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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCAR1
Full Name:
Cell division cycle and apoptosis regulator protein 1
Alias:
Cell cycle and apoptosis regulatory protein 1
Type:
Apoptosis protein
Mass (Da):
132821
Number AA:
1150
UniProt ID:
Q8IX12
International Prot ID:
IPI00217357
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005634
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007049
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
Q
P
S
L
L
G
A
S
P
T
I
Y
T
Q
Q
Site 2
T57
A
A
G
L
T
T
Q
T
P
A
N
Y
Q
L
T
Site 3
Y84
A
A
A
L
Q
Q
Q
Y
S
Q
P
Q
Q
A
L
Site 4
S85
A
A
L
Q
Q
Q
Y
S
Q
P
Q
Q
A
L
Y
Site 5
Y92
S
Q
P
Q
Q
A
L
Y
S
V
Q
Q
Q
L
Q
Site 6
S93
Q
P
Q
Q
A
L
Y
S
V
Q
Q
Q
L
Q
Q
Site 7
S120
L
P
T
S
L
S
L
S
T
P
Q
P
T
A
Q
Site 8
T121
P
T
S
L
S
L
S
T
P
Q
P
T
A
Q
I
Site 9
T129
P
Q
P
T
A
Q
I
T
V
S
Y
P
T
P
R
Site 10
S131
P
T
A
Q
I
T
V
S
Y
P
T
P
R
S
S
Site 11
Y132
T
A
Q
I
T
V
S
Y
P
T
P
R
S
S
Q
Site 12
T134
Q
I
T
V
S
Y
P
T
P
R
S
S
Q
Q
Q
Site 13
S137
V
S
Y
P
T
P
R
S
S
Q
Q
Q
T
Q
P
Site 14
S138
S
Y
P
T
P
R
S
S
Q
Q
Q
T
Q
P
Q
Site 15
T142
P
R
S
S
Q
Q
Q
T
Q
P
Q
K
Q
R
V
Site 16
T151
P
Q
K
Q
R
V
F
T
G
V
V
T
K
L
H
Site 17
T160
V
V
T
K
L
H
D
T
F
G
F
V
D
E
D
Site 18
T179
L
S
A
V
K
G
K
T
P
Q
V
G
D
R
V
Site 19
T191
D
R
V
L
V
E
A
T
Y
N
P
N
M
P
F
Site 20
Y192
R
V
L
V
E
A
T
Y
N
P
N
M
P
F
K
Site 21
T207
W
N
A
Q
R
I
Q
T
L
P
N
Q
N
Q
S
Site 22
S214
T
L
P
N
Q
N
Q
S
Q
T
Q
P
L
L
K
Site 23
T222
Q
T
Q
P
L
L
K
T
P
P
A
V
L
Q
P
Site 24
S246
Q
T
Q
P
Q
P
Q
S
L
L
Q
A
Q
I
S
Site 25
S287
Q
P
P
V
R
I
V
S
Q
P
Q
P
A
R
R
Site 26
S299
A
R
R
L
D
P
P
S
R
F
S
G
R
N
D
Site 27
S302
L
D
P
P
S
R
F
S
G
R
N
D
R
G
D
Site 28
S319
P
N
R
K
D
D
R
S
R
E
R
E
R
E
R
Site 29
S329
R
E
R
E
R
R
R
S
R
E
R
S
P
Q
R
Site 30
S333
R
R
R
S
R
E
R
S
P
Q
R
K
R
S
R
Site 31
S339
R
S
P
Q
R
K
R
S
R
E
R
S
P
R
R
Site 32
S343
R
K
R
S
R
E
R
S
P
R
R
E
R
E
R
Site 33
S351
P
R
R
E
R
E
R
S
P
R
R
V
R
R
V
Site 34
Y362
V
R
R
V
V
P
R
Y
T
V
Q
F
S
K
F
Site 35
T363
R
R
V
V
P
R
Y
T
V
Q
F
S
K
F
S
Site 36
S367
P
R
Y
T
V
Q
F
S
K
F
S
L
D
C
P
Site 37
S370
T
V
Q
F
S
K
F
S
L
D
C
P
S
C
D
Site 38
Y385
M
M
E
L
R
R
R
Y
Q
N
L
Y
I
P
S
Site 39
Y389
R
R
R
Y
Q
N
L
Y
I
P
S
D
F
F
D
Site 40
S408
W
V
D
A
F
P
L
S
R
P
F
Q
L
G
N
Site 41
Y420
L
G
N
Y
C
N
F
Y
V
M
H
R
E
V
E
Site 42
Y445
P
P
D
A
D
H
L
Y
S
A
K
V
M
L
M
Site 43
S456
V
M
L
M
A
S
P
S
M
E
D
L
Y
H
K
Site 44
Y461
S
P
S
M
E
D
L
Y
H
K
S
C
A
L
A
Site 45
S505
M
A
I
G
G
H
W
S
P
S
L
D
G
P
D
Site 46
S507
I
G
G
H
W
S
P
S
L
D
G
P
D
P
E
Site 47
S518
P
D
P
E
K
D
P
S
V
L
I
K
T
A
I
Site 48
Y550
Y
R
F
A
E
I
R
Y
H
R
P
E
E
T
H
Site 49
T588
P
T
R
S
E
W
E
T
L
S
R
G
Y
K
Q
Site 50
S590
R
S
E
W
E
T
L
S
R
G
Y
K
Q
Q
L
Site 51
Y593
W
E
T
L
S
R
G
Y
K
Q
Q
L
V
E
K
Site 52
S626
D
G
E
A
K
E
I
S
T
P
T
H
W
S
K
Site 53
T627
G
E
A
K
E
I
S
T
P
T
H
W
S
K
L
Site 54
T629
A
K
E
I
S
T
P
T
H
W
S
K
L
D
P
Site 55
T638
W
S
K
L
D
P
K
T
M
K
V
N
D
L
R
Site 56
S650
D
L
R
K
E
L
E
S
R
A
L
S
S
K
G
Site 57
S654
E
L
E
S
R
A
L
S
S
K
G
L
K
S
Q
Site 58
S660
L
S
S
K
G
L
K
S
Q
L
I
A
R
L
T
Site 59
T667
S
Q
L
I
A
R
L
T
K
Q
L
K
V
E
E
Site 60
S685
E
Q
K
E
L
E
K
S
E
K
E
E
D
E
D
Site 61
S697
D
E
D
D
D
R
K
S
E
D
D
K
E
E
E
Site 62
Y721
R
Q
R
R
E
R
R
Y
I
L
P
D
E
P
A
Site 63
Y755
S
L
S
V
L
L
D
Y
R
L
E
D
N
K
E
Site 64
S764
L
E
D
N
K
E
H
S
F
E
V
S
L
F
A
Site 65
S768
K
E
H
S
F
E
V
S
L
F
A
E
L
F
N
Site 66
Y787
R
D
F
G
V
R
I
Y
K
S
L
L
S
L
P
Site 67
S792
R
I
Y
K
S
L
L
S
L
P
E
K
E
D
K
Site 68
S806
K
K
E
K
D
K
K
S
K
K
D
E
R
K
D
Site 69
T822
K
E
E
R
D
D
E
T
D
E
P
K
P
K
R
Site 70
S832
P
K
P
K
R
R
K
S
G
D
D
K
D
K
K
Site 71
S855
E
D
K
R
K
D
D
S
K
D
D
D
E
T
E
Site 72
T861
D
S
K
D
D
D
E
T
E
E
D
N
N
Q
D
Site 73
Y870
E
D
N
N
Q
D
E
Y
D
P
M
E
A
E
E
Site 74
T891
D
R
D
E
E
E
M
T
K
R
D
D
K
R
D
Site 75
Y902
D
K
R
D
I
N
R
Y
C
K
E
R
P
S
K
Site 76
S908
R
Y
C
K
E
R
P
S
K
D
K
E
K
E
K
Site 77
T916
K
D
K
E
K
E
K
T
Q
M
I
T
I
N
R
Site 78
S957
Y
T
L
G
L
H
L
S
R
A
Q
V
K
K
L
Site 79
S973
N
K
V
V
L
R
E
S
C
F
Y
R
K
L
T
Site 80
Y976
V
L
R
E
S
C
F
Y
R
K
L
T
D
T
S
Site 81
T980
S
C
F
Y
R
K
L
T
D
T
S
K
D
E
E
Site 82
T982
F
Y
R
K
L
T
D
T
S
K
D
E
E
N
H
Site 83
S983
Y
R
K
L
T
D
T
S
K
D
E
E
N
H
E
Site 84
S994
E
N
H
E
E
S
E
S
L
Q
E
D
M
L
G
Site 85
T1008
G
N
R
L
L
L
P
T
P
T
V
K
Q
E
S
Site 86
T1010
R
L
L
L
P
T
P
T
V
K
Q
E
S
K
D
Site 87
S1044
L
L
Q
K
L
E
K
S
E
K
V
R
A
E
V
Site 88
T1062
L
Q
L
L
E
E
K
T
D
E
D
E
K
T
I
Site 89
T1068
K
T
D
E
D
E
K
T
I
L
N
L
E
N
S
Site 90
S1075
T
I
L
N
L
E
N
S
N
K
S
L
S
G
E
Site 91
S1078
N
L
E
N
S
N
K
S
L
S
G
E
L
R
E
Site 92
S1080
E
N
S
N
K
S
L
S
G
E
L
R
E
V
K
Site 93
S1091
R
E
V
K
K
D
L
S
Q
L
Q
E
N
L
K
Site 94
T1114
F
E
N
Q
M
N
K
T
I
R
N
L
S
T
V
Site 95
S1119
N
K
T
I
R
N
L
S
T
V
M
D
E
I
H
Site 96
T1120
K
T
I
R
N
L
S
T
V
M
D
E
I
H
T
Site 97
S1143
N
E
D
K
D
Q
K
S
K
E
N
G
A
S
V
Site 98
S1149
K
S
K
E
N
G
A
S
V
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation