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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOCK3
Full Name:
Dedicator of cytokinesis protein 3
Alias:
MOCA; Modifier of cell adhesion; PBP; Presenilin-binding protein
Type:
Adhesion protein
Mass (Da):
233103
Number AA:
2030
UniProt ID:
Q8IZD9
International Prot ID:
IPI00217985
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0051020
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
T
P
T
E
E
E
K
Y
G
V
V
I
C
S
F
Site 2
Y43
L
E
K
C
E
G
W
Y
R
G
V
S
T
K
K
Site 3
S47
E
G
W
Y
R
G
V
S
T
K
K
P
N
V
K
Site 4
S70
H
L
K
K
A
I
V
S
N
R
G
Q
Y
E
T
Site 5
Y75
I
V
S
N
R
G
Q
Y
E
T
V
V
P
L
E
Site 6
T77
S
N
R
G
Q
Y
E
T
V
V
P
L
E
D
S
Site 7
Y104
A
S
L
W
K
Q
L
Y
V
K
H
K
V
D
L
Site 8
Y113
K
H
K
V
D
L
F
Y
K
L
R
H
V
M
N
Site 9
S131
D
L
R
R
Q
L
L
S
G
H
L
T
Q
D
Q
Site 10
T135
Q
L
L
S
G
H
L
T
Q
D
Q
V
R
E
V
Site 11
T147
R
E
V
K
R
H
I
T
V
R
L
D
W
G
N
Site 12
S172
K
D
F
E
V
V
D
S
D
Q
I
S
V
S
D
Site 13
S176
V
V
D
S
D
Q
I
S
V
S
D
L
Y
K
M
Site 14
S178
D
S
D
Q
I
S
V
S
D
L
Y
K
M
H
L
Site 15
Y181
Q
I
S
V
S
D
L
Y
K
M
H
L
S
S
R
Site 16
S186
D
L
Y
K
M
H
L
S
S
R
Q
S
V
Q
Q
Site 17
S187
L
Y
K
M
H
L
S
S
R
Q
S
V
Q
Q
S
Site 18
S190
M
H
L
S
S
R
Q
S
V
Q
Q
S
T
S
Q
Site 19
S194
S
R
Q
S
V
Q
Q
S
T
S
Q
V
D
T
M
Site 20
S196
Q
S
V
Q
Q
S
T
S
Q
V
D
T
M
R
P
Site 21
T200
Q
S
T
S
Q
V
D
T
M
R
P
R
H
G
E
Site 22
Y226
L
S
L
K
S
F
T
Y
N
T
I
G
E
D
T
Site 23
T233
Y
N
T
I
G
E
D
T
D
V
F
F
S
L
Y
Site 24
S238
E
D
T
D
V
F
F
S
L
Y
D
M
R
E
G
Site 25
Y240
T
D
V
F
F
S
L
Y
D
M
R
E
G
K
Q
Site 26
S249
M
R
E
G
K
Q
I
S
E
R
F
L
V
R
L
Site 27
T276
E
R
M
C
A
L
F
T
D
L
S
S
K
D
M
Site 28
S279
C
A
L
F
T
D
L
S
S
K
D
M
K
R
D
Site 29
Y288
K
D
M
K
R
D
L
Y
I
V
A
H
V
I
R
Site 30
S304
G
R
M
L
L
N
D
S
K
K
G
P
P
H
L
Site 31
Y313
K
G
P
P
H
L
H
Y
R
R
P
Y
G
C
A
Site 32
Y317
H
L
H
Y
R
R
P
Y
G
C
A
V
L
S
I
Site 33
S330
S
I
L
D
V
L
Q
S
L
T
E
V
K
E
E
Site 34
Y345
K
D
F
V
L
K
V
Y
T
C
N
N
E
S
E
Site 35
S364
H
E
N
I
I
R
K
S
S
A
K
Y
S
A
P
Site 36
S365
E
N
I
I
R
K
S
S
A
K
Y
S
A
P
S
Site 37
Y368
I
R
K
S
S
A
K
Y
S
A
P
S
A
S
H
Site 38
S369
R
K
S
S
A
K
Y
S
A
P
S
A
S
H
G
Site 39
Y425
G
D
I
R
N
D
L
Y
L
T
L
E
K
G
D
Site 40
T427
I
R
N
D
L
Y
L
T
L
E
K
G
D
F
E
Site 41
S439
D
F
E
R
G
G
K
S
V
Q
K
N
I
E
V
Site 42
Y449
K
N
I
E
V
T
M
Y
V
L
Y
A
D
G
E
Site 43
S463
E
I
L
K
D
C
I
S
L
G
S
G
E
P
N
Site 44
S466
K
D
C
I
S
L
G
S
G
E
P
N
R
S
S
Site 45
S472
G
S
G
E
P
N
R
S
S
Y
H
S
F
V
L
Site 46
S473
S
G
E
P
N
R
S
S
Y
H
S
F
V
L
Y
Site 47
Y474
G
E
P
N
R
S
S
Y
H
S
F
V
L
Y
H
Site 48
S476
P
N
R
S
S
Y
H
S
F
V
L
Y
H
S
N
Site 49
Y480
S
Y
H
S
F
V
L
Y
H
S
N
S
P
R
W
Site 50
S482
H
S
F
V
L
Y
H
S
N
S
P
R
W
G
E
Site 51
S484
F
V
L
Y
H
S
N
S
P
R
W
G
E
I
I
Site 52
S503
P
I
D
R
F
R
G
S
H
L
R
F
E
F
R
Site 53
S513
R
F
E
F
R
H
C
S
T
K
D
K
G
E
K
Site 54
T536
T
L
M
R
D
D
G
T
T
L
S
D
D
I
H
Site 55
T537
L
M
R
D
D
G
T
T
L
S
D
D
I
H
E
Site 56
S539
R
D
D
G
T
T
L
S
D
D
I
H
E
L
Y
Site 57
Y546
S
D
D
I
H
E
L
Y
V
Y
K
C
D
E
N
Site 58
Y548
D
I
H
E
L
Y
V
Y
K
C
D
E
N
S
T
Site 59
Y572
L
P
C
C
K
E
D
Y
N
G
C
P
N
I
P
Site 60
S580
N
G
C
P
N
I
P
S
S
L
I
F
Q
R
S
Site 61
S581
G
C
P
N
I
P
S
S
L
I
F
Q
R
S
T
Site 62
S587
S
S
L
I
F
Q
R
S
T
K
E
S
F
F
I
Site 63
T588
S
L
I
F
Q
R
S
T
K
E
S
F
F
I
S
Site 64
S591
F
Q
R
S
T
K
E
S
F
F
I
S
T
Q
L
Site 65
S595
T
K
E
S
F
F
I
S
T
Q
L
S
S
T
K
Site 66
T596
K
E
S
F
F
I
S
T
Q
L
S
S
T
K
L
Site 67
S599
F
F
I
S
T
Q
L
S
S
T
K
L
T
Q
N
Site 68
T604
Q
L
S
S
T
K
L
T
Q
N
V
D
L
L
A
Site 69
S633
L
G
R
L
R
H
V
S
G
E
E
I
V
K
F
Site 70
Y679
N
L
L
R
D
I
K
Y
F
H
F
R
P
V
M
Site 71
Y689
F
R
P
V
M
D
T
Y
I
Q
K
H
F
A
G
Site 72
Y700
H
F
A
G
A
L
A
Y
K
E
L
I
R
C
L
Site 73
T748
R
I
L
Y
S
R
A
T
C
G
M
E
E
E
Q
Site 74
S758
M
E
E
E
Q
F
R
S
S
I
Q
E
L
F
Q
Site 75
S759
E
E
E
Q
F
R
S
S
I
Q
E
L
F
Q
S
Site 76
S772
Q
S
I
R
F
V
L
S
L
D
S
R
N
S
E
Site 77
S778
L
S
L
D
S
R
N
S
E
T
L
L
F
T
Q
Site 78
S821
G
T
L
G
S
M
P
S
T
V
H
I
G
Q
S
Site 79
T840
K
L
Q
S
I
A
R
T
V
D
S
R
L
F
S
Site 80
S843
S
I
A
R
T
V
D
S
R
L
F
S
F
S
E
Site 81
S847
T
V
D
S
R
L
F
S
F
S
E
S
R
R
I
Site 82
S849
D
S
R
L
F
S
F
S
E
S
R
R
I
L
L
Site 83
S920
Q
T
L
L
T
I
M
S
K
S
H
A
Q
E
A
Site 84
S922
L
L
T
I
M
S
K
S
H
A
Q
E
A
V
R
Site 85
T937
G
Q
R
C
P
Q
C
T
A
E
I
T
G
E
Y
Site 86
S969
H
L
L
D
N
F
Q
S
K
D
E
L
K
E
F
Site 87
T1024
S
A
L
H
K
N
F
T
E
T
D
F
D
F
K
Site 88
Y1066
R
K
K
I
L
D
K
Y
G
D
M
R
V
M
M
Site 89
S1145
E
L
I
D
K
L
D
S
M
V
S
E
G
K
G
Site 90
S1148
D
K
L
D
S
M
V
S
E
G
K
G
D
E
S
Site 91
S1155
S
E
G
K
G
D
E
S
Y
R
E
L
F
S
L
Site 92
Y1156
E
G
K
G
D
E
S
Y
R
E
L
F
S
L
L
Site 93
S1161
E
S
Y
R
E
L
F
S
L
L
T
Q
L
F
G
Site 94
S1172
Q
L
F
G
P
Y
P
S
L
L
E
K
V
E
Q
Site 95
T1185
E
Q
E
T
W
R
E
T
G
I
S
F
V
T
S
Site 96
S1188
T
W
R
E
T
G
I
S
F
V
T
S
V
T
R
Site 97
Y1203
L
M
E
R
L
L
D
Y
R
D
C
M
K
G
E
Site 98
Y1237
E
I
N
K
E
E
M
Y
I
R
Y
I
H
K
L
Site 99
Y1281
P
L
R
E
F
L
H
Y
P
S
Q
T
E
W
Q
Site 100
S1283
R
E
F
L
H
Y
P
S
Q
T
E
W
Q
R
K
Site 101
Y1300
L
C
R
K
I
I
H
Y
F
N
K
G
K
S
W
Site 102
S1323
E
L
A
C
Q
Y
E
S
L
Y
D
Y
Q
S
L
Site 103
Y1325
A
C
Q
Y
E
S
L
Y
D
Y
Q
S
L
S
W
Site 104
Y1327
Q
Y
E
S
L
Y
D
Y
Q
S
L
S
W
I
R
Site 105
S1329
E
S
L
Y
D
Y
Q
S
L
S
W
I
R
K
M
Site 106
Y1341
R
K
M
E
A
S
Y
Y
D
N
I
M
E
Q
Q
Site 107
Y1373
F
F
L
R
N
K
E
Y
V
C
R
G
H
D
Y
Site 108
Y1380
Y
V
C
R
G
H
D
Y
E
R
L
E
A
F
Q
Site 109
S1392
A
F
Q
Q
R
M
L
S
E
F
P
Q
A
V
A
Site 110
S1444
R
V
P
D
R
V
K
S
F
Y
R
V
N
N
V
Site 111
Y1446
P
D
R
V
K
S
F
Y
R
V
N
N
V
R
K
Site 112
Y1456
N
N
V
R
K
F
R
Y
D
R
P
F
H
K
G
Site 113
S1473
D
K
E
N
E
F
K
S
L
W
I
E
R
T
T
Site 114
T1479
K
S
L
W
I
E
R
T
T
L
T
L
T
H
S
Site 115
T1482
W
I
E
R
T
T
L
T
L
T
H
S
L
P
G
Site 116
T1484
E
R
T
T
L
T
L
T
H
S
L
P
G
I
S
Site 117
S1486
T
T
L
T
L
T
H
S
L
P
G
I
S
R
W
Site 118
S1505
R
R
E
L
V
E
V
S
P
L
E
N
A
I
Q
Site 119
S1523
N
K
N
Q
E
L
R
S
L
I
S
Q
Y
Q
H
Site 120
S1526
Q
E
L
R
S
L
I
S
Q
Y
Q
H
K
Q
V
Site 121
Y1528
L
R
S
L
I
S
Q
Y
Q
H
K
Q
V
H
G
Site 122
Y1559
V
N
G
G
I
A
R
Y
Q
E
A
F
F
D
K
Site 123
Y1568
E
A
F
F
D
K
D
Y
I
N
K
H
P
G
D
Site 124
T1580
P
G
D
A
E
K
I
T
Q
L
K
E
L
M
Q
Site 125
Y1627
Q
M
M
R
A
S
L
Y
H
E
F
P
G
L
D
Site 126
S1637
F
P
G
L
D
K
L
S
P
A
C
S
G
T
S
Site 127
S1641
D
K
L
S
P
A
C
S
G
T
S
T
P
R
G
Site 128
T1643
L
S
P
A
C
S
G
T
S
T
P
R
G
N
V
Site 129
S1644
S
P
A
C
S
G
T
S
T
P
R
G
N
V
L
Site 130
T1645
P
A
C
S
G
T
S
T
P
R
G
N
V
L
A
Site 131
S1653
P
R
G
N
V
L
A
S
H
S
P
M
S
P
E
Site 132
S1655
G
N
V
L
A
S
H
S
P
M
S
P
E
S
I
Site 133
S1658
L
A
S
H
S
P
M
S
P
E
S
I
K
M
T
Site 134
S1661
H
S
P
M
S
P
E
S
I
K
M
T
H
R
H
Site 135
T1665
S
P
E
S
I
K
M
T
H
R
H
S
P
M
N
Site 136
S1669
I
K
M
T
H
R
H
S
P
M
N
L
M
G
T
Site 137
T1676
S
P
M
N
L
M
G
T
G
R
H
S
S
S
S
Site 138
S1680
L
M
G
T
G
R
H
S
S
S
S
L
S
S
H
Site 139
S1681
M
G
T
G
R
H
S
S
S
S
L
S
S
H
A
Site 140
S1682
G
T
G
R
H
S
S
S
S
L
S
S
H
A
S
Site 141
S1683
T
G
R
H
S
S
S
S
L
S
S
H
A
S
S
Site 142
S1685
R
H
S
S
S
S
L
S
S
H
A
S
S
E
A
Site 143
S1686
H
S
S
S
S
L
S
S
H
A
S
S
E
A
G
Site 144
S1689
S
S
L
S
S
H
A
S
S
E
A
G
N
M
V
Site 145
S1690
S
L
S
S
H
A
S
S
E
A
G
N
M
V
M
Site 146
S1702
M
V
M
L
G
D
G
S
M
G
D
A
P
E
D
Site 147
Y1711
G
D
A
P
E
D
L
Y
H
H
M
Q
L
A
Y
Site 148
Y1718
Y
H
H
M
Q
L
A
Y
P
N
P
R
Y
Q
G
Site 149
Y1723
L
A
Y
P
N
P
R
Y
Q
G
S
V
T
N
V
Site 150
S1726
P
N
P
R
Y
Q
G
S
V
T
N
V
S
V
L
Site 151
T1728
P
R
Y
Q
G
S
V
T
N
V
S
V
L
S
S
Site 152
S1731
Q
G
S
V
T
N
V
S
V
L
S
S
S
Q
A
Site 153
S1734
V
T
N
V
S
V
L
S
S
S
Q
A
S
P
S
Site 154
S1735
T
N
V
S
V
L
S
S
S
Q
A
S
P
S
S
Site 155
S1736
N
V
S
V
L
S
S
S
Q
A
S
P
S
S
S
Site 156
S1739
V
L
S
S
S
Q
A
S
P
S
S
S
S
L
S
Site 157
S1741
S
S
S
Q
A
S
P
S
S
S
S
L
S
S
T
Site 158
S1742
S
S
Q
A
S
P
S
S
S
S
L
S
S
T
H
Site 159
S1743
S
Q
A
S
P
S
S
S
S
L
S
S
T
H
S
Site 160
S1744
Q
A
S
P
S
S
S
S
L
S
S
T
H
S
A
Site 161
S1746
S
P
S
S
S
S
L
S
S
T
H
S
A
P
S
Site 162
S1747
P
S
S
S
S
L
S
S
T
H
S
A
P
S
Q
Site 163
T1748
S
S
S
S
L
S
S
T
H
S
A
P
S
Q
M
Site 164
S1750
S
S
L
S
S
T
H
S
A
P
S
Q
M
I
T
Site 165
S1753
S
S
T
H
S
A
P
S
Q
M
I
T
S
A
P
Site 166
T1757
S
A
P
S
Q
M
I
T
S
A
P
S
S
A
R
Site 167
S1758
A
P
S
Q
M
I
T
S
A
P
S
S
A
R
G
Site 168
S1761
Q
M
I
T
S
A
P
S
S
A
R
G
S
P
S
Site 169
S1762
M
I
T
S
A
P
S
S
A
R
G
S
P
S
L
Site 170
S1766
A
P
S
S
A
R
G
S
P
S
L
P
D
K
Y
Site 171
S1768
S
S
A
R
G
S
P
S
L
P
D
K
Y
R
H
Site 172
Y1773
S
P
S
L
P
D
K
Y
R
H
A
R
E
M
M
Site 173
T1785
E
M
M
L
L
L
P
T
Y
R
D
R
P
S
S
Site 174
Y1786
M
M
L
L
L
P
T
Y
R
D
R
P
S
S
A
Site 175
S1791
P
T
Y
R
D
R
P
S
S
A
M
Y
P
A
A
Site 176
S1792
T
Y
R
D
R
P
S
S
A
M
Y
P
A
A
I
Site 177
Y1795
D
R
P
S
S
A
M
Y
P
A
A
I
L
E
N
Site 178
S1829
P
C
S
D
P
N
L
S
V
A
E
K
G
H
Y
Site 179
Y1836
S
V
A
E
K
G
H
Y
S
L
H
F
D
A
F
Site 180
T1850
F
H
H
P
L
G
D
T
P
P
A
L
P
A
R
Site 181
T1858
P
P
A
L
P
A
R
T
L
R
K
S
P
L
H
Site 182
S1862
P
A
R
T
L
R
K
S
P
L
H
P
I
P
A
Site 183
S1870
P
L
H
P
I
P
A
S
P
T
S
P
Q
S
G
Site 184
T1872
H
P
I
P
A
S
P
T
S
P
Q
S
G
L
D
Site 185
S1873
P
I
P
A
S
P
T
S
P
Q
S
G
L
D
G
Site 186
S1876
A
S
P
T
S
P
Q
S
G
L
D
G
S
N
S
Site 187
S1881
P
Q
S
G
L
D
G
S
N
S
T
L
S
G
S
Site 188
S1883
S
G
L
D
G
S
N
S
T
L
S
G
S
A
S
Site 189
T1884
G
L
D
G
S
N
S
T
L
S
G
S
A
S
S
Site 190
S1886
D
G
S
N
S
T
L
S
G
S
A
S
S
G
V
Site 191
S1888
S
N
S
T
L
S
G
S
A
S
S
G
V
S
S
Site 192
S1890
S
T
L
S
G
S
A
S
S
G
V
S
S
L
S
Site 193
S1891
T
L
S
G
S
A
S
S
G
V
S
S
L
S
E
Site 194
S1894
G
S
A
S
S
G
V
S
S
L
S
E
S
N
F
Site 195
S1895
S
A
S
S
G
V
S
S
L
S
E
S
N
F
G
Site 196
S1897
S
S
G
V
S
S
L
S
E
S
N
F
G
H
S
Site 197
S1899
G
V
S
S
L
S
E
S
N
F
G
H
S
S
E
Site 198
S1905
E
S
N
F
G
H
S
S
E
A
P
P
R
T
D
Site 199
T1911
S
S
E
A
P
P
R
T
D
T
M
D
S
M
P
Site 200
T1913
E
A
P
P
R
T
D
T
M
D
S
M
P
S
Q
Site 201
S1916
P
R
T
D
T
M
D
S
M
P
S
Q
A
W
N
Site 202
Y1932
D
E
D
L
E
P
P
Y
L
P
V
H
Y
S
L
Site 203
S1942
V
H
Y
S
L
S
E
S
A
V
L
D
S
I
K
Site 204
S1947
S
E
S
A
V
L
D
S
I
K
A
Q
P
C
R
Site 205
S1955
I
K
A
Q
P
C
R
S
H
S
A
P
G
C
V
Site 206
S1957
A
Q
P
C
R
S
H
S
A
P
G
C
V
I
P
Site 207
Y1978
P
A
L
P
P
K
P
Y
H
P
R
L
P
A
L
Site 208
T1997
G
V
L
L
R
E
E
T
E
R
P
R
G
L
H
Site 209
S2013
K
A
P
L
P
P
G
S
A
K
E
E
Q
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation