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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHC2
Full Name:
Polyhomeotic-like protein 2
Alias:
EDR2; HPH2; Polyhomeotic 2
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
90713
Number AA:
858
UniProt ID:
Q8IXK0
International Prot ID:
IPI00646056
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0042802
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
N
E
L
P
V
P
H
T
S
S
S
A
C
A
T
Site 2
S11
E
L
P
V
P
H
T
S
S
S
A
C
A
T
S
Site 3
S13
P
V
P
H
T
S
S
S
A
C
A
T
S
S
T
Site 4
T17
T
S
S
S
A
C
A
T
S
S
T
S
G
A
S
Site 5
S18
S
S
S
A
C
A
T
S
S
T
S
G
A
S
S
Site 6
S19
S
S
A
C
A
T
S
S
T
S
G
A
S
S
S
Site 7
T20
S
A
C
A
T
S
S
T
S
G
A
S
S
S
S
Site 8
S21
A
C
A
T
S
S
T
S
G
A
S
S
S
S
G
Site 9
S25
S
S
T
S
G
A
S
S
S
S
G
C
N
N
S
Site 10
S26
S
T
S
G
A
S
S
S
S
G
C
N
N
S
S
Site 11
S27
T
S
G
A
S
S
S
S
G
C
N
N
S
S
S
Site 12
S32
S
S
S
G
C
N
N
S
S
S
G
G
S
G
R
Site 13
S33
S
S
G
C
N
N
S
S
S
G
G
S
G
R
P
Site 14
S34
S
G
C
N
N
S
S
S
G
G
S
G
R
P
T
Site 15
S37
N
N
S
S
S
G
G
S
G
R
P
T
G
P
Q
Site 16
T41
S
G
G
S
G
R
P
T
G
P
Q
I
S
V
Y
Site 17
S46
R
P
T
G
P
Q
I
S
V
Y
S
G
I
P
D
Site 18
Y48
T
G
P
Q
I
S
V
Y
S
G
I
P
D
R
Q
Site 19
T56
S
G
I
P
D
R
Q
T
V
Q
V
I
Q
Q
A
Site 20
S69
Q
A
L
H
R
Q
P
S
T
A
A
Q
Y
L
Q
Site 21
Y79
A
Q
Y
L
Q
Q
M
Y
A
A
Q
Q
Q
H
L
Site 22
S99
A
L
Q
Q
Q
H
L
S
S
A
Q
L
Q
S
L
Site 23
S113
L
A
A
V
Q
Q
A
S
L
V
S
N
R
Q
G
Site 24
S116
V
Q
Q
A
S
L
V
S
N
R
Q
G
S
T
S
Site 25
S121
L
V
S
N
R
Q
G
S
T
S
G
S
N
V
S
Site 26
S123
S
N
R
Q
G
S
T
S
G
S
N
V
S
A
Q
Site 27
S125
R
Q
G
S
T
S
G
S
N
V
S
A
Q
A
P
Site 28
S135
S
A
Q
A
P
A
Q
S
S
S
I
N
L
A
A
Site 29
S137
Q
A
P
A
Q
S
S
S
I
N
L
A
A
S
P
Site 30
S155
Q
L
L
N
R
A
Q
S
V
N
S
A
A
A
S
Site 31
S158
N
R
A
Q
S
V
N
S
A
A
A
S
G
I
A
Site 32
T180
N
T
S
S
P
A
L
T
A
S
Q
A
Q
M
Y
Site 33
S182
S
S
P
A
L
T
A
S
Q
A
Q
M
Y
L
R
Site 34
S212
Q
P
E
L
G
T
G
S
P
A
R
P
P
T
P
Site 35
T218
G
S
P
A
R
P
P
T
P
A
Q
V
Q
N
L
Site 36
T226
P
A
Q
V
Q
N
L
T
L
R
T
Q
Q
T
P
Site 37
T232
L
T
L
R
T
Q
Q
T
P
A
A
A
A
S
G
Site 38
T243
A
A
S
G
P
T
P
T
Q
P
V
L
P
S
L
Site 39
S249
P
T
Q
P
V
L
P
S
L
A
L
K
P
T
P
Site 40
T255
P
S
L
A
L
K
P
T
P
G
G
S
Q
P
L
Site 41
S259
L
K
P
T
P
G
G
S
Q
P
L
P
T
P
A
Site 42
T264
G
G
S
Q
P
L
P
T
P
A
Q
S
R
N
T
Site 43
T271
T
P
A
Q
S
R
N
T
A
Q
A
S
P
A
G
Site 44
S275
S
R
N
T
A
Q
A
S
P
A
G
A
K
P
G
Site 45
S286
A
K
P
G
I
A
D
S
V
M
E
P
H
K
K
Site 46
S298
H
K
K
G
D
G
N
S
S
V
P
G
S
M
E
Site 47
S299
K
K
G
D
G
N
S
S
V
P
G
S
M
E
G
Site 48
S303
G
N
S
S
V
P
G
S
M
E
G
R
A
G
L
Site 49
Y327
H
P
L
I
A
P
A
Y
A
Q
L
Q
P
H
Q
Site 50
S340
H
Q
L
L
P
Q
P
S
S
K
H
L
Q
P
Q
Site 51
S341
Q
L
L
P
Q
P
S
S
K
H
L
Q
P
Q
F
Site 52
S380
E
P
H
P
Q
L
A
S
V
S
P
S
V
A
L
Site 53
S382
H
P
Q
L
A
S
V
S
P
S
V
A
L
Q
P
Site 54
S420
N
L
H
K
P
G
G
S
Q
Q
C
H
P
P
T
Site 55
T427
S
Q
Q
C
H
P
P
T
P
D
T
G
P
Q
N
Site 56
T430
C
H
P
P
T
P
D
T
G
P
Q
N
G
H
P
Site 57
T443
H
P
E
G
V
P
H
T
P
Q
R
R
F
Q
H
Site 58
T451
P
Q
R
R
F
Q
H
T
S
A
V
I
L
Q
L
Site 59
S452
Q
R
R
F
Q
H
T
S
A
V
I
L
Q
L
Q
Site 60
S462
I
L
Q
L
Q
P
A
S
P
P
Q
Q
C
V
P
Site 61
S481
E
V
A
P
G
E
K
S
V
P
E
T
R
S
G
Site 62
T485
G
E
K
S
V
P
E
T
R
S
G
P
S
P
H
Site 63
S487
K
S
V
P
E
T
R
S
G
P
S
P
H
Q
Q
Site 64
S490
P
E
T
R
S
G
P
S
P
H
Q
Q
A
I
V
Site 65
S509
G
G
L
P
V
P
T
S
P
N
I
Q
P
S
P
Site 66
S515
T
S
P
N
I
Q
P
S
P
A
H
E
T
G
Q
Site 67
S532
V
H
A
L
T
D
L
S
S
P
G
M
T
S
G
Site 68
S533
H
A
L
T
D
L
S
S
P
G
M
T
S
G
N
Site 69
S538
L
S
S
P
G
M
T
S
G
N
G
N
S
A
S
Site 70
S543
M
T
S
G
N
G
N
S
A
S
S
I
A
G
T
Site 71
S545
S
G
N
G
N
S
A
S
S
I
A
G
T
A
P
Site 72
S546
G
N
G
N
S
A
S
S
I
A
G
T
A
P
Q
Site 73
T550
S
A
S
S
I
A
G
T
A
P
Q
N
G
E
N
Site 74
S591
P
F
P
V
G
R
S
S
L
L
V
G
N
L
K
Site 75
Y601
V
G
N
L
K
K
K
Y
A
Q
G
F
L
P
E
Site 76
T616
K
L
P
Q
Q
D
H
T
T
T
T
D
S
E
M
Site 77
T617
L
P
Q
Q
D
H
T
T
T
T
D
S
E
M
E
Site 78
T618
P
Q
Q
D
H
T
T
T
T
D
S
E
M
E
E
Site 79
T619
Q
Q
D
H
T
T
T
T
D
S
E
M
E
E
P
Site 80
S621
D
H
T
T
T
T
D
S
E
M
E
E
P
Y
L
Site 81
Y627
D
S
E
M
E
E
P
Y
L
Q
E
S
K
E
E
Site 82
Y652
C
G
R
V
D
F
A
Y
K
F
K
R
S
K
R
Site 83
S662
K
R
S
K
R
F
C
S
M
A
C
A
K
R
Y
Site 84
Y669
S
M
A
C
A
K
R
Y
N
V
G
C
T
K
R
Site 85
S682
K
R
V
G
L
F
H
S
D
R
S
K
L
Q
K
Site 86
S701
T
H
N
R
R
R
A
S
K
A
S
L
P
P
L
Site 87
S704
R
R
R
A
S
K
A
S
L
P
P
L
T
K
D
Site 88
T719
T
K
K
Q
P
T
G
T
V
P
L
S
V
T
A
Site 89
T731
V
T
A
A
L
Q
L
T
H
S
Q
E
D
S
S
Site 90
S733
A
A
L
Q
L
T
H
S
Q
E
D
S
S
R
C
Site 91
S737
L
T
H
S
Q
E
D
S
S
R
C
S
D
N
S
Site 92
S738
T
H
S
Q
E
D
S
S
R
C
S
D
N
S
S
Site 93
S741
Q
E
D
S
S
R
C
S
D
N
S
S
Y
E
E
Site 94
S744
S
S
R
C
S
D
N
S
S
Y
E
E
P
L
S
Site 95
S745
S
R
C
S
D
N
S
S
Y
E
E
P
L
S
P
Site 96
Y746
R
C
S
D
N
S
S
Y
E
E
P
L
S
P
I
Site 97
S751
S
S
Y
E
E
P
L
S
P
I
S
A
S
S
S
Site 98
S754
E
E
P
L
S
P
I
S
A
S
S
S
T
S
R
Site 99
S756
P
L
S
P
I
S
A
S
S
S
T
S
R
R
R
Site 100
S758
S
P
I
S
A
S
S
S
T
S
R
R
R
Q
G
Site 101
T759
P
I
S
A
S
S
S
T
S
R
R
R
Q
G
Q
Site 102
S760
I
S
A
S
S
S
T
S
R
R
R
Q
G
Q
R
Site 103
Y800
K
W
N
V
E
D
V
Y
E
F
I
R
S
L
P
Site 104
S805
D
V
Y
E
F
I
R
S
L
P
G
C
Q
E
I
Site 105
S853
L
K
I
Y
A
R
I
S
M
L
K
D
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation