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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC144C
Full Name:
Coiled-coil domain-containing protein 144C
Alias:
Type:
Mass (Da):
143112
Number AA:
1237
UniProt ID:
Q8IYA2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
K
R
G
G
A
E
G
S
P
K
P
A
V
Y
A
Site 2
Y21
G
S
P
K
P
A
V
Y
A
T
R
K
T
G
S
Site 3
T26
A
V
Y
A
T
R
K
T
G
S
V
R
S
Q
E
Site 4
S28
Y
A
T
R
K
T
G
S
V
R
S
Q
E
D
Q
Site 5
S31
R
K
T
G
S
V
R
S
Q
E
D
Q
W
Y
L
Site 6
Y37
R
S
Q
E
D
Q
W
Y
L
G
Y
P
G
D
Q
Site 7
Y40
E
D
Q
W
Y
L
G
Y
P
G
D
Q
W
S
S
Site 8
S57
S
Y
S
W
W
K
N
S
V
G
S
E
S
K
H
Site 9
S60
W
W
K
N
S
V
G
S
E
S
K
H
G
E
G
Site 10
S115
D
K
R
D
R
K
K
S
I
Q
Q
L
V
P
E
Site 11
T128
P
E
Y
K
E
K
Q
T
P
E
S
L
P
Q
N
Site 12
S131
K
E
K
Q
T
P
E
S
L
P
Q
N
N
N
P
Site 13
T146
D
W
H
P
T
N
L
T
L
S
D
E
T
C
Q
Site 14
S148
H
P
T
N
L
T
L
S
D
E
T
C
Q
R
S
Site 15
T151
N
L
T
L
S
D
E
T
C
Q
R
S
K
N
L
Site 16
S166
K
V
D
D
K
C
P
S
V
S
P
S
M
P
E
Site 17
S168
D
D
K
C
P
S
V
S
P
S
M
P
E
N
Q
Site 18
S170
K
C
P
S
V
S
P
S
M
P
E
N
Q
S
A
Site 19
S176
P
S
M
P
E
N
Q
S
A
T
K
E
L
G
Q
Site 20
T187
E
L
G
Q
M
N
L
T
E
R
E
K
M
D
T
Site 21
T194
T
E
R
E
K
M
D
T
G
V
K
T
S
Q
E
Site 22
S199
M
D
T
G
V
K
T
S
Q
E
P
E
M
A
K
Site 23
Y216
D
R
E
D
I
P
I
Y
P
V
L
P
H
V
Q
Site 24
Y256
K
Q
R
F
G
E
I
Y
E
K
Y
K
I
P
A
Site 25
Y259
F
G
E
I
Y
E
K
Y
K
I
P
A
C
P
E
Site 26
S274
E
E
P
L
L
D
N
S
T
R
G
T
D
V
K
Site 27
T278
L
D
N
S
T
R
G
T
D
V
K
D
I
P
F
Site 28
T288
K
D
I
P
F
N
L
T
N
N
I
P
G
C
E
Site 29
S300
G
C
E
E
E
D
A
S
E
I
S
V
S
V
V
Site 30
S303
E
E
D
A
S
E
I
S
V
S
V
V
F
E
T
Site 31
S318
F
P
E
Q
K
E
P
S
L
K
N
I
I
H
S
Site 32
Y326
L
K
N
I
I
H
S
Y
Y
H
P
Y
S
G
S
Site 33
Y327
K
N
I
I
H
S
Y
Y
H
P
Y
S
G
S
Q
Site 34
S340
S
Q
E
H
V
C
Q
S
S
S
K
L
H
L
H
Site 35
S342
E
H
V
C
Q
S
S
S
K
L
H
L
H
E
N
Site 36
T387
A
R
N
P
E
V
V
T
V
E
M
K
E
D
Q
Site 37
S408
T
K
N
M
N
Q
N
S
D
S
G
S
T
N
N
Site 38
S410
N
M
N
Q
N
S
D
S
G
S
T
N
N
Y
K
Site 39
S412
N
Q
N
S
D
S
G
S
T
N
N
Y
K
S
L
Site 40
Y416
D
S
G
S
T
N
N
Y
K
S
L
K
P
K
L
Site 41
S418
G
S
T
N
N
Y
K
S
L
K
P
K
L
E
N
Site 42
S427
K
P
K
L
E
N
L
S
S
L
P
P
D
S
D
Site 43
S428
P
K
L
E
N
L
S
S
L
P
P
D
S
D
R
Site 44
S433
L
S
S
L
P
P
D
S
D
R
T
S
E
V
Y
Site 45
T436
L
P
P
D
S
D
R
T
S
E
V
Y
L
H
E
Site 46
S437
P
P
D
S
D
R
T
S
E
V
Y
L
H
E
E
Site 47
Y440
S
D
R
T
S
E
V
Y
L
H
E
E
L
Q
Q
Site 48
S486
E
E
M
E
K
H
R
S
N
S
T
E
L
S
G
Site 49
S488
M
E
K
H
R
S
N
S
T
E
L
S
G
T
L
Site 50
S492
R
S
N
S
T
E
L
S
G
T
L
T
D
G
T
Site 51
T494
N
S
T
E
L
S
G
T
L
T
D
G
T
T
V
Site 52
T496
T
E
L
S
G
T
L
T
D
G
T
T
V
G
N
Site 53
T499
S
G
T
L
T
D
G
T
T
V
G
N
D
D
D
Site 54
T500
G
T
L
T
D
G
T
T
V
G
N
D
D
D
G
Site 55
Y539
K
R
N
A
D
M
L
Y
N
K
D
S
E
Q
L
Site 56
T576
R
L
V
K
E
L
R
T
V
V
Q
E
R
N
D
Site 57
S604
L
Q
D
Q
I
L
T
S
K
Q
K
E
L
E
M
Site 58
S621
K
K
R
N
P
E
I
S
H
R
H
Q
K
E
K
Site 59
T650
L
L
R
L
E
I
D
T
I
K
N
Q
N
K
Q
Site 60
Y662
N
K
Q
K
E
K
K
Y
F
E
D
I
E
V
V
Site 61
T688
K
R
N
E
E
T
L
T
E
T
I
L
Q
Y
S
Site 62
S728
R
L
E
I
E
M
E
S
Y
R
C
R
L
A
A
Site 63
Y729
L
E
I
E
M
E
S
Y
R
C
R
L
A
A
A
Site 64
S743
A
V
H
D
C
D
Q
S
Q
T
A
R
D
L
K
Site 65
S782
Q
A
K
N
E
I
L
S
E
K
L
S
N
A
E
Site 66
S786
E
I
L
S
E
K
L
S
N
A
E
S
K
I
N
Site 67
S790
E
K
L
S
N
A
E
S
K
I
N
S
L
Q
I
Site 68
S794
N
A
E
S
K
I
N
S
L
Q
I
Q
L
H
N
Site 69
S810
R
D
A
L
G
R
E
S
L
I
L
E
R
V
Q
Site 70
S821
E
R
V
Q
R
D
L
S
Q
T
Q
C
Q
K
K
Site 71
T823
V
Q
R
D
L
S
Q
T
Q
C
Q
K
K
E
T
Site 72
Y834
K
K
E
T
E
Q
M
Y
Q
S
K
L
K
K
Y
Site 73
Y841
Y
Q
S
K
L
K
K
Y
I
A
K
Q
E
S
V
Site 74
S847
K
Y
I
A
K
Q
E
S
V
E
E
R
L
S
Q
Site 75
S853
E
S
V
E
E
R
L
S
Q
L
Q
S
E
N
M
Site 76
S857
E
R
L
S
Q
L
Q
S
E
N
M
L
L
R
Q
Site 77
S875
D
V
H
K
K
A
N
S
Q
E
K
T
I
S
T
Site 78
T879
K
A
N
S
Q
E
K
T
I
S
T
I
Q
D
Q
Site 79
S889
T
I
Q
D
Q
F
H
S
A
A
K
N
L
Q
A
Site 80
S904
E
S
E
K
Q
I
L
S
L
Q
E
K
N
K
E
Site 81
Y916
N
K
E
L
M
D
E
Y
N
H
L
K
E
R
M
Site 82
T938
A
G
R
K
I
D
L
T
E
A
Q
E
T
V
P
Site 83
T943
D
L
T
E
A
Q
E
T
V
P
S
R
C
L
H
Site 84
S946
E
A
Q
E
T
V
P
S
R
C
L
H
L
D
A
Site 85
Y994
E
V
V
N
L
K
S
Y
M
E
R
N
M
L
E
Site 86
T1050
A
Q
L
R
E
D
N
T
T
S
I
K
T
Q
M
Site 87
T1051
Q
L
R
E
D
N
T
T
S
I
K
T
Q
M
E
Site 88
T1060
I
K
T
Q
M
E
L
T
V
I
D
L
E
S
E
Site 89
S1069
I
D
L
E
S
E
I
S
R
I
K
T
S
Q
A
Site 90
T1073
S
E
I
S
R
I
K
T
S
Q
A
D
F
N
K
Site 91
S1074
E
I
S
R
I
K
T
S
Q
A
D
F
N
K
T
Site 92
Y1090
L
E
R
Y
K
E
L
Y
L
E
E
V
K
V
R
Site 93
S1099
E
E
V
K
V
R
E
S
L
S
N
E
L
S
R
Site 94
S1101
V
K
V
R
E
S
L
S
N
E
L
S
R
T
N
Site 95
S1105
E
S
L
S
N
E
L
S
R
T
N
E
M
I
A
Site 96
T1107
L
S
N
E
L
S
R
T
N
E
M
I
A
E
V
Site 97
T1119
A
E
V
S
T
Q
L
T
V
E
K
E
Q
T
R
Site 98
T1125
L
T
V
E
K
E
Q
T
R
S
R
S
L
F
T
Site 99
S1127
V
E
K
E
Q
T
R
S
R
S
L
F
T
A
Y
Site 100
S1129
K
E
Q
T
R
S
R
S
L
F
T
A
Y
A
T
Site 101
S1142
A
T
R
P
V
L
E
S
P
C
V
G
N
L
N
Site 102
S1172
S
A
L
K
D
M
E
S
Y
L
L
K
M
Q
Q
Site 103
T1186
Q
K
L
Q
N
D
L
T
A
E
V
A
G
S
S
Site 104
S1192
L
T
A
E
V
A
G
S
S
Q
T
G
L
H
R
Site 105
S1204
L
H
R
I
P
Q
C
S
S
F
S
S
S
S
L
Site 106
S1205
H
R
I
P
Q
C
S
S
F
S
S
S
S
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation