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Updated November 2019
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Protein Info
Short Name:
GPR116
Full Name:
Probable G-protein coupled receptor 116
Alias:
DKFZp564O1923; G protein-coupled receptor 116; GP116; G-protein coupled receptor 116; Ig-Hepta homolog; KIAA0758
Type:
Receptor, GPCR
Mass (Da):
149460
Number AA:
UniProt ID:
Q8IZF2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004930
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
K
S
P
R
R
T
T
L
C
Site 2
Y27
K
A
A
L
N
W
N
Y
E
S
T
I
H
P
L
Site 3
S35
E
S
T
I
H
P
L
S
L
H
E
H
E
P
A
Site 4
S57
K
R
A
V
A
T
K
S
P
T
A
E
E
Y
T
Site 5
T64
S
P
T
A
E
E
Y
T
V
N
I
E
I
S
F
Site 6
S75
E
I
S
F
E
N
A
S
F
L
D
P
I
K
A
Site 7
S88
K
A
Y
L
N
S
L
S
F
P
I
H
G
N
N
Site 8
T100
G
N
N
T
D
Q
I
T
D
I
L
S
I
N
V
Site 9
S152
F
L
P
G
H
H
C
S
C
L
K
E
L
P
P
Site 10
S191
E
D
L
M
N
T
S
S
A
L
Y
R
S
Y
K
Site 11
Y194
M
N
T
S
S
A
L
Y
R
S
Y
K
T
D
L
Site 12
Y197
S
S
A
L
Y
R
S
Y
K
T
D
L
E
T
A
Site 13
T203
S
Y
K
T
D
L
E
T
A
F
R
K
G
Y
G
Site 14
Y209
E
T
A
F
R
K
G
Y
G
I
L
P
G
F
K
Site 15
T221
G
F
K
G
V
T
V
T
G
F
K
S
G
S
V
Site 16
T231
K
S
G
S
V
V
V
T
Y
E
V
K
T
T
P
Site 17
Y232
S
G
S
V
V
V
T
Y
E
V
K
T
T
P
P
Site 18
S240
E
V
K
T
T
P
P
S
L
E
L
I
H
K
A
Site 19
Y263
N
Q
T
Y
K
M
D
Y
N
S
F
Q
A
V
T
Site 20
T279
N
E
S
N
F
F
V
T
P
E
I
I
F
E
G
Site 21
S299
V
C
E
K
E
V
L
S
S
N
V
S
W
R
Y
Site 22
S300
C
E
K
E
V
L
S
S
N
V
S
W
R
Y
E
Site 23
S303
E
V
L
S
S
N
V
S
W
R
Y
E
E
Q
Q
Site 24
Y306
S
S
N
V
S
W
R
Y
E
E
Q
Q
L
E
I
Site 25
S316
Q
Q
L
E
I
Q
N
S
S
R
F
S
I
Y
T
Site 26
S320
I
Q
N
S
S
R
F
S
I
Y
T
A
L
F
N
Site 27
Y322
N
S
S
R
F
S
I
Y
T
A
L
F
N
N
M
Site 28
T323
S
S
R
F
S
I
Y
T
A
L
F
N
N
M
T
Site 29
T341
K
L
T
I
H
N
I
T
P
G
D
A
G
E
Y
Site 30
Y359
L
I
L
D
I
F
E
Y
E
C
K
K
K
I
D
Site 31
T415
G
K
I
N
I
P
G
T
P
E
T
D
I
D
S
Site 32
T418
N
I
P
G
T
P
E
T
D
I
D
S
S
C
S
Site 33
S422
T
P
E
T
D
I
D
S
S
C
S
R
Y
T
L
Site 34
S423
P
E
T
D
I
D
S
S
C
S
R
Y
T
L
K
Site 35
Y427
I
D
S
S
C
S
R
Y
T
L
K
A
D
G
T
Site 36
T428
D
S
S
C
S
R
Y
T
L
K
A
D
G
T
Q
Site 37
T434
Y
T
L
K
A
D
G
T
Q
C
P
S
G
S
S
Site 38
S438
A
D
G
T
Q
C
P
S
G
S
S
G
T
T
V
Site 39
S440
G
T
Q
C
P
S
G
S
S
G
T
T
V
I
Y
Site 40
T444
P
S
G
S
S
G
T
T
V
I
Y
T
C
E
F
Site 41
Y455
T
C
E
F
I
S
A
Y
G
A
R
G
S
A
N
Site 42
S460
S
A
Y
G
A
R
G
S
A
N
I
K
V
T
F
Site 43
S481
T
I
T
P
D
P
I
S
V
S
E
G
Q
N
F
Site 44
S483
T
P
D
P
I
S
V
S
E
G
Q
N
F
S
I
Site 45
S489
V
S
E
G
Q
N
F
S
I
K
C
I
S
D
V
Site 46
S494
N
F
S
I
K
C
I
S
D
V
S
N
Y
D
E
Site 47
Y499
C
I
S
D
V
S
N
Y
D
E
V
Y
W
N
T
Site 48
Y503
V
S
N
Y
D
E
V
Y
W
N
T
S
A
G
I
Site 49
Y513
T
S
A
G
I
K
I
Y
Q
R
F
Y
T
T
R
Site 50
Y517
I
K
I
Y
Q
R
F
Y
T
T
R
R
Y
L
D
Site 51
T518
K
I
Y
Q
R
F
Y
T
T
R
R
Y
L
D
G
Site 52
Y522
R
F
Y
T
T
R
R
Y
L
D
G
A
E
S
V
Site 53
S528
R
Y
L
D
G
A
E
S
V
L
T
V
K
T
S
Site 54
T531
D
G
A
E
S
V
L
T
V
K
T
S
T
R
E
Site 55
T534
E
S
V
L
T
V
K
T
S
T
R
E
W
N
G
Site 56
S535
S
V
L
T
V
K
T
S
T
R
E
W
N
G
T
Site 57
Y543
T
R
E
W
N
G
T
Y
H
C
I
F
R
Y
K
Site 58
Y549
T
Y
H
C
I
F
R
Y
K
N
S
Y
S
I
A
Site 59
S581
D
P
L
E
A
T
V
S
C
S
G
S
H
H
I
Site 60
Y598
C
I
E
E
D
G
D
Y
K
V
T
F
H
T
G
Site 61
T601
E
D
G
D
Y
K
V
T
F
H
T
G
S
S
S
Site 62
T604
D
Y
K
V
T
F
H
T
G
S
S
S
L
P
A
Site 63
S606
K
V
T
F
H
T
G
S
S
S
L
P
A
A
K
Site 64
S608
T
F
H
T
G
S
S
S
L
P
A
A
K
E
V
Site 65
S632
N
F
N
A
S
S
V
S
W
C
S
K
T
V
D
Site 66
S654
A
A
N
N
S
V
W
S
P
S
M
K
L
N
L
Site 67
S690
I
Q
K
L
C
R
F
S
N
V
P
S
S
P
E
Site 68
S694
C
R
F
S
N
V
P
S
S
P
E
S
P
I
G
Site 69
S695
R
F
S
N
V
P
S
S
P
E
S
P
I
G
G
Site 70
S698
N
V
P
S
S
P
E
S
P
I
G
G
T
I
T
Site 71
T705
S
P
I
G
G
T
I
T
Y
K
C
V
G
S
Q
Site 72
Y706
P
I
G
G
T
I
T
Y
K
C
V
G
S
Q
W
Site 73
S722
E
K
R
N
D
C
I
S
A
P
I
N
S
L
L
Site 74
S738
M
A
K
A
L
I
K
S
P
S
Q
D
E
M
L
Site 75
S740
K
A
L
I
K
S
P
S
Q
D
E
M
L
P
T
Site 76
T747
S
Q
D
E
M
L
P
T
Y
L
K
D
L
S
I
Site 77
Y748
Q
D
E
M
L
P
T
Y
L
K
D
L
S
I
S
Site 78
S753
P
T
Y
L
K
D
L
S
I
S
I
D
K
A
E
Site 79
S764
D
K
A
E
H
E
I
S
S
S
P
G
S
L
G
Site 80
S765
K
A
E
H
E
I
S
S
S
P
G
S
L
G
A
Site 81
S766
A
E
H
E
I
S
S
S
P
G
S
L
G
A
I
Site 82
T785
D
L
L
S
T
V
P
T
Q
V
N
S
E
M
M
Site 83
T793
Q
V
N
S
E
M
M
T
H
V
L
S
T
V
N
Site 84
S823
Q
Q
W
T
N
Q
S
S
Q
L
L
H
S
V
E
Site 85
S828
Q
S
S
Q
L
L
H
S
V
E
R
F
S
Q
A
Site 86
S833
L
H
S
V
E
R
F
S
Q
A
L
Q
S
G
D
Site 87
S838
R
F
S
Q
A
L
Q
S
G
D
S
P
P
L
S
Site 88
S841
Q
A
L
Q
S
G
D
S
P
P
L
S
F
S
Q
Site 89
S845
S
G
D
S
P
P
L
S
F
S
Q
T
N
V
Q
Site 90
S847
D
S
P
P
L
S
F
S
Q
T
N
V
Q
M
S
Site 91
T849
P
P
L
S
F
S
Q
T
N
V
Q
M
S
S
M
Site 92
S855
Q
T
N
V
Q
M
S
S
M
V
I
K
S
S
H
Site 93
S860
M
S
S
M
V
I
K
S
S
H
P
E
T
Y
Q
Site 94
S861
S
S
M
V
I
K
S
S
H
P
E
T
Y
Q
Q
Site 95
T865
I
K
S
S
H
P
E
T
Y
Q
Q
R
F
V
F
Site 96
Y866
K
S
S
H
P
E
T
Y
Q
Q
R
F
V
F
P
Site 97
Y874
Q
Q
R
F
V
F
P
Y
F
D
L
W
G
N
V
Site 98
S886
G
N
V
V
I
D
K
S
Y
L
E
N
L
Q
S
Site 99
Y887
N
V
V
I
D
K
S
Y
L
E
N
L
Q
S
D
Site 100
S893
S
Y
L
E
N
L
Q
S
D
S
S
I
V
T
M
Site 101
S896
E
N
L
Q
S
D
S
S
I
V
T
M
A
F
P
Site 102
S921
Q
E
N
N
F
A
E
S
L
V
M
T
T
T
V
Site 103
T927
E
S
L
V
M
T
T
T
V
S
H
N
T
T
M
Site 104
T933
T
T
V
S
H
N
T
T
M
P
F
R
I
S
M
Site 105
T941
M
P
F
R
I
S
M
T
F
K
N
N
S
P
S
Site 106
S946
S
M
T
F
K
N
N
S
P
S
G
G
E
T
K
Site 107
S948
T
F
K
N
N
S
P
S
G
G
E
T
K
C
V
Site 108
T965
N
F
R
L
A
N
N
T
G
G
W
D
S
S
G
Site 109
S971
N
T
G
G
W
D
S
S
G
C
Y
V
E
E
G
Site 110
Y974
G
W
D
S
S
G
C
Y
V
E
E
G
D
G
D
Site 111
S994
C
D
H
L
T
S
F
S
I
L
M
S
P
D
S
Site 112
S998
T
S
F
S
I
L
M
S
P
D
S
P
D
P
S
Site 113
S1001
S
I
L
M
S
P
D
S
P
D
P
S
S
L
L
Site 114
S1006
P
D
S
P
D
P
S
S
L
L
G
I
L
L
D
Site 115
S1040
V
E
A
V
V
W
K
S
V
T
K
N
R
T
S
Site 116
Y1048
V
T
K
N
R
T
S
Y
M
R
H
T
C
I
V
Site 117
S1123
V
F
I
L
H
E
T
S
R
S
T
Q
K
A
I
Site 118
S1125
I
L
H
E
T
S
R
S
T
Q
K
A
I
A
F
Site 119
T1126
L
H
E
T
S
R
S
T
Q
K
A
I
A
F
C
Site 120
Y1156
A
T
Q
P
R
E
V
Y
T
R
K
N
V
C
W
Site 121
S1201
I
T
K
I
L
R
P
S
I
G
D
K
P
C
K
Site 122
S1212
K
P
C
K
Q
E
K
S
S
L
F
Q
I
S
K
Site 123
S1213
P
C
K
Q
E
K
S
S
L
F
Q
I
S
K
S
Site 124
T1243
L
T
T
V
F
P
G
T
N
L
V
F
H
I
I
Site 125
S1282
E
A
L
L
N
K
F
S
L
S
R
W
S
S
Q
Site 126
S1284
L
L
N
K
F
S
L
S
R
W
S
S
Q
H
S
Site 127
S1287
K
F
S
L
S
R
W
S
S
Q
H
S
K
S
T
Site 128
S1288
F
S
L
S
R
W
S
S
Q
H
S
K
S
T
S
Site 129
S1291
S
R
W
S
S
Q
H
S
K
S
T
S
L
G
S
Site 130
S1293
W
S
S
Q
H
S
K
S
T
S
L
G
S
S
T
Site 131
T1294
S
S
Q
H
S
K
S
T
S
L
G
S
S
T
P
Site 132
S1295
S
Q
H
S
K
S
T
S
L
G
S
S
T
P
V
Site 133
S1298
S
K
S
T
S
L
G
S
S
T
P
V
F
S
M
Site 134
S1299
K
S
T
S
L
G
S
S
T
P
V
F
S
M
S
Site 135
T1300
S
T
S
L
G
S
S
T
P
V
F
S
M
S
S
Site 136
S1304
G
S
S
T
P
V
F
S
M
S
S
P
I
S
R
Site 137
S1306
S
T
P
V
F
S
M
S
S
P
I
S
R
R
F
Site 138
S1307
T
P
V
F
S
M
S
S
P
I
S
R
R
F
N
Site 139
S1310
F
S
M
S
S
P
I
S
R
R
F
N
N
L
F
Site 140
T1322
N
L
F
G
K
T
G
T
Y
N
V
S
T
P
E
Site 141
Y1323
L
F
G
K
T
G
T
Y
N
V
S
T
P
E
A
Site 142
S1326
K
T
G
T
Y
N
V
S
T
P
E
A
T
S
S
Site 143
T1327
T
G
T
Y
N
V
S
T
P
E
A
T
S
S
S
Site 144
S1333
S
T
P
E
A
T
S
S
S
L
E
N
S
S
S
Site 145
S1334
T
P
E
A
T
S
S
S
L
E
N
S
S
S
A
Site 146
S1338
T
S
S
S
L
E
N
S
S
S
A
S
S
L
L
Site 147
S1339
S
S
S
L
E
N
S
S
S
A
S
S
L
L
N
Site 148
S1340
S
S
L
E
N
S
S
S
A
S
S
L
L
N
_
Site 149
S1342
L
E
N
S
S
S
A
S
S
L
L
N
_
_
_
Site 150
S1343
E
N
S
S
S
A
S
S
L
L
N
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation