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Updated November 2019
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Protein Info
Short Name:
MLL5
Full Name:
Histone-lysine N-methyltransferase MLL5
Alias:
HDCMC04P; KMT2E; myeloid/lymphoid or mixed-lineage leukemia 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax)
Type:
Methyltransferase; Transcription, coactivator/corepressor; Cell cycle regulation; EC 2.1.1.43
Mass (Da):
204788
Number AA:
1858
UniProt ID:
Q8IZD2
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070688
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0019899
GO:0042800
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0006306
GO:0007050
GO:0030218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
Y
L
E
M
A
A
G
S
E
P
E
S
V
E
A
Site 2
S27
A
A
G
S
E
P
E
S
V
E
A
S
P
V
V
Site 3
S31
E
P
E
S
V
E
A
S
P
V
V
V
E
K
S
Site 4
S38
S
P
V
V
V
E
K
S
N
S
Y
P
H
Q
L
Site 5
S40
V
V
V
E
K
S
N
S
Y
P
H
Q
L
Y
T
Site 6
Y41
V
V
E
K
S
N
S
Y
P
H
Q
L
Y
T
S
Site 7
Y46
N
S
Y
P
H
Q
L
Y
T
S
S
S
H
H
S
Site 8
T47
S
Y
P
H
Q
L
Y
T
S
S
S
H
H
S
H
Site 9
S48
Y
P
H
Q
L
Y
T
S
S
S
H
H
S
H
S
Site 10
S49
P
H
Q
L
Y
T
S
S
S
H
H
S
H
S
Y
Site 11
S50
H
Q
L
Y
T
S
S
S
H
H
S
H
S
Y
I
Site 12
S53
Y
T
S
S
S
H
H
S
H
S
Y
I
G
L
P
Site 13
S55
S
S
S
H
H
S
H
S
Y
I
G
L
P
Y
A
Site 14
Y66
L
P
Y
A
D
H
N
Y
G
A
R
P
P
P
T
Site 15
T73
Y
G
A
R
P
P
P
T
P
P
A
S
P
P
P
Site 16
S77
P
P
P
T
P
P
A
S
P
P
P
S
V
L
I
Site 17
S81
P
P
A
S
P
P
P
S
V
L
I
S
K
N
E
Site 18
T94
N
E
V
G
I
F
T
T
P
N
F
D
E
T
S
Site 19
S102
P
N
F
D
E
T
S
S
A
T
T
I
S
T
S
Site 20
T105
D
E
T
S
S
A
T
T
I
S
T
S
E
D
G
Site 21
S107
T
S
S
A
T
T
I
S
T
S
E
D
G
S
Y
Site 22
T108
S
S
A
T
T
I
S
T
S
E
D
G
S
Y
G
Site 23
S109
S
A
T
T
I
S
T
S
E
D
G
S
Y
G
T
Site 24
S113
I
S
T
S
E
D
G
S
Y
G
T
D
V
T
R
Site 25
Y114
S
T
S
E
D
G
S
Y
G
T
D
V
T
R
C
Site 26
Y158
R
Q
H
I
P
D
T
Y
L
C
E
R
C
Q
P
Site 27
T189
E
N
M
S
D
G
D
T
S
A
T
E
S
G
D
Site 28
S190
N
M
S
D
G
D
T
S
A
T
E
S
G
D
E
Site 29
S194
G
D
T
S
A
T
E
S
G
D
E
V
P
V
E
Site 30
Y203
D
E
V
P
V
E
L
Y
T
A
F
Q
H
T
P
Site 31
S212
A
F
Q
H
T
P
T
S
I
T
L
T
A
S
R
Site 32
T214
Q
H
T
P
T
S
I
T
L
T
A
S
R
V
S
Site 33
S218
T
S
I
T
L
T
A
S
R
V
S
K
V
N
D
Site 34
S221
T
L
T
A
S
R
V
S
K
V
N
D
K
R
R
Site 35
S231
N
D
K
R
R
K
K
S
G
E
K
E
Q
H
I
Site 36
S239
G
E
K
E
Q
H
I
S
K
C
K
K
A
F
R
Site 37
S249
K
K
A
F
R
E
G
S
R
K
S
S
R
V
K
Site 38
S252
F
R
E
G
S
R
K
S
S
R
V
K
G
S
A
Site 39
S253
R
E
G
S
R
K
S
S
R
V
K
G
S
A
P
Site 40
S258
K
S
S
R
V
K
G
S
A
P
E
I
D
P
S
Site 41
S265
S
A
P
E
I
D
P
S
S
D
G
S
N
F
G
Site 42
S266
A
P
E
I
D
P
S
S
D
G
S
N
F
G
W
Site 43
S269
I
D
P
S
S
D
G
S
N
F
G
W
E
T
K
Site 44
Y284
I
K
A
W
M
D
R
Y
E
E
A
N
N
N
Q
Site 45
S319
D
K
K
E
M
N
K
S
D
L
N
T
N
N
L
Site 46
T323
M
N
K
S
D
L
N
T
N
N
L
L
F
K
P
Site 47
S345
K
N
K
K
I
L
K
S
A
K
D
L
P
P
D
Site 48
Y358
P
D
A
L
I
I
E
Y
R
G
K
F
M
L
R
Site 49
Y373
E
Q
F
E
A
N
G
Y
F
F
K
R
P
Y
P
Site 50
T399
E
M
C
V
D
A
R
T
F
G
N
E
A
R
F
Site 51
S410
E
A
R
F
I
R
R
S
C
T
P
N
A
E
V
Site 52
T412
R
F
I
R
R
S
C
T
P
N
A
E
V
R
H
Site 53
T440
I
H
S
I
P
K
G
T
E
I
T
I
A
F
D
Site 54
Y450
T
I
A
F
D
F
D
Y
G
N
C
K
Y
K
V
Site 55
S475
C
P
V
L
K
R
S
S
E
S
M
E
N
I
N
Site 56
S477
V
L
K
R
S
S
E
S
M
E
N
I
N
S
G
Site 57
S483
E
S
M
E
N
I
N
S
G
Y
E
T
R
R
K
Site 58
T487
N
I
N
S
G
Y
E
T
R
R
K
K
G
K
K
Site 59
S499
G
K
K
D
K
D
I
S
K
E
K
D
T
Q
N
Site 60
S522
G
T
T
N
K
M
K
S
P
E
T
K
Q
R
K
Site 61
T525
N
K
M
K
S
P
E
T
K
Q
R
K
L
S
P
Site 62
S531
E
T
K
Q
R
K
L
S
P
L
R
L
S
V
S
Site 63
S536
K
L
S
P
L
R
L
S
V
S
N
N
Q
E
P
Site 64
S538
S
P
L
R
L
S
V
S
N
N
Q
E
P
D
F
Site 65
T553
I
D
D
I
E
E
K
T
P
I
S
N
E
V
E
Site 66
S556
I
E
E
K
T
P
I
S
N
E
V
E
M
E
S
Site 67
T575
A
E
R
K
R
K
M
T
R
E
E
R
K
M
E
Site 68
S606
E
Q
A
L
E
R
I
S
T
A
K
T
E
V
K
Site 69
T607
Q
A
L
E
R
I
S
T
A
K
T
E
V
K
T
Site 70
T610
E
R
I
S
T
A
K
T
E
V
K
T
E
C
K
Site 71
T619
V
K
T
E
C
K
D
T
Q
I
V
S
D
A
E
Site 72
T641
E
E
N
A
S
K
P
T
P
A
K
V
N
R
T
Site 73
S653
N
R
T
K
Q
R
K
S
F
S
R
S
R
T
H
Site 74
S655
T
K
Q
R
K
S
F
S
R
S
R
T
H
I
G
Site 75
S657
Q
R
K
S
F
S
R
S
R
T
H
I
G
Q
Q
Site 76
T659
K
S
F
S
R
S
R
T
H
I
G
Q
Q
R
R
Site 77
T670
Q
Q
R
R
R
H
R
T
V
S
M
C
S
D
I
Site 78
S672
R
R
R
H
R
T
V
S
M
C
S
D
I
Q
P
Site 79
S675
H
R
T
V
S
M
C
S
D
I
Q
P
S
S
P
Site 80
S681
C
S
D
I
Q
P
S
S
P
D
I
E
V
T
S
Site 81
S688
S
P
D
I
E
V
T
S
Q
Q
N
D
I
E
N
Site 82
T699
D
I
E
N
T
V
L
T
I
E
P
E
T
E
T
Site 83
T725
P
A
L
N
K
C
P
T
K
Y
P
K
T
K
K
Site 84
Y727
L
N
K
C
P
T
K
Y
P
K
T
K
K
H
L
Site 85
T746
L
S
E
K
N
E
K
T
G
K
P
S
D
G
L
Site 86
S750
N
E
K
T
G
K
P
S
D
G
L
S
E
R
P
Site 87
S754
G
K
P
S
D
G
L
S
E
R
P
L
R
I
T
Site 88
T761
S
E
R
P
L
R
I
T
T
D
P
E
V
L
A
Site 89
T762
E
R
P
L
R
I
T
T
D
P
E
V
L
A
T
Site 90
T769
T
D
P
E
V
L
A
T
Q
L
N
S
L
P
G
Site 91
T778
L
N
S
L
P
G
L
T
Y
S
P
H
V
Y
S
Site 92
S780
S
L
P
G
L
T
Y
S
P
H
V
Y
S
T
P
Site 93
Y784
L
T
Y
S
P
H
V
Y
S
T
P
K
H
Y
I
Site 94
S785
T
Y
S
P
H
V
Y
S
T
P
K
H
Y
I
R
Site 95
T786
Y
S
P
H
V
Y
S
T
P
K
H
Y
I
R
F
Site 96
Y790
V
Y
S
T
P
K
H
Y
I
R
F
T
S
P
F
Site 97
T794
P
K
H
Y
I
R
F
T
S
P
F
L
S
E
K
Site 98
S795
K
H
Y
I
R
F
T
S
P
F
L
S
E
K
R
Site 99
S799
R
F
T
S
P
F
L
S
E
K
R
R
R
K
E
Site 100
T808
K
R
R
R
K
E
P
T
E
N
I
S
G
S
C
Site 101
S812
K
E
P
T
E
N
I
S
G
S
C
K
K
R
W
Site 102
S814
P
T
E
N
I
S
G
S
C
K
K
R
W
L
K
Site 103
S837
A
I
L
H
R
F
N
S
P
C
Q
E
R
S
R
Site 104
S843
N
S
P
C
Q
E
R
S
R
S
P
A
V
N
G
Site 105
S845
P
C
Q
E
R
S
R
S
P
A
V
N
G
E
N
Site 106
S854
A
V
N
G
E
N
K
S
P
L
L
L
N
D
S
Site 107
T868
S
C
S
L
P
D
L
T
T
P
L
K
K
R
R
Site 108
T869
C
S
L
P
D
L
T
T
P
L
K
K
R
R
F
Site 109
Y877
P
L
K
K
R
R
F
Y
Q
L
L
D
S
V
Y
Site 110
S882
R
F
Y
Q
L
L
D
S
V
Y
S
E
T
S
T
Site 111
Y884
Y
Q
L
L
D
S
V
Y
S
E
T
S
T
P
T
Site 112
S885
Q
L
L
D
S
V
Y
S
E
T
S
T
P
T
P
Site 113
T887
L
D
S
V
Y
S
E
T
S
T
P
T
P
S
P
Site 114
S888
D
S
V
Y
S
E
T
S
T
P
T
P
S
P
Y
Site 115
T889
S
V
Y
S
E
T
S
T
P
T
P
S
P
Y
A
Site 116
T891
Y
S
E
T
S
T
P
T
P
S
P
Y
A
T
P
Site 117
S893
E
T
S
T
P
T
P
S
P
Y
A
T
P
T
H
Site 118
Y895
S
T
P
T
P
S
P
Y
A
T
P
T
H
T
D
Site 119
T897
P
T
P
S
P
Y
A
T
P
T
H
T
D
I
T
Site 120
T899
P
S
P
Y
A
T
P
T
H
T
D
I
T
P
M
Site 121
T904
T
P
T
H
T
D
I
T
P
M
D
P
S
F
A
Site 122
S909
D
I
T
P
M
D
P
S
F
A
T
P
P
R
I
Site 123
T912
P
M
D
P
S
F
A
T
P
P
R
I
K
S
D
Site 124
S918
A
T
P
P
R
I
K
S
D
D
E
T
C
R
N
Site 125
T922
R
I
K
S
D
D
E
T
C
R
N
G
Y
K
P
Site 126
Y927
D
E
T
C
R
N
G
Y
K
P
I
Y
S
P
V
Site 127
Y931
R
N
G
Y
K
P
I
Y
S
P
V
T
P
V
T
Site 128
S932
N
G
Y
K
P
I
Y
S
P
V
T
P
V
T
P
Site 129
T935
K
P
I
Y
S
P
V
T
P
V
T
P
G
T
P
Site 130
T938
Y
S
P
V
T
P
V
T
P
G
T
P
G
N
T
Site 131
T941
V
T
P
V
T
P
G
T
P
G
N
T
M
H
F
Site 132
S952
T
M
H
F
E
N
I
S
S
P
E
S
S
P
E
Site 133
S953
M
H
F
E
N
I
S
S
P
E
S
S
P
E
I
Site 134
S956
E
N
I
S
S
P
E
S
S
P
E
I
K
R
R
Site 135
S957
N
I
S
S
P
E
S
S
P
E
I
K
R
R
T
Site 136
T964
S
P
E
I
K
R
R
T
Y
S
Q
E
G
Y
D
Site 137
Y965
P
E
I
K
R
R
T
Y
S
Q
E
G
Y
D
R
Site 138
S966
E
I
K
R
R
T
Y
S
Q
E
G
Y
D
R
S
Site 139
Y970
R
T
Y
S
Q
E
G
Y
D
R
S
S
T
M
L
Site 140
S973
S
Q
E
G
Y
D
R
S
S
T
M
L
T
L
G
Site 141
S974
Q
E
G
Y
D
R
S
S
T
M
L
T
L
G
P
Site 142
T975
E
G
Y
D
R
S
S
T
M
L
T
L
G
P
F
Site 143
T978
D
R
S
S
T
M
L
T
L
G
P
F
R
N
S
Site 144
S985
T
L
G
P
F
R
N
S
N
L
T
E
L
G
L
Site 145
T988
P
F
R
N
S
N
L
T
E
L
G
L
Q
E
I
Site 146
T997
L
G
L
Q
E
I
K
T
I
G
Y
T
S
P
R
Site 147
Y1000
Q
E
I
K
T
I
G
Y
T
S
P
R
S
R
T
Site 148
T1001
E
I
K
T
I
G
Y
T
S
P
R
S
R
T
E
Site 149
S1002
I
K
T
I
G
Y
T
S
P
R
S
R
T
E
V
Site 150
S1005
I
G
Y
T
S
P
R
S
R
T
E
V
N
R
Q
Site 151
T1007
Y
T
S
P
R
S
R
T
E
V
N
R
Q
C
P
Site 152
S1021
P
G
E
K
E
P
V
S
D
L
Q
L
G
L
D
Site 153
T1038
E
P
T
A
L
H
K
T
L
E
T
P
A
H
D
Site 154
T1041
A
L
H
K
T
L
E
T
P
A
H
D
R
A
E
Site 155
S1051
H
D
R
A
E
P
N
S
Q
L
D
S
T
H
S
Site 156
S1055
E
P
N
S
Q
L
D
S
T
H
S
G
R
G
T
Site 157
T1056
P
N
S
Q
L
D
S
T
H
S
G
R
G
T
M
Site 158
S1058
S
Q
L
D
S
T
H
S
G
R
G
T
M
Y
S
Site 159
T1062
S
T
H
S
G
R
G
T
M
Y
S
S
W
V
K
Site 160
Y1064
H
S
G
R
G
T
M
Y
S
S
W
V
K
S
P
Site 161
S1065
S
G
R
G
T
M
Y
S
S
W
V
K
S
P
D
Site 162
S1066
G
R
G
T
M
Y
S
S
W
V
K
S
P
D
R
Site 163
S1070
M
Y
S
S
W
V
K
S
P
D
R
T
G
V
N
Site 164
T1074
W
V
K
S
P
D
R
T
G
V
N
F
S
V
N
Site 165
S1079
D
R
T
G
V
N
F
S
V
N
S
N
L
R
D
Site 166
S1082
G
V
N
F
S
V
N
S
N
L
R
D
L
T
P
Site 167
T1088
N
S
N
L
R
D
L
T
P
S
H
Q
L
E
V
Site 168
S1090
N
L
R
D
L
T
P
S
H
Q
L
E
V
G
G
Site 169
S1102
V
G
G
G
F
R
I
S
E
S
K
C
L
M
Q
Site 170
T1147
N
L
I
D
G
N
C
T
P
Q
N
P
P
Q
K
Site 171
Y1162
K
K
V
S
L
L
E
Y
R
K
R
Q
R
E
A
Site 172
S1172
R
Q
R
E
A
R
K
S
G
S
K
T
E
N
F
Site 173
T1176
A
R
K
S
G
S
K
T
E
N
F
P
L
I
S
Site 174
S1183
T
E
N
F
P
L
I
S
V
S
P
H
A
S
G
Site 175
S1189
I
S
V
S
P
H
A
S
G
S
L
S
N
N
G
Site 176
S1191
V
S
P
H
A
S
G
S
L
S
N
N
G
D
G
Site 177
S1193
P
H
A
S
G
S
L
S
N
N
G
D
G
C
A
Site 178
S1202
N
G
D
G
C
A
S
S
N
D
N
G
E
Q
V
Site 179
T1212
N
G
E
Q
V
D
H
T
A
S
L
P
L
P
T
Site 180
S1214
E
Q
V
D
H
T
A
S
L
P
L
P
T
P
A
Site 181
T1222
L
P
L
P
T
P
A
T
V
Y
N
A
T
S
E
Site 182
Y1224
L
P
T
P
A
T
V
Y
N
A
T
S
E
E
T
Site 183
S1232
N
A
T
S
E
E
T
S
N
N
C
P
V
K
D
Site 184
T1241
N
C
P
V
K
D
A
T
A
S
E
K
N
E
P
Site 185
S1243
P
V
K
D
A
T
A
S
E
K
N
E
P
E
V
Site 186
T1253
N
E
P
E
V
Q
W
T
A
S
T
S
V
E
Q
Site 187
S1257
V
Q
W
T
A
S
T
S
V
E
Q
V
R
E
R
Site 188
S1265
V
E
Q
V
R
E
R
S
Y
Q
R
A
L
L
L
Site 189
Y1266
E
Q
V
R
E
R
S
Y
Q
R
A
L
L
L
S
Site 190
S1273
Y
Q
R
A
L
L
L
S
D
H
R
K
D
K
D
Site 191
S1281
D
H
R
K
D
K
D
S
G
G
E
S
P
C
V
Site 192
S1285
D
K
D
S
G
G
E
S
P
C
V
S
C
S
P
Site 193
S1289
G
G
E
S
P
C
V
S
C
S
P
S
H
V
Q
Site 194
S1291
E
S
P
C
V
S
C
S
P
S
H
V
Q
S
S
Site 195
S1293
P
C
V
S
C
S
P
S
H
V
Q
S
S
P
S
Site 196
S1297
C
S
P
S
H
V
Q
S
S
P
S
S
H
S
N
Site 197
S1298
S
P
S
H
V
Q
S
S
P
S
S
H
S
N
H
Site 198
S1300
S
H
V
Q
S
S
P
S
S
H
S
N
H
I
P
Site 199
S1301
H
V
Q
S
S
P
S
S
H
S
N
H
I
P
Q
Site 200
S1317
Q
A
K
G
P
V
P
S
F
S
E
L
M
E
D
Site 201
S1319
K
G
P
V
P
S
F
S
E
L
M
E
D
P
D
Site 202
T1334
P
E
N
P
E
P
T
T
T
N
E
C
P
S
P
Site 203
T1335
E
N
P
E
P
T
T
T
N
E
C
P
S
P
D
Site 204
S1340
T
T
T
N
E
C
P
S
P
D
T
S
Q
N
T
Site 205
S1344
E
C
P
S
P
D
T
S
Q
N
T
C
K
S
P
Site 206
S1350
T
S
Q
N
T
C
K
S
P
P
K
M
S
K
P
Site 207
S1355
C
K
S
P
P
K
M
S
K
P
G
S
P
G
S
Site 208
S1359
P
K
M
S
K
P
G
S
P
G
S
V
I
P
A
Site 209
S1362
S
K
P
G
S
P
G
S
V
I
P
A
Q
A
H
Site 210
S1382
K
P
D
P
Q
W
D
S
T
V
S
A
S
E
A
Site 211
T1383
P
D
P
Q
W
D
S
T
V
S
A
S
E
A
E
Site 212
S1385
P
Q
W
D
S
T
V
S
A
S
E
A
E
N
G
Site 213
S1405
E
L
Q
Q
K
Q
L
S
N
N
N
Q
A
L
S
Site 214
S1412
S
N
N
N
Q
A
L
S
K
N
H
P
P
Q
T
Site 215
T1419
S
K
N
H
P
P
Q
T
H
V
R
N
S
S
E
Site 216
S1424
P
Q
T
H
V
R
N
S
S
E
Q
L
S
Q
K
Site 217
S1425
Q
T
H
V
R
N
S
S
E
Q
L
S
Q
K
L
Site 218
S1429
R
N
S
S
E
Q
L
S
Q
K
L
P
S
V
P
Site 219
S1434
Q
L
S
Q
K
L
P
S
V
P
T
K
L
H
C
Site 220
S1444
T
K
L
H
C
P
P
S
P
H
L
E
N
P
P
Site 221
S1453
H
L
E
N
P
P
K
S
S
T
P
H
T
P
V
Site 222
S1454
L
E
N
P
P
K
S
S
T
P
H
T
P
V
Q
Site 223
T1455
E
N
P
P
K
S
S
T
P
H
T
P
V
Q
H
Site 224
T1458
P
K
S
S
T
P
H
T
P
V
Q
H
G
Y
L
Site 225
Y1464
H
T
P
V
Q
H
G
Y
L
S
P
K
P
P
S
Site 226
S1466
P
V
Q
H
G
Y
L
S
P
K
P
P
S
Q
Q
Site 227
S1471
Y
L
S
P
K
P
P
S
Q
Q
L
G
S
P
Y
Site 228
S1476
P
P
S
Q
Q
L
G
S
P
Y
R
P
H
H
S
Site 229
S1483
S
P
Y
R
P
H
H
S
Q
S
P
Q
V
G
T
Site 230
S1485
Y
R
P
H
H
S
Q
S
P
Q
V
G
T
P
Q
Site 231
T1490
S
Q
S
P
Q
V
G
T
P
Q
R
E
P
Q
R
Site 232
Y1500
R
E
P
Q
R
N
F
Y
P
A
A
Q
N
L
P
Site 233
T1520
A
T
S
G
T
L
F
T
Q
T
P
S
G
Q
S
Site 234
T1522
S
G
T
L
F
T
Q
T
P
S
G
Q
S
S
A
Site 235
S1524
T
L
F
T
Q
T
P
S
G
Q
S
S
A
T
Y
Site 236
S1528
Q
T
P
S
G
Q
S
S
A
T
Y
S
Q
F
N
Site 237
T1530
P
S
G
Q
S
S
A
T
Y
S
Q
F
N
Q
Q
Site 238
Y1531
S
G
Q
S
S
A
T
Y
S
Q
F
N
Q
Q
S
Site 239
S1532
G
Q
S
S
A
T
Y
S
Q
F
N
Q
Q
S
L
Site 240
S1538
Y
S
Q
F
N
Q
Q
S
L
N
S
T
A
P
P
Site 241
S1541
F
N
Q
Q
S
L
N
S
T
A
P
P
P
P
P
Site 242
T1542
N
Q
Q
S
L
N
S
T
A
P
P
P
P
P
P
Site 243
S1553
P
P
P
P
P
P
P
S
S
S
Y
Y
Q
N
Q
Site 244
S1554
P
P
P
P
P
P
S
S
S
Y
Y
Q
N
Q
Q
Site 245
S1555
P
P
P
P
P
S
S
S
Y
Y
Q
N
Q
Q
P
Site 246
Y1557
P
P
P
S
S
S
Y
Y
Q
N
Q
Q
P
S
A
Site 247
Y1569
P
S
A
N
F
Q
N
Y
N
Q
L
K
G
S
L
Site 248
S1575
N
Y
N
Q
L
K
G
S
L
S
Q
Q
T
V
F
Site 249
S1577
N
Q
L
K
G
S
L
S
Q
Q
T
V
F
T
S
Site 250
T1580
K
G
S
L
S
Q
Q
T
V
F
T
S
G
P
N
Site 251
S1595
Q
A
L
P
G
T
T
S
Q
Q
T
V
P
G
H
Site 252
T1598
P
G
T
T
S
Q
Q
T
V
P
G
H
H
V
T
Site 253
T1605
T
V
P
G
H
H
V
T
P
G
H
F
L
P
S
Site 254
S1612
T
P
G
H
F
L
P
S
Q
N
P
T
I
H
H
Site 255
T1616
F
L
P
S
Q
N
P
T
I
H
H
Q
T
A
A
Site 256
S1646
H
L
V
Q
Q
P
N
S
H
Q
Q
H
S
V
A
Site 257
S1666
V
H
A
V
T
P
G
S
H
I
H
S
Q
T
A
Site 258
S1670
T
P
G
S
H
I
H
S
Q
T
A
G
H
H
L
Site 259
S1697
H
H
P
P
P
H
P
S
T
G
L
Q
G
L
Q
Site 260
S1713
Q
H
Q
H
V
V
N
S
A
P
P
P
P
P
P
Site 261
S1724
P
P
P
P
P
P
P
S
S
V
L
A
S
G
H
Site 262
S1725
P
P
P
P
P
P
S
S
V
L
A
S
G
H
H
Site 263
S1729
P
P
S
S
V
L
A
S
G
H
H
T
T
S
A
Site 264
T1733
V
L
A
S
G
H
H
T
T
S
A
Q
A
L
H
Site 265
S1735
A
S
G
H
H
T
T
S
A
Q
A
L
H
H
P
Site 266
S1752
Q
G
P
P
L
F
P
S
S
A
H
P
T
V
P
Site 267
S1753
G
P
P
L
F
P
S
S
A
H
P
T
V
P
P
Site 268
T1757
F
P
S
S
A
H
P
T
V
P
P
Y
P
S
Q
Site 269
Y1761
A
H
P
T
V
P
P
Y
P
S
Q
A
T
H
H
Site 270
S1763
P
T
V
P
P
Y
P
S
Q
A
T
H
H
T
T
Site 271
T1770
S
Q
A
T
H
H
T
T
L
G
P
G
P
Q
H
Site 272
S1780
P
G
P
Q
H
Q
P
S
G
T
G
P
H
C
P
Site 273
T1782
P
Q
H
Q
P
S
G
T
G
P
H
C
P
L
P
Site 274
T1791
P
H
C
P
L
P
V
T
G
P
H
L
Q
P
Q
Site 275
S1802
L
Q
P
Q
G
P
N
S
I
P
T
P
T
A
S
Site 276
T1805
Q
G
P
N
S
I
P
T
P
T
A
S
G
F
C
Site 277
T1807
P
N
S
I
P
T
P
T
A
S
G
F
C
P
H
Site 278
S1809
S
I
P
T
P
T
A
S
G
F
C
P
H
P
G
Site 279
S1831
V
Q
G
P
Q
Q
A
S
P
V
P
G
Q
I
P
Site 280
T1847
H
R
A
Q
V
P
P
T
F
Q
N
N
Y
H
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation