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Updated November 2019
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Protein Info
Short Name:
C10orf6
Full Name:
Protein FAM178A
Alias:
Chromosome 10 open reading frame 6; CJ006; Family with sequence similarity 178, member A; FLJ10512; FLJ25012; LOC55719
Type:
Unknown function
Mass (Da):
131873
Number AA:
1173
UniProt ID:
Q8IX21
International Prot ID:
IPI00293188
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
A
R
P
G
F
P
S
S
P
A
P
G
S
S
Site 2
S15
A
R
P
G
F
P
S
S
P
A
P
G
S
S
P
Site 3
S20
P
S
S
P
A
P
G
S
S
P
P
R
C
H
L
Site 4
S21
S
S
P
A
P
G
S
S
P
P
R
C
H
L
R
Site 5
S31
R
C
H
L
R
P
G
S
T
A
H
A
A
A
G
Site 6
T41
H
A
A
A
G
K
R
T
E
S
P
G
D
R
K
Site 7
S43
A
A
G
K
R
T
E
S
P
G
D
R
K
Q
S
Site 8
S50
S
P
G
D
R
K
Q
S
I
I
D
F
F
K
P
Site 9
S68
Q
D
R
H
M
L
D
S
P
Q
K
S
N
I
K
Site 10
S72
M
L
D
S
P
Q
K
S
N
I
K
Y
G
G
S
Site 11
Y76
P
Q
K
S
N
I
K
Y
G
G
S
R
L
S
I
Site 12
S79
S
N
I
K
Y
G
G
S
R
L
S
I
T
G
T
Site 13
S82
K
Y
G
G
S
R
L
S
I
T
G
T
E
Q
F
Site 14
T86
S
R
L
S
I
T
G
T
E
Q
F
E
R
K
L
Site 15
S94
E
Q
F
E
R
K
L
S
S
P
K
E
S
K
P
Site 16
S95
Q
F
E
R
K
L
S
S
P
K
E
S
K
P
K
Site 17
S99
K
L
S
S
P
K
E
S
K
P
K
R
V
P
P
Site 18
S109
K
R
V
P
P
E
K
S
P
I
I
E
A
F
M
Site 19
S131
E
D
H
G
I
H
E
S
R
R
P
C
L
S
L
Site 20
S137
E
S
R
R
P
C
L
S
L
A
S
K
Y
L
A
Site 21
T147
S
K
Y
L
A
K
G
T
N
I
Y
V
P
S
S
Site 22
Y150
L
A
K
G
T
N
I
Y
V
P
S
S
Y
H
L
Site 23
S154
T
N
I
Y
V
P
S
S
Y
H
L
P
K
E
M
Site 24
Y155
N
I
Y
V
P
S
S
Y
H
L
P
K
E
M
K
Site 25
S163
H
L
P
K
E
M
K
S
L
K
K
K
H
R
S
Site 26
S170
S
L
K
K
K
H
R
S
P
E
R
R
K
S
L
Site 27
S176
R
S
P
E
R
R
K
S
L
F
I
H
E
N
N
Site 28
T193
N
D
R
D
R
G
K
T
N
A
D
S
K
K
Q
Site 29
S197
R
G
K
T
N
A
D
S
K
K
Q
T
T
V
A
Site 30
S212
E
A
D
I
F
N
N
S
S
R
S
L
S
S
R
Site 31
S213
A
D
I
F
N
N
S
S
R
S
L
S
S
R
S
Site 32
S215
I
F
N
N
S
S
R
S
L
S
S
R
S
S
L
Site 33
S217
N
N
S
S
R
S
L
S
S
R
S
S
L
S
R
Site 34
S218
N
S
S
R
S
L
S
S
R
S
S
L
S
R
H
Site 35
S220
S
R
S
L
S
S
R
S
S
L
S
R
H
H
P
Site 36
S221
R
S
L
S
S
R
S
S
L
S
R
H
H
P
E
Site 37
S223
L
S
S
R
S
S
L
S
R
H
H
P
E
E
S
Site 38
S230
S
R
H
H
P
E
E
S
P
L
G
A
K
F
Q
Site 39
S239
L
G
A
K
F
Q
L
S
L
A
S
Y
C
R
E
Site 40
S242
K
F
Q
L
S
L
A
S
Y
C
R
E
R
E
L
Site 41
Y243
F
Q
L
S
L
A
S
Y
C
R
E
R
E
L
K
Site 42
S263
Q
M
E
Q
R
I
N
S
E
N
S
F
S
E
A
Site 43
S266
Q
R
I
N
S
E
N
S
F
S
E
A
S
S
L
Site 44
S268
I
N
S
E
N
S
F
S
E
A
S
S
L
S
L
Site 45
S272
N
S
F
S
E
A
S
S
L
S
L
K
S
S
I
Site 46
S274
F
S
E
A
S
S
L
S
L
K
S
S
I
E
R
Site 47
S277
A
S
S
L
S
L
K
S
S
I
E
R
K
Y
K
Site 48
S278
S
S
L
S
L
K
S
S
I
E
R
K
Y
K
P
Site 49
Y283
K
S
S
I
E
R
K
Y
K
P
R
Q
E
Q
R
Site 50
S303
I
P
G
K
N
N
L
S
N
V
E
N
G
H
L
Site 51
S311
N
V
E
N
G
H
L
S
R
K
R
S
S
S
D
Site 52
S315
G
H
L
S
R
K
R
S
S
S
D
S
W
E
P
Site 53
S316
H
L
S
R
K
R
S
S
S
D
S
W
E
P
T
Site 54
S317
L
S
R
K
R
S
S
S
D
S
W
E
P
T
S
Site 55
S319
R
K
R
S
S
S
D
S
W
E
P
T
S
A
G
Site 56
T323
S
S
D
S
W
E
P
T
S
A
G
S
K
Q
N
Site 57
S324
S
D
S
W
E
P
T
S
A
G
S
K
Q
N
K
Site 58
S340
P
E
K
R
K
R
N
S
V
D
S
D
L
K
S
Site 59
S343
R
K
R
N
S
V
D
S
D
L
K
S
T
R
E
Site 60
S347
S
V
D
S
D
L
K
S
T
R
E
S
M
I
P
Site 61
S351
D
L
K
S
T
R
E
S
M
I
P
K
A
R
E
Site 62
S359
M
I
P
K
A
R
E
S
F
L
E
K
R
P
D
Site 63
S393
V
L
R
L
E
D
I
S
K
E
P
S
D
E
T
Site 64
S397
E
D
I
S
K
E
P
S
D
E
T
D
G
S
S
Site 65
T400
S
K
E
P
S
D
E
T
D
G
S
S
A
G
L
Site 66
S403
P
S
D
E
T
D
G
S
S
A
G
L
A
P
S
Site 67
S404
S
D
E
T
D
G
S
S
A
G
L
A
P
S
N
Site 68
S410
S
S
A
G
L
A
P
S
N
S
G
N
S
G
H
Site 69
S412
A
G
L
A
P
S
N
S
G
N
S
G
H
H
S
Site 70
S415
A
P
S
N
S
G
N
S
G
H
H
S
T
R
N
Site 71
S419
S
G
N
S
G
H
H
S
T
R
N
S
D
Q
I
Site 72
S423
G
H
H
S
T
R
N
S
D
Q
I
Q
V
A
G
Site 73
S444
Q
K
P
H
L
P
L
S
Q
E
K
S
A
I
K
Site 74
S448
L
P
L
S
Q
E
K
S
A
I
K
K
A
S
N
Site 75
S454
K
S
A
I
K
K
A
S
N
L
Q
K
N
K
T
Site 76
T461
S
N
L
Q
K
N
K
T
A
S
S
T
T
K
E
Site 77
S477
E
T
K
L
P
L
L
S
R
V
P
S
A
G
S
Site 78
S481
P
L
L
S
R
V
P
S
A
G
S
S
L
V
P
Site 79
S485
R
V
P
S
A
G
S
S
L
V
P
L
N
A
K
Site 80
S499
K
N
C
A
L
P
V
S
K
K
D
K
E
R
S
Site 81
S506
S
K
K
D
K
E
R
S
S
S
K
E
C
S
G
Site 82
S507
K
K
D
K
E
R
S
S
S
K
E
C
S
G
H
Site 83
S508
K
D
K
E
R
S
S
S
K
E
C
S
G
H
S
Site 84
S512
R
S
S
S
K
E
C
S
G
H
S
T
E
S
T
Site 85
S515
S
K
E
C
S
G
H
S
T
E
S
T
K
H
K
Site 86
T516
K
E
C
S
G
H
S
T
E
S
T
K
H
K
E
Site 87
S518
C
S
G
H
S
T
E
S
T
K
H
K
E
H
K
Site 88
T519
S
G
H
S
T
E
S
T
K
H
K
E
H
K
A
Site 89
S533
A
K
T
N
K
A
D
S
N
V
S
S
G
K
I
Site 90
S537
K
A
D
S
N
V
S
S
G
K
I
S
G
G
P
Site 91
S541
N
V
S
S
G
K
I
S
G
G
P
L
R
S
E
Site 92
S547
I
S
G
G
P
L
R
S
E
Y
G
T
P
T
K
Site 93
Y549
G
G
P
L
R
S
E
Y
G
T
P
T
K
S
P
Site 94
T551
P
L
R
S
E
Y
G
T
P
T
K
S
P
P
A
Site 95
T553
R
S
E
Y
G
T
P
T
K
S
P
P
A
A
L
Site 96
S555
E
Y
G
T
P
T
K
S
P
P
A
A
L
E
V
Site 97
S568
E
V
V
P
C
I
P
S
P
A
A
P
S
D
K
Site 98
S578
A
P
S
D
K
A
P
S
E
G
E
S
S
G
N
Site 99
S582
K
A
P
S
E
G
E
S
S
G
N
S
N
A
G
Site 100
S583
A
P
S
E
G
E
S
S
G
N
S
N
A
G
S
Site 101
S586
E
G
E
S
S
G
N
S
N
A
G
S
S
A
L
Site 102
S590
S
G
N
S
N
A
G
S
S
A
L
K
R
K
L
Site 103
S603
K
L
R
G
D
F
D
S
D
E
E
S
L
G
Y
Site 104
S607
D
F
D
S
D
E
E
S
L
G
Y
N
L
D
S
Site 105
Y610
S
D
E
E
S
L
G
Y
N
L
D
S
D
E
E
Site 106
S614
S
L
G
Y
N
L
D
S
D
E
E
E
E
T
L
Site 107
T620
D
S
D
E
E
E
E
T
L
K
S
L
E
E
I
Site 108
S623
E
E
E
E
T
L
K
S
L
E
E
I
M
A
L
Site 109
T635
M
A
L
N
F
N
Q
T
P
A
A
T
G
K
P
Site 110
S646
T
G
K
P
P
A
L
S
K
G
L
R
S
Q
S
Site 111
S651
A
L
S
K
G
L
R
S
Q
S
S
D
Y
T
G
Site 112
S653
S
K
G
L
R
S
Q
S
S
D
Y
T
G
H
V
Site 113
S654
K
G
L
R
S
Q
S
S
D
Y
T
G
H
V
H
Site 114
Y656
L
R
S
Q
S
S
D
Y
T
G
H
V
H
P
G
Site 115
T657
R
S
Q
S
S
D
Y
T
G
H
V
H
P
G
T
Site 116
T664
T
G
H
V
H
P
G
T
Y
T
N
T
L
E
R
Site 117
T679
L
V
K
E
M
E
D
T
Q
R
L
D
E
L
Q
Site 118
S701
R
Q
G
R
G
I
K
S
P
I
R
I
G
E
E
Site 119
S710
I
R
I
G
E
E
D
S
T
D
D
E
D
G
L
Site 120
T711
R
I
G
E
E
D
S
T
D
D
E
D
G
L
L
Site 121
Y757
S
G
K
I
F
N
Q
Y
T
L
D
L
R
D
S
Site 122
T758
G
K
I
F
N
Q
Y
T
L
D
L
R
D
S
G
Site 123
S764
Y
T
L
D
L
R
D
S
G
F
I
G
Q
S
A
Site 124
S779
V
E
K
L
I
L
K
S
G
K
T
D
Q
I
F
Site 125
T788
K
T
D
Q
I
F
L
T
T
Q
G
F
L
T
S
Site 126
T839
E
I
T
I
R
N
D
T
F
S
D
S
P
V
W
Site 127
S843
R
N
D
T
F
S
D
S
P
V
W
P
W
I
P
Site 128
Y883
Q
P
D
F
N
E
D
Y
L
V
S
E
T
Q
T
Site 129
T890
Y
L
V
S
E
T
Q
T
T
S
R
G
K
E
S
Site 130
T891
L
V
S
E
T
Q
T
T
S
R
G
K
E
S
E
Site 131
S892
V
S
E
T
Q
T
T
S
R
G
K
E
S
E
D
Site 132
S897
T
T
S
R
G
K
E
S
E
D
S
S
Y
K
P
Site 133
S900
R
G
K
E
S
E
D
S
S
Y
K
P
I
F
S
Site 134
S901
G
K
E
S
E
D
S
S
Y
K
P
I
F
S
T
Site 135
Y902
K
E
S
E
D
S
S
Y
K
P
I
F
S
T
L
Site 136
S907
S
S
Y
K
P
I
F
S
T
L
P
E
T
N
I
Site 137
T908
S
Y
K
P
I
F
S
T
L
P
E
T
N
I
L
Site 138
S926
K
F
L
G
L
C
T
S
I
H
P
E
G
Y
Q
Site 139
Y932
T
S
I
H
P
E
G
Y
Q
D
R
E
I
M
L
Site 140
T977
K
N
I
R
D
W
N
T
K
V
P
E
L
C
L
Site 141
S990
C
L
G
I
N
E
L
S
S
H
P
H
N
L
L
Site 142
S991
L
G
I
N
E
L
S
S
H
P
H
N
L
L
W
Site 143
T1007
V
Q
L
V
P
N
W
T
S
R
G
R
Q
L
R
Site 144
S1018
R
Q
L
R
Q
C
L
S
L
V
I
I
S
K
L
Site 145
Y1047
Q
V
S
V
L
H
R
Y
L
V
Q
M
K
P
S
Site 146
S1076
P
D
G
I
I
D
D
S
L
H
L
E
L
E
K
Site 147
Y1087
E
L
E
K
Q
A
Y
Y
L
T
Y
I
L
L
H
Site 148
S1102
L
V
G
E
V
S
C
S
H
S
F
S
S
G
Q
Site 149
S1104
G
E
V
S
C
S
H
S
F
S
S
G
Q
R
K
Site 150
S1106
V
S
C
S
H
S
F
S
S
G
Q
R
K
H
F
Site 151
S1107
S
C
S
H
S
F
S
S
G
Q
R
K
H
F
V
Site 152
Y1136
R
E
D
A
R
L
F
Y
R
T
K
V
K
D
L
Site 153
T1138
D
A
R
L
F
Y
R
T
K
V
K
D
L
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation