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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCUBE1
Full Name:
Signal peptide, CUB and EGF-like domain-containing protein 1
Alias:
SCUB1; signal peptide, CUB and EGF-like domain-containing protein 1; signal peptide, CUB domain, EGF-like 1
Type:
Mass (Da):
107910
Number AA:
UniProt ID:
Q8IWY4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009897
GO:0005615
GO:0019897
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0042802
GO:0046982
PhosphoSite+
KinaseNET
Biological Process:
GO:0007512
GO:0007596
GO:0045446
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
C
V
L
L
A
L
G
T
R
G
R
L
A
G
G
Site 2
S26
R
G
R
L
A
G
G
S
G
L
P
G
S
V
D
Site 3
S31
G
G
S
G
L
P
G
S
V
D
V
D
E
C
S
Site 4
S38
S
V
D
V
D
E
C
S
E
G
T
D
D
C
H
Site 5
T53
I
D
A
I
C
Q
N
T
P
K
S
Y
K
C
L
Site 6
Y65
K
C
L
C
K
P
G
Y
K
G
E
G
K
Q
C
Site 7
Y82
I
D
E
C
E
N
D
Y
Y
N
G
G
C
V
H
Site 8
Y83
D
E
C
E
N
D
Y
Y
N
G
G
C
V
H
E
Site 9
S216
G
N
G
G
C
Q
H
S
C
E
D
T
D
T
G
Site 10
T220
C
Q
H
S
C
E
D
T
D
T
G
P
T
C
G
Site 11
Y232
T
C
G
C
H
Q
K
Y
A
L
H
S
D
G
R
Site 12
T255
N
N
G
G
C
D
R
T
C
K
D
T
A
T
G
Site 13
T259
C
D
R
T
C
K
D
T
A
T
G
V
R
C
S
Site 14
T261
R
T
C
K
D
T
A
T
G
V
R
C
S
C
P
Site 15
T279
T
L
Q
P
D
G
K
T
C
K
D
I
N
E
C
Site 16
Y312
E
C
G
C
R
K
G
Y
K
L
L
T
D
E
R
Site 17
T316
R
K
G
Y
K
L
L
T
D
E
R
T
C
Q
D
Site 18
T320
K
L
L
T
D
E
R
T
C
Q
D
I
D
E
C
Site 19
Y355
C
H
R
G
Y
I
L
Y
G
T
T
H
C
G
D
Site 20
S369
D
V
D
E
C
S
M
S
N
G
S
C
D
Q
G
Site 21
Y384
C
V
N
T
K
G
S
Y
E
C
V
C
P
P
G
Site 22
S409
V
E
T
G
K
C
L
S
R
A
K
T
S
P
R
Site 23
T413
K
C
L
S
R
A
K
T
S
P
R
A
Q
L
S
Site 24
S414
C
L
S
R
A
K
T
S
P
R
A
Q
L
S
C
Site 25
S420
T
S
P
R
A
Q
L
S
C
S
K
A
G
G
V
Site 26
S422
P
R
A
Q
L
S
C
S
K
A
G
G
V
E
S
Site 27
S444
H
T
L
F
V
P
D
S
E
N
S
Y
V
L
S
Site 28
Y448
V
P
D
S
E
N
S
Y
V
L
S
C
G
V
P
Site 29
S451
S
E
N
S
Y
V
L
S
C
G
V
P
G
P
Q
Site 30
T468
A
L
Q
K
R
N
G
T
S
S
G
L
G
P
S
Site 31
S470
Q
K
R
N
G
T
S
S
G
L
G
P
S
C
S
Site 32
S475
T
S
S
G
L
G
P
S
C
S
D
A
P
T
T
Site 33
S477
S
G
L
G
P
S
C
S
D
A
P
T
T
P
I
Site 34
T481
P
S
C
S
D
A
P
T
T
P
I
K
Q
K
A
Site 35
T482
S
C
S
D
A
P
T
T
P
I
K
Q
K
A
R
Site 36
S503
K
C
H
L
R
P
H
S
Q
A
R
A
K
E
T
Site 37
T510
S
Q
A
R
A
K
E
T
A
R
Q
P
L
L
D
Site 38
T525
H
C
H
V
T
F
V
T
L
K
C
D
S
S
K
Site 39
S531
V
T
L
K
C
D
S
S
K
K
R
R
R
G
R
Site 40
S540
K
R
R
R
G
R
K
S
P
S
K
E
V
S
H
Site 41
S542
R
R
G
R
K
S
P
S
K
E
V
S
H
I
T
Site 42
S546
K
S
P
S
K
E
V
S
H
I
T
A
E
F
E
Site 43
T564
K
M
E
E
A
S
D
T
C
E
A
D
C
L
R
Site 44
T584
S
L
Q
A
A
I
K
T
L
R
K
S
I
G
R
Site 45
S588
A
I
K
T
L
R
K
S
I
G
R
Q
Q
F
Y
Site 46
Y595
S
I
G
R
Q
Q
F
Y
V
Q
V
S
G
T
E
Site 47
Y603
V
Q
V
S
G
T
E
Y
E
V
A
Q
R
P
A
Site 48
Y654
V
S
C
M
P
G
T
Y
Q
D
M
E
G
Q
L
Site 49
S662
Q
D
M
E
G
Q
L
S
C
T
P
C
P
S
S
Site 50
T664
M
E
G
Q
L
S
C
T
P
C
P
S
S
D
G
Site 51
S669
S
C
T
P
C
P
S
S
D
G
L
G
L
P
G
Site 52
S681
L
P
G
A
R
N
V
S
E
C
G
G
Q
C
S
Site 53
S688
S
E
C
G
G
Q
C
S
P
G
F
F
S
A
D
Site 54
T707
C
Q
A
C
P
V
G
T
Y
Q
P
E
P
G
R
Site 55
T715
Y
Q
P
E
P
G
R
T
G
C
F
P
C
G
G
Site 56
T726
P
C
G
G
G
L
L
T
K
H
E
G
T
T
S
Site 57
S733
T
K
H
E
G
T
T
S
F
Q
D
C
E
A
K
Site 58
Y764
I
R
C
P
V
G
T
Y
Q
P
E
F
G
Q
N
Site 59
T782
T
C
P
G
N
T
S
T
D
F
D
G
S
T
N
Site 60
S787
T
S
T
D
F
D
G
S
T
N
V
T
H
C
K
Site 61
T788
S
T
D
F
D
G
S
T
N
V
T
H
C
K
N
Site 62
Y805
C
G
G
E
L
G
D
Y
T
G
Y
I
E
S
P
Site 63
T806
G
G
E
L
G
D
Y
T
G
Y
I
E
S
P
N
Site 64
Y808
E
L
G
D
Y
T
G
Y
I
E
S
P
N
Y
P
Site 65
Y814
G
Y
I
E
S
P
N
Y
P
G
D
Y
P
A
N
Site 66
Y818
S
P
N
Y
P
G
D
Y
P
A
N
A
E
C
V
Site 67
S862
L
V
M
R
K
S
A
S
P
T
S
I
T
T
Y
Site 68
T864
M
R
K
S
A
S
P
T
S
I
T
T
Y
E
T
Site 69
S865
R
K
S
A
S
P
T
S
I
T
T
Y
E
T
C
Site 70
Y869
S
P
T
S
I
T
T
Y
E
T
C
Q
T
Y
E
Site 71
T874
T
T
Y
E
T
C
Q
T
Y
E
R
P
I
A
F
Site 72
Y875
T
Y
E
T
C
Q
T
Y
E
R
P
I
A
F
T
Site 73
T882
Y
E
R
P
I
A
F
T
S
R
S
R
K
L
W
Site 74
S883
E
R
P
I
A
F
T
S
R
S
R
K
L
W
I
Site 75
S894
K
L
W
I
Q
F
K
S
N
E
G
N
S
G
K
Site 76
Y907
G
K
G
F
Q
V
P
Y
V
T
Y
D
E
D
Y
Site 77
Y914
Y
V
T
Y
D
E
D
Y
Q
Q
L
I
E
D
I
Site 78
Y928
I
V
R
D
G
R
L
Y
A
S
E
N
H
Q
E
Site 79
S930
R
D
G
R
L
Y
A
S
E
N
H
Q
E
I
L
Site 80
Y956
V
L
A
H
P
Q
N
Y
F
K
Y
T
A
Q
E
Site 81
Y959
H
P
Q
N
Y
F
K
Y
T
A
Q
E
S
K
E
Site 82
S964
F
K
Y
T
A
Q
E
S
K
E
M
F
P
R
S
Site 83
S971
S
K
E
M
F
P
R
S
F
I
K
L
L
R
S
Site 84
S978
S
F
I
K
L
L
R
S
K
V
S
R
F
L
R
Site 85
S981
K
L
L
R
S
K
V
S
R
F
L
R
P
Y
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation