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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARC
Full Name:
Cullin-9
Alias:
Cullin 9; H7AP1; KIAA0708; P53-associated parkin-like cytoplasmic protein; Parkin-like cytoplasmic p53 binding protein; UbcH7-associated 1
Type:
Ubiquitin conjugating system
Mass (Da):
281230
Number AA:
UniProt ID:
Q8IWT3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
GO:0031461
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0031625
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030071
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
L
G
P
R
L
Q
A
Y
P
E
E
L
I
R
Q
Site 2
Y38
G
H
D
G
H
P
E
Y
L
I
R
W
S
V
L
Site 3
S43
P
E
Y
L
I
R
W
S
V
L
K
C
G
E
V
Site 4
S86
L
L
G
E
R
A
L
S
K
G
L
Q
H
E
P
Site 5
S99
E
P
A
G
V
S
G
S
F
P
R
D
P
G
G
Site 6
S133
A
A
R
Q
L
A
E
S
G
T
P
S
L
T
A
Site 7
T135
R
Q
L
A
E
S
G
T
P
S
L
T
A
A
V
Site 8
S185
P
E
P
Q
I
R
R
S
A
G
K
M
L
Q
A
Site 9
S207
S
R
A
H
V
L
L
S
L
S
Q
Q
D
G
I
Site 10
S209
A
H
V
L
L
S
L
S
Q
Q
D
G
I
E
Q
Site 11
S222
E
Q
H
M
D
F
D
S
R
Y
T
L
L
E
L
Site 12
Y224
H
M
D
F
D
S
R
Y
T
L
L
E
L
F
A
Site 13
T225
M
D
F
D
S
R
Y
T
L
L
E
L
F
A
E
Site 14
S236
L
F
A
E
T
T
S
S
E
E
H
C
M
A
F
Site 15
S268
K
R
Y
L
C
V
T
S
L
L
D
Q
L
N
S
Site 16
S275
S
L
L
D
Q
L
N
S
S
P
E
L
G
A
G
Site 17
S276
L
L
D
Q
L
N
S
S
P
E
L
G
A
G
D
Site 18
S286
L
G
A
G
D
Q
S
S
P
C
A
T
R
E
K
Site 19
T290
D
Q
S
S
P
C
A
T
R
E
K
S
R
G
Q
Site 20
S294
P
C
A
T
R
E
K
S
R
G
Q
R
E
L
E
Site 21
S316
L
I
S
E
L
V
R
S
M
G
W
A
R
N
L
Site 22
S324
M
G
W
A
R
N
L
S
E
Q
G
M
S
P
P
Site 23
S329
N
L
S
E
Q
G
M
S
P
P
R
P
T
R
S
Site 24
T334
G
M
S
P
P
R
P
T
R
S
I
F
Q
P
Y
Site 25
S336
S
P
P
R
P
T
R
S
I
F
Q
P
Y
I
S
Site 26
S367
G
W
V
F
R
Q
R
S
E
F
S
S
R
S
G
Site 27
S370
F
R
Q
R
S
E
F
S
S
R
S
G
Y
G
E
Site 28
S371
R
Q
R
S
E
F
S
S
R
S
G
Y
G
E
Y
Site 29
S373
R
S
E
F
S
S
R
S
G
Y
G
E
Y
V
Q
Site 30
Y375
E
F
S
S
R
S
G
Y
G
E
Y
V
Q
Q
T
Site 31
Y378
S
R
S
G
Y
G
E
Y
V
Q
Q
T
L
Q
P
Site 32
T382
Y
G
E
Y
V
Q
Q
T
L
Q
P
G
M
R
V
Site 33
Y395
R
V
R
M
L
D
D
Y
E
E
I
S
A
G
D
Site 34
S399
L
D
D
Y
E
E
I
S
A
G
D
E
G
E
F
Site 35
S409
D
E
G
E
F
R
Q
S
N
N
G
I
P
P
V
Site 36
S448
E
A
T
E
D
K
A
S
A
A
V
E
K
G
A
Site 37
Y476
W
N
P
M
D
G
L
Y
P
L
P
Y
L
Q
P
Site 38
Y480
D
G
L
Y
P
L
P
Y
L
Q
P
E
P
Q
K
Site 39
Y493
Q
K
N
E
R
V
G
Y
L
T
Q
A
E
W
W
Site 40
T528
L
W
K
N
L
D
E
T
L
G
E
K
A
L
G
Site 41
S552
E
S
L
L
Q
V
L
S
S
R
F
E
G
S
T
Site 42
S558
L
S
S
R
F
E
G
S
T
L
N
D
L
L
N
Site 43
T559
S
S
R
F
E
G
S
T
L
N
D
L
L
N
S
Site 44
S566
T
L
N
D
L
L
N
S
Q
I
Y
T
K
Y
G
Site 45
Y569
D
L
L
N
S
Q
I
Y
T
K
Y
G
L
L
S
Site 46
T570
L
L
N
S
Q
I
Y
T
K
Y
G
L
L
S
N
Site 47
Y572
N
S
Q
I
Y
T
K
Y
G
L
L
S
N
E
P
Site 48
S576
Y
T
K
Y
G
L
L
S
N
E
P
S
S
S
S
Site 49
S580
G
L
L
S
N
E
P
S
S
S
S
T
S
R
N
Site 50
S581
L
L
S
N
E
P
S
S
S
S
T
S
R
N
H
Site 51
S582
L
S
N
E
P
S
S
S
S
T
S
R
N
H
S
Site 52
S583
S
N
E
P
S
S
S
S
T
S
R
N
H
S
C
Site 53
T584
N
E
P
S
S
S
S
T
S
R
N
H
S
C
T
Site 54
S585
E
P
S
S
S
S
T
S
R
N
H
S
C
T
P
Site 55
S589
S
S
T
S
R
N
H
S
C
T
P
D
P
E
E
Site 56
T591
T
S
R
N
H
S
C
T
P
D
P
E
E
E
S
Site 57
S598
T
P
D
P
E
E
E
S
K
S
E
A
S
F
S
Site 58
S600
D
P
E
E
E
S
K
S
E
A
S
F
S
E
E
Site 59
S603
E
E
S
K
S
E
A
S
F
S
E
E
E
T
E
Site 60
S605
S
K
S
E
A
S
F
S
E
E
E
T
E
S
L
Site 61
T609
A
S
F
S
E
E
E
T
E
S
L
K
A
K
A
Site 62
S611
F
S
E
E
E
T
E
S
L
K
A
K
A
E
A
Site 63
T621
A
K
A
E
A
P
K
T
E
A
E
P
T
K
T
Site 64
T626
P
K
T
E
A
E
P
T
K
T
R
T
E
T
P
Site 65
T628
T
E
A
E
P
T
K
T
R
T
E
T
P
M
A
Site 66
T632
P
T
K
T
R
T
E
T
P
M
A
Q
S
D
S
Site 67
S639
T
P
M
A
Q
S
D
S
Q
L
F
N
Q
L
L
Site 68
S675
L
R
G
P
G
P
R
S
S
L
D
Q
H
V
A
Site 69
S676
R
G
P
G
P
R
S
S
L
D
Q
H
V
A
A
Site 70
T713
S
Q
A
V
E
E
V
T
E
R
D
H
P
L
V
Site 71
S725
P
L
V
R
P
D
R
S
L
R
E
K
L
V
K
Site 72
T811
A
S
S
S
E
I
P
T
F
V
T
G
R
D
S
Site 73
T814
S
E
I
P
T
F
V
T
G
R
D
S
I
H
S
Site 74
S818
T
F
V
T
G
R
D
S
I
H
S
L
F
D
A
Site 75
S821
T
G
R
D
S
I
H
S
L
F
D
A
Q
M
T
Site 76
S834
M
T
R
E
I
F
A
S
I
D
S
A
T
R
P
Site 77
S837
E
I
F
A
S
I
D
S
A
T
R
P
G
S
E
Site 78
T839
F
A
S
I
D
S
A
T
R
P
G
S
E
S
L
Site 79
S843
D
S
A
T
R
P
G
S
E
S
L
L
L
T
V
Site 80
S865
L
N
T
E
G
C
S
S
A
A
R
N
G
L
L
Site 81
T896
I
T
Q
E
L
R
D
T
L
F
R
H
S
G
I
Site 82
S901
R
D
T
L
F
R
H
S
G
I
A
P
R
T
E
Site 83
T907
H
S
G
I
A
P
R
T
E
P
M
P
T
T
R
Site 84
T912
P
R
T
E
P
M
P
T
T
R
T
I
L
M
M
Site 85
Y924
L
M
M
L
L
N
R
Y
S
E
P
P
G
S
P
Site 86
S925
M
M
L
L
N
R
Y
S
E
P
P
G
S
P
E
Site 87
S930
R
Y
S
E
P
P
G
S
P
E
R
A
A
L
E
Site 88
T938
P
E
R
A
A
L
E
T
P
I
I
Q
G
Q
D
Site 89
S947
I
I
Q
G
Q
D
G
S
P
E
L
L
I
R
S
Site 90
S976
R
V
L
C
R
E
G
S
P
G
G
A
V
R
P
Site 91
T992
L
K
R
L
Q
Q
E
T
Q
P
F
L
L
L
L
Site 92
T1010
D
A
P
G
P
N
K
T
L
L
L
S
V
L
R
Site 93
S1045
E
P
C
L
N
C
L
S
G
P
S
S
D
S
E
Site 94
S1049
N
C
L
S
G
P
S
S
D
S
E
I
V
Q
E
Site 95
S1051
L
S
G
P
S
S
D
S
E
I
V
Q
E
L
T
Site 96
S1085
L
G
A
K
E
I
L
S
K
V
L
D
K
H
S
Site 97
T1106
C
E
L
R
D
L
V
T
E
C
E
K
Y
A
Q
Site 98
Y1111
L
V
T
E
C
E
K
Y
A
Q
L
Y
S
N
L
Site 99
Y1115
C
E
K
Y
A
Q
L
Y
S
N
L
T
S
S
I
Site 100
S1116
E
K
Y
A
Q
L
Y
S
N
L
T
S
S
I
L
Site 101
T1140
Q
I
E
D
H
R
R
T
H
Q
P
I
N
I
P
Site 102
S1161
R
H
L
C
Q
G
S
S
V
E
V
K
E
D
K
Site 103
S1183
S
S
N
P
H
R
A
S
K
L
T
D
H
N
P
Site 104
T1186
P
H
R
A
S
K
L
T
D
H
N
P
K
T
Y
Site 105
T1192
L
T
D
H
N
P
K
T
Y
W
E
S
N
G
S
Site 106
Y1193
T
D
H
N
P
K
T
Y
W
E
S
N
G
S
T
Site 107
S1196
N
P
K
T
Y
W
E
S
N
G
S
T
G
S
H
Site 108
T1200
Y
W
E
S
N
G
S
T
G
S
H
Y
I
T
L
Site 109
S1202
E
S
N
G
S
T
G
S
H
Y
I
T
L
H
M
Site 110
Y1204
N
G
S
T
G
S
H
Y
I
T
L
H
M
H
R
Site 111
T1206
S
T
G
S
H
Y
I
T
L
H
M
H
R
G
V
Site 112
S1224
Q
L
T
L
L
V
A
S
E
D
S
S
Y
M
P
Site 113
T1247
D
S
T
S
C
I
G
T
E
L
N
T
V
N
V
Site 114
T1301
E
V
L
G
P
K
P
T
F
W
P
L
F
R
E
Site 115
S1326
T
I
R
A
Q
A
W
S
R
D
I
A
E
D
H
Site 116
S1385
P
L
V
Q
N
I
T
S
P
D
A
E
G
V
S
Site 117
Y1401
L
G
W
L
L
D
Q
Y
L
E
Q
R
E
T
S
Site 118
T1407
Q
Y
L
E
Q
R
E
T
S
R
N
P
L
S
R
Site 119
S1408
Y
L
E
Q
R
E
T
S
R
N
P
L
S
R
A
Site 120
S1413
E
T
S
R
N
P
L
S
R
A
A
S
F
A
S
Site 121
S1417
N
P
L
S
R
A
A
S
F
A
S
R
V
R
R
Site 122
S1420
S
R
A
A
S
F
A
S
R
V
R
R
L
C
H
Site 123
S1439
V
E
P
P
P
G
P
S
P
E
P
S
T
R
P
Site 124
S1443
P
G
P
S
P
E
P
S
T
R
P
F
S
K
N
Site 125
T1444
G
P
S
P
E
P
S
T
R
P
F
S
K
N
S
Site 126
S1448
E
P
S
T
R
P
F
S
K
N
S
K
G
R
D
Site 127
S1451
T
R
P
F
S
K
N
S
K
G
R
D
R
S
P
Site 128
S1457
N
S
K
G
R
D
R
S
P
A
P
S
P
V
L
Site 129
S1461
R
D
R
S
P
A
P
S
P
V
L
P
S
S
S
Site 130
S1467
P
S
P
V
L
P
S
S
S
L
R
N
I
T
Q
Site 131
S1468
S
P
V
L
P
S
S
S
L
R
N
I
T
Q
C
Site 132
Y1501
A
P
D
F
V
P
R
Y
C
K
L
Y
E
H
L
Site 133
Y1505
V
P
R
Y
C
K
L
Y
E
H
L
Q
R
A
G
Site 134
S1513
E
H
L
Q
R
A
G
S
E
L
F
G
P
R
A
Site 135
T1592
S
G
L
E
L
A
T
T
F
E
H
F
Y
Q
H
Site 136
Y1600
F
E
H
F
Y
Q
H
Y
M
A
D
R
L
L
S
Site 137
S1607
Y
M
A
D
R
L
L
S
F
G
S
S
W
L
E
Site 138
S1636
L
P
Q
L
M
L
Q
S
L
S
T
S
E
E
L
Site 139
S1638
Q
L
M
L
Q
S
L
S
T
S
E
E
L
Q
R
Site 140
S1640
M
L
Q
S
L
S
T
S
E
E
L
Q
R
Q
F
Site 141
Y1714
V
S
P
L
C
Y
L
Y
H
P
R
K
C
L
P
Site 142
T1722
H
P
R
K
C
L
P
T
E
F
C
D
A
L
D
Site 143
S1732
C
D
A
L
D
R
F
S
S
F
Y
S
Q
S
Q
Site 144
S1733
D
A
L
D
R
F
S
S
F
Y
S
Q
S
Q
N
Site 145
Y1735
L
D
R
F
S
S
F
Y
S
Q
S
Q
N
H
P
Site 146
S1736
D
R
F
S
S
F
Y
S
Q
S
Q
N
H
P
V
Site 147
S1738
F
S
S
F
Y
S
Q
S
Q
N
H
P
V
L
D
Site 148
T1755
P
H
R
R
L
Q
W
T
W
L
G
R
A
E
L
Site 149
T1785
L
L
L
K
F
N
Q
T
E
E
V
S
V
E
T
Site 150
S1797
V
E
T
L
L
K
D
S
D
L
S
P
E
L
L
Site 151
T1819
T
S
G
N
G
P
L
T
L
H
E
G
Q
D
F
Site 152
T1910
K
G
P
N
P
P
G
T
L
G
H
T
V
A
G
Site 153
Y1938
L
H
L
L
G
Q
G
Y
V
K
R
R
D
D
R
Site 154
Y1951
D
R
P
Q
I
L
M
Y
A
A
P
E
P
M
G
Site 155
S1971
A
D
V
P
F
C
G
S
Q
S
E
T
S
K
P
Site 156
S1973
V
P
F
C
G
S
Q
S
E
T
S
K
P
S
P
Site 157
T1975
F
C
G
S
Q
S
E
T
S
K
P
S
P
E
A
Site 158
S1979
Q
S
E
T
S
K
P
S
P
E
A
V
A
T
L
Site 159
S1998
L
P
A
G
R
T
M
S
P
Q
E
V
E
G
L
Site 160
T2009
V
E
G
L
M
K
Q
T
V
R
Q
V
Q
E
T
Site 161
T2016
T
V
R
Q
V
Q
E
T
L
N
L
E
P
D
V
Site 162
S2041
G
A
E
Q
L
L
Q
S
Y
S
E
D
P
E
P
Site 163
S2043
E
Q
L
L
Q
S
Y
S
E
D
P
E
P
L
L
Site 164
Y2142
S
P
E
V
I
S
K
Y
E
K
A
L
L
R
G
Site 165
Y2150
E
K
A
L
L
R
G
Y
V
E
S
C
S
N
L
Site 166
Y2215
Q
W
V
D
D
G
G
Y
Y
D
G
M
S
V
E
Site 167
Y2216
W
V
D
D
G
G
Y
Y
D
G
M
S
V
E
A
Site 168
S2220
G
G
Y
Y
D
G
M
S
V
E
A
Q
S
K
H
Site 169
S2233
K
H
L
A
K
L
I
S
K
R
C
P
S
C
Q
Site 170
S2238
L
I
S
K
R
C
P
S
C
Q
A
P
I
E
K
Site 171
Y2277
K
P
N
H
K
D
Y
Y
N
C
S
A
M
V
S
Site 172
S2284
Y
N
C
S
A
M
V
S
K
A
A
R
Q
E
K
Site 173
Y2296
Q
E
K
R
F
Q
D
Y
N
E
R
C
T
F
H
Site 174
S2318
V
N
L
R
N
R
V
S
A
I
H
E
V
P
P
Site 175
S2328
H
E
V
P
P
P
R
S
F
T
F
L
N
D
A
Site 176
T2330
V
P
P
P
R
S
F
T
F
L
N
D
A
C
Q
Site 177
Y2361
F
Y
S
Q
D
A
E
Y
M
D
V
V
E
Q
Q
Site 178
S2395
L
R
C
R
D
L
A
S
S
L
R
L
L
R
A
Site 179
S2396
R
C
R
D
L
A
S
S
L
R
L
L
R
A
D
Site 180
S2436
D
F
R
V
G
L
Q
S
P
S
V
E
A
W
E
Site 181
S2438
R
V
G
L
Q
S
P
S
V
E
A
W
E
A
K
Site 182
S2452
K
G
P
N
M
P
G
S
Q
P
Q
A
S
S
G
Site 183
S2489
D
E
E
L
D
N
D
S
F
S
Y
D
E
S
E
Site 184
S2491
E
L
D
N
D
S
F
S
Y
D
E
S
E
N
L
Site 185
S2495
D
S
F
S
Y
D
E
S
E
N
L
D
Q
E
T
Site 186
T2502
S
E
N
L
D
Q
E
T
F
F
F
G
D
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation