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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZZZ3
Full Name:
ZZ-type zinc finger-containing protein 3
Alias:
Zinc finger
Type:
DNA binding protein
Mass (Da):
102023
Number AA:
903
UniProt ID:
Q8IYH5
International Prot ID:
IPI00217773
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
A
S
R
S
T
R
V
T
R
S
T
Site 2
T7
_
M
A
A
S
R
S
T
R
V
T
R
S
T
V
Site 3
T10
A
S
R
S
T
R
V
T
R
S
T
V
G
L
N
Site 4
S12
R
S
T
R
V
T
R
S
T
V
G
L
N
G
L
Site 5
T13
S
T
R
V
T
R
S
T
V
G
L
N
G
L
D
Site 6
S22
G
L
N
G
L
D
E
S
F
C
G
R
T
L
R
Site 7
T27
D
E
S
F
C
G
R
T
L
R
N
R
S
I
A
Site 8
S32
G
R
T
L
R
N
R
S
I
A
H
P
E
E
I
Site 9
S41
A
H
P
E
E
I
S
S
N
S
Q
V
R
S
R
Site 10
S43
P
E
E
I
S
S
N
S
Q
V
R
S
R
S
P
Site 11
S47
S
S
N
S
Q
V
R
S
R
S
P
K
K
R
P
Site 12
S49
N
S
Q
V
R
S
R
S
P
K
K
R
P
E
P
Site 13
T69
G
N
N
N
G
R
T
T
D
L
K
Q
Q
S
T
Site 14
S75
T
T
D
L
K
Q
Q
S
T
R
E
S
W
V
S
Site 15
S79
K
Q
Q
S
T
R
E
S
W
V
S
P
R
K
R
Site 16
S82
S
T
R
E
S
W
V
S
P
R
K
R
G
L
S
Site 17
S89
S
P
R
K
R
G
L
S
S
S
E
K
D
N
I
Site 18
S90
P
R
K
R
G
L
S
S
S
E
K
D
N
I
E
Site 19
S91
R
K
R
G
L
S
S
S
E
K
D
N
I
E
R
Site 20
T109
E
N
C
E
R
R
Q
T
E
P
V
S
P
V
L
Site 21
S113
R
R
Q
T
E
P
V
S
P
V
L
K
R
I
K
Site 22
S125
R
I
K
R
C
L
R
S
E
A
P
N
S
S
E
Site 23
S130
L
R
S
E
A
P
N
S
S
E
E
D
S
P
I
Site 24
S131
R
S
E
A
P
N
S
S
E
E
D
S
P
I
K
Site 25
S135
P
N
S
S
E
E
D
S
P
I
K
S
D
K
E
Site 26
S139
E
E
D
S
P
I
K
S
D
K
E
S
V
E
Q
Site 27
S143
P
I
K
S
D
K
E
S
V
E
Q
R
S
T
V
Site 28
T149
E
S
V
E
Q
R
S
T
V
V
D
N
D
A
D
Site 29
S183
E
I
K
K
V
N
V
S
E
E
G
P
L
N
S
Site 30
S190
S
E
E
G
P
L
N
S
A
V
V
E
E
I
T
Site 31
S210
N
G
V
D
D
S
D
S
A
V
I
N
C
D
D
Site 32
T224
D
C
Q
P
D
G
N
T
K
Q
N
S
I
G
S
Site 33
S228
D
G
N
T
K
Q
N
S
I
G
S
Y
V
L
Q
Site 34
Y232
K
Q
N
S
I
G
S
Y
V
L
Q
E
K
S
V
Site 35
S238
S
Y
V
L
Q
E
K
S
V
A
E
N
G
D
T
Site 36
T245
S
V
A
E
N
G
D
T
D
T
Q
T
S
M
F
Site 37
T247
A
E
N
G
D
T
D
T
Q
T
S
M
F
L
D
Site 38
T249
N
G
D
T
D
T
Q
T
S
M
F
L
D
S
R
Site 39
S255
Q
T
S
M
F
L
D
S
R
K
E
D
S
Y
I
Site 40
Y261
D
S
R
K
E
D
S
Y
I
D
H
K
V
P
C
Site 41
T269
I
D
H
K
V
P
C
T
D
S
Q
V
Q
V
K
Site 42
S271
H
K
V
P
C
T
D
S
Q
V
Q
V
K
L
E
Site 43
T296
V
E
H
V
N
Q
L
T
T
E
P
A
T
G
P
Site 44
S305
E
P
A
T
G
P
F
S
E
T
Q
S
S
L
R
Site 45
S309
G
P
F
S
E
T
Q
S
S
L
R
D
S
E
E
Site 46
S310
P
F
S
E
T
Q
S
S
L
R
D
S
E
E
E
Site 47
S314
T
Q
S
S
L
R
D
S
E
E
E
V
D
V
V
Site 48
S324
E
V
D
V
V
G
D
S
S
A
S
K
E
Q
C
Site 49
S325
V
D
V
V
G
D
S
S
A
S
K
E
Q
C
K
Site 50
S342
T
N
N
E
L
D
T
S
L
E
S
M
P
A
S
Site 51
S345
E
L
D
T
S
L
E
S
M
P
A
S
G
E
P
Site 52
S349
S
L
E
S
M
P
A
S
G
E
P
E
P
S
P
Site 53
S355
A
S
G
E
P
E
P
S
P
V
L
D
C
V
S
Site 54
S367
C
V
S
A
Q
M
M
S
L
S
E
P
Q
E
H
Site 55
S369
S
A
Q
M
M
S
L
S
E
P
Q
E
H
R
Y
Site 56
Y376
S
E
P
Q
E
H
R
Y
T
L
R
T
S
P
R
Site 57
T377
E
P
Q
E
H
R
Y
T
L
R
T
S
P
R
R
Site 58
T380
E
H
R
Y
T
L
R
T
S
P
R
R
A
A
P
Site 59
S381
H
R
Y
T
L
R
T
S
P
R
R
A
A
P
T
Site 60
T388
S
P
R
R
A
A
P
T
R
G
S
P
T
K
N
Site 61
S391
R
A
A
P
T
R
G
S
P
T
K
N
S
S
P
Site 62
T393
A
P
T
R
G
S
P
T
K
N
S
S
P
Y
R
Site 63
S396
R
G
S
P
T
K
N
S
S
P
Y
R
E
N
G
Site 64
S397
G
S
P
T
K
N
S
S
P
Y
R
E
N
G
Q
Site 65
S411
Q
F
E
E
N
N
L
S
P
N
E
T
N
A
T
Site 66
T415
N
N
L
S
P
N
E
T
N
A
T
V
S
D
N
Site 67
T418
S
P
N
E
T
N
A
T
V
S
D
N
V
S
Q
Site 68
S420
N
E
T
N
A
T
V
S
D
N
V
S
Q
S
P
Site 69
S424
A
T
V
S
D
N
V
S
Q
S
P
T
N
P
G
Site 70
S426
V
S
D
N
V
S
Q
S
P
T
N
P
G
E
I
Site 71
T428
D
N
V
S
Q
S
P
T
N
P
G
E
I
S
Q
Site 72
S434
P
T
N
P
G
E
I
S
Q
N
E
K
G
I
C
Site 73
S444
E
K
G
I
C
C
D
S
Q
N
N
G
S
E
G
Site 74
S449
C
D
S
Q
N
N
G
S
E
G
V
S
K
P
P
Site 75
S453
N
N
G
S
E
G
V
S
K
P
P
S
E
A
R
Site 76
S457
E
G
V
S
K
P
P
S
E
A
R
L
N
I
G
Site 77
S468
L
N
I
G
H
L
P
S
A
K
E
S
A
S
Q
Site 78
S472
H
L
P
S
A
K
E
S
A
S
Q
H
I
T
E
Site 79
S474
P
S
A
K
E
S
A
S
Q
H
I
T
E
E
E
Site 80
T478
E
S
A
S
Q
H
I
T
E
E
E
D
D
D
P
Site 81
Y488
E
D
D
D
P
D
V
Y
Y
F
E
S
D
H
V
Site 82
Y489
D
D
D
P
D
V
Y
Y
F
E
S
D
H
V
A
Site 83
Y503
A
L
K
H
N
K
D
Y
Q
R
L
L
Q
T
I
Site 84
S518
A
V
L
E
A
Q
R
S
Q
A
V
Q
D
L
E
Site 85
Y555
K
A
D
I
G
L
P
Y
P
Q
R
V
V
Q
L
Site 86
Y570
P
E
I
V
W
D
Q
Y
T
H
S
L
G
N
F
Site 87
T588
F
K
N
R
K
R
H
T
R
R
V
K
L
V
F
Site 88
S606
G
L
P
A
R
P
K
S
P
L
D
P
K
K
D
Site 89
S616
D
P
K
K
D
G
E
S
L
S
Y
S
M
L
P
Site 90
S618
K
K
D
G
E
S
L
S
Y
S
M
L
P
L
S
Site 91
Y619
K
D
G
E
S
L
S
Y
S
M
L
P
L
S
D
Site 92
S620
D
G
E
S
L
S
Y
S
M
L
P
L
S
D
G
Site 93
S625
S
Y
S
M
L
P
L
S
D
G
P
E
G
S
S
Site 94
S631
L
S
D
G
P
E
G
S
S
S
R
P
Q
M
I
Site 95
S632
S
D
G
P
E
G
S
S
S
R
P
Q
M
I
R
Site 96
S633
D
G
P
E
G
S
S
S
R
P
Q
M
I
R
G
Site 97
T646
R
G
R
L
C
D
D
T
K
P
E
T
F
N
Q
Site 98
T656
E
T
F
N
Q
L
W
T
V
E
E
Q
K
K
L
Site 99
Y670
L
E
Q
L
L
I
K
Y
P
P
E
E
V
E
S
Site 100
S677
Y
P
P
E
E
V
E
S
R
R
W
Q
K
I
A
Site 101
Y702
V
A
S
R
V
Q
K
Y
F
I
K
L
T
K
A
Site 102
T717
G
I
P
V
P
G
R
T
P
N
L
Y
I
Y
S
Site 103
Y721
P
G
R
T
P
N
L
Y
I
Y
S
K
K
S
S
Site 104
Y723
R
T
P
N
L
Y
I
Y
S
K
K
S
S
T
S
Site 105
S724
T
P
N
L
Y
I
Y
S
K
K
S
S
T
S
R
Site 106
S727
L
Y
I
Y
S
K
K
S
S
T
S
R
R
Q
H
Site 107
S728
Y
I
Y
S
K
K
S
S
T
S
R
R
Q
H
P
Site 108
T729
I
Y
S
K
K
S
S
T
S
R
R
Q
H
P
L
Site 109
S730
Y
S
K
K
S
S
T
S
R
R
Q
H
P
L
N
Site 110
S744
N
K
H
L
F
K
P
S
T
F
M
T
S
H
E
Site 111
T745
K
H
L
F
K
P
S
T
F
M
T
S
H
E
P
Site 112
T748
F
K
P
S
T
F
M
T
S
H
E
P
P
V
Y
Site 113
S749
K
P
S
T
F
M
T
S
H
E
P
P
V
Y
M
Site 114
Y755
T
S
H
E
P
P
V
Y
M
D
E
D
D
D
R
Site 115
T771
C
F
H
S
H
M
N
T
A
V
E
D
A
S
D
Site 116
S777
N
T
A
V
E
D
A
S
D
D
E
S
I
P
I
Site 117
S781
E
D
A
S
D
D
E
S
I
P
I
M
Y
R
N
Site 118
Y792
M
Y
R
N
L
P
E
Y
K
E
L
L
Q
F
K
Site 119
Y873
D
H
Q
L
E
P
I
Y
R
S
E
T
F
L
D
Site 120
T877
E
P
I
Y
R
S
E
T
F
L
D
R
D
Y
C
Site 121
Y883
E
T
F
L
D
R
D
Y
C
V
S
Q
G
T
S
Site 122
Y891
C
V
S
Q
G
T
S
Y
N
Y
L
D
P
N
Y
Site 123
Y893
S
Q
G
T
S
Y
N
Y
L
D
P
N
Y
F
P
Site 124
Y898
Y
N
Y
L
D
P
N
Y
F
P
A
N
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation