
A
T
C
P
A
R
Site 44
Y320
A
T
C
P
A
R
I
Y
I
K
K
V
Q
K
F
Site 45
Y330
K
V
Q
K
F
P
E
Y
R
V
P
T
D
P
K
Site 46
T334
F
P
E
Y
R
V
P
T
D
P
K
I
D
K
K
Site 47
Y368
A
G
G
V
L
R
W
Y
V
Q
L
P
T
Q
Q
Site 48
Y379
P
T
Q
Q
A
H
Q
Y
H
E
L
E
T
P
C
Site 49
T384
H
Q
Y
H
E
L
E
T
P
C
L
T
L
S
P
Site 50
T388
E
L
E
T
P
C
L
T
L
S
P
S
P
F
P
Site 51
S397
S
P
S
P
F
P
V
S
S
L
E
E
E
E
T
Site 52
S398
P
S
P
F
P
V
S
S
L
E
E
E
E
T
A
Site 53
T404
S
S
L
E
E
E
E
T
A
V
R
D
E
N
C
Site 54
S430
H
K
I
Q
E
L
V
S
Q
G
I
E
Q
V
Y
Site 55
Y437
S
Q
G
I
E
Q
V
Y
A
V
R
K
Q
L
R
Site 56
S464
V
P
E
R
H
N
L
S
F
F
P
T
V
N
D
Site 57
S482
H
I
H
E
V
Q
K
S
L
R
N
G
D
T
V
Site 58
T488
K
S
L
R
N
G
D
T
V
Y
N
S
E
I
I
Site 59
Y490
L
R
N
G
D
T
V
Y
N
S
E
I
I
P
A
Site 60
T498
N
S
E
I
I
P
A
T
L
Q
W
T
T
D
S
Site 61
S505
T
L
Q
W
T
T
D
S
G
N
I
L
K
E
T
Site 62
T512
S
G
N
I
L
K
E
T
M
T
V
T
F
A
E
Site 63
T514
N
I
L
K
E
T
M
T
V
T
F
A
E
G
N
Site 64
T516
L
K
E
T
M
T
V
T
F
A
E
G
N
S
P
Site 65
S522
V
T
F
A
E
G
N
S
P
G
E
S
I
T
T
Site 66
S526
E
G
N
S
P
G
E
S
I
T
T
K
V
E
T
Site 67
T529
S
P
G
E
S
I
T
T
K
V
E
T
N
Q
T
Site 68
S539
E
T
N
Q
T
R
G
S
L
S
P
E
P
T
H
Site 69
S541
N
Q
T
R
G
S
L
S
P
E
P
T
H
L
L
Site 70
T545
G
S
L
S
P
E
P
T
H
L
L
S
S
L
S
Site 71
S549
P
E
P
T
H
L
L
S
S
L
S
S
F
Q
P
Site 72
S550
E
P
T
H
L
L
S
S
L
S
S
F
Q
P
K
Site 73
Y571
G
L
Q
L
Q
P
R
Y
T
S
P
D
E
S
P
Site 74
T572
L
Q
L
Q
P
R
Y
T
S
P
D
E
S
P
A
Site 75
S573
Q
L
Q
P
R
Y
T
S
P
D
E
S
P
A
V
Site 76
S577
R
Y
T
S
P
D
E
S
P
A
V
V
S
V
N
Site 77
S582
D
E
S
P
A
V
V
S
V
N
N
Q
P
S
S
Site 78
S588
V
S
V
N
N
Q
P
S
S
S
P
S
G
L
L
Site 79
S589
S
V
N
N
Q
P
S
S
S
P
S
G
L
L
D
Site 80
S590
V
N
N
Q
P
S
S
S
P
S
G
L
L
D
T
Site 81
S592
N
Q
P
S
S
S
P
S
G
L
L
D
T
I
G
Site 82
S607
S
A
V
M
N
N
N
S
L
L
L
G
Q
S
H
Site 83
S613
N
S
L
L
L
G
Q
S
H
S
L
Q
R
D
T
Site 84
S615
L
L
L
G
Q
S
H
S
L
Q
R
D
T
C
L
Site 85
T620
S
H
S
L
Q
R
D
T
C
L
T
Q
N
N
S
Site 86
T623
L
Q
R
D
T
C
L
T
Q
N
N
S
T
A
S
Site 87
S627
T
C
L
T
Q
N
N
S
T
A
S
T
M
G
N
Site 88
T631
Q
N
N
S
T
A
S
T
M
G
N
L
P
E
P
Site 89
T657
E
V
G
D
V
E
D
T
G
N
L
E
G
T
V
Site 90
T663
D
T
G
N
L
E
G
T
V
H
R
I
L
L
G
Site 91
S684
I
Q
I
I
D
N
H
S
A
L
I
E
E
N
P
Site 92
S693
L
I
E
E
N
P
E
S
T
I
S
V
S
Q
V
Site 93
S696
E
N
P
E
S
T
I
S
V
S
Q
V
K
Q
E
Site 94
S698
P
E
S
T
I
S
V
S
Q
V
K
Q
E
P
K
Site 95
S710
E
P
K
E
P
A
L
S
M
E
A
K
K
T
V
Site 96
T716
L
S
M
E
A
K
K
T
V
D
Y
K
K
L
S
Site 97
Y719
E
A
K
K
T
V
D
Y
K
K
L
S
A
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation