KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZC3H3
Full Name:
Zinc finger CCCH domain-containing protein 3
Alias:
KIAA0150; ZC3HDC3; Zinc finger CCCH-type containing 3
Type:
Mass (Da):
101930
Number AA:
948
UniProt ID:
Q8IXZ2
International Prot ID:
IPI00410013
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005488
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
L
Q
G
L
I
D
D
Y
K
T
L
H
G
N
A
Site 2
T23
G
L
I
D
D
Y
K
T
L
H
G
N
A
P
A
Site 3
T33
G
N
A
P
A
P
G
T
P
A
A
S
G
W
Q
Site 4
S37
A
P
G
T
P
A
A
S
G
W
Q
P
P
T
Y
Site 5
T43
A
S
G
W
Q
P
P
T
Y
H
S
G
R
A
F
Site 6
Y44
S
G
W
Q
P
P
T
Y
H
S
G
R
A
F
S
Site 7
S46
W
Q
P
P
T
Y
H
S
G
R
A
F
S
A
R
Site 8
S51
Y
H
S
G
R
A
F
S
A
R
Y
P
R
P
S
Site 9
Y54
G
R
A
F
S
A
R
Y
P
R
P
S
R
R
G
Site 10
S58
S
A
R
Y
P
R
P
S
R
R
G
Y
S
S
H
Site 11
Y62
P
R
P
S
R
R
G
Y
S
S
H
H
G
P
S
Site 12
S63
R
P
S
R
R
G
Y
S
S
H
H
G
P
S
W
Site 13
S64
P
S
R
R
G
Y
S
S
H
H
G
P
S
W
R
Site 14
S69
Y
S
S
H
H
G
P
S
W
R
K
K
Y
S
L
Site 15
Y74
G
P
S
W
R
K
K
Y
S
L
V
N
R
P
P
Site 16
S75
P
S
W
R
K
K
Y
S
L
V
N
R
P
P
G
Site 17
S84
V
N
R
P
P
G
P
S
D
P
P
A
D
H
A
Site 18
S118
L
E
R
Q
V
Q
L
S
Q
G
Q
N
V
V
I
Site 19
S131
V
I
K
V
K
P
P
S
K
S
G
S
A
S
A
Site 20
S133
K
V
K
P
P
S
K
S
G
S
A
S
A
S
G
Site 21
S135
K
P
P
S
K
S
G
S
A
S
A
S
G
A
Q
Site 22
S137
P
S
K
S
G
S
A
S
A
S
G
A
Q
R
G
Site 23
S139
K
S
G
S
A
S
A
S
G
A
Q
R
G
S
L
Site 24
S145
A
S
G
A
Q
R
G
S
L
E
E
F
E
E
T
Site 25
T152
S
L
E
E
F
E
E
T
P
W
S
D
Q
R
P
Site 26
S155
E
F
E
E
T
P
W
S
D
Q
R
P
R
E
G
Site 27
S174
P
R
G
Q
L
Q
P
S
R
P
T
R
A
R
G
Site 28
T177
Q
L
Q
P
S
R
P
T
R
A
R
G
T
C
S
Site 29
T182
R
P
T
R
A
R
G
T
C
S
V
E
D
P
L
Site 30
S184
T
R
A
R
G
T
C
S
V
E
D
P
L
L
V
Site 31
S204
G
K
P
R
M
V
K
S
V
G
S
V
G
D
S
Site 32
S207
R
M
V
K
S
V
G
S
V
G
D
S
P
R
E
Site 33
S211
S
V
G
S
V
G
D
S
P
R
E
P
R
R
T
Site 34
T218
S
P
R
E
P
R
R
T
V
S
E
S
V
I
A
Site 35
S220
R
E
P
R
R
T
V
S
E
S
V
I
A
V
K
Site 36
S222
P
R
R
T
V
S
E
S
V
I
A
V
K
A
S
Site 37
S233
V
K
A
S
F
A
S
S
A
L
P
P
R
T
G
Site 38
T239
S
S
A
L
P
P
R
T
G
V
A
L
G
R
K
Site 39
S251
G
R
K
L
G
S
H
S
V
A
S
C
A
P
Q
Site 40
T270
R
R
V
D
A
G
H
T
D
Q
P
V
P
S
G
Site 41
S276
H
T
D
Q
P
V
P
S
G
S
V
G
G
P
A
Site 42
S278
D
Q
P
V
P
S
G
S
V
G
G
P
A
R
P
Site 43
S287
G
G
P
A
R
P
A
S
G
P
R
Q
A
R
E
Site 44
S296
P
R
Q
A
R
E
A
S
L
V
V
T
C
R
T
Site 45
T300
R
E
A
S
L
V
V
T
C
R
T
N
K
F
R
Site 46
T303
S
L
V
V
T
C
R
T
N
K
F
R
K
N
N
Site 47
S320
W
V
A
A
S
S
K
S
P
R
V
A
R
R
A
Site 48
S329
R
V
A
R
R
A
L
S
P
R
V
A
A
E
N
Site 49
S341
A
E
N
V
C
K
A
S
A
G
M
A
N
K
V
Site 50
T366
P
K
P
R
K
P
A
T
S
S
K
P
G
S
A
Site 51
S367
K
P
R
K
P
A
T
S
S
K
P
G
S
A
P
Site 52
S368
P
R
K
P
A
T
S
S
K
P
G
S
A
P
S
Site 53
S372
A
T
S
S
K
P
G
S
A
P
S
K
Y
K
W
Site 54
S375
S
K
P
G
S
A
P
S
K
Y
K
W
K
A
S
Site 55
Y377
P
G
S
A
P
S
K
Y
K
W
K
A
S
S
P
Site 56
S382
S
K
Y
K
W
K
A
S
S
P
S
A
S
S
S
Site 57
S383
K
Y
K
W
K
A
S
S
P
S
A
S
S
S
S
Site 58
S385
K
W
K
A
S
S
P
S
A
S
S
S
S
S
F
Site 59
S387
K
A
S
S
P
S
A
S
S
S
S
S
F
R
W
Site 60
S388
A
S
S
P
S
A
S
S
S
S
S
F
R
W
Q
Site 61
S389
S
S
P
S
A
S
S
S
S
S
F
R
W
Q
S
Site 62
S390
S
P
S
A
S
S
S
S
S
F
R
W
Q
S
E
Site 63
S391
P
S
A
S
S
S
S
S
F
R
W
Q
S
E
A
Site 64
S396
S
S
S
F
R
W
Q
S
E
A
S
S
K
D
H
Site 65
S400
R
W
Q
S
E
A
S
S
K
D
H
A
S
Q
L
Site 66
S405
A
S
S
K
D
H
A
S
Q
L
S
P
V
L
S
Site 67
S408
K
D
H
A
S
Q
L
S
P
V
L
S
R
S
P
Site 68
S412
S
Q
L
S
P
V
L
S
R
S
P
S
G
D
R
Site 69
S414
L
S
P
V
L
S
R
S
P
S
G
D
R
P
A
Site 70
S416
P
V
L
S
R
S
P
S
G
D
R
P
A
V
G
Site 71
S425
D
R
P
A
V
G
H
S
G
L
K
P
L
S
G
Site 72
S431
H
S
G
L
K
P
L
S
G
E
T
P
L
S
A
Site 73
T434
L
K
P
L
S
G
E
T
P
L
S
A
Y
K
V
Site 74
S437
L
S
G
E
T
P
L
S
A
Y
K
V
K
S
R
Site 75
Y439
G
E
T
P
L
S
A
Y
K
V
K
S
R
T
K
Site 76
S443
L
S
A
Y
K
V
K
S
R
T
K
I
I
R
R
Site 77
S453
K
I
I
R
R
R
G
S
T
S
L
P
G
D
K
Site 78
T454
I
I
R
R
R
G
S
T
S
L
P
G
D
K
K
Site 79
S455
I
R
R
R
G
S
T
S
L
P
G
D
K
K
S
Site 80
S462
S
L
P
G
D
K
K
S
G
T
S
P
A
A
T
Site 81
T464
P
G
D
K
K
S
G
T
S
P
A
A
T
A
K
Site 82
S465
G
D
K
K
S
G
T
S
P
A
A
T
A
K
S
Site 83
T469
S
G
T
S
P
A
A
T
A
K
S
H
L
S
L
Site 84
S475
A
T
A
K
S
H
L
S
L
R
R
R
Q
A
L
Site 85
S486
R
Q
A
L
R
G
K
S
S
P
V
L
K
K
T
Site 86
S487
Q
A
L
R
G
K
S
S
P
V
L
K
K
T
P
Site 87
T493
S
S
P
V
L
K
K
T
P
N
K
G
L
V
Q
Site 88
T503
K
G
L
V
Q
V
T
T
H
R
L
C
R
L
P
Site 89
S512
R
L
C
R
L
P
P
S
R
A
H
L
P
T
K
Site 90
T518
P
S
R
A
H
L
P
T
K
E
A
S
S
L
H
Site 91
S533
A
V
R
T
A
P
T
S
K
V
I
K
T
R
Y
Site 92
T538
P
T
S
K
V
I
K
T
R
Y
R
I
V
K
K
Site 93
T546
R
Y
R
I
V
K
K
T
P
A
S
P
L
S
A
Site 94
S552
K
T
P
A
S
P
L
S
A
P
P
F
P
L
S
Site 95
S559
S
A
P
P
F
P
L
S
L
P
S
W
R
A
R
Site 96
S562
P
F
P
L
S
L
P
S
W
R
A
R
R
L
S
Site 97
S569
S
W
R
A
R
R
L
S
L
S
R
S
L
V
L
Site 98
S571
R
A
R
R
L
S
L
S
R
S
L
V
L
N
R
Site 99
S573
R
R
L
S
L
S
R
S
L
V
L
N
R
L
R
Site 100
S584
N
R
L
R
P
V
A
S
G
G
G
K
A
Q
P
Site 101
S593
G
G
K
A
Q
P
G
S
P
W
W
R
S
K
G
Site 102
Y601
P
W
W
R
S
K
G
Y
R
C
I
G
G
V
L
Site 103
Y609
R
C
I
G
G
V
L
Y
K
V
S
A
N
K
L
Site 104
S612
G
G
V
L
Y
K
V
S
A
N
K
L
S
K
T
Site 105
S617
K
V
S
A
N
K
L
S
K
T
S
G
Q
P
S
Site 106
T619
S
A
N
K
L
S
K
T
S
G
Q
P
S
D
A
Site 107
S620
A
N
K
L
S
K
T
S
G
Q
P
S
D
A
G
Site 108
S624
S
K
T
S
G
Q
P
S
D
A
G
S
R
P
L
Site 109
S628
G
Q
P
S
D
A
G
S
R
P
L
L
R
T
G
Site 110
T634
G
S
R
P
L
L
R
T
G
R
L
D
P
A
G
Site 111
S642
G
R
L
D
P
A
G
S
C
S
R
S
L
A
S
Site 112
S644
L
D
P
A
G
S
C
S
R
S
L
A
S
R
A
Site 113
S646
P
A
G
S
C
S
R
S
L
A
S
R
A
V
Q
Site 114
S649
S
C
S
R
S
L
A
S
R
A
V
Q
R
S
L
Site 115
S655
A
S
R
A
V
Q
R
S
L
A
I
I
R
Q
A
Site 116
Y672
R
R
E
K
R
K
E
Y
C
M
Y
Y
N
R
F
Site 117
Y675
K
R
K
E
Y
C
M
Y
Y
N
R
F
G
R
C
Site 118
Y690
N
R
G
E
R
C
P
Y
I
H
D
P
E
K
V
Site 119
T707
C
T
R
F
V
R
G
T
C
K
K
T
D
G
T
Site 120
T711
V
R
G
T
C
K
K
T
D
G
T
C
P
F
S
Site 121
S718
T
D
G
T
C
P
F
S
H
H
V
S
K
E
K
Site 122
Y744
C
S
N
S
N
C
P
Y
S
H
V
Y
V
S
R
Site 123
S745
S
N
S
N
C
P
Y
S
H
V
Y
V
S
R
K
Site 124
Y748
N
C
P
Y
S
H
V
Y
V
S
R
K
A
E
V
Site 125
T799
Q
C
Q
L
L
H
R
T
Q
K
R
H
S
R
R
Site 126
S804
H
R
T
Q
K
R
H
S
R
R
A
A
T
S
P
Site 127
T809
R
H
S
R
R
A
A
T
S
P
A
P
G
P
S
Site 128
S810
H
S
R
R
A
A
T
S
P
A
P
G
P
S
D
Site 129
S816
T
S
P
A
P
G
P
S
D
A
T
A
R
S
R
Site 130
T819
A
P
G
P
S
D
A
T
A
R
S
R
V
S
A
Site 131
S822
P
S
D
A
T
A
R
S
R
V
S
A
S
H
G
Site 132
S825
A
T
A
R
S
R
V
S
A
S
H
G
P
R
K
Site 133
S827
A
R
S
R
V
S
A
S
H
G
P
R
K
P
S
Site 134
S834
S
H
G
P
R
K
P
S
A
S
Q
R
P
T
R
Site 135
S836
G
P
R
K
P
S
A
S
Q
R
P
T
R
Q
T
Site 136
T840
P
S
A
S
Q
R
P
T
R
Q
T
P
S
S
A
Site 137
T843
S
Q
R
P
T
R
Q
T
P
S
S
A
A
L
T
Site 138
S845
R
P
T
R
Q
T
P
S
S
A
A
L
T
A
A
Site 139
S846
P
T
R
Q
T
P
S
S
A
A
L
T
A
A
A
Site 140
S864
P
P
H
C
P
G
G
S
A
S
P
S
S
S
K
Site 141
S866
H
C
P
G
G
S
A
S
P
S
S
S
K
A
S
Site 142
S868
P
G
G
S
A
S
P
S
S
S
K
A
S
S
S
Site 143
S869
G
G
S
A
S
P
S
S
S
K
A
S
S
S
S
Site 144
S870
G
S
A
S
P
S
S
S
K
A
S
S
S
S
S
Site 145
S873
S
P
S
S
S
K
A
S
S
S
S
S
S
S
S
Site 146
S874
P
S
S
S
K
A
S
S
S
S
S
S
S
S
S
Site 147
S875
S
S
S
K
A
S
S
S
S
S
S
S
S
S
P
Site 148
S876
S
S
K
A
S
S
S
S
S
S
S
S
S
P
P
Site 149
S877
S
K
A
S
S
S
S
S
S
S
S
S
P
P
A
Site 150
S878
K
A
S
S
S
S
S
S
S
S
S
P
P
A
S
Site 151
S879
A
S
S
S
S
S
S
S
S
S
P
P
A
S
L
Site 152
S880
S
S
S
S
S
S
S
S
S
P
P
A
S
L
D
Site 153
S881
S
S
S
S
S
S
S
S
P
P
A
S
L
D
H
Site 154
S885
S
S
S
S
P
P
A
S
L
D
H
E
A
P
S
Site 155
S892
S
L
D
H
E
A
P
S
L
Q
E
A
A
L
A
Site 156
S911
N
R
L
C
K
L
P
S
F
I
S
L
Q
S
S
Site 157
S914
C
K
L
P
S
F
I
S
L
Q
S
S
P
S
P
Site 158
S917
P
S
F
I
S
L
Q
S
S
P
S
P
G
A
Q
Site 159
S918
S
F
I
S
L
Q
S
S
P
S
P
G
A
Q
P
Site 160
S920
I
S
L
Q
S
S
P
S
P
G
A
Q
P
R
V
Site 161
T935
R
A
P
R
A
P
L
T
K
D
S
G
K
P
L
Site 162
S938
R
A
P
L
T
K
D
S
G
K
P
L
H
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation