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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MGA
Full Name:
MAX gene-associated protein
Alias:
KIAA0518
Type:
Enzyme, hydrolase; Nucleus protein
Mass (Da):
331822
Number AA:
3026
UniProt ID:
Q8IWI9
International Prot ID:
IPI00741005
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005667
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
L
A
N
Q
D
G
G
T
V
A
G
A
A
P
T
Site 2
T36
K
Q
P
G
N
G
K
T
D
Q
G
I
L
V
T
Site 3
S55
C
A
L
A
S
S
V
S
S
P
V
K
S
K
G
Site 4
S56
A
L
A
S
S
V
S
S
P
V
K
S
K
G
K
Site 5
S60
S
V
S
S
P
V
K
S
K
G
K
I
C
L
P
Site 6
T93
N
E
F
Y
H
R
S
T
E
M
I
L
T
K
Q
Site 7
T98
R
S
T
E
M
I
L
T
K
Q
G
R
R
M
F
Site 8
S162
R
V
F
I
H
P
E
S
P
S
T
G
H
Y
W
Site 9
Y168
E
S
P
S
T
G
H
Y
W
M
H
Q
P
V
S
Site 10
T225
L
N
G
P
G
V
H
T
F
T
F
P
Q
T
E
Site 11
T227
G
P
G
V
H
T
F
T
F
P
Q
T
E
F
F
Site 12
Y251
I
T
Q
L
K
I
D
Y
N
P
F
A
K
G
F
Site 13
S277
D
G
K
Q
K
N
S
S
D
Q
E
G
N
N
I
Site 14
S285
D
Q
E
G
N
N
I
S
S
S
S
G
H
R
V
Site 15
S287
E
G
N
N
I
S
S
S
S
G
H
R
V
R
L
Site 16
S288
G
N
N
I
S
S
S
S
G
H
R
V
R
L
T
Site 17
T295
S
G
H
R
V
R
L
T
E
G
Q
G
S
E
I
Site 18
S300
R
L
T
E
G
Q
G
S
E
I
Q
P
G
D
L
Site 19
S311
P
G
D
L
D
P
L
S
R
G
H
E
T
S
G
Site 20
S317
L
S
R
G
H
E
T
S
G
K
G
L
E
K
T
Site 21
T324
S
G
K
G
L
E
K
T
S
L
N
I
K
R
D
Site 22
S325
G
K
G
L
E
K
T
S
L
N
I
K
R
D
F
Site 23
S340
L
G
F
M
D
T
D
S
A
L
S
E
V
P
Q
Site 24
S353
P
Q
L
K
Q
E
I
S
E
C
L
I
A
S
S
Site 25
S360
S
E
C
L
I
A
S
S
F
E
D
D
S
R
V
Site 26
S365
A
S
S
F
E
D
D
S
R
V
A
S
P
L
D
Site 27
S369
E
D
D
S
R
V
A
S
P
L
D
Q
N
G
S
Site 28
S376
S
P
L
D
Q
N
G
S
F
N
V
V
I
K
E
Site 29
Y389
K
E
E
P
L
D
D
Y
D
Y
E
L
G
E
C
Site 30
Y391
E
P
L
D
D
Y
D
Y
E
L
G
E
C
P
E
Site 31
T411
Q
E
E
T
D
E
E
T
D
V
Y
S
N
S
D
Site 32
Y414
T
D
E
E
T
D
V
Y
S
N
S
D
D
D
P
Site 33
S417
E
T
D
V
Y
S
N
S
D
D
D
P
I
L
E
Site 34
S442
N
P
E
A
D
H
L
S
S
K
W
L
P
S
S
Site 35
S443
P
E
A
D
H
L
S
S
K
W
L
P
S
S
P
Site 36
S448
L
S
S
K
W
L
P
S
S
P
S
G
V
A
K
Site 37
S449
S
S
K
W
L
P
S
S
P
S
G
V
A
K
A
Site 38
S451
K
W
L
P
S
S
P
S
G
V
A
K
A
K
M
Site 39
S479
E
P
C
A
V
T
R
S
T
V
K
I
S
E
L
Site 40
S492
E
L
P
D
N
M
L
S
T
S
R
K
D
K
S
Site 41
T493
L
P
D
N
M
L
S
T
S
R
K
D
K
S
S
Site 42
S494
P
D
N
M
L
S
T
S
R
K
D
K
S
S
M
Site 43
S499
S
T
S
R
K
D
K
S
S
M
L
A
E
L
E
Site 44
S500
T
S
R
K
D
K
S
S
M
L
A
E
L
E
Y
Site 45
Y507
S
M
L
A
E
L
E
Y
L
P
T
Y
I
E
N
Site 46
T510
A
E
L
E
Y
L
P
T
Y
I
E
N
S
N
E
Site 47
Y511
E
L
E
Y
L
P
T
Y
I
E
N
S
N
E
T
Site 48
S526
A
F
C
L
G
K
E
S
E
N
G
L
R
K
H
Site 49
S534
E
N
G
L
R
K
H
S
P
D
L
R
V
V
Q
Site 50
Y543
D
L
R
V
V
Q
K
Y
P
L
L
K
E
P
Q
Site 51
Y553
L
K
E
P
Q
W
K
Y
P
D
I
S
D
S
I
Site 52
S557
Q
W
K
Y
P
D
I
S
D
S
I
S
T
E
R
Site 53
S559
K
Y
P
D
I
S
D
S
I
S
T
E
R
I
L
Site 54
S561
P
D
I
S
D
S
I
S
T
E
R
I
L
D
D
Site 55
S569
T
E
R
I
L
D
D
S
K
D
S
V
G
D
S
Site 56
S572
I
L
D
D
S
K
D
S
V
G
D
S
L
S
G
Site 57
S576
S
K
D
S
V
G
D
S
L
S
G
K
E
D
L
Site 58
S578
D
S
V
G
D
S
L
S
G
K
E
D
L
G
R
Site 59
T588
E
D
L
G
R
K
R
T
T
M
L
K
I
A
T
Site 60
T589
D
L
G
R
K
R
T
T
M
L
K
I
A
T
A
Site 61
S607
V
N
A
N
Q
N
A
S
P
N
V
P
G
K
R
Site 62
T632
A
G
R
P
P
K
N
T
G
K
S
L
I
S
T
Site 63
S635
P
P
K
N
T
G
K
S
L
I
S
T
K
N
T
Site 64
S638
N
T
G
K
S
L
I
S
T
K
N
T
P
V
S
Site 65
T639
T
G
K
S
L
I
S
T
K
N
T
P
V
S
P
Site 66
T642
S
L
I
S
T
K
N
T
P
V
S
P
G
S
T
Site 67
S645
S
T
K
N
T
P
V
S
P
G
S
T
F
P
D
Site 68
S648
N
T
P
V
S
P
G
S
T
F
P
D
V
K
P
Site 69
T649
T
P
V
S
P
G
S
T
F
P
D
V
K
P
D
Site 70
T682
D
I
H
A
V
D
G
T
T
E
E
S
S
S
L
Site 71
T683
I
H
A
V
D
G
T
T
E
E
S
S
S
L
Q
Site 72
S688
G
T
T
E
E
S
S
S
L
Q
A
S
T
T
N
Site 73
S692
E
S
S
S
L
Q
A
S
T
T
N
D
S
G
Y
Site 74
T693
S
S
S
L
Q
A
S
T
T
N
D
S
G
Y
R
Site 75
T694
S
S
L
Q
A
S
T
T
N
D
S
G
Y
R
A
Site 76
Y699
S
T
T
N
D
S
G
Y
R
A
R
I
S
Q
L
Site 77
S704
S
G
Y
R
A
R
I
S
Q
L
E
K
E
L
I
Site 78
S716
E
L
I
E
D
L
K
S
L
R
H
K
Q
V
I
Site 79
T740
K
L
N
S
V
D
P
T
M
S
I
D
L
K
Y
Site 80
S742
N
S
V
D
P
T
M
S
I
D
L
K
Y
L
G
Site 81
T766
S
F
P
F
W
N
L
T
G
T
N
P
A
S
P
Site 82
T768
P
F
W
N
L
T
G
T
N
P
A
S
P
D
A
Site 83
S772
L
T
G
T
N
P
A
S
P
D
A
G
F
P
F
Site 84
T790
T
G
K
T
N
D
F
T
K
I
K
G
W
R
G
Site 85
S801
G
W
R
G
K
F
H
S
A
S
A
S
R
N
E
Site 86
S803
R
G
K
F
H
S
A
S
A
S
R
N
E
G
G
Site 87
S805
K
F
H
S
A
S
A
S
R
N
E
G
G
N
S
Site 88
S812
S
R
N
E
G
G
N
S
E
S
S
L
K
N
R
Site 89
S815
E
G
G
N
S
E
S
S
L
K
N
R
S
A
F
Site 90
S820
E
S
S
L
K
N
R
S
A
F
C
S
D
K
L
Site 91
S824
K
N
R
S
A
F
C
S
D
K
L
D
E
Y
L
Site 92
Y830
C
S
D
K
L
D
E
Y
L
E
N
E
G
K
L
Site 93
T840
N
E
G
K
L
M
E
T
S
M
G
F
S
S
N
Site 94
S841
E
G
K
L
M
E
T
S
M
G
F
S
S
N
A
Site 95
S845
M
E
T
S
M
G
F
S
S
N
A
P
T
S
P
Site 96
S846
E
T
S
M
G
F
S
S
N
A
P
T
S
P
V
Site 97
T850
G
F
S
S
N
A
P
T
S
P
V
V
Y
Q
L
Site 98
S851
F
S
S
N
A
P
T
S
P
V
V
Y
Q
L
P
Site 99
Y855
A
P
T
S
P
V
V
Y
Q
L
P
T
K
S
T
Site 100
T859
P
V
V
Y
Q
L
P
T
K
S
T
S
Y
V
R
Site 101
S863
Q
L
P
T
K
S
T
S
Y
V
R
T
L
D
S
Site 102
Y864
L
P
T
K
S
T
S
Y
V
R
T
L
D
S
V
Site 103
T867
K
S
T
S
Y
V
R
T
L
D
S
V
L
K
K
Site 104
S870
S
Y
V
R
T
L
D
S
V
L
K
K
Q
S
T
Site 105
S876
D
S
V
L
K
K
Q
S
T
I
S
P
S
T
S
Site 106
T877
S
V
L
K
K
Q
S
T
I
S
P
S
T
S
Y
Site 107
S879
L
K
K
Q
S
T
I
S
P
S
T
S
Y
S
L
Site 108
S881
K
Q
S
T
I
S
P
S
T
S
Y
S
L
K
P
Site 109
S883
S
T
I
S
P
S
T
S
Y
S
L
K
P
H
S
Site 110
S885
I
S
P
S
T
S
Y
S
L
K
P
H
S
V
P
Site 111
S890
S
Y
S
L
K
P
H
S
V
P
P
V
S
R
K
Site 112
S895
P
H
S
V
P
P
V
S
R
K
A
K
S
Q
N
Site 113
S900
P
V
S
R
K
A
K
S
Q
N
R
Q
A
T
F
Site 114
T906
K
S
Q
N
R
Q
A
T
F
S
G
R
T
K
S
Site 115
S908
Q
N
R
Q
A
T
F
S
G
R
T
K
S
S
Y
Site 116
S913
T
F
S
G
R
T
K
S
S
Y
K
S
I
L
P
Site 117
S914
F
S
G
R
T
K
S
S
Y
K
S
I
L
P
Y
Site 118
Y915
S
G
R
T
K
S
S
Y
K
S
I
L
P
Y
P
Site 119
S917
R
T
K
S
S
Y
K
S
I
L
P
Y
P
V
S
Site 120
Y921
S
Y
K
S
I
L
P
Y
P
V
S
P
K
Q
K
Site 121
S924
S
I
L
P
Y
P
V
S
P
K
Q
K
Y
S
H
Site 122
Y929
P
V
S
P
K
Q
K
Y
S
H
V
I
L
G
D
Site 123
S943
D
K
V
T
K
N
S
S
G
I
I
S
E
N
Q
Site 124
S947
K
N
S
S
G
I
I
S
E
N
Q
A
N
N
F
Site 125
S969
N
I
F
P
K
Q
I
S
L
R
Q
A
Q
Q
Q
Site 126
S983
Q
Q
Q
Q
Q
Q
G
S
R
P
P
G
L
S
K
Site 127
S989
G
S
R
P
P
G
L
S
K
S
Q
V
K
L
M
Site 128
S991
R
P
P
G
L
S
K
S
Q
V
K
L
M
D
L
Site 129
Y1011
W
E
G
K
P
R
T
Y
I
T
E
E
R
A
D
Site 130
S1020
T
E
E
R
A
D
V
S
L
T
T
L
L
T
A
Site 131
S1030
T
L
L
T
A
Q
A
S
L
K
T
K
P
I
H
Site 132
S1060
R
L
G
C
V
C
S
S
L
A
L
E
K
R
Q
Site 133
S1094
V
V
L
V
K
G
G
S
K
T
K
H
F
Q
R
Site 134
Y1111
A
H
R
D
P
V
F
Y
D
T
L
G
E
E
A
Site 135
T1113
R
D
P
V
F
Y
D
T
L
G
E
E
A
R
E
Site 136
Y1143
K
K
R
K
K
L
E
Y
T
I
C
E
T
E
P
Site 137
Y1157
P
E
Q
P
V
R
H
Y
P
L
W
V
K
V
E
Site 138
S1178
P
V
Y
I
P
T
P
S
V
I
E
P
M
K
P
Site 139
S1195
L
P
Q
P
E
V
L
S
P
T
V
K
G
K
L
Site 140
T1197
Q
P
E
V
L
S
P
T
V
K
G
K
L
L
T
Site 141
T1204
T
V
K
G
K
L
L
T
G
I
K
S
P
R
S
Site 142
S1208
K
L
L
T
G
I
K
S
P
R
S
Y
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D
I
S
P
R
I
S
K
Q
Q
Site 295
S2506
F
D
I
S
P
R
I
S
K
Q
Q
E
G
S
S
Site 296
S2512
I
S
K
Q
Q
E
G
S
S
A
S
S
V
D
L
Site 297
S2513
S
K
Q
Q
E
G
S
S
A
S
S
V
D
L
G
Site 298
S2516
Q
E
G
S
S
A
S
S
V
D
L
G
Q
M
F
Site 299
S2535
R
G
K
P
L
I
L
S
R
K
K
D
Q
A
T
Site 300
T2542
S
R
K
K
D
Q
A
T
E
N
T
S
P
L
N
Site 301
S2546
D
Q
A
T
E
N
T
S
P
L
N
T
P
H
T
Site 302
T2550
E
N
T
S
P
L
N
T
P
H
T
S
A
N
L
Site 303
T2553
S
P
L
N
T
P
H
T
S
A
N
L
V
M
T
Site 304
T2567
T
P
Q
G
Q
L
L
T
L
K
G
P
L
F
S
Site 305
S2587
V
S
P
D
L
L
E
S
D
L
K
P
Q
V
A
Site 306
Y2632
V
D
M
G
G
S
K
Y
P
H
E
V
P
D
S
Site 307
S2639
Y
P
H
E
V
P
D
S
K
P
S
D
H
L
K
Site 308
T2648
P
S
D
H
L
K
D
T
V
R
N
E
D
N
S
Site 309
S2655
T
V
R
N
E
D
N
S
L
E
D
K
G
R
I
Site 310
S2663
L
E
D
K
G
R
I
S
S
R
G
N
R
D
G
Site 311
S2664
E
D
K
G
R
I
S
S
R
G
N
R
D
G
R
Site 312
T2673
G
N
R
D
G
R
V
T
L
G
P
T
Q
V
F
Site 313
S2686
V
F
L
A
N
K
D
S
G
Y
P
Q
I
V
D
Site 314
Y2688
L
A
N
K
D
S
G
Y
P
Q
I
V
D
V
S
Site 315
S2709
E
F
L
P
K
K
I
S
G
D
M
R
G
I
Q
Site 316
Y2717
G
D
M
R
G
I
Q
Y
K
W
K
E
S
E
S
Site 317
S2731
S
R
G
E
R
V
K
S
K
D
S
S
F
H
K
Site 318
S2734
E
R
V
K
S
K
D
S
S
F
H
K
L
K
M
Site 319
S2735
R
V
K
S
K
D
S
S
F
H
K
L
K
M
K
Site 320
S2747
K
M
K
D
L
K
D
S
S
I
E
M
E
L
R
Site 321
S2748
M
K
D
L
K
D
S
S
I
E
M
E
L
R
K
Site 322
T2757
E
M
E
L
R
K
V
T
S
A
I
E
E
A
A
Site 323
S2768
E
E
A
A
L
D
S
S
E
L
L
T
N
M
E
Site 324
T2772
L
D
S
S
E
L
L
T
N
M
E
D
E
D
D
Site 325
T2780
N
M
E
D
E
D
D
T
D
E
T
L
T
S
L
Site 326
T2783
D
E
D
D
T
D
E
T
L
T
S
L
L
N
E
Site 327
S2786
D
T
D
E
T
L
T
S
L
L
N
E
I
A
F
Site 328
S2802
N
Q
Q
L
N
D
D
S
V
G
L
A
E
L
P
Site 329
S2810
V
G
L
A
E
L
P
S
S
M
D
T
E
F
P
Site 330
S2811
G
L
A
E
L
P
S
S
M
D
T
E
F
P
G
Site 331
T2814
E
L
P
S
S
M
D
T
E
F
P
G
D
A
R
Site 332
S2826
D
A
R
R
A
F
I
S
K
V
P
P
G
S
R
Site 333
S2832
I
S
K
V
P
P
G
S
R
A
T
F
Q
V
E
Site 334
T2835
V
P
P
G
S
R
A
T
F
Q
V
E
H
L
G
Site 335
T2843
F
Q
V
E
H
L
G
T
G
L
K
E
L
P
D
Site 336
S2855
L
P
D
V
Q
G
E
S
D
S
I
S
P
L
L
Site 337
S2857
D
V
Q
G
E
S
D
S
I
S
P
L
L
L
H
Site 338
S2859
Q
G
E
S
D
S
I
S
P
L
L
L
H
L
E
Site 339
S2871
H
L
E
D
D
D
F
S
E
N
E
K
Q
L
A
Site 340
S2882
K
Q
L
A
E
P
A
S
E
P
D
V
L
K
I
Site 341
S2898
I
D
S
E
I
K
D
S
L
L
S
N
K
K
A
Site 342
S2901
E
I
K
D
S
L
L
S
N
K
K
A
I
D
G
Site 343
S2921
G
L
P
A
E
P
E
S
V
S
S
P
P
T
L
Site 344
S2923
P
A
E
P
E
S
V
S
S
P
P
T
L
H
M
Site 345
S2924
A
E
P
E
S
V
S
S
P
P
T
L
H
M
K
Site 346
T2927
E
S
V
S
S
P
P
T
L
H
M
K
T
G
L
Site 347
T2932
P
P
T
L
H
M
K
T
G
L
E
N
S
N
S
Site 348
S2937
M
K
T
G
L
E
N
S
N
S
T
D
T
L
W
Site 349
S2939
T
G
L
E
N
S
N
S
T
D
T
L
W
R
P
Site 350
T2942
E
N
S
N
S
T
D
T
L
W
R
P
M
P
K
Site 351
S2962
L
K
V
A
N
P
S
S
D
A
D
G
Q
S
L
Site 352
S2968
S
S
D
A
D
G
Q
S
L
K
V
M
P
C
L
Site 353
T2992
V
G
H
K
M
N
L
T
G
N
D
Q
E
G
R
Site 354
S3001
N
D
Q
E
G
R
E
S
K
V
M
P
T
L
A
Site 355
S3020
K
L
G
N
S
G
A
S
P
S
S
A
G
K
_
Site 356
S3022
G
N
S
G
A
S
P
S
S
A
G
K
_
_
_
Site 357
S3023
N
S
G
A
S
P
S
S
A
G
K
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation