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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XRN1
Full Name:
5'-3' exoribonuclease 1
Alias:
SEP1; strand-exchange protein 1
Type:
EC 3.1.11.-; Ribonuclease
Mass (Da):
194107
Number AA:
1706
UniProt ID:
Q8IZH2
International Prot ID:
IPI00657805
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008409
GO:0003677
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
Y
R
W
I
S
E
R
Y
P
C
L
S
E
V
V
Site 2
S18
S
E
R
Y
P
C
L
S
E
V
V
K
E
H
Q
Site 3
S56
D
D
V
H
F
R
I
S
D
D
K
I
F
T
D
Site 4
S104
Q
R
G
R
R
F
R
S
A
K
E
A
E
D
K
Site 5
T121
K
A
I
E
K
G
E
T
L
P
T
E
A
R
F
Site 6
T124
E
K
G
E
T
L
P
T
E
A
R
F
D
S
N
Site 7
S130
P
T
E
A
R
F
D
S
N
C
I
T
P
G
T
Site 8
T134
R
F
D
S
N
C
I
T
P
G
T
E
F
M
A
Site 9
Y149
R
L
H
E
H
L
K
Y
F
V
N
M
K
I
S
Site 10
Y167
S
W
Q
G
V
T
I
Y
F
S
G
H
E
T
P
Site 11
S169
Q
G
V
T
I
Y
F
S
G
H
E
T
P
G
E
Site 12
T173
I
Y
F
S
G
H
E
T
P
G
E
G
E
H
K
Site 13
S187
K
I
M
E
F
I
R
S
E
K
A
K
P
D
H
Site 14
T198
K
P
D
H
D
P
N
T
R
H
C
L
Y
G
L
Site 15
S222
T
S
H
E
A
H
F
S
L
L
R
E
E
V
R
Site 16
T235
V
R
F
G
G
K
K
T
Q
R
V
C
A
P
E
Site 17
Y257
H
L
S
L
M
R
E
Y
I
D
Y
E
F
S
V
Site 18
Y260
L
M
R
E
Y
I
D
Y
E
F
S
V
L
K
E
Site 19
S263
E
Y
I
D
Y
E
F
S
V
L
K
E
K
I
T
Site 20
T270
S
V
L
K
E
K
I
T
F
K
Y
D
I
E
R
Site 21
Y273
K
E
K
I
T
F
K
Y
D
I
E
R
I
I
D
Site 22
S328
L
G
G
Y
I
N
E
S
G
H
L
N
L
P
R
Site 23
Y339
N
L
P
R
F
E
K
Y
L
V
K
L
S
D
F
Site 24
S344
E
K
Y
L
V
K
L
S
D
F
D
R
E
H
F
Site 25
Y369
E
S
K
V
G
N
K
Y
L
N
E
A
A
G
V
Site 26
Y384
A
A
E
E
A
R
N
Y
K
E
K
K
K
L
K
Site 27
S396
K
L
K
G
Q
E
N
S
L
C
W
T
A
L
D
Site 28
T400
Q
E
N
S
L
C
W
T
A
L
D
K
N
E
G
Site 29
S412
N
E
G
E
M
I
T
S
K
D
N
L
E
D
E
Site 30
T420
K
D
N
L
E
D
E
T
E
D
D
D
L
F
E
Site 31
Y433
F
E
T
E
F
R
Q
Y
K
R
T
Y
Y
M
T
Site 32
Y437
F
R
Q
Y
K
R
T
Y
Y
M
T
K
M
G
V
Site 33
Y438
R
Q
Y
K
R
T
Y
Y
M
T
K
M
G
V
D
Site 34
S448
K
M
G
V
D
V
V
S
D
D
F
L
A
D
Q
Site 35
Y485
S
W
Y
Y
P
Y
H
Y
A
P
F
L
S
D
I
Site 36
T535
A
C
Y
Q
H
L
M
T
N
E
D
S
P
I
I
Site 37
S539
H
L
M
T
N
E
D
S
P
I
I
E
Y
Y
P
Site 38
Y544
E
D
S
P
I
I
E
Y
Y
P
P
D
F
K
T
Site 39
Y545
D
S
P
I
I
E
Y
Y
P
P
D
F
K
T
D
Site 40
T551
Y
Y
P
P
D
F
K
T
D
L
N
G
K
Q
Q
Site 41
T580
R
L
L
E
A
M
E
T
C
N
H
S
L
K
K
Site 42
Y611
D
R
D
T
E
F
I
Y
P
S
P
W
P
E
K
Site 43
S613
D
T
E
F
I
Y
P
S
P
W
P
E
K
F
P
Site 44
S682
G
V
Q
V
F
Q
Q
S
S
R
G
E
N
M
M
Site 45
S698
E
I
L
V
D
A
E
S
D
E
L
T
V
E
N
Site 46
T702
D
A
E
S
D
E
L
T
V
E
N
V
A
S
S
Site 47
S731
E
A
R
V
V
A
V
S
D
G
E
T
K
F
Y
Site 48
T735
V
A
V
S
D
G
E
T
K
F
Y
L
E
E
P
Site 49
Y738
S
D
G
E
T
K
F
Y
L
E
E
P
P
G
T
Site 50
T745
Y
L
E
E
P
P
G
T
Q
K
L
Y
S
G
R
Site 51
Y749
P
P
G
T
Q
K
L
Y
S
G
R
T
A
P
P
Site 52
S750
P
G
T
Q
K
L
Y
S
G
R
T
A
P
P
S
Site 53
T753
Q
K
L
Y
S
G
R
T
A
P
P
S
K
V
V
Site 54
S757
S
G
R
T
A
P
P
S
K
V
V
H
L
G
D
Site 55
Y781
V
Q
G
I
S
E
H
Y
L
R
R
K
G
I
I
Site 56
Y797
N
E
T
S
A
V
V
Y
A
Q
L
L
T
G
R
Site 57
Y806
Q
L
L
T
G
R
K
Y
Q
I
N
Q
N
G
E
Site 58
S821
V
R
L
E
K
Q
W
S
K
Q
V
V
P
F
V
Site 59
Y829
K
Q
V
V
P
F
V
Y
Q
T
I
V
K
D
I
Site 60
S844
R
A
F
D
S
R
F
S
N
I
K
T
L
D
D
Site 61
T848
S
R
F
S
N
I
K
T
L
D
D
L
F
P
L
Site 62
S876
C
T
G
E
V
Q
D
S
G
D
V
I
T
E
G
Site 63
Y907
L
I
Q
N
Q
H
K
Y
S
I
K
Y
N
P
G
Site 64
Y915
S
I
K
Y
N
P
G
Y
V
L
A
S
R
L
G
Site 65
S941
S
I
F
I
G
R
G
S
R
R
N
P
H
G
D
Site 66
Y969
K
N
E
E
V
P
G
Y
T
K
K
V
G
S
E
Site 67
S975
G
Y
T
K
K
V
G
S
E
W
M
Y
S
S
A
Site 68
Y979
K
V
G
S
E
W
M
Y
S
S
A
A
E
Q
L
Site 69
S980
V
G
S
E
W
M
Y
S
S
A
A
E
Q
L
L
Site 70
S981
G
S
E
W
M
Y
S
S
A
A
E
Q
L
L
A
Site 71
Y990
A
E
Q
L
L
A
E
Y
L
E
R
A
P
E
L
Site 72
Y1000
R
A
P
E
L
F
S
Y
I
A
K
N
S
Q
E
Site 73
S1005
F
S
Y
I
A
K
N
S
Q
E
D
V
F
Y
E
Site 74
Y1011
N
S
Q
E
D
V
F
Y
E
D
D
I
W
P
G
Site 75
S1040
W
L
K
G
H
P
V
S
T
L
S
R
S
S
C
Site 76
T1041
L
K
G
H
P
V
S
T
L
S
R
S
S
C
D
Site 77
S1043
G
H
P
V
S
T
L
S
R
S
S
C
D
L
Q
Site 78
S1046
V
S
T
L
S
R
S
S
C
D
L
Q
I
L
D
Site 79
T1079
N
N
K
K
V
R
V
T
V
K
P
H
L
L
Y
Site 80
S1117
V
N
V
R
E
N
F
S
V
P
V
G
L
R
G
Site 81
T1153
E
E
F
P
G
G
L
T
I
R
C
S
P
G
R
Site 82
S1157
G
G
L
T
I
R
C
S
P
G
R
G
Y
R
L
Site 83
Y1162
R
C
S
P
G
R
G
Y
R
L
P
T
S
A
L
Site 84
T1166
G
R
G
Y
R
L
P
T
S
A
L
V
N
L
S
Site 85
S1167
R
G
Y
R
L
P
T
S
A
L
V
N
L
S
H
Site 86
S1173
T
S
A
L
V
N
L
S
H
G
S
R
S
E
T
Site 87
S1176
L
V
N
L
S
H
G
S
R
S
E
T
G
N
Q
Site 88
T1180
S
H
G
S
R
S
E
T
G
N
Q
K
L
T
A
Site 89
T1186
E
T
G
N
Q
K
L
T
A
I
V
K
P
Q
P
Site 90
S1199
Q
P
A
V
H
Q
H
S
S
S
S
S
V
S
S
Site 91
S1200
P
A
V
H
Q
H
S
S
S
S
S
V
S
S
G
Site 92
S1201
A
V
H
Q
H
S
S
S
S
S
V
S
S
G
H
Site 93
S1202
V
H
Q
H
S
S
S
S
S
V
S
S
G
H
L
Site 94
S1203
H
Q
H
S
S
S
S
S
V
S
S
G
H
L
G
Site 95
S1205
H
S
S
S
S
S
V
S
S
G
H
L
G
A
L
Site 96
S1206
S
S
S
S
S
V
S
S
G
H
L
G
A
L
N
Site 97
S1215
H
L
G
A
L
N
H
S
P
Q
S
L
F
V
P
Site 98
S1218
A
L
N
H
S
P
Q
S
L
F
V
P
T
Q
V
Site 99
T1223
P
Q
S
L
F
V
P
T
Q
V
P
T
K
D
D
Site 100
Y1248
Q
G
S
G
K
M
Q
Y
F
Q
P
T
I
Q
E
Site 101
S1265
A
V
L
P
Q
E
I
S
Q
V
N
Q
H
H
K
Site 102
S1279
K
S
G
F
N
D
N
S
V
K
Y
Q
Q
R
K
Site 103
Y1282
F
N
D
N
S
V
K
Y
Q
Q
R
K
H
D
P
Site 104
S1299
K
F
K
E
E
C
K
S
P
K
A
E
C
W
S
Site 105
S1306
S
P
K
A
E
C
W
S
Q
K
M
S
N
K
Q
Site 106
S1316
M
S
N
K
Q
P
N
S
G
I
E
N
F
L
A
Site 107
S1324
G
I
E
N
F
L
A
S
L
N
I
S
K
E
N
Site 108
S1328
F
L
A
S
L
N
I
S
K
E
N
E
V
Q
S
Site 109
S1336
K
E
N
E
V
Q
S
S
H
H
G
E
P
P
S
Site 110
S1343
S
H
H
G
E
P
P
S
E
E
H
L
S
P
Q
Site 111
S1348
P
P
S
E
E
H
L
S
P
Q
S
F
A
M
G
Site 112
S1351
E
E
H
L
S
P
Q
S
F
A
M
G
T
R
M
Site 113
S1368
E
I
L
K
I
D
G
S
N
T
V
D
H
K
N
Site 114
S1387
I
A
N
E
I
P
V
S
S
N
R
R
D
E
Y
Site 115
S1388
A
N
E
I
P
V
S
S
N
R
R
D
E
Y
G
Site 116
Y1394
S
S
N
R
R
D
E
Y
G
L
P
S
Q
P
K
Site 117
S1398
R
D
E
Y
G
L
P
S
Q
P
K
Q
N
K
K
Site 118
S1408
K
Q
N
K
K
L
A
S
Y
M
N
K
P
H
S
Site 119
Y1419
K
P
H
S
A
N
E
Y
H
N
V
Q
S
M
D
Site 120
S1440
P
S
Q
I
P
P
V
S
T
P
V
T
E
L
S
Site 121
T1441
S
Q
I
P
P
V
S
T
P
V
T
E
L
S
R
Site 122
T1444
P
P
V
S
T
P
V
T
E
L
S
R
I
C
S
Site 123
S1451
T
E
L
S
R
I
C
S
L
V
G
M
P
Q
P
Site 124
S1461
G
M
P
Q
P
D
F
S
F
L
R
M
P
Q
T
Site 125
S1516
G
M
N
F
P
L
P
S
Q
V
F
A
N
Y
P
Site 126
Y1522
P
S
Q
V
F
A
N
Y
P
S
A
V
P
P
G
Site 127
T1539
P
P
A
F
P
P
P
T
G
W
D
H
Y
G
S
Site 128
Y1544
P
P
T
G
W
D
H
Y
G
S
N
Y
A
L
G
Site 129
S1560
A
N
I
M
P
S
S
S
H
L
F
G
S
M
P
Site 130
S1565
S
S
S
H
L
F
G
S
M
P
W
G
P
S
V
Site 131
S1571
G
S
M
P
W
G
P
S
V
P
V
P
G
K
P
Site 132
T1582
P
G
K
P
F
H
H
T
L
Y
S
G
T
M
P
Site 133
Y1584
K
P
F
H
H
T
L
Y
S
G
T
M
P
M
A
Site 134
S1626
E
N
K
E
A
Q
S
S
Q
A
T
P
V
Q
T
Site 135
T1629
E
A
Q
S
S
Q
A
T
P
V
Q
T
S
Q
P
Site 136
T1633
S
Q
A
T
P
V
Q
T
S
Q
P
D
S
S
N
Site 137
S1634
Q
A
T
P
V
Q
T
S
Q
P
D
S
S
N
I
Site 138
S1638
V
Q
T
S
Q
P
D
S
S
N
I
V
K
V
S
Site 139
S1639
Q
T
S
Q
P
D
S
S
N
I
V
K
V
S
P
Site 140
S1645
S
S
N
I
V
K
V
S
P
R
E
S
S
S
A
Site 141
S1649
V
K
V
S
P
R
E
S
S
S
A
S
L
K
S
Site 142
S1650
K
V
S
P
R
E
S
S
S
A
S
L
K
S
S
Site 143
S1651
V
S
P
R
E
S
S
S
A
S
L
K
S
S
P
Site 144
S1653
P
R
E
S
S
S
A
S
L
K
S
S
P
I
A
Site 145
S1656
S
S
S
A
S
L
K
S
S
P
I
A
Q
P
A
Site 146
S1657
S
S
A
S
L
K
S
S
P
I
A
Q
P
A
S
Site 147
S1664
S
P
I
A
Q
P
A
S
S
F
Q
V
E
T
A
Site 148
S1665
P
I
A
Q
P
A
S
S
F
Q
V
E
T
A
S
Site 149
S1672
S
F
Q
V
E
T
A
S
Q
G
H
S
I
S
H
Site 150
S1676
E
T
A
S
Q
G
H
S
I
S
H
H
K
S
T
Site 151
S1678
A
S
Q
G
H
S
I
S
H
H
K
S
T
P
I
Site 152
S1682
H
S
I
S
H
H
K
S
T
P
I
S
S
S
R
Site 153
T1683
S
I
S
H
H
K
S
T
P
I
S
S
S
R
R
Site 154
S1686
H
H
K
S
T
P
I
S
S
S
R
R
K
S
R
Site 155
S1687
H
K
S
T
P
I
S
S
S
R
R
K
S
R
K
Site 156
S1688
K
S
T
P
I
S
S
S
R
R
K
S
R
K
L
Site 157
S1692
I
S
S
S
R
R
K
S
R
K
L
A
V
N
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation