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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HTF9C
Full Name:
tRNA (uracil-5-)-methyltransferase homolog A
Alias:
HpaII tiny fragments locus 9C; HpaII tinys locus 9C; TRM2 tRNA methyltransferase 2 A
Type:
Mass (Da):
68730
Number AA:
625
UniProt ID:
Q8IZ69
International Prot ID:
IPI00878912
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0008168
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
G
P
K
P
M
E
S
C
G
Q
E
S
S
S
Site 2
S20
M
E
S
C
G
Q
E
S
S
S
A
L
S
C
P
Site 3
S21
E
S
C
G
Q
E
S
S
S
A
L
S
C
P
T
Site 4
S22
S
C
G
Q
E
S
S
S
A
L
S
C
P
T
V
Site 5
S25
Q
E
S
S
S
A
L
S
C
P
T
V
S
V
P
Site 6
Y60
P
G
P
Q
P
G
L
Y
S
Y
I
R
D
D
L
Site 7
S61
G
P
Q
P
G
L
Y
S
Y
I
R
D
D
L
F
Site 8
Y62
P
Q
P
G
L
Y
S
Y
I
R
D
D
L
F
T
Site 9
T69
Y
I
R
D
D
L
F
T
S
E
I
F
K
L
E
Site 10
S85
Q
N
V
P
R
H
A
S
F
S
D
V
R
R
F
Site 11
S87
V
P
R
H
A
S
F
S
D
V
R
R
F
L
G
Site 12
T103
F
G
L
Q
P
H
K
T
K
L
F
G
Q
P
P
Site 13
T115
Q
P
P
C
A
F
V
T
F
R
S
A
A
E
R
Site 14
S140
L
W
K
G
R
P
L
S
V
R
L
A
R
P
K
Site 15
S161
R
R
R
Q
E
G
E
S
E
P
P
V
T
R
V
Site 16
T166
G
E
S
E
P
P
V
T
R
V
A
D
V
V
T
Site 17
T173
T
R
V
A
D
V
V
T
P
L
W
T
V
P
Y
Site 18
Y180
T
P
L
W
T
V
P
Y
A
E
Q
L
E
R
K
Site 19
S204
K
L
A
K
E
I
G
S
T
N
R
A
L
L
P
Site 20
T205
L
A
K
E
I
G
S
T
N
R
A
L
L
P
W
Site 21
S233
P
L
E
G
V
R
P
S
P
Q
Q
T
E
Y
R
Site 22
T237
V
R
P
S
P
Q
Q
T
E
Y
R
N
K
C
E
Site 23
Y239
P
S
P
Q
Q
T
E
Y
R
N
K
C
E
F
L
Site 24
T257
G
V
D
G
E
D
N
T
V
G
C
R
L
G
K
Site 25
S298
A
F
Q
E
F
I
R
S
T
P
Y
S
A
Y
D
Site 26
T299
F
Q
E
F
I
R
S
T
P
Y
S
A
Y
D
P
Site 27
S302
F
I
R
S
T
P
Y
S
A
Y
D
P
E
T
Y
Site 28
Y309
S
A
Y
D
P
E
T
Y
T
G
H
W
K
Q
L
Site 29
T310
A
Y
D
P
E
T
Y
T
G
H
W
K
Q
L
T
Site 30
T317
T
G
H
W
K
Q
L
T
V
R
T
S
R
R
H
Site 31
S321
K
Q
L
T
V
R
T
S
R
R
H
Q
A
M
A
Site 32
Y331
H
Q
A
M
A
I
A
Y
F
H
P
Q
K
L
S
Site 33
S338
Y
F
H
P
Q
K
L
S
P
E
E
L
A
E
L
Site 34
S348
E
L
A
E
L
K
T
S
L
A
Q
H
F
T
A
Site 35
Y367
A
S
G
V
T
C
L
Y
F
V
E
E
G
Q
R
Site 36
T376
V
E
E
G
Q
R
K
T
P
S
Q
E
G
L
P
Site 37
S378
E
G
Q
R
K
T
P
S
Q
E
G
L
P
L
E
Site 38
T401
H
E
D
L
L
G
L
T
F
R
I
S
P
H
A
Site 39
Y535
K
N
L
R
R
L
L
Y
V
S
C
N
P
R
A
Site 40
S555
V
D
L
C
R
A
P
S
N
R
V
K
G
I
P
Site 41
T595
R
V
E
H
P
N
G
T
G
V
L
G
P
H
S
Site 42
S602
T
G
V
L
G
P
H
S
P
P
A
Q
P
T
P
Site 43
T608
H
S
P
P
A
Q
P
T
P
G
P
P
D
N
T
Site 44
T615
T
P
G
P
P
D
N
T
L
Q
E
T
G
T
F
Site 45
T621
N
T
L
Q
E
T
G
T
F
P
S
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation