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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NALCN
Full Name:
Sodium leak channel non-selective protein
Alias:
BA430M15.1; Putative 4 repeat voltage-gated ion channel; Putative four repeat ion channel; VGCNL1; Voltage gated channel-like protein 1
Type:
Channel, calcium
Mass (Da):
200331
Number AA:
1738
UniProt ID:
Q8IZF0
International Prot ID:
IPI00217996
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005272
GO:0031402
GO:0005244
PhosphoSite+
KinaseNET
Biological Process:
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Sodium leak channel non-selective protein pan-specific antibody AB-NN293-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN293-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
L
K
R
K
Q
S
S
R
V
E
A
Q
P
Site 2
S23
T
D
F
G
P
D
E
S
L
S
D
N
A
D
I
Site 3
S25
F
G
P
D
E
S
L
S
D
N
A
D
I
L
W
Site 4
Y64
T
P
M
T
F
E
H
Y
P
P
L
Q
Y
V
T
Site 5
Y69
E
H
Y
P
P
L
Q
Y
V
T
F
T
L
D
T
Site 6
S100
R
G
I
V
K
G
D
S
S
Y
V
K
D
R
W
Site 7
Y102
I
V
K
G
D
S
S
Y
V
K
D
R
W
C
V
Site 8
Y157
M
I
R
A
F
R
I
Y
F
R
F
E
L
P
R
Site 9
T165
F
R
F
E
L
P
R
T
R
I
T
N
I
L
K
Site 10
T168
E
L
P
R
T
R
I
T
N
I
L
K
R
S
G
Site 11
S174
I
T
N
I
L
K
R
S
G
E
Q
I
W
S
V
Site 12
S221
P
G
N
V
T
W
N
S
L
A
I
P
D
T
H
Site 13
T227
N
S
L
A
I
P
D
T
H
C
S
P
E
L
E
Site 14
S230
A
I
P
D
T
H
C
S
P
E
L
E
E
G
Y
Site 15
Y237
S
P
E
L
E
E
G
Y
Q
C
P
P
G
F
K
Site 16
Y260
L
S
R
Q
E
L
G
Y
S
G
F
N
E
I
G
Site 17
S261
S
R
Q
E
L
G
Y
S
G
F
N
E
I
G
T
Site 18
Y274
G
T
S
I
F
T
V
Y
E
A
A
S
Q
E
G
Site 19
S338
Q
F
Q
Q
M
W
G
S
R
S
S
T
T
S
T
Site 20
S340
Q
Q
M
W
G
S
R
S
S
T
T
S
T
A
T
Site 21
S341
Q
M
W
G
S
R
S
S
T
T
S
T
A
T
T
Site 22
T342
M
W
G
S
R
S
S
T
T
S
T
A
T
T
Q
Site 23
S344
G
S
R
S
S
T
T
S
T
A
T
T
Q
M
F
Site 24
T345
S
R
S
S
T
T
S
T
A
T
T
Q
M
F
H
Site 25
T348
S
T
T
S
T
A
T
T
Q
M
F
H
E
D
A
Site 26
Y415
G
E
N
F
R
R
Q
Y
D
E
F
Y
L
A
E
Site 27
Y419
R
R
Q
Y
D
E
F
Y
L
A
E
V
A
F
T
Site 28
S447
L
G
F
T
G
Y
I
S
S
S
L
H
K
F
E
Site 29
S448
G
F
T
G
Y
I
S
S
S
L
H
K
F
E
L
Site 30
Y466
I
G
T
T
L
H
V
Y
P
D
L
Y
H
S
Q
Site 31
Y470
L
H
V
Y
P
D
L
Y
H
S
Q
F
T
Y
F
Site 32
Y497
P
A
L
E
D
F
V
Y
K
I
F
G
P
G
K
Site 33
T538
V
E
E
L
D
R
F
T
T
F
P
R
A
F
M
Site 34
T539
E
E
L
D
R
F
T
T
F
P
R
A
F
M
S
Site 35
T623
Q
S
E
A
N
A
D
T
K
E
K
L
P
L
R
Site 36
S647
R
P
Q
M
V
K
I
S
K
L
P
S
D
F
T
Site 37
T654
S
K
L
P
S
D
F
T
V
P
K
I
R
E
S
Site 38
S661
T
V
P
K
I
R
E
S
F
M
K
Q
F
I
D
Site 39
T674
I
D
R
Q
Q
Q
D
T
C
C
L
L
R
S
L
Site 40
S680
D
T
C
C
L
L
R
S
L
P
T
T
S
S
S
Site 41
T683
C
L
L
R
S
L
P
T
T
S
S
S
S
C
D
Site 42
T684
L
L
R
S
L
P
T
T
S
S
S
S
C
D
H
Site 43
S685
L
R
S
L
P
T
T
S
S
S
S
C
D
H
S
Site 44
S686
R
S
L
P
T
T
S
S
S
S
C
D
H
S
K
Site 45
S687
S
L
P
T
T
S
S
S
S
C
D
H
S
K
R
Site 46
S688
L
P
T
T
S
S
S
S
C
D
H
S
K
R
S
Site 47
S692
S
S
S
S
C
D
H
S
K
R
S
A
I
E
D
Site 48
Y702
S
A
I
E
D
N
K
Y
I
D
Q
K
L
R
K
Site 49
S710
I
D
Q
K
L
R
K
S
V
F
S
I
R
A
R
Site 50
S713
K
L
R
K
S
V
F
S
I
R
A
R
N
L
L
Site 51
T734
T
K
I
L
R
A
C
T
R
Q
R
M
L
S
G
Site 52
S740
C
T
R
Q
R
M
L
S
G
S
F
E
G
Q
P
Site 53
S742
R
Q
R
M
L
S
G
S
F
E
G
Q
P
A
K
Site 54
S752
G
Q
P
A
K
E
R
S
I
L
S
V
Q
H
H
Site 55
S755
A
K
E
R
S
I
L
S
V
Q
H
H
I
R
Q
Site 56
S766
H
I
R
Q
E
R
R
S
L
R
H
G
S
N
S
Site 57
S771
R
R
S
L
R
H
G
S
N
S
Q
R
I
S
R
Site 58
S773
S
L
R
H
G
S
N
S
Q
R
I
S
R
G
K
Site 59
S777
G
S
N
S
Q
R
I
S
R
G
K
S
L
E
T
Site 60
S781
Q
R
I
S
R
G
K
S
L
E
T
L
T
Q
D
Site 61
T786
G
K
S
L
E
T
L
T
Q
D
H
S
N
T
V
Site 62
S790
E
T
L
T
Q
D
H
S
N
T
V
R
Y
R
N
Site 63
T792
L
T
Q
D
H
S
N
T
V
R
Y
R
N
A
Q
Site 64
S803
R
N
A
Q
R
E
D
S
E
I
K
M
I
Q
E
Site 65
Y832
E
L
R
E
N
H
P
Y
F
D
K
P
L
F
I
Site 66
T863
A
R
F
N
A
S
K
T
D
P
V
T
G
A
V
Site 67
T867
A
S
K
T
D
P
V
T
G
A
V
K
N
T
K
Site 68
Y875
G
A
V
K
N
T
K
Y
H
Q
L
Y
D
L
L
Site 69
Y879
N
T
K
Y
H
Q
L
Y
D
L
L
G
L
V
T
Site 70
T917
R
R
V
M
H
A
P
T
L
Q
I
A
E
Y
V
Site 71
Y923
P
T
L
Q
I
A
E
Y
V
F
V
I
F
M
S
Site 72
T1169
N
K
G
T
A
L
L
T
V
D
Q
R
R
W
E
Site 73
S1180
R
R
W
E
D
L
K
S
R
L
K
I
A
Q
P
Site 74
Y1204
D
G
F
R
A
K
M
Y
D
I
T
Q
H
P
F
Site 75
S1271
S
P
A
G
F
W
Q
S
R
R
N
R
Y
D
L
Site 76
Y1276
W
Q
S
R
R
N
R
Y
D
L
L
V
T
S
L
Site 77
Y1362
V
L
F
G
T
V
K
Y
G
E
N
I
N
R
H
Site 78
S1373
I
N
R
H
A
N
F
S
S
A
G
K
A
I
T
Site 79
S1455
E
N
F
S
L
F
Y
S
T
E
E
D
Q
L
L
Site 80
S1463
T
E
E
D
Q
L
L
S
Y
N
D
L
R
H
F
Site 81
Y1464
E
E
D
Q
L
L
S
Y
N
D
L
R
H
F
Q
Site 82
S1538
H
D
V
L
S
M
L
S
Y
R
S
V
D
I
R
Site 83
Y1539
D
V
L
S
M
L
S
Y
R
S
V
D
I
R
K
Site 84
S1541
L
S
M
L
S
Y
R
S
V
D
I
R
K
S
L
Site 85
S1547
R
S
V
D
I
R
K
S
L
Q
L
E
E
L
L
Site 86
Y1561
L
A
R
E
Q
L
E
Y
T
I
E
E
E
V
A
Site 87
S1590
I
R
A
K
Q
Q
Q
S
C
S
I
I
H
S
L
Site 88
S1592
A
K
Q
Q
Q
S
C
S
I
I
H
S
L
R
E
Site 89
S1596
Q
S
C
S
I
I
H
S
L
R
E
S
Q
Q
Q
Site 90
S1600
I
I
H
S
L
R
E
S
Q
Q
Q
E
L
S
R
Site 91
S1606
E
S
Q
Q
Q
E
L
S
R
F
L
N
P
P
S
Site 92
S1613
S
R
F
L
N
P
P
S
I
E
T
T
Q
P
S
Site 93
T1617
N
P
P
S
I
E
T
T
Q
P
S
E
D
T
N
Site 94
S1627
S
E
D
T
N
A
N
S
Q
D
N
S
M
Q
P
Site 95
S1631
N
A
N
S
Q
D
N
S
M
Q
P
E
T
S
S
Site 96
S1638
S
M
Q
P
E
T
S
S
Q
Q
Q
L
L
S
P
Site 97
S1644
S
S
Q
Q
Q
L
L
S
P
T
L
S
D
R
G
Site 98
T1646
Q
Q
Q
L
L
S
P
T
L
S
D
R
G
G
S
Site 99
S1648
Q
L
L
S
P
T
L
S
D
R
G
G
S
R
Q
Site 100
S1653
T
L
S
D
R
G
G
S
R
Q
D
A
A
D
A
Site 101
S1674
F
G
Q
W
R
L
P
S
A
P
K
P
I
S
H
Site 102
S1680
P
S
A
P
K
P
I
S
H
S
V
S
S
V
N
Site 103
S1682
A
P
K
P
I
S
H
S
V
S
S
V
N
L
R
Site 104
S1684
K
P
I
S
H
S
V
S
S
V
N
L
R
F
G
Site 105
S1685
P
I
S
H
S
V
S
S
V
N
L
R
F
G
G
Site 106
T1694
N
L
R
F
G
G
R
T
T
M
K
S
V
V
C
Site 107
T1695
L
R
F
G
G
R
T
T
M
K
S
V
V
C
K
Site 108
S1698
G
G
R
T
T
M
K
S
V
V
C
K
M
N
P
Site 109
T1707
V
C
K
M
N
P
M
T
D
A
A
S
C
G
S
Site 110
T1725
K
W
W
T
R
Q
L
T
V
E
S
D
E
S
G
Site 111
S1731
L
T
V
E
S
D
E
S
G
D
D
L
L
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation