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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HACE1
Full Name:
E3 ubiquitin-protein ligase HACE1
Alias:
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1; KIAA1320
Type:
Ubiquitin ligase; Ligase; EC 6.3.2.-
Mass (Da):
102342
Number AA:
909
UniProt ID:
Q8IYU2
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0016881
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
M
E
Q
L
N
R
L
T
R
S
L
R
R
A
R
Site 2
S14
Q
L
N
R
L
T
R
S
L
R
R
A
R
T
V
Site 3
T20
R
S
L
R
R
A
R
T
V
E
L
P
E
D
N
Site 4
T29
E
L
P
E
D
N
E
T
A
V
Y
T
L
M
P
Site 5
S45
V
M
A
D
Q
H
R
S
V
S
E
L
L
S
N
Site 6
S47
A
D
Q
H
R
S
V
S
E
L
L
S
N
S
K
Site 7
S51
R
S
V
S
E
L
L
S
N
S
K
F
D
V
N
Site 8
S53
V
S
E
L
L
S
N
S
K
F
D
V
N
Y
A
Site 9
Y59
N
S
K
F
D
V
N
Y
A
F
G
R
V
K
R
Site 10
Y93
K
K
G
A
N
P
N
Y
Q
D
I
S
G
C
T
Site 11
T100
Y
Q
D
I
S
G
C
T
P
L
H
L
A
A
R
Site 12
S155
H
D
L
V
Q
H
V
S
D
V
D
V
E
D
A
Site 13
S186
T
V
Q
C
L
L
D
S
G
A
D
I
N
R
P
Site 14
T199
R
P
N
V
S
G
A
T
P
L
Y
F
A
C
S
Site 15
T212
C
S
H
G
Q
R
D
T
A
Q
I
L
L
L
R
Site 16
Y223
L
L
L
R
G
A
K
Y
L
P
D
K
N
G
V
Site 17
T231
L
P
D
K
N
G
V
T
P
L
D
L
C
V
Q
Site 18
Y251
T
C
E
V
L
I
Q
Y
H
P
R
L
F
Q
T
Site 19
S281
R
Q
V
L
E
H
L
S
Q
Q
S
E
S
Q
Y
Site 20
S284
L
E
H
L
S
Q
Q
S
E
S
Q
Y
L
K
I
Site 21
Y288
S
Q
Q
S
E
S
Q
Y
L
K
I
L
T
S
L
Site 22
T301
S
L
A
E
V
A
T
T
N
G
H
K
L
L
S
Site 23
S308
T
N
G
H
K
L
L
S
L
S
S
N
Y
D
A
Site 24
S310
G
H
K
L
L
S
L
S
S
N
Y
D
A
Q
M
Site 25
S311
H
K
L
L
S
L
S
S
N
Y
D
A
Q
M
K
Site 26
S319
N
Y
D
A
Q
M
K
S
L
L
R
I
V
R
M
Site 27
S337
V
F
R
I
G
P
S
S
P
S
N
G
I
D
M
Site 28
S339
R
I
G
P
S
S
P
S
N
G
I
D
M
G
Y
Site 29
Y346
S
N
G
I
D
M
G
Y
N
G
N
K
T
P
R
Site 30
T351
M
G
Y
N
G
N
K
T
P
R
S
Q
V
F
K
Site 31
S354
N
G
N
K
T
P
R
S
Q
V
F
K
P
L
E
Site 32
S385
L
M
K
N
K
R
D
S
T
E
I
T
S
I
L
Site 33
T386
M
K
N
K
R
D
S
T
E
I
T
S
I
L
L
Site 34
T389
K
R
D
S
T
E
I
T
S
I
L
L
K
Q
K
Site 35
S390
R
D
S
T
E
I
T
S
I
L
L
K
Q
K
G
Site 36
S404
G
Q
D
Q
D
A
A
S
I
P
P
F
E
P
P
Site 37
S415
F
E
P
P
G
P
G
S
Y
E
N
L
S
T
G
Site 38
Y416
E
P
P
G
P
G
S
Y
E
N
L
S
T
G
T
Site 39
S420
P
G
S
Y
E
N
L
S
T
G
T
R
E
S
K
Site 40
T421
G
S
Y
E
N
L
S
T
G
T
R
E
S
K
P
Site 41
S426
L
S
T
G
T
R
E
S
K
P
D
A
L
A
G
Site 42
S446
A
D
C
Q
D
V
I
S
M
T
A
N
R
L
S
Site 43
S473
Q
M
P
P
G
M
T
S
P
R
F
I
E
F
V
Site 44
Y532
K
D
R
C
E
W
F
Y
E
H
L
H
S
G
Q
Site 45
S542
L
H
S
G
Q
P
D
S
D
M
V
H
R
P
V
Site 46
S565
H
R
D
S
I
F
R
S
S
C
E
V
V
S
K
Site 47
S566
R
D
S
I
F
R
S
S
C
E
V
V
S
K
A
Site 48
Y613
N
E
I
V
N
P
D
Y
A
L
F
T
Q
S
A
Site 49
S619
D
Y
A
L
F
T
Q
S
A
D
G
T
T
F
Q
Site 50
T623
F
T
Q
S
A
D
G
T
T
F
Q
P
N
S
N
Site 51
T624
T
Q
S
A
D
G
T
T
F
Q
P
N
S
N
S
Site 52
S629
G
T
T
F
Q
P
N
S
N
S
Y
V
N
P
D
Site 53
S631
T
F
Q
P
N
S
N
S
Y
V
N
P
D
H
L
Site 54
Y632
F
Q
P
N
S
N
S
Y
V
N
P
D
H
L
N
Site 55
Y640
V
N
P
D
H
L
N
Y
F
R
F
A
G
Q
I
Site 56
Y661
H
R
Q
L
V
N
I
Y
F
T
R
S
F
Y
K
Site 57
Y677
I
L
G
I
P
V
N
Y
Q
D
V
A
S
I
D
Site 58
S682
V
N
Y
Q
D
V
A
S
I
D
P
E
Y
A
K
Site 59
Y687
V
A
S
I
D
P
E
Y
A
K
N
L
Q
W
I
Site 60
T733
G
G
G
S
I
L
V
T
Q
N
N
K
A
E
Y
Site 61
Y740
T
Q
N
N
K
A
E
Y
V
Q
L
V
T
E
L
Site 62
T800
V
S
D
W
I
K
N
T
E
Y
T
S
G
Y
E
Site 63
Y802
D
W
I
K
N
T
E
Y
T
S
G
Y
E
R
E
Site 64
Y806
N
T
E
Y
T
S
G
Y
E
R
E
D
P
V
I
Site 65
T824
W
E
V
V
E
D
I
T
Q
E
E
R
V
L
L
Site 66
S839
L
Q
F
V
T
G
S
S
R
V
P
H
G
G
F
Site 67
Y885
N
M
L
K
L
P
E
Y
P
S
K
E
I
L
K
Site 68
S887
L
K
L
P
E
Y
P
S
K
E
I
L
K
D
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation