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Updated November 2019
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Protein Info
Short Name:
ASPM
Full Name:
Abnormal spindle-like microcephaly-associated protein
Alias:
abnormal spindle protein; ASP; asp (abnormal spindle), microcephaly associated; Calmbp1; FLJ10517; FLJ10549; MCPH5
Type:
Cell cycle regulation
Mass (Da):
409800
Number AA:
3477
UniProt ID:
Q8IZT6
International Prot ID:
IPI00296362
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
G
R
G
C
W
E
V
S
P
T
E
R
R
P
P
Site 2
T16
G
C
W
E
V
S
P
T
E
R
R
P
P
A
G
Site 3
S34
P
A
A
E
E
E
A
S
S
P
P
V
L
S
L
Site 4
S35
A
A
E
E
E
A
S
S
P
P
V
L
S
L
S
Site 5
S40
A
S
S
P
P
V
L
S
L
S
H
F
C
R
S
Site 6
S64
L
G
A
S
R
T
L
S
L
A
L
D
N
P
N
Site 7
S107
P
K
E
K
I
V
I
S
V
N
W
T
P
L
K
Site 8
S149
E
Q
K
K
K
K
R
S
L
W
D
T
I
K
K
Site 9
T153
K
K
R
S
L
W
D
T
I
K
K
K
K
I
S
Site 10
S160
T
I
K
K
K
K
I
S
A
S
T
S
H
N
R
Site 11
S162
K
K
K
K
I
S
A
S
T
S
H
N
R
R
V
Site 12
S164
K
K
I
S
A
S
T
S
H
N
R
R
V
S
N
Site 13
S170
T
S
H
N
R
R
V
S
N
I
Q
N
V
N
K
Site 14
T178
N
I
Q
N
V
N
K
T
F
S
V
S
Q
K
V
Site 15
S182
V
N
K
T
F
S
V
S
Q
K
V
D
R
V
R
Site 16
S190
Q
K
V
D
R
V
R
S
P
L
Q
A
C
E
N
Site 17
T207
M
N
E
G
G
P
P
T
E
N
N
S
L
I
L
Site 18
S222
E
E
N
K
I
P
I
S
P
I
S
P
A
F
N
Site 19
S225
K
I
P
I
S
P
I
S
P
A
F
N
E
C
H
Site 20
S240
G
A
T
C
L
P
L
S
V
R
R
S
T
T
Y
Site 21
S244
L
P
L
S
V
R
R
S
T
T
Y
S
S
L
H
Site 22
T245
P
L
S
V
R
R
S
T
T
Y
S
S
L
H
A
Site 23
T246
L
S
V
R
R
S
T
T
Y
S
S
L
H
A
S
Site 24
Y247
S
V
R
R
S
T
T
Y
S
S
L
H
A
S
E
Site 25
S248
V
R
R
S
T
T
Y
S
S
L
H
A
S
E
N
Site 26
S249
R
R
S
T
T
Y
S
S
L
H
A
S
E
N
R
Site 27
S253
T
Y
S
S
L
H
A
S
E
N
R
E
L
L
N
Site 28
S263
R
E
L
L
N
V
H
S
A
N
V
S
K
V
S
Site 29
S267
N
V
H
S
A
N
V
S
K
V
S
F
N
E
K
Site 30
S270
S
A
N
V
S
K
V
S
F
N
E
K
A
V
T
Site 31
T277
S
F
N
E
K
A
V
T
E
T
S
F
N
S
V
Site 32
S280
E
K
A
V
T
E
T
S
F
N
S
V
N
V
N
Site 33
S283
V
T
E
T
S
F
N
S
V
N
V
N
G
Q
R
Site 34
S294
N
G
Q
R
G
E
N
S
K
L
S
L
T
P
N
Site 35
S297
R
G
E
N
S
K
L
S
L
T
P
N
C
S
S
Site 36
T299
E
N
S
K
L
S
L
T
P
N
C
S
S
T
L
Site 37
S303
L
S
L
T
P
N
C
S
S
T
L
N
I
T
Q
Site 38
T305
L
T
P
N
C
S
S
T
L
N
I
T
Q
S
Q
Site 39
S311
S
T
L
N
I
T
Q
S
Q
I
H
F
L
S
P
Site 40
S317
Q
S
Q
I
H
F
L
S
P
D
S
F
V
N
N
Site 41
S320
I
H
F
L
S
P
D
S
F
V
N
N
S
H
G
Site 42
S348
D
M
F
M
K
D
N
S
Q
P
V
H
L
E
S
Site 43
Y362
S
T
I
A
H
E
I
Y
Q
K
I
L
S
P
D
Site 44
S367
E
I
Y
Q
K
I
L
S
P
D
S
F
I
K
D
Site 45
S370
Q
K
I
L
S
P
D
S
F
I
K
D
N
Y
G
Site 46
Y376
D
S
F
I
K
D
N
Y
G
L
N
Q
D
L
E
Site 47
S384
G
L
N
Q
D
L
E
S
E
S
V
N
P
I
L
Site 48
S386
N
Q
D
L
E
S
E
S
V
N
P
I
L
S
P
Site 49
S392
E
S
V
N
P
I
L
S
P
N
Q
F
L
K
D
Site 50
Y403
F
L
K
D
N
M
A
Y
M
C
T
S
Q
Q
T
Site 51
S416
Q
T
C
K
V
P
L
S
N
E
N
S
Q
V
P
Site 52
S420
V
P
L
S
N
E
N
S
Q
V
P
Q
S
P
E
Site 53
S425
E
N
S
Q
V
P
Q
S
P
E
D
W
R
K
S
Site 54
S432
S
P
E
D
W
R
K
S
E
V
S
P
R
I
P
Site 55
S435
D
W
R
K
S
E
V
S
P
R
I
P
E
C
Q
Site 56
S444
R
I
P
E
C
Q
G
S
K
S
P
K
A
I
F
Site 57
S446
P
E
C
Q
G
S
K
S
P
K
A
I
F
E
E
Site 58
S459
E
E
L
V
E
M
K
S
N
Y
Y
S
F
I
K
Site 59
Y461
L
V
E
M
K
S
N
Y
Y
S
F
I
K
Q
N
Site 60
Y462
V
E
M
K
S
N
Y
Y
S
F
I
K
Q
N
N
Site 61
S463
E
M
K
S
N
Y
Y
S
F
I
K
Q
N
N
P
Site 62
S473
K
Q
N
N
P
K
F
S
A
V
Q
D
I
S
S
Site 63
S479
F
S
A
V
Q
D
I
S
S
H
S
H
N
K
Q
Site 64
S480
S
A
V
Q
D
I
S
S
H
S
H
N
K
Q
P
Site 65
S494
P
K
R
R
P
I
L
S
A
T
V
T
K
R
K
Site 66
T496
R
R
P
I
L
S
A
T
V
T
K
R
K
A
T
Site 67
T498
P
I
L
S
A
T
V
T
K
R
K
A
T
C
T
Site 68
T503
T
V
T
K
R
K
A
T
C
T
R
E
N
Q
T
Site 69
T505
T
K
R
K
A
T
C
T
R
E
N
Q
T
E
I
Site 70
S543
K
E
K
E
D
F
H
S
Y
L
P
I
I
D
P
Site 71
Y544
E
K
E
D
F
H
S
Y
L
P
I
I
D
P
I
Site 72
S553
P
I
I
D
P
I
L
S
K
S
K
S
Y
K
N
Site 73
S555
I
D
P
I
L
S
K
S
K
S
Y
K
N
E
V
Site 74
S557
P
I
L
S
K
S
K
S
Y
K
N
E
V
T
P
Site 75
T563
K
S
Y
K
N
E
V
T
P
S
S
T
T
A
S
Site 76
S565
Y
K
N
E
V
T
P
S
S
T
T
A
S
V
A
Site 77
S566
K
N
E
V
T
P
S
S
T
T
A
S
V
A
R
Site 78
S570
T
P
S
S
T
T
A
S
V
A
R
K
R
K
S
Site 79
S577
S
V
A
R
K
R
K
S
D
G
S
M
E
D
A
Site 80
S580
R
K
R
K
S
D
G
S
M
E
D
A
N
V
R
Site 81
S605
E
I
K
R
I
H
F
S
P
S
E
P
K
T
S
Site 82
S607
K
R
I
H
F
S
P
S
E
P
K
T
S
A
V
Site 83
T611
F
S
P
S
E
P
K
T
S
A
V
K
K
T
K
Site 84
S612
S
P
S
E
P
K
T
S
A
V
K
K
T
K
N
Site 85
T622
K
K
T
K
N
V
T
T
P
I
S
K
R
I
S
Site 86
S625
K
N
V
T
T
P
I
S
K
R
I
S
N
R
E
Site 87
S629
T
P
I
S
K
R
I
S
N
R
E
K
L
N
L
Site 88
S643
L
K
K
K
T
D
L
S
I
F
R
T
P
I
S
Site 89
T647
T
D
L
S
I
F
R
T
P
I
S
K
T
N
K
Site 90
S650
S
I
F
R
T
P
I
S
K
T
N
K
R
T
K
Site 91
T652
F
R
T
P
I
S
K
T
N
K
R
T
K
P
I
Site 92
S666
I
I
A
V
A
Q
S
S
L
T
F
I
K
P
L
Site 93
T675
T
F
I
K
P
L
K
T
D
I
P
R
H
P
M
Site 94
Y691
F
A
A
K
N
M
F
Y
D
E
R
W
K
E
K
Site 95
T717
I
L
T
P
D
D
F
T
V
K
T
N
I
S
E
Site 96
T720
P
D
D
F
T
V
K
T
N
I
S
E
V
N
A
Site 97
T729
I
S
E
V
N
A
A
T
L
L
L
G
I
E
N
Site 98
S741
I
E
N
Q
H
K
I
S
V
P
R
A
P
T
K
Site 99
T747
I
S
V
P
R
A
P
T
K
E
E
M
S
L
R
Site 100
S752
A
P
T
K
E
E
M
S
L
R
A
Y
T
A
R
Site 101
Y756
E
E
M
S
L
R
A
Y
T
A
R
C
R
L
N
Site 102
T757
E
M
S
L
R
A
Y
T
A
R
C
R
L
N
R
Site 103
T774
R
A
A
C
R
L
F
T
S
E
K
M
V
K
A
Site 104
Y832
R
I
G
L
E
T
T
Y
G
E
L
I
S
L
E
Site 105
S837
T
T
Y
G
E
L
I
S
L
E
D
N
S
D
V
Site 106
Y865
N
P
D
I
A
A
E
Y
R
H
P
T
V
P
H
Site 107
T869
A
A
E
Y
R
H
P
T
V
P
H
L
Y
R
D
Site 108
S883
D
G
H
E
E
A
L
S
K
F
T
L
K
K
L
Site 109
S922
K
D
A
E
F
K
A
S
K
E
I
L
L
A
F
Site 110
S935
A
F
S
R
D
F
L
S
G
E
G
D
L
S
R
Site 111
S941
L
S
G
E
G
D
L
S
R
H
L
G
L
L
G
Site 112
T956
L
P
V
N
H
V
Q
T
P
F
D
E
F
D
F
Site 113
T986
V
R
T
M
E
L
L
T
Q
N
W
D
L
S
K
Site 114
S1001
K
L
R
I
P
A
I
S
R
L
Q
K
M
H
N
Site 115
S1018
I
V
L
Q
V
L
K
S
R
G
I
E
L
S
D
Site 116
S1024
K
S
R
G
I
E
L
S
D
E
H
G
N
T
I
Site 117
T1030
L
S
D
E
H
G
N
T
I
L
S
K
D
I
V
Site 118
T1044
V
D
R
H
R
E
K
T
L
R
L
L
W
K
I
Site 119
S1078
A
F
L
K
H
T
K
S
I
K
K
T
I
S
L
Site 120
T1082
H
T
K
S
I
K
K
T
I
S
L
L
S
C
H
Site 121
S1084
K
S
I
K
K
T
I
S
L
L
S
C
H
S
D
Site 122
S1087
K
K
T
I
S
L
L
S
C
H
S
D
D
L
I
Site 123
S1090
I
S
L
L
S
C
H
S
D
D
L
I
N
K
K
Site 124
S1103
K
K
K
G
K
R
D
S
G
S
F
E
Q
Y
S
Site 125
S1105
K
G
K
R
D
S
G
S
F
E
Q
Y
S
E
N
Site 126
Y1109
D
S
G
S
F
E
Q
Y
S
E
N
I
K
L
L
Site 127
S1110
S
G
S
F
E
Q
Y
S
E
N
I
K
L
L
M
Site 128
T1135
N
K
K
V
E
N
F
T
V
S
F
S
D
G
R
Site 129
S1137
K
V
E
N
F
T
V
S
F
S
D
G
R
V
L
Site 130
S1139
E
N
F
T
V
S
F
S
D
G
R
V
L
C
Y
Site 131
Y1146
S
D
G
R
V
L
C
Y
L
I
H
H
Y
H
P
Site 132
T1168
I
C
Q
R
T
T
Q
T
V
E
C
T
Q
T
G
Site 133
T1174
Q
T
V
E
C
T
Q
T
G
S
V
V
L
N
S
Site 134
S1176
V
E
C
T
Q
T
G
S
V
V
L
N
S
S
S
Site 135
S1181
T
G
S
V
V
L
N
S
S
S
E
S
D
D
S
Site 136
S1182
G
S
V
V
L
N
S
S
S
E
S
D
D
S
S
Site 137
S1183
S
V
V
L
N
S
S
S
E
S
D
D
S
S
L
Site 138
S1185
V
L
N
S
S
S
E
S
D
D
S
S
L
D
M
Site 139
S1188
S
S
S
E
S
D
D
S
S
L
D
M
S
L
K
Site 140
S1189
S
S
E
S
D
D
S
S
L
D
M
S
L
K
A
Site 141
S1193
D
D
S
S
L
D
M
S
L
K
A
F
D
H
E
Site 142
S1222
K
N
F
H
L
V
R
S
A
V
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R
N
R
A
A
S
V
I
Q
K
A
V
R
Site 295
S3206
K
K
Q
E
K
F
T
S
G
I
I
K
I
Q
A
Site 296
Y3218
I
Q
A
L
W
R
G
Y
S
W
R
K
K
N
D
Site 297
S3235
K
I
K
A
I
R
L
S
L
Q
V
V
N
R
E
Site 298
Y3250
I
R
E
E
N
K
L
Y
K
R
T
A
L
A
L
Site 299
S3334
S
K
Y
E
K
T
T
S
A
V
Y
D
V
E
N
Site 300
Y3353
L
L
E
L
L
Q
I
Y
R
E
K
P
G
N
K
Site 301
S3387
L
K
T
T
N
R
A
S
D
V
R
S
R
S
K
Site 302
S3391
N
R
A
S
D
V
R
S
R
S
K
V
V
D
R
Site 303
S3393
A
S
D
V
R
S
R
S
K
V
V
D
R
I
Y
Site 304
Y3400
S
K
V
V
D
R
I
Y
S
L
Y
K
L
T
A
Site 305
S3401
K
V
V
D
R
I
Y
S
L
Y
K
L
T
A
H
Site 306
Y3403
V
D
R
I
Y
S
L
Y
K
L
T
A
H
K
H
Site 307
T3406
I
Y
S
L
Y
K
L
T
A
H
K
H
K
M
N
Site 308
Y3419
M
N
T
E
R
I
L
Y
K
Q
K
K
N
S
S
Site 309
S3426
Y
K
Q
K
K
N
S
S
I
S
I
P
F
I
P
Site 310
S3428
Q
K
K
N
S
S
I
S
I
P
F
I
P
E
T
Site 311
T3435
S
I
P
F
I
P
E
T
P
V
R
T
R
I
V
Site 312
S3443
P
V
R
T
R
I
V
S
R
L
K
P
D
W
V
Site 313
Y3477
M
D
T
L
G
I
P
Y
F
R
M
H
R
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation