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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPAMD8
Full Name:
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
Alias:
alpha-2 macroglobulin family protein VIP; C3 and PZP-like, alpha-2-macroglobulin domain containing 8; CPMD8; K-CAP; KIAA1283; VIP
Type:
Mass (Da):
206660
Number AA:
UniProt ID:
Q8IZJ3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T52
V
E
E
V
I
S
V
T
I
F
N
S
P
R
E
Site 2
T61
F
N
S
P
R
E
V
T
V
Q
A
Q
L
V
A
Site 3
S76
Q
G
E
P
V
V
Q
S
Q
G
A
I
L
D
K
Site 4
S120
P
L
F
H
N
Q
T
S
V
T
V
D
G
R
G
Site 5
T122
F
H
N
Q
T
S
V
T
V
D
G
R
G
A
S
Site 6
S129
T
V
D
G
R
G
A
S
V
F
I
Q
T
D
K
Site 7
T134
G
A
S
V
F
I
Q
T
D
K
P
V
Y
R
P
Site 8
S196
T
N
M
S
F
P
L
S
D
Q
P
V
L
G
E
Site 9
Y215
V
E
M
Q
G
H
A
Y
N
K
S
F
E
V
Q
Site 10
Y224
K
S
F
E
V
Q
K
Y
V
L
P
K
F
E
L
Site 11
T249
L
D
A
C
E
T
G
T
V
R
A
R
Y
T
F
Site 12
Y254
T
G
T
V
R
A
R
Y
T
F
G
K
P
V
A
Site 13
T255
G
T
V
R
A
R
Y
T
F
G
K
P
V
A
G
Site 14
T269
G
A
L
M
I
N
M
T
V
N
G
V
G
Y
Y
Site 15
Y275
M
T
V
N
G
V
G
Y
Y
S
H
E
V
G
R
Site 16
S277
V
N
G
V
G
Y
Y
S
H
E
V
G
R
P
V
Site 17
T287
V
G
R
P
V
L
R
T
T
K
I
L
G
S
R
Site 18
T288
G
R
P
V
L
R
T
T
K
I
L
G
S
R
D
Site 19
S328
M
V
T
S
V
D
G
S
Q
Q
V
A
F
D
D
Site 20
S336
Q
Q
V
A
F
D
D
S
T
P
V
Q
R
Q
L
Site 21
T337
Q
V
A
F
D
D
S
T
P
V
Q
R
Q
L
V
Site 22
Y348
R
Q
L
V
D
I
R
Y
S
K
D
T
R
K
Q
Site 23
S349
Q
L
V
D
I
R
Y
S
K
D
T
R
K
Q
F
Site 24
T352
D
I
R
Y
S
K
D
T
R
K
Q
F
K
P
G
Site 25
Y362
Q
F
K
P
G
L
A
Y
V
G
K
V
E
L
S
Site 26
S369
Y
V
G
K
V
E
L
S
Y
P
D
G
S
P
A
Site 27
Y370
V
G
K
V
E
L
S
Y
P
D
G
S
P
A
E
Site 28
S374
E
L
S
Y
P
D
G
S
P
A
E
G
V
T
V
Site 29
T388
V
Q
I
K
A
E
L
T
P
K
D
N
I
Y
T
Site 30
Y394
L
T
P
K
D
N
I
Y
T
S
E
V
V
S
Q
Site 31
S396
P
K
D
N
I
Y
T
S
E
V
V
S
Q
R
G
Site 32
S400
I
Y
T
S
E
V
V
S
Q
R
G
L
V
G
F
Site 33
S415
E
I
P
S
I
P
T
S
A
Q
H
V
W
L
E
Site 34
Y437
G
K
P
V
G
A
Q
Y
L
P
S
Y
L
S
L
Site 35
Y441
G
A
Q
Y
L
P
S
Y
L
S
L
G
S
W
Y
Site 36
S443
Q
Y
L
P
S
Y
L
S
L
G
S
W
Y
S
P
Site 37
S446
P
S
Y
L
S
L
G
S
W
Y
S
P
S
Q
C
Site 38
S449
L
S
L
G
S
W
Y
S
P
S
Q
C
Y
L
Q
Site 39
S451
L
G
S
W
Y
S
P
S
Q
C
Y
L
Q
L
Q
Site 40
S461
Y
L
Q
L
Q
P
P
S
H
P
L
Q
V
G
E
Site 41
Y471
L
Q
V
G
E
E
A
Y
F
S
V
K
S
T
C
Site 42
S473
V
G
E
E
A
Y
F
S
V
K
S
T
C
P
C
Site 43
Y486
P
C
N
F
T
L
Y
Y
E
V
A
A
R
G
N
Site 44
S497
A
R
G
N
I
V
L
S
G
Q
Q
P
A
H
T
Site 45
T504
S
G
Q
Q
P
A
H
T
T
Q
Q
R
S
K
R
Site 46
T505
G
Q
Q
P
A
H
T
T
Q
Q
R
S
K
R
A
Site 47
S509
A
H
T
T
Q
Q
R
S
K
R
A
A
P
A
L
Site 48
T523
L
E
K
P
I
R
L
T
H
L
S
E
T
E
P
Site 49
S526
P
I
R
L
T
H
L
S
E
T
E
P
P
P
A
Site 50
S574
N
G
E
G
V
A
D
S
L
Q
F
A
V
E
T
Site 51
S588
T
F
F
E
N
Q
V
S
V
T
Y
S
A
N
E
Site 52
S592
N
Q
V
S
V
T
Y
S
A
N
E
T
Q
P
G
Site 53
T596
V
T
Y
S
A
N
E
T
Q
P
G
E
V
V
D
Site 54
Y624
A
A
V
D
K
S
V
Y
L
L
R
S
G
F
R
Site 55
T633
L
R
S
G
F
R
L
T
P
A
Q
V
F
Q
E
Site 56
Y644
V
F
Q
E
L
E
D
Y
D
V
S
D
S
F
G
Site 57
S647
E
L
E
D
Y
D
V
S
D
S
F
G
V
S
R
Site 58
S649
E
D
Y
D
V
S
D
S
F
G
V
S
R
E
D
Site 59
S653
V
S
D
S
F
G
V
S
R
E
D
G
P
F
W
Site 60
T665
P
F
W
W
A
G
L
T
A
Q
R
R
R
R
S
Site 61
S672
T
A
Q
R
R
R
R
S
S
V
F
P
W
P
W
Site 62
S673
A
Q
R
R
R
R
S
S
V
F
P
W
P
W
G
Site 63
S685
P
W
G
I
T
K
D
S
G
F
A
F
T
E
T
Site 64
T698
E
T
G
L
V
V
M
T
D
R
V
S
L
N
H
Site 65
S702
V
V
M
T
D
R
V
S
L
N
H
R
Q
D
G
Site 66
T713
R
Q
D
G
G
L
Y
T
D
E
A
V
P
A
F
Site 67
T739
P
S
R
H
P
P
R
T
E
K
R
K
R
T
F
Site 68
T745
R
T
E
K
R
K
R
T
F
F
P
E
T
W
I
Site 69
S762
C
L
N
I
S
D
P
S
G
E
G
T
L
S
V
Site 70
T766
S
D
P
S
G
E
G
T
L
S
V
K
V
P
D
Site 71
S768
P
S
G
E
G
T
L
S
V
K
V
P
D
S
I
Site 72
T859
H
P
G
K
R
H
V
T
K
K
M
C
V
A
P
Site 73
S905
C
C
R
D
G
R
S
S
K
H
P
E
E
N
H
Site 74
S927
G
V
D
H
V
R
R
S
V
M
V
E
A
E
G
Site 75
T940
E
G
V
P
R
A
Y
T
Y
S
A
F
F
C
P
Site 76
S942
V
P
R
A
Y
T
Y
S
A
F
F
C
P
S
E
Site 77
T955
S
E
R
V
H
I
S
T
P
N
K
Y
E
F
Q
Site 78
Y959
H
I
S
T
P
N
K
Y
E
F
Q
Y
V
Q
R
Site 79
Y963
P
N
K
Y
E
F
Q
Y
V
Q
R
P
L
R
L
Site 80
T971
V
Q
R
P
L
R
L
T
R
F
D
V
A
V
R
Site 81
S989
D
A
R
V
A
L
S
S
G
P
Q
D
T
A
G
Site 82
S1010
G
G
H
Q
N
T
R
S
W
I
S
T
S
K
M
Site 83
T1014
N
T
R
S
W
I
S
T
S
K
M
G
E
P
V
Site 84
S1031
A
H
T
A
K
I
L
S
W
D
E
F
R
T
F
Site 85
S1056
V
G
H
G
P
E
P
S
N
E
S
V
I
V
A
Site 86
S1059
G
P
E
P
S
N
E
S
V
I
V
A
W
T
L
Site 87
S1098
R
K
M
E
V
D
E
S
Y
S
E
A
F
T
L
Site 88
Y1099
K
M
E
V
D
E
S
Y
S
E
A
F
T
L
G
Site 89
S1100
M
E
V
D
E
S
Y
S
E
A
F
T
L
G
V
Site 90
T1104
E
S
Y
S
E
A
F
T
L
G
V
P
H
G
A
Site 91
S1115
P
H
G
A
I
P
G
S
E
R
A
T
A
S
I
Site 92
S1121
G
S
E
R
A
T
A
S
I
I
G
D
V
M
G
Site 93
Y1161
P
N
V
F
V
L
K
Y
L
Q
K
T
Q
Q
L
Site 94
T1165
V
L
K
Y
L
Q
K
T
Q
Q
L
S
P
E
V
Site 95
S1169
L
Q
K
T
Q
Q
L
S
P
E
V
E
R
E
T
Site 96
T1176
S
P
E
V
E
R
E
T
T
D
Y
L
V
Q
G
Site 97
T1177
P
E
V
E
R
E
T
T
D
Y
L
V
Q
G
Y
Site 98
Y1179
V
E
R
E
T
T
D
Y
L
V
Q
G
Y
Q
R
Site 99
Y1184
T
D
Y
L
V
Q
G
Y
Q
R
Q
L
T
Y
K
Site 100
T1189
Q
G
Y
Q
R
Q
L
T
Y
K
R
Q
D
G
S
Site 101
Y1190
G
Y
Q
R
Q
L
T
Y
K
R
Q
D
G
S
Y
Site 102
S1196
T
Y
K
R
Q
D
G
S
Y
S
A
F
G
E
R
Site 103
Y1197
Y
K
R
Q
D
G
S
Y
S
A
F
G
E
R
D
Site 104
S1206
A
F
G
E
R
D
A
S
G
S
M
W
L
T
A
Site 105
S1208
G
E
R
D
A
S
G
S
M
W
L
T
A
F
V
Site 106
S1224
K
S
F
A
Q
A
R
S
F
I
F
V
D
P
R
Site 107
S1238
R
E
L
A
A
A
K
S
W
I
I
Q
Q
Q
Q
Site 108
S1249
Q
Q
Q
Q
A
D
G
S
F
L
A
V
G
R
V
Site 109
S1292
A
S
E
E
E
R
G
S
T
D
K
A
R
H
F
Site 110
T1293
S
E
E
E
R
G
S
T
D
K
A
R
H
F
L
Site 111
S1302
K
A
R
H
F
L
E
S
A
A
P
L
A
M
D
Site 112
S1337
E
A
L
R
K
L
R
S
L
A
I
M
R
D
G
Site 113
T1346
A
I
M
R
D
G
V
T
H
W
S
L
S
N
S
Site 114
S1349
R
D
G
V
T
H
W
S
L
S
N
S
W
D
V
Site 115
S1353
T
H
W
S
L
S
N
S
W
D
V
D
K
G
T
Site 116
T1360
S
W
D
V
D
K
G
T
F
L
S
F
S
D
R
Site 117
S1363
V
D
K
G
T
F
L
S
F
S
D
R
V
S
Q
Site 118
S1365
K
G
T
F
L
S
F
S
D
R
V
S
Q
S
V
Site 119
S1369
L
S
F
S
D
R
V
S
Q
S
V
V
S
A
E
Site 120
S1371
F
S
D
R
V
S
Q
S
V
V
S
A
E
V
E
Site 121
S1404
L
P
V
V
K
W
L
S
Q
Q
R
N
A
L
G
Site 122
T1447
L
T
V
S
L
A
S
T
N
L
D
Y
Q
E
T
Site 123
Y1451
L
A
S
T
N
L
D
Y
Q
E
T
F
E
L
H
Site 124
T1454
T
N
L
D
Y
Q
E
T
F
E
L
H
R
T
N
Site 125
T1460
E
T
F
E
L
H
R
T
N
Q
K
V
L
Q
T
Site 126
T1467
T
N
Q
K
V
L
Q
T
A
A
I
P
S
L
P
Site 127
S1511
P
A
F
Q
L
L
V
S
L
Q
E
P
E
A
Q
Site 128
S1527
R
P
P
P
M
P
A
S
A
A
E
G
S
R
G
Site 129
S1588
G
F
R
A
D
I
E
S
L
E
Q
L
L
L
D
Site 130
Y1603
K
H
M
G
M
K
R
Y
E
V
A
G
R
R
V
Site 131
Y1613
A
G
R
R
V
L
F
Y
F
D
E
I
P
S
R
Site 132
S1644
R
T
S
A
L
P
V
S
V
Y
D
Y
Y
E
P
Site 133
Y1648
L
P
V
S
V
Y
D
Y
Y
E
P
A
F
E
A
Site 134
Y1649
P
V
S
V
Y
D
Y
Y
E
P
A
F
E
A
T
Site 135
Y1659
A
F
E
A
T
R
F
Y
N
V
S
T
H
S
P
Site 136
S1662
A
T
R
F
Y
N
V
S
T
H
S
P
L
A
R
Site 137
T1663
T
R
F
Y
N
V
S
T
H
S
P
L
A
R
E
Site 138
S1665
F
Y
N
V
S
T
H
S
P
L
A
R
E
L
C
Site 139
S1695
P
G
W
F
P
G
E
S
G
P
A
V
A
P
E
Site 140
S1726
Q
G
N
P
V
C
G
S
D
G
V
V
Y
A
S
Site 141
S1733
S
D
G
V
V
Y
A
S
A
C
R
L
R
E
A
Site 142
S1754
P
L
E
P
A
P
P
S
C
C
A
L
E
Q
R
Site 143
S1765
L
E
Q
R
L
P
A
S
S
S
S
T
Y
G
D
Site 144
S1766
E
Q
R
L
P
A
S
S
S
S
T
Y
G
D
D
Site 145
S1767
Q
R
L
P
A
S
S
S
S
T
Y
G
D
D
L
Site 146
T1769
L
P
A
S
S
S
S
T
Y
G
D
D
L
A
S
Site 147
Y1770
P
A
S
S
S
S
T
Y
G
D
D
L
A
S
V
Site 148
S1776
T
Y
G
D
D
L
A
S
V
A
P
G
P
L
Q
Site 149
S1798
A
G
L
E
V
E
D
S
D
P
E
P
E
G
E
Site 150
T1811
G
E
A
E
D
R
V
T
A
G
P
R
P
P
V
Site 151
S1819
A
G
P
R
P
P
V
S
S
G
N
L
E
S
S
Site 152
S1820
G
P
R
P
P
V
S
S
G
N
L
E
S
S
T
Site 153
S1825
V
S
S
G
N
L
E
S
S
T
Q
S
A
S
P
Site 154
S1826
S
S
G
N
L
E
S
S
T
Q
S
A
S
P
F
Site 155
T1827
S
G
N
L
E
S
S
T
Q
S
A
S
P
F
H
Site 156
S1829
N
L
E
S
S
T
Q
S
A
S
P
F
H
R
W
Site 157
S1831
E
S
S
T
Q
S
A
S
P
F
H
R
W
G
Q
Site 158
T1839
P
F
H
R
W
G
Q
T
P
A
P
Q
R
H
S
Site 159
S1846
T
P
A
P
Q
R
H
S
G
R
V
V
G
A
H
Site 160
S1870
V
Y
S
P
A
F
Q
S
G
G
E
E
G
L
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation