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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
4930429A22Rik Probable exonuclease
Full Name:
DIS3-like exonuclease 2
Alias:
DI3L2
Type:
Mass (Da):
99210
Number AA:
885
UniProt ID:
Q8IYB7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0004527
GO:0004540
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
M
N
L
R
P
L
G
T
P
R
G
V
S
A
V
Site 2
S20
L
G
T
P
R
G
V
S
A
V
A
G
P
H
D
Site 3
S31
G
P
H
D
I
G
A
S
P
G
D
K
K
S
K
Site 4
S37
A
S
P
G
D
K
K
S
K
N
R
S
T
R
G
Site 5
S41
D
K
K
S
K
N
R
S
T
R
G
K
K
K
S
Site 6
T42
K
K
S
K
N
R
S
T
R
G
K
K
K
S
I
Site 7
S48
S
T
R
G
K
K
K
S
I
F
E
T
Y
M
S
Site 8
T52
K
K
K
S
I
F
E
T
Y
M
S
K
E
D
V
Site 9
S55
S
I
F
E
T
Y
M
S
K
E
D
V
S
E
G
Site 10
S60
Y
M
S
K
E
D
V
S
E
G
L
K
R
G
T
Site 11
T67
S
E
G
L
K
R
G
T
L
I
Q
G
V
L
R
Site 12
S87
F
H
E
A
F
I
P
S
P
D
G
D
R
D
I
Site 13
S128
W
K
V
V
K
P
E
S
N
D
K
E
T
E
A
Site 14
T133
P
E
S
N
D
K
E
T
E
A
A
Y
E
S
D
Site 15
Y137
D
K
E
T
E
A
A
Y
E
S
D
I
P
E
E
Site 16
S139
E
T
E
A
A
Y
E
S
D
I
P
E
E
L
C
Site 17
S154
G
H
H
L
P
Q
Q
S
L
K
S
Y
N
D
S
Site 18
S157
L
P
Q
Q
S
L
K
S
Y
N
D
S
P
D
V
Site 19
S161
S
L
K
S
Y
N
D
S
P
D
V
I
V
E
A
Site 20
S173
V
E
A
Q
F
D
G
S
D
S
E
D
G
H
G
Site 21
S175
A
Q
F
D
G
S
D
S
E
D
G
H
G
I
T
Site 22
S194
V
D
G
V
K
K
L
S
V
C
V
S
E
K
G
Site 23
S198
K
K
L
S
V
C
V
S
E
K
G
R
E
D
G
Site 24
T214
A
P
V
T
K
D
E
T
T
C
I
S
Q
D
T
Site 25
S218
K
D
E
T
T
C
I
S
Q
D
T
R
A
L
S
Site 26
S225
S
Q
D
T
R
A
L
S
E
K
S
L
Q
R
S
Site 27
S228
T
R
A
L
S
E
K
S
L
Q
R
S
A
K
V
Site 28
S232
S
E
K
S
L
Q
R
S
A
K
V
V
Y
I
L
Site 29
S244
Y
I
L
E
K
K
H
S
R
A
A
T
G
F
L
Site 30
T248
K
K
H
S
R
A
A
T
G
F
L
K
L
L
A
Site 31
S259
K
L
L
A
D
K
N
S
E
L
F
R
K
Y
A
Site 32
Y265
N
S
E
L
F
R
K
Y
A
L
F
S
P
S
D
Site 33
S269
F
R
K
Y
A
L
F
S
P
S
D
H
R
V
P
Site 34
S271
K
Y
A
L
F
S
P
S
D
H
R
V
P
R
I
Site 35
Y279
D
H
R
V
P
R
I
Y
V
P
L
K
D
C
P
Site 36
T333
A
G
E
I
E
P
E
T
E
G
I
L
T
E
Y
Site 37
T338
P
E
T
E
G
I
L
T
E
Y
G
V
D
F
S
Site 38
Y340
T
E
G
I
L
T
E
Y
G
V
D
F
S
D
F
Site 39
S345
T
E
Y
G
V
D
F
S
D
F
S
S
E
V
L
Site 40
T362
L
P
Q
G
L
P
W
T
I
P
P
E
E
F
S
Site 41
S369
T
I
P
P
E
E
F
S
K
R
R
D
L
R
K
Site 42
T381
L
R
K
D
C
I
F
T
I
D
P
S
T
A
R
Site 43
S385
C
I
F
T
I
D
P
S
T
A
R
D
L
D
D
Site 44
T386
I
F
T
I
D
P
S
T
A
R
D
L
D
D
A
Site 45
S395
R
D
L
D
D
A
L
S
C
K
P
L
A
D
G
Site 46
S421
S
Y
F
V
P
E
G
S
D
L
D
K
V
A
A
Site 47
T432
K
V
A
A
E
R
A
T
S
V
Y
L
V
Q
K
Site 48
S454
L
L
C
E
E
L
C
S
L
N
P
M
S
D
K
Site 49
S488
F
G
R
T
I
I
R
S
C
T
K
L
S
Y
E
Site 50
T490
R
T
I
I
R
S
C
T
K
L
S
Y
E
H
A
Site 51
S493
I
R
S
C
T
K
L
S
Y
E
H
A
Q
S
M
Site 52
Y494
R
S
C
T
K
L
S
Y
E
H
A
Q
S
M
I
Site 53
S499
L
S
Y
E
H
A
Q
S
M
I
E
S
P
T
E
Site 54
S503
H
A
Q
S
M
I
E
S
P
T
E
K
I
P
A
Site 55
S517
A
K
E
L
P
P
I
S
P
E
H
S
S
E
E
Site 56
S521
P
P
I
S
P
E
H
S
S
E
E
V
H
Q
A
Site 57
T559
D
Q
L
K
L
A
F
T
L
D
H
E
T
G
L
Site 58
T564
A
F
T
L
D
H
E
T
G
L
P
Q
G
C
H
Site 59
Y573
L
P
Q
G
C
H
I
Y
E
Y
R
E
S
N
K
Site 60
Y575
Q
G
C
H
I
Y
E
Y
R
E
S
N
K
L
V
Site 61
T615
R
R
H
P
P
P
Q
T
R
M
L
S
D
L
V
Site 62
S619
P
P
Q
T
R
M
L
S
D
L
V
E
F
C
D
Site 63
S636
G
L
P
V
D
F
S
S
A
G
A
L
N
K
S
Site 64
S643
S
A
G
A
L
N
K
S
L
T
Q
T
F
G
D
Site 65
T645
G
A
L
N
K
S
L
T
Q
T
F
G
D
D
K
Site 66
T647
L
N
K
S
L
T
Q
T
F
G
D
D
K
Y
S
Site 67
Y653
Q
T
F
G
D
D
K
Y
S
L
A
R
K
E
V
Site 68
S654
T
F
G
D
D
K
Y
S
L
A
R
K
E
V
L
Site 69
T662
L
A
R
K
E
V
L
T
N
M
C
S
R
P
M
Site 70
Y689
D
P
A
Q
F
R
H
Y
A
L
N
V
P
L
Y
Site 71
S701
P
L
Y
T
H
F
T
S
P
I
R
R
F
A
D
Site 72
T731
R
L
D
M
A
P
D
T
L
Q
K
Q
A
D
H
Site 73
S746
C
N
D
R
R
M
A
S
K
R
V
Q
E
L
S
Site 74
Y796
Y
G
V
Q
K
R
I
Y
C
N
A
L
A
L
R
Site 75
T817
V
G
K
K
P
E
L
T
L
V
W
E
P
E
D
Site 76
T862
A
I
L
K
R
P
G
T
Q
G
H
L
G
P
E
Site 77
S875
P
E
K
E
E
E
E
S
D
G
E
P
E
D
S
Site 78
S882
S
D
G
E
P
E
D
S
S
T
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation