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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UNC45B
Full Name:
Protein unc-45 homolog B
Alias:
Cardiomyopathy associated 4; CMYA4; SMUNC45; striated muscle UNC45
Type:
Mass (Da):
103733
Number AA:
931
UniProt ID:
Q8IWX7
International Prot ID:
IPI00217428
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007517
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
R
H
F
Q
L
Q
D
Y
K
A
A
T
N
S
Y
Site 2
T26
L
Q
D
Y
K
A
A
T
N
S
Y
S
Q
A
L
Site 3
S30
K
A
A
T
N
S
Y
S
Q
A
L
K
L
T
K
Site 4
T44
K
D
K
A
L
L
A
T
L
Y
R
N
R
A
A
Site 5
Y46
K
A
L
L
A
T
L
Y
R
N
R
A
A
C
G
Site 6
T56
R
A
A
C
G
L
K
T
E
S
Y
V
Q
A
A
Site 7
S58
A
C
G
L
K
T
E
S
Y
V
Q
A
A
S
D
Site 8
Y59
C
G
L
K
T
E
S
Y
V
Q
A
A
S
D
A
Site 9
S64
E
S
Y
V
Q
A
A
S
D
A
S
R
A
I
D
Site 10
S74
S
R
A
I
D
I
N
S
S
D
I
K
A
L
Y
Site 11
S75
R
A
I
D
I
N
S
S
D
I
K
A
L
Y
R
Site 12
Y81
S
S
D
I
K
A
L
Y
R
R
C
Q
A
L
E
Site 13
T105
K
D
V
Q
R
C
A
T
L
E
P
R
N
Q
N
Site 14
T122
E
M
L
R
R
L
N
T
S
I
Q
E
K
L
R
Site 15
S123
M
L
R
R
L
N
T
S
I
Q
E
K
L
R
V
Site 16
S133
E
K
L
R
V
Q
F
S
T
D
S
R
V
Q
K
Site 17
T134
K
L
R
V
Q
F
S
T
D
S
R
V
Q
K
M
Site 18
S150
E
I
L
L
D
E
N
S
E
A
D
K
R
E
K
Site 19
S208
R
T
L
S
G
M
C
S
G
H
Q
A
R
A
T
Site 20
T215
S
G
H
Q
A
R
A
T
V
I
L
H
A
V
R
Site 21
S251
L
L
Q
A
I
I
D
S
L
S
G
E
D
K
R
Site 22
S253
Q
A
I
I
D
S
L
S
G
E
D
K
R
E
H
Site 23
S288
H
L
L
D
M
L
V
S
K
K
V
S
G
Q
G
Site 24
S292
M
L
V
S
K
K
V
S
G
Q
G
R
D
Q
A
Site 25
Y322
H
D
N
S
R
T
I
Y
V
V
D
N
G
L
R
Site 26
S343
G
Q
V
P
D
L
P
S
C
L
P
L
T
D
N
Site 27
Y363
S
I
L
I
N
K
L
Y
D
D
L
R
C
D
P
Site 28
T384
K
I
C
E
E
Y
I
T
G
K
F
D
P
Q
D
Site 29
S432
M
M
V
A
L
C
G
S
E
R
E
T
D
Q
L
Site 30
T436
L
C
G
S
E
R
E
T
D
Q
L
V
A
V
E
Site 31
T495
K
L
G
S
A
G
G
T
D
Y
G
L
R
Q
F
Site 32
Y497
G
S
A
G
G
T
D
Y
G
L
R
Q
F
A
E
Site 33
T527
N
M
S
I
D
T
R
T
R
R
W
A
V
E
G
Site 34
S567
E
L
A
K
A
G
T
S
D
K
T
I
L
Y
S
Site 35
T570
K
A
G
T
S
D
K
T
I
L
Y
S
V
A
T
Site 36
T646
K
A
D
S
A
I
L
T
D
Q
T
K
E
L
L
Site 37
T669
D
N
P
K
D
R
G
T
I
V
A
Q
G
G
G
Site 38
Y717
A
F
P
G
E
R
V
Y
E
V
V
R
P
L
V
Site 39
T729
P
L
V
R
L
L
D
T
Q
R
D
G
L
Q
N
Site 40
Y737
Q
R
D
G
L
Q
N
Y
E
A
L
L
G
L
T
Site 41
S747
L
L
G
L
T
N
L
S
G
R
S
D
K
L
R
Site 42
T843
K
K
L
C
L
K
M
T
Q
V
T
T
Q
W
L
Site 43
T913
K
K
A
E
V
V
Q
T
A
R
E
C
L
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation