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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHX37
Full Name:
Probable ATP-dependent RNA helicase DHX37
Alias:
ATP-dependent RNA helicase DHX37; DDX37; DEAH (Asp-Glu-Ala-His) box polypeptide 37; DEAH box protein 37; KIAA1517; MGC2695; MGC4322
Type:
EC 3.6.1.-; Helicase
Mass (Da):
129545
Number AA:
1157
UniProt ID:
Q8IY37
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004386
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
G
K
L
R
R
R
Y
N
I
K
G
R
Q
Q
Site 2
T39
L
E
L
E
D
K
D
T
L
K
G
V
D
A
S
Site 3
T59
P
G
K
K
K
K
K
T
K
A
P
P
L
S
K
Site 4
S65
K
T
K
A
P
P
L
S
K
K
E
K
K
P
L
Site 5
T73
K
K
E
K
K
P
L
T
K
K
E
K
K
V
L
Site 6
S91
L
E
Q
K
E
K
K
S
Q
R
A
E
M
L
Q
Site 7
S101
A
E
M
L
Q
K
L
S
E
V
Q
A
S
E
A
Site 8
S106
K
L
S
E
V
Q
A
S
E
A
E
M
R
L
F
Site 9
Y114
E
A
E
M
R
L
F
Y
T
T
S
K
L
G
T
Site 10
T115
A
E
M
R
L
F
Y
T
T
S
K
L
G
T
G
Site 11
T116
E
M
R
L
F
Y
T
T
S
K
L
G
T
G
N
Site 12
S117
M
R
L
F
Y
T
T
S
K
L
G
T
G
N
R
Site 13
T121
Y
T
T
S
K
L
G
T
G
N
R
M
Y
H
T
Site 14
Y126
L
G
T
G
N
R
M
Y
H
T
K
E
K
A
D
Site 15
S145
P
G
Q
E
K
I
S
S
L
S
G
A
H
R
K
Site 16
S147
Q
E
K
I
S
S
L
S
G
A
H
R
K
R
R
Site 17
S158
R
K
R
R
R
W
P
S
A
E
E
E
E
E
E
Site 18
S169
E
E
E
E
E
E
E
S
E
S
E
L
E
E
E
Site 19
S171
E
E
E
E
E
S
E
S
E
L
E
E
E
S
E
Site 20
S177
E
S
E
L
E
E
E
S
E
L
D
E
D
P
A
Site 21
S206
L
P
P
A
P
A
P
S
S
Q
P
V
P
A
G
Site 22
S207
P
P
A
P
A
P
S
S
Q
P
V
P
A
G
M
Site 23
S242
V
F
I
P
V
N
R
S
P
E
M
Q
E
E
R
Site 24
T283
E
T
G
S
G
K
T
T
Q
V
P
Q
F
L
Y
Site 25
Y290
T
Q
V
P
Q
F
L
Y
E
A
G
F
S
S
E
Site 26
S295
F
L
Y
E
A
G
F
S
S
E
D
S
I
I
G
Site 27
S299
A
G
F
S
S
E
D
S
I
I
G
V
T
E
P
Site 28
S325
V
A
K
E
M
N
L
S
Q
R
V
V
S
Y
Q
Site 29
S330
N
L
S
Q
R
V
V
S
Y
Q
I
R
Y
E
G
Site 30
Y331
L
S
Q
R
V
V
S
Y
Q
I
R
Y
E
G
N
Site 31
T340
I
R
Y
E
G
N
V
T
E
E
T
R
I
K
F
Site 32
T349
E
T
R
I
K
F
M
T
D
G
V
L
L
K
E
Site 33
S378
I
D
E
A
H
E
R
S
V
Y
T
D
I
L
I
Site 34
Y380
E
A
H
E
R
S
V
Y
T
D
I
L
I
G
L
Site 35
T417
T
L
R
V
E
D
F
T
Q
N
P
R
L
F
A
Site 36
T440
E
S
R
Q
F
P
V
T
V
H
F
N
K
R
T
Site 37
T447
T
V
H
F
N
K
R
T
P
L
E
D
Y
S
G
Site 38
Y452
K
R
T
P
L
E
D
Y
S
G
E
C
F
R
K
Site 39
S453
R
T
P
L
E
D
Y
S
G
E
C
F
R
K
V
Site 40
S496
L
R
K
A
F
P
P
S
R
A
R
P
Q
E
K
Site 41
S510
K
D
D
D
Q
K
D
S
V
E
E
M
R
K
F
Site 42
S520
E
M
R
K
F
K
K
S
R
A
R
A
K
K
A
Site 43
Y540
P
Q
I
N
L
D
H
Y
S
V
L
P
A
G
E
Site 44
S541
Q
I
N
L
D
H
Y
S
V
L
P
A
G
E
G
Site 45
S565
E
E
E
G
A
L
D
S
D
L
D
L
D
L
G
Site 46
S585
G
G
E
Q
P
D
A
S
L
P
L
H
V
L
P
Site 47
T613
F
K
P
P
P
E
G
T
R
L
C
V
V
A
T
Site 48
Y645
C
G
K
V
K
K
R
Y
Y
D
R
V
T
G
V
Site 49
Y646
G
K
V
K
K
R
Y
Y
D
R
V
T
G
V
S
Site 50
T650
K
R
Y
Y
D
R
V
T
G
V
S
S
F
R
V
Site 51
S653
Y
D
R
V
T
G
V
S
S
F
R
V
T
W
V
Site 52
S654
D
R
V
T
G
V
S
S
F
R
V
T
W
V
S
Site 53
S661
S
F
R
V
T
W
V
S
Q
A
S
A
D
Q
R
Site 54
Y681
R
T
E
P
G
H
C
Y
R
L
Y
S
S
A
V
Site 55
Y684
P
G
H
C
Y
R
L
Y
S
S
A
V
F
G
D
Site 56
S765
Q
L
Q
E
N
R
L
S
C
P
I
T
A
L
G
Site 57
S822
E
L
D
R
P
A
A
S
D
E
E
L
T
R
L
Site 58
S831
E
E
L
T
R
L
K
S
K
R
A
R
V
A
Q
Site 59
Y882
C
E
A
N
G
L
R
Y
K
A
M
M
E
I
R
Site 60
T896
R
R
L
R
G
Q
L
T
T
A
V
N
A
V
C
Site 61
T918
D
P
K
M
Q
P
P
T
E
S
Q
V
T
Y
L
Site 62
S920
K
M
Q
P
P
T
E
S
Q
V
T
Y
L
R
Q
Site 63
T923
P
P
T
E
S
Q
V
T
Y
L
R
Q
I
V
T
Site 64
Y924
P
T
E
S
Q
V
T
Y
L
R
Q
I
V
T
A
Site 65
S943
H
L
A
R
R
V
Q
S
E
E
M
L
E
D
K
Site 66
Y955
E
D
K
W
R
N
A
Y
K
T
P
L
L
D
D
Site 67
T957
K
W
R
N
A
Y
K
T
P
L
L
D
D
P
V
Site 68
T1024
P
L
E
E
P
A
P
T
Y
C
P
E
R
G
R
Site 69
Y1025
L
E
E
P
A
P
T
Y
C
P
E
R
G
R
V
Site 70
Y1041
C
H
R
A
S
V
F
Y
R
V
G
W
P
L
P
Site 71
Y1061
F
P
E
G
I
D
R
Y
K
H
F
A
R
F
L
Site 72
S1079
Q
V
F
R
K
L
A
S
Y
R
S
C
L
L
S
Site 73
Y1080
V
F
R
K
L
A
S
Y
R
S
C
L
L
S
S
Site 74
S1082
R
K
L
A
S
Y
R
S
C
L
L
S
S
P
G
Site 75
S1086
S
Y
R
S
C
L
L
S
S
P
G
T
M
L
K
Site 76
S1087
Y
R
S
C
L
L
S
S
P
G
T
M
L
K
T
Site 77
T1094
S
P
G
T
M
L
K
T
W
A
R
L
Q
P
R
Site 78
T1102
W
A
R
L
Q
P
R
T
E
S
L
L
R
A
L
Site 79
S1104
R
L
Q
P
R
T
E
S
L
L
R
A
L
V
A
Site 80
Y1130
A
W
K
K
N
P
K
Y
L
L
A
E
Y
C
E
Site 81
Y1135
P
K
Y
L
L
A
E
Y
C
E
W
L
P
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation