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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TAGAP
Full Name:
T-cell activation Rho GTPase-activating protein
Alias:
T-cell activation GTPase-activating protein
Type:
Mass (Da):
80703
Number AA:
731
UniProt ID:
Q8N103
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
K
L
R
S
S
H
N
A
S
K
T
L
Site 2
S10
L
R
S
S
H
N
A
S
K
T
L
N
A
N
N
Site 3
T12
S
S
H
N
A
S
K
T
L
N
A
N
N
M
E
Site 4
S26
E
T
L
I
E
C
Q
S
E
G
D
I
K
E
H
Site 5
S38
K
E
H
P
L
L
A
S
C
E
S
E
D
S
I
Site 6
S59
K
K
R
K
K
V
L
S
W
P
F
L
M
R
R
Site 7
S68
P
F
L
M
R
R
L
S
P
A
S
D
F
S
G
Site 8
S71
M
R
R
L
S
P
A
S
D
F
S
G
A
L
E
Site 9
S74
L
S
P
A
S
D
F
S
G
A
L
E
T
D
L
Site 10
S84
L
E
T
D
L
K
A
S
L
F
D
Q
P
L
S
Site 11
T99
I
I
C
G
D
S
D
T
L
P
R
P
I
Q
D
Site 12
T118
L
C
L
K
G
P
S
T
E
G
I
F
R
R
A
Site 13
S140
E
L
K
E
E
L
N
S
G
D
A
V
D
L
E
Site 14
S171
S
I
P
R
K
L
L
S
S
D
L
F
E
E
W
Site 15
S172
I
P
R
K
L
L
S
S
D
L
F
E
E
W
M
Site 16
S223
L
H
L
I
S
K
N
S
E
V
N
R
M
D
S
Site 17
S230
S
E
V
N
R
M
D
S
S
N
L
A
I
C
I
Site 18
T243
C
I
G
P
N
M
L
T
L
E
N
D
Q
S
L
Site 19
S249
L
T
L
E
N
D
Q
S
L
S
F
E
A
Q
K
Site 20
S251
L
E
N
D
Q
S
L
S
F
E
A
Q
K
D
L
Site 21
S286
E
N
I
P
V
H
S
S
I
T
S
D
D
S
L
Site 22
S289
P
V
H
S
S
I
T
S
D
D
S
L
E
H
T
Site 23
S292
S
S
I
T
S
D
D
S
L
E
H
T
D
S
S
Site 24
T296
S
D
D
S
L
E
H
T
D
S
S
D
V
S
T
Site 25
S298
D
S
L
E
H
T
D
S
S
D
V
S
T
L
Q
Site 26
S299
S
L
E
H
T
D
S
S
D
V
S
T
L
Q
N
Site 27
S302
H
T
D
S
S
D
V
S
T
L
Q
N
D
S
A
Site 28
T303
T
D
S
S
D
V
S
T
L
Q
N
D
S
A
Y
Site 29
S308
V
S
T
L
Q
N
D
S
A
Y
D
S
N
D
P
Site 30
Y310
T
L
Q
N
D
S
A
Y
D
S
N
D
P
D
V
Site 31
S312
Q
N
D
S
A
Y
D
S
N
D
P
D
V
E
S
Site 32
S319
S
N
D
P
D
V
E
S
N
S
S
S
G
I
S
Site 33
S321
D
P
D
V
E
S
N
S
S
S
G
I
S
S
P
Site 34
S322
P
D
V
E
S
N
S
S
S
G
I
S
S
P
S
Site 35
S323
D
V
E
S
N
S
S
S
G
I
S
S
P
S
R
Site 36
S326
S
N
S
S
S
G
I
S
S
P
S
R
Q
P
Q
Site 37
S327
N
S
S
S
G
I
S
S
P
S
R
Q
P
Q
V
Site 38
S329
S
S
G
I
S
S
P
S
R
Q
P
Q
V
P
M
Site 39
S344
A
T
A
A
G
L
D
S
A
G
P
Q
D
A
R
Site 40
S354
P
Q
D
A
R
E
V
S
P
E
P
I
V
S
T
Site 41
S367
S
T
V
A
R
L
K
S
S
L
A
Q
P
D
R
Site 42
Y376
L
A
Q
P
D
R
R
Y
S
E
P
S
M
P
S
Site 43
S377
A
Q
P
D
R
R
Y
S
E
P
S
M
P
S
S
Site 44
S380
D
R
R
Y
S
E
P
S
M
P
S
S
Q
E
C
Site 45
S384
S
E
P
S
M
P
S
S
Q
E
C
L
E
S
R
Site 46
S390
S
S
Q
E
C
L
E
S
R
V
T
N
Q
T
L
Site 47
T393
E
C
L
E
S
R
V
T
N
Q
T
L
T
K
S
Site 48
T396
E
S
R
V
T
N
Q
T
L
T
K
S
E
G
D
Site 49
T398
R
V
T
N
Q
T
L
T
K
S
E
G
D
F
P
Site 50
S400
T
N
Q
T
L
T
K
S
E
G
D
F
P
V
P
Site 51
S411
F
P
V
P
R
V
G
S
R
L
E
S
E
E
A
Site 52
S415
R
V
G
S
R
L
E
S
E
E
A
E
D
P
F
Site 53
T434
F
P
A
V
Q
G
K
T
K
R
P
V
D
L
K
Site 54
S463
V
L
K
A
F
S
S
S
S
L
D
A
S
S
D
Site 55
S464
L
K
A
F
S
S
S
S
L
D
A
S
S
D
S
Site 56
S468
S
S
S
S
L
D
A
S
S
D
S
S
P
V
A
Site 57
S469
S
S
S
L
D
A
S
S
D
S
S
P
V
A
S
Site 58
S471
S
L
D
A
S
S
D
S
S
P
V
A
S
P
S
Site 59
S472
L
D
A
S
S
D
S
S
P
V
A
S
P
S
S
Site 60
S476
S
D
S
S
P
V
A
S
P
S
S
P
K
R
N
Site 61
S478
S
S
P
V
A
S
P
S
S
P
K
R
N
F
F
Site 62
S479
S
P
V
A
S
P
S
S
P
K
R
N
F
F
S
Site 63
S486
S
P
K
R
N
F
F
S
R
H
Q
S
F
T
T
Site 64
S490
N
F
F
S
R
H
Q
S
F
T
T
K
T
E
K
Site 65
T492
F
S
R
H
Q
S
F
T
T
K
T
E
K
G
K
Site 66
T495
H
Q
S
F
T
T
K
T
E
K
G
K
P
S
R
Site 67
S501
K
T
E
K
G
K
P
S
R
E
I
K
K
H
S
Site 68
S508
S
R
E
I
K
K
H
S
M
S
F
T
F
A
P
Site 69
S510
E
I
K
K
H
S
M
S
F
T
F
A
P
H
K
Site 70
T512
K
K
H
S
M
S
F
T
F
A
P
H
K
K
V
Site 71
T521
A
P
H
K
K
V
L
T
K
N
L
S
A
G
S
Site 72
S525
K
V
L
T
K
N
L
S
A
G
S
G
K
S
Q
Site 73
S531
L
S
A
G
S
G
K
S
Q
D
F
T
R
D
H
Site 74
T535
S
G
K
S
Q
D
F
T
R
D
H
V
P
R
G
Site 75
S547
P
R
G
V
R
K
E
S
Q
L
A
G
R
I
V
Site 76
T561
V
Q
E
N
G
C
E
T
H
N
Q
T
A
R
G
Site 77
S592
A
D
W
E
R
P
G
S
P
P
S
Y
E
E
A
Site 78
S595
E
R
P
G
S
P
P
S
Y
E
E
A
M
Q
G
Site 79
Y596
R
P
G
S
P
P
S
Y
E
E
A
M
Q
G
P
Site 80
S612
A
R
L
V
A
S
E
S
Q
T
V
G
S
M
T
Site 81
T614
L
V
A
S
E
S
Q
T
V
G
S
M
T
V
G
Site 82
S617
S
E
S
Q
T
V
G
S
M
T
V
G
S
M
R
Site 83
T619
S
Q
T
V
G
S
M
T
V
G
S
M
R
A
R
Site 84
S646
P
A
H
H
V
E
D
S
R
H
R
G
S
K
E
Site 85
S651
E
D
S
R
H
R
G
S
K
E
P
L
P
G
H
Site 86
S661
P
L
P
G
H
G
L
S
P
L
P
E
R
W
K
Site 87
T672
E
R
W
K
Q
S
R
T
V
H
A
S
G
D
S
Site 88
S676
Q
S
R
T
V
H
A
S
G
D
S
L
G
H
V
Site 89
S679
T
V
H
A
S
G
D
S
L
G
H
V
S
G
P
Site 90
S684
G
D
S
L
G
H
V
S
G
P
G
R
P
E
L
Site 91
T696
P
E
L
L
P
L
R
T
V
S
E
S
V
Q
R
Site 92
S698
L
L
P
L
R
T
V
S
E
S
V
Q
R
N
K
Site 93
S700
P
L
R
T
V
S
E
S
V
Q
R
N
K
R
D
Site 94
S714
D
C
L
V
R
R
C
S
Q
P
V
F
E
A
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation