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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPAP2
Full Name:
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
Alias:
LOC79871
Type:
Uncharacterized
Mass (Da):
69509
Number AA:
612
UniProt ID:
Q8IXW5
International Prot ID:
IPI00293375
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
D
F
A
G
P
S
S
A
G
R
K
A
G
A
Site 2
S20
K
A
G
A
P
R
C
S
R
K
A
A
G
T
K
Site 3
T26
C
S
R
K
A
A
G
T
K
Q
T
S
T
L
K
Site 4
T31
A
G
T
K
Q
T
S
T
L
K
Q
E
D
A
S
Site 5
T71
Q
L
L
E
E
N
I
T
E
E
F
L
M
E
C
Site 6
T83
M
E
C
G
R
F
I
T
P
A
H
Y
S
D
V
Site 7
S88
F
I
T
P
A
H
Y
S
D
V
V
D
E
R
S
Site 8
S95
S
D
V
V
D
E
R
S
I
V
K
L
C
G
Y
Site 9
Y117
G
I
V
P
K
Q
K
Y
K
I
S
T
K
T
N
Site 10
S120
P
K
Q
K
Y
K
I
S
T
K
T
N
K
V
Y
Site 11
Y127
S
T
K
T
N
K
V
Y
D
I
T
E
R
K
S
Site 12
T130
T
N
K
V
Y
D
I
T
E
R
K
S
F
C
S
Site 13
Y141
S
F
C
S
N
F
C
Y
Q
A
S
K
F
F
E
Site 14
T154
F
E
A
Q
I
P
K
T
P
V
W
V
R
E
E
Site 15
S186
G
E
E
V
Q
L
C
S
K
A
I
K
T
S
D
Site 16
S192
C
S
K
A
I
K
T
S
D
I
D
N
P
S
H
Site 17
S198
T
S
D
I
D
N
P
S
H
F
E
K
Q
Y
E
Site 18
Y204
P
S
H
F
E
K
Q
Y
E
S
S
S
S
S
T
Site 19
S206
H
F
E
K
Q
Y
E
S
S
S
S
S
T
H
S
Site 20
S207
F
E
K
Q
Y
E
S
S
S
S
S
T
H
S
D
Site 21
S208
E
K
Q
Y
E
S
S
S
S
S
T
H
S
D
S
Site 22
S209
K
Q
Y
E
S
S
S
S
S
T
H
S
D
S
S
Site 23
S210
Q
Y
E
S
S
S
S
S
T
H
S
D
S
S
S
Site 24
T211
Y
E
S
S
S
S
S
T
H
S
D
S
S
S
D
Site 25
S213
S
S
S
S
S
T
H
S
D
S
S
S
D
N
E
Site 26
S215
S
S
S
T
H
S
D
S
S
S
D
N
E
Q
D
Site 27
S216
S
S
T
H
S
D
S
S
S
D
N
E
Q
D
F
Site 28
S217
S
T
H
S
D
S
S
S
D
N
E
Q
D
F
V
Site 29
S235
L
P
G
N
R
P
N
S
T
N
I
R
P
Q
L
Site 30
S246
R
P
Q
L
H
Q
K
S
I
M
K
K
K
A
G
Site 31
T271
E
Q
T
V
V
D
V
T
E
Q
L
G
D
C
K
Site 32
S281
L
G
D
C
K
L
D
S
Q
E
K
D
A
T
C
Site 33
T287
D
S
Q
E
K
D
A
T
C
E
L
P
L
Q
K
Site 34
T297
L
P
L
Q
K
V
N
T
Q
S
S
S
N
S
T
Site 35
S299
L
Q
K
V
N
T
Q
S
S
S
N
S
T
L
P
Site 36
S301
K
V
N
T
Q
S
S
S
N
S
T
L
P
E
R
Site 37
S303
N
T
Q
S
S
S
N
S
T
L
P
E
R
L
K
Site 38
T304
T
Q
S
S
S
N
S
T
L
P
E
R
L
K
A
Site 39
S312
L
P
E
R
L
K
A
S
E
N
S
E
S
E
Y
Site 40
S315
R
L
K
A
S
E
N
S
E
S
E
Y
S
R
S
Site 41
S317
K
A
S
E
N
S
E
S
E
Y
S
R
S
E
I
Site 42
Y319
S
E
N
S
E
S
E
Y
S
R
S
E
I
T
L
Site 43
S320
E
N
S
E
S
E
Y
S
R
S
E
I
T
L
V
Site 44
S322
S
E
S
E
Y
S
R
S
E
I
T
L
V
G
I
Site 45
T325
E
Y
S
R
S
E
I
T
L
V
G
I
S
K
K
Site 46
S333
L
V
G
I
S
K
K
S
A
E
H
F
K
R
K
Site 47
S344
F
K
R
K
F
A
K
S
N
Q
V
S
R
S
V
Site 48
S348
F
A
K
S
N
Q
V
S
R
S
V
S
S
S
V
Site 49
S350
K
S
N
Q
V
S
R
S
V
S
S
S
V
Q
V
Site 50
S352
N
Q
V
S
R
S
V
S
S
S
V
Q
V
C
P
Site 51
T379
E
T
L
I
E
W
K
T
E
E
T
L
R
F
L
Site 52
T382
I
E
W
K
T
E
E
T
L
R
F
L
Y
G
Q
Site 53
Y387
E
E
T
L
R
F
L
Y
G
Q
N
Y
A
S
V
Site 54
Y391
R
F
L
Y
G
Q
N
Y
A
S
V
C
L
K
P
Site 55
S393
L
Y
G
Q
N
Y
A
S
V
C
L
K
P
E
A
Site 56
S401
V
C
L
K
P
E
A
S
L
V
K
E
E
L
D
Site 57
S414
L
D
E
D
D
I
I
S
D
P
D
S
H
F
P
Site 58
S418
D
I
I
S
D
P
D
S
H
F
P
A
W
R
E
Site 59
S426
H
F
P
A
W
R
E
S
Q
N
S
L
D
E
S
Site 60
S429
A
W
R
E
S
Q
N
S
L
D
E
S
L
P
F
Site 61
S433
S
E
N
S
E
S
E
Y
S
R
S
E
I
T
L
Site 62
S439
E
S
L
P
F
R
G
S
G
T
A
I
K
P
L
Site 63
Y449
A
I
K
P
L
P
S
Y
E
N
L
K
K
E
T
Site 64
Y467
N
L
R
I
R
E
F
Y
R
G
R
Y
V
L
G
Site 65
Y471
R
E
F
Y
R
G
R
Y
V
L
G
E
E
T
T
Site 66
S480
L
G
E
E
T
T
K
S
Q
D
S
E
E
H
D
Site 67
S488
Q
D
S
E
E
H
D
S
T
F
P
L
I
D
S
Site 68
T489
D
S
E
E
H
D
S
T
F
P
L
I
D
S
S
Site 69
S495
S
T
F
P
L
I
D
S
S
S
Q
N
Q
I
R
Site 70
S496
T
F
P
L
I
D
S
S
S
Q
N
Q
I
R
K
Site 71
S497
F
P
L
I
D
S
S
S
Q
N
Q
I
R
K
R
Site 72
T538
Q
L
K
N
L
V
R
T
F
R
L
T
N
R
N
Site 73
T542
L
V
R
T
F
R
L
T
N
R
N
I
I
H
K
Site 74
S600
L
K
N
E
D
L
E
S
L
T
I
I
F
R
T
Site 75
T602
N
E
D
L
E
S
L
T
I
I
F
R
T
S
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation