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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Smc5
Full Name:
Structural maintenance of chromosomes protein 5
Alias:
HSMC5; KIAA0594; SMC5L1; Structural maintenance of chromosomes 5
Type:
DNA replication
Mass (Da):
128806
Number AA:
1101
UniProt ID:
Q8IY18
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
GO:0006310
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
T
P
S
K
K
T
S
T
P
S
P
Q
P
Site 2
S9
A
T
P
S
K
K
T
S
T
P
S
P
Q
P
S
Site 3
T10
T
P
S
K
K
T
S
T
P
S
P
Q
P
S
K
Site 4
S12
S
K
K
T
S
T
P
S
P
Q
P
S
K
R
A
Site 5
S16
S
T
P
S
P
Q
P
S
K
R
A
L
P
R
D
Site 6
S25
R
A
L
P
R
D
P
S
S
E
V
P
S
K
R
Site 7
S26
A
L
P
R
D
P
S
S
E
V
P
S
K
R
K
Site 8
S30
D
P
S
S
E
V
P
S
K
R
K
N
S
A
P
Site 9
S35
V
P
S
K
R
K
N
S
A
P
Q
L
P
L
L
Site 10
S44
P
Q
L
P
L
L
Q
S
S
G
P
F
V
E
G
Site 11
Y64
S
M
E
N
F
L
T
Y
D
I
C
E
V
S
P
Site 12
T199
K
I
E
L
L
E
A
T
E
K
S
I
G
P
P
Site 13
Y211
G
P
P
E
M
H
K
Y
H
C
E
L
K
N
L
Site 14
S228
K
E
K
Q
L
E
T
S
C
K
E
K
T
E
Y
Site 15
Y235
S
C
K
E
K
T
E
Y
L
Q
K
M
V
Q
R
Site 16
Y246
M
V
Q
R
N
E
R
Y
K
Q
D
V
E
R
F
Site 17
Y254
K
Q
D
V
E
R
F
Y
E
R
K
R
H
L
D
Site 18
Y275
A
K
R
P
W
V
E
Y
E
N
V
R
Q
E
Y
Site 19
Y282
Y
E
N
V
R
Q
E
Y
E
E
V
K
L
V
R
Site 20
T307
K
E
G
Q
I
P
V
T
C
R
I
E
E
M
E
Site 21
S335
A
T
D
I
K
E
A
S
Q
K
C
K
Q
K
Q
Site 22
T376
R
Q
R
R
I
G
N
T
R
K
M
I
E
D
L
Site 23
T390
L
Q
N
E
L
K
T
T
E
N
C
E
N
L
Q
Site 24
T430
D
K
R
R
E
R
E
T
L
E
K
E
K
K
S
Site 25
S437
T
L
E
K
E
K
K
S
V
D
D
H
I
V
R
Site 26
T463
L
R
Q
R
F
R
D
T
Y
D
A
V
L
W
L
Site 27
Y464
R
Q
R
F
R
D
T
Y
D
A
V
L
W
L
R
Site 28
Y499
K
D
N
K
N
A
K
Y
I
E
N
H
I
P
S
Site 29
S543
N
A
V
I
A
P
K
S
S
Y
A
D
K
A
P
Site 30
S553
A
D
K
A
P
S
R
S
L
N
E
L
K
Q
Y
Site 31
Y560
S
L
N
E
L
K
Q
Y
G
F
F
S
Y
L
R
Site 32
S564
L
K
Q
Y
G
F
F
S
Y
L
R
E
L
F
D
Site 33
Y565
K
Q
Y
G
F
F
S
Y
L
R
E
L
F
D
A
Site 34
Y613
E
T
R
L
K
Q
I
Y
T
A
E
E
K
Y
V
Site 35
Y619
I
Y
T
A
E
E
K
Y
V
V
K
T
S
F
Y
Site 36
S624
E
K
Y
V
V
K
T
S
F
Y
S
N
K
V
I
Site 37
Y626
Y
V
V
K
T
S
F
Y
S
N
K
V
I
S
S
Site 38
S627
V
V
K
T
S
F
Y
S
N
K
V
I
S
S
N
Site 39
S632
F
Y
S
N
K
V
I
S
S
N
T
S
L
K
V
Site 40
S633
Y
S
N
K
V
I
S
S
N
T
S
L
K
V
A
Site 41
T646
V
A
Q
F
L
T
V
T
V
D
L
E
Q
R
R
Site 42
S671
R
K
L
Q
A
V
D
S
G
L
I
A
L
R
E
Site 43
T679
G
L
I
A
L
R
E
T
S
K
H
L
E
H
K
Site 44
S680
L
I
A
L
R
E
T
S
K
H
L
E
H
K
D
Site 45
T702
K
E
L
L
E
R
K
T
K
K
R
Q
L
E
Q
Site 46
S712
R
Q
L
E
Q
K
I
S
S
K
L
G
S
L
K
Site 47
S713
Q
L
E
Q
K
I
S
S
K
L
G
S
L
K
L
Site 48
S717
K
I
S
S
K
L
G
S
L
K
L
M
E
Q
D
Site 49
T725
L
K
L
M
E
Q
D
T
C
N
L
E
E
E
E
Site 50
S736
E
E
E
E
R
K
A
S
T
K
I
K
E
I
N
Site 51
T751
V
Q
K
A
K
L
V
T
E
L
T
N
L
I
K
Site 52
T754
A
K
L
V
T
E
L
T
N
L
I
K
I
C
T
Site 53
S779
L
Q
N
T
T
V
I
S
E
K
N
K
L
E
S
Site 54
S786
S
E
K
N
K
L
E
S
D
Y
M
A
A
S
S
Site 55
Y788
K
N
K
L
E
S
D
Y
M
A
A
S
S
Q
L
Site 56
S792
E
S
D
Y
M
A
A
S
S
Q
L
R
L
T
E
Site 57
S793
S
D
Y
M
A
A
S
S
Q
L
R
L
T
E
Q
Site 58
T798
A
S
S
Q
L
R
L
T
E
Q
H
F
I
E
L
Site 59
T841
T
L
P
Q
E
Y
Q
T
Q
V
P
T
I
P
N
Site 60
S853
I
P
N
G
H
N
S
S
L
P
M
V
F
Q
D
Site 61
T873
D
E
I
D
A
L
L
T
E
E
R
S
R
A
S
Site 62
S877
A
L
L
T
E
E
R
S
R
A
S
C
F
T
G
Site 63
S880
T
E
E
R
S
R
A
S
C
F
T
G
L
N
P
Site 64
T883
R
S
R
A
S
C
F
T
G
L
N
P
T
I
V
Site 65
Y917
K
K
V
E
L
D
Q
Y
R
E
N
I
S
Q
V
Site 66
S922
D
Q
Y
R
E
N
I
S
Q
V
K
E
R
W
L
Site 67
S944
E
K
I
N
E
K
F
S
N
F
F
S
S
M
Q
Site 68
S948
E
K
F
S
N
F
F
S
S
M
Q
C
A
G
E
Site 69
T960
A
G
E
V
D
L
H
T
E
N
E
E
D
Y
D
Site 70
Y966
H
T
E
N
E
E
D
Y
D
K
Y
G
I
R
I
Site 71
Y969
N
E
E
D
Y
D
K
Y
G
I
R
I
R
V
K
Site 72
S979
R
I
R
V
K
F
R
S
S
T
Q
L
H
E
L
Site 73
S980
I
R
V
K
F
R
S
S
T
Q
L
H
E
L
T
Site 74
T981
R
V
K
F
R
S
S
T
Q
L
H
E
L
T
P
Site 75
T987
S
T
Q
L
H
E
L
T
P
H
H
Q
S
G
G
Site 76
S997
H
Q
S
G
G
E
R
S
V
S
T
M
L
Y
L
Site 77
Y1049
C
K
E
N
T
S
Q
Y
F
F
I
T
P
K
L
Site 78
T1096
Q
R
R
R
R
R
I
T
F
T
Q
P
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation