KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TBC1D3
Full Name:
TBC1 domain family member 3
Alias:
Prostate cancer gene 17 protein;Protein TRE17-alpha;Rab GTPase-activating protein PRC17
Type:
Mass (Da):
62168
Number AA:
549
UniProt ID:
Q8IZP1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
D
V
V
E
V
A
G
S
W
W
A
Q
E
R
E
Site 2
Y22
R
E
D
I
I
M
K
Y
E
K
G
H
R
A
G
Site 3
Y42
G
P
K
P
F
R
S
Y
N
N
N
V
D
H
L
Site 4
T61
E
T
E
L
P
P
L
T
A
R
E
A
K
Q
I
Site 5
S73
K
Q
I
R
R
E
I
S
R
K
S
K
W
V
D
Site 6
S76
R
R
E
I
S
R
K
S
K
W
V
D
M
L
G
Site 7
Y88
M
L
G
D
W
E
K
Y
K
S
S
R
K
L
I
Site 8
S90
G
D
W
E
K
Y
K
S
S
R
K
L
I
D
R
Site 9
Y99
R
K
L
I
D
R
A
Y
K
G
M
P
M
N
I
Site 10
S112
N
I
R
G
P
M
W
S
V
L
L
N
I
E
E
Site 11
S139
K
E
K
G
K
R
S
S
E
H
I
Q
R
I
D
Site 12
S150
Q
R
I
D
R
D
V
S
G
T
L
R
K
H
I
Site 13
T152
I
D
R
D
V
S
G
T
L
R
K
H
I
F
F
Site 14
Y163
H
I
F
F
R
D
R
Y
G
T
K
Q
R
E
L
Site 15
T165
F
F
R
D
R
Y
G
T
K
Q
R
E
L
L
H
Site 16
Y186
E
Y
N
P
E
V
G
Y
C
R
D
L
S
H
I
Site 17
S220
L
L
A
S
E
R
H
S
L
Q
G
F
H
S
P
Site 18
S226
H
S
L
Q
G
F
H
S
P
N
G
G
T
V
Q
Site 19
S246
Q
E
H
V
V
A
T
S
Q
P
K
T
M
G
H
Site 20
T250
V
A
T
S
Q
P
K
T
M
G
H
Q
D
K
K
Site 21
Y289
T
L
R
L
W
D
V
Y
L
V
E
G
E
Q
A
Site 22
T313
K
V
Q
Q
K
R
L
T
K
T
S
R
C
G
P
Site 23
T315
Q
Q
K
R
L
T
K
T
S
R
C
G
P
W
A
Site 24
S316
Q
K
R
L
T
K
T
S
R
C
G
P
W
A
R
Site 25
T338
T
W
A
R
D
E
D
T
V
L
K
H
L
R
A
Site 26
S346
V
L
K
H
L
R
A
S
M
K
K
L
T
R
K
Site 27
S368
A
K
P
E
Q
G
S
S
A
S
R
P
V
P
A
Site 28
S370
P
E
Q
G
S
S
A
S
R
P
V
P
A
S
R
Site 29
S376
A
S
R
P
V
P
A
S
R
G
G
K
T
L
C
Site 30
T381
P
A
S
R
G
G
K
T
L
C
K
G
D
R
Q
Site 31
S403
R
F
P
R
P
I
W
S
A
S
P
P
R
A
P
Site 32
S405
P
R
P
I
W
S
A
S
P
P
R
A
P
R
S
Site 33
S412
S
P
P
R
A
P
R
S
S
T
P
C
P
G
G
Site 34
S413
P
P
R
A
P
R
S
S
T
P
C
P
G
G
A
Site 35
T414
P
R
A
P
R
S
S
T
P
C
P
G
G
A
V
Site 36
T425
G
G
A
V
R
E
D
T
Y
P
V
G
T
Q
G
Site 37
Y426
G
A
V
R
E
D
T
Y
P
V
G
T
Q
G
V
Site 38
T460
N
S
M
P
R
L
P
T
D
L
D
V
E
G
P
Site 39
S484
S
C
W
V
R
A
I
S
Q
E
D
Q
L
A
P
Site 40
S504
H
P
A
E
R
V
R
S
A
F
A
A
P
S
T
Site 41
T511
S
A
F
A
A
P
S
T
D
S
D
Q
G
T
P
Site 42
S513
F
A
A
P
S
T
D
S
D
Q
G
T
P
F
R
Site 43
T517
S
T
D
S
D
Q
G
T
P
F
R
A
R
D
E
Site 44
S531
E
Q
Q
C
A
P
T
S
G
P
C
L
C
G
L
Site 45
S543
C
G
L
H
L
E
S
S
Q
F
P
P
G
F
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation