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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHM2
Full Name:
Pleckstrin homology domain-containing family M member 2
Alias:
KIAA0842; Novel RUN and PH domain-containing; PKHM2; Pleckstrin homology domain-containing M2; Pleckstriny domain containing, family M (with RUN domain) member 2; Salmonella-induced filaments A and kinesin-interacting protein; SifA and kinesin-interacting protein; SKIP
Type:
Mass (Da):
112762
Number AA:
1019
UniProt ID:
Q8IWE5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0019894
PhosphoSite+
KinaseNET
Biological Process:
GO:0007030
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
D
R
I
L
E
N
I
S
L
S
V
K
K
L
Q
Site 2
S17
I
L
E
N
I
S
L
S
V
K
K
L
Q
S
Y
Site 3
Y24
S
V
K
K
L
Q
S
Y
F
A
A
C
E
D
E
Site 4
Y55
H
L
D
H
A
L
L
Y
G
L
Q
D
L
S
S
Site 5
T88
E
V
L
Q
H
V
A
T
N
L
G
R
S
R
A
Site 6
Y98
G
R
S
R
A
W
L
Y
L
A
L
N
E
N
S
Site 7
S105
Y
L
A
L
N
E
N
S
L
E
S
Y
L
R
L
Site 8
Y109
N
E
N
S
L
E
S
Y
L
R
L
F
Q
E
N
Site 9
Y165
P
Y
L
D
L
A
P
Y
M
P
D
Y
Y
K
P
Site 10
Y169
L
A
P
Y
M
P
D
Y
Y
K
P
Q
Y
L
L
Site 11
Y170
A
P
Y
M
P
D
Y
Y
K
P
Q
Y
L
L
D
Site 12
Y174
P
D
Y
Y
K
P
Q
Y
L
L
D
F
E
D
R
Site 13
S184
D
F
E
D
R
L
P
S
S
V
H
G
S
D
S
Site 14
S185
F
E
D
R
L
P
S
S
V
H
G
S
D
S
L
Site 15
S189
L
P
S
S
V
H
G
S
D
S
L
S
L
N
S
Site 16
S191
S
S
V
H
G
S
D
S
L
S
L
N
S
F
N
Site 17
S193
V
H
G
S
D
S
L
S
L
N
S
F
N
S
V
Site 18
S196
S
D
S
L
S
L
N
S
F
N
S
V
T
S
T
Site 19
S199
L
S
L
N
S
F
N
S
V
T
S
T
N
L
E
Site 20
T203
S
F
N
S
V
T
S
T
N
L
E
W
D
D
S
Site 21
S210
T
N
L
E
W
D
D
S
A
I
A
P
S
S
E
Site 22
S216
D
S
A
I
A
P
S
S
E
D
Y
D
F
G
D
Site 23
Y219
I
A
P
S
S
E
D
Y
D
F
G
D
V
F
P
Site 24
S230
D
V
F
P
A
V
P
S
V
P
S
T
D
W
E
Site 25
T234
A
V
P
S
V
P
S
T
D
W
E
D
G
D
L
Site 26
T242
D
W
E
D
G
D
L
T
D
T
V
S
G
P
R
Site 27
T244
E
D
G
D
L
T
D
T
V
S
G
P
R
S
T
Site 28
S246
G
D
L
T
D
T
V
S
G
P
R
S
T
A
S
Site 29
S250
D
T
V
S
G
P
R
S
T
A
S
D
L
T
S
Site 30
T251
T
V
S
G
P
R
S
T
A
S
D
L
T
S
S
Site 31
S253
S
G
P
R
S
T
A
S
D
L
T
S
S
K
A
Site 32
T256
R
S
T
A
S
D
L
T
S
S
K
A
S
T
R
Site 33
S257
S
T
A
S
D
L
T
S
S
K
A
S
T
R
S
Site 34
S258
T
A
S
D
L
T
S
S
K
A
S
T
R
S
P
Site 35
S261
D
L
T
S
S
K
A
S
T
R
S
P
T
Q
R
Site 36
T262
L
T
S
S
K
A
S
T
R
S
P
T
Q
R
Q
Site 37
S264
S
S
K
A
S
T
R
S
P
T
Q
R
Q
N
P
Site 38
T266
K
A
S
T
R
S
P
T
Q
R
Q
N
P
F
N
Site 39
T279
F
N
E
E
P
A
E
T
V
S
S
S
D
T
T
Site 40
S281
E
E
P
A
E
T
V
S
S
S
D
T
T
P
V
Site 41
S282
E
P
A
E
T
V
S
S
S
D
T
T
P
V
H
Site 42
S283
P
A
E
T
V
S
S
S
D
T
T
P
V
H
T
Site 43
T285
E
T
V
S
S
S
D
T
T
P
V
H
T
T
S
Site 44
T286
T
V
S
S
S
D
T
T
P
V
H
T
T
S
Q
Site 45
S292
T
T
P
V
H
T
T
S
Q
E
K
E
E
A
Q
Site 46
T316
E
L
E
V
I
R
V
T
K
K
K
K
I
G
K
Site 47
S327
K
I
G
K
K
K
K
S
R
S
D
E
E
A
S
Site 48
S329
G
K
K
K
K
S
R
S
D
E
E
A
S
P
L
Site 49
S334
S
R
S
D
E
E
A
S
P
L
H
P
A
C
S
Site 50
S341
S
P
L
H
P
A
C
S
Q
K
K
C
A
K
Q
Site 51
S353
A
K
Q
G
D
G
D
S
R
N
G
S
P
S
L
Site 52
S357
D
G
D
S
R
N
G
S
P
S
L
G
R
D
S
Site 53
S359
D
S
R
N
G
S
P
S
L
G
R
D
S
P
D
Site 54
S364
S
P
S
L
G
R
D
S
P
D
T
M
L
A
S
Site 55
T367
L
G
R
D
S
P
D
T
M
L
A
S
P
Q
E
Site 56
S371
S
P
D
T
M
L
A
S
P
Q
E
E
G
E
G
Site 57
S381
E
E
G
E
G
P
S
S
T
T
E
S
S
E
R
Site 58
T382
E
G
E
G
P
S
S
T
T
E
S
S
E
R
S
Site 59
S385
G
P
S
S
T
T
E
S
S
E
R
S
E
P
G
Site 60
S386
P
S
S
T
T
E
S
S
E
R
S
E
P
G
L
Site 61
S389
T
T
E
S
S
E
R
S
E
P
G
L
L
I
P
Site 62
T401
L
I
P
E
M
K
D
T
S
M
E
R
L
G
Q
Site 63
S402
I
P
E
M
K
D
T
S
M
E
R
L
G
Q
P
Site 64
S411
E
R
L
G
Q
P
L
S
K
V
I
D
Q
L
N
Site 65
S424
L
N
G
Q
L
D
P
S
T
W
C
S
R
A
E
Site 66
T425
N
G
Q
L
D
P
S
T
W
C
S
R
A
E
P
Site 67
S428
L
D
P
S
T
W
C
S
R
A
E
P
P
D
Q
Site 68
S436
R
A
E
P
P
D
Q
S
F
R
T
G
S
P
G
Site 69
T439
P
P
D
Q
S
F
R
T
G
S
P
G
D
A
P
Site 70
S441
D
Q
S
F
R
T
G
S
P
G
D
A
P
E
R
Site 71
S455
R
P
P
L
C
D
F
S
E
G
L
S
A
P
M
Site 72
S459
C
D
F
S
E
G
L
S
A
P
M
D
F
Y
R
Site 73
Y465
L
S
A
P
M
D
F
Y
R
F
T
V
E
S
P
Site 74
T468
P
M
D
F
Y
R
F
T
V
E
S
P
S
T
V
Site 75
S471
F
Y
R
F
T
V
E
S
P
S
T
V
T
S
G
Site 76
S473
R
F
T
V
E
S
P
S
T
V
T
S
G
G
G
Site 77
T474
F
T
V
E
S
P
S
T
V
T
S
G
G
G
H
Site 78
S477
E
S
P
S
T
V
T
S
G
G
G
H
H
D
P
Site 79
S496
Q
P
L
H
V
P
S
S
P
E
A
A
G
Q
E
Site 80
T513
G
G
G
G
E
G
Q
T
P
R
P
L
E
D
T
Site 81
T520
T
P
R
P
L
E
D
T
T
R
E
A
Q
E
L
Site 82
S532
Q
E
L
E
A
Q
L
S
L
V
R
E
G
P
V
Site 83
S540
L
V
R
E
G
P
V
S
E
P
E
P
G
T
Q
Site 84
S559
Q
L
K
R
D
Q
P
S
P
C
L
S
S
A
E
Site 85
S563
D
Q
P
S
P
C
L
S
S
A
E
D
S
G
V
Site 86
S564
Q
P
S
P
C
L
S
S
A
E
D
S
G
V
D
Site 87
S568
C
L
S
S
A
E
D
S
G
V
D
E
G
Q
G
Site 88
S576
G
V
D
E
G
Q
G
S
P
S
E
M
V
H
S
Site 89
S578
D
E
G
Q
G
S
P
S
E
M
V
H
S
S
E
Site 90
T616
F
K
M
I
R
M
S
T
G
H
M
E
G
N
L
Site 91
Y647
K
G
A
T
E
K
P
Y
L
V
E
E
A
V
S
Site 92
S654
Y
L
V
E
E
A
V
S
Y
N
E
L
D
Y
V
Site 93
Y655
L
V
E
E
A
V
S
Y
N
E
L
D
Y
V
S
Site 94
Y660
V
S
Y
N
E
L
D
Y
V
S
V
G
L
D
Q
Site 95
T675
Q
T
V
K
L
V
C
T
N
R
R
K
Q
F
L
Site 96
Y711
K
G
C
R
E
P
P
Y
P
S
I
L
T
D
A
Site 97
S733
A
K
F
V
A
Q
E
S
K
C
E
A
S
A
V
Site 98
T754
L
V
H
W
E
D
P
T
D
E
S
L
G
P
T
Site 99
S757
W
E
D
P
T
D
E
S
L
G
P
T
P
C
H
Site 100
T761
T
D
E
S
L
G
P
T
P
C
H
C
S
P
P
Site 101
S766
G
P
T
P
C
H
C
S
P
P
E
G
T
I
T
Site 102
T773
S
P
P
E
G
T
I
T
K
E
G
M
L
H
Y
Site 103
Y780
T
K
E
G
M
L
H
Y
K
A
G
T
S
Y
L
Site 104
Y786
H
Y
K
A
G
T
S
Y
L
G
K
E
H
W
K
Site 105
Y805
V
L
S
N
G
I
L
Y
Q
Y
P
D
R
T
D
Site 106
Y807
S
N
G
I
L
Y
Q
Y
P
D
R
T
D
V
I
Site 107
T811
L
Y
Q
Y
P
D
R
T
D
V
I
P
L
L
S
Site 108
T834
G
G
C
R
R
A
N
T
T
D
R
P
H
A
F
Site 109
T835
G
C
R
R
A
N
T
T
D
R
P
H
A
F
Q
Site 110
S854
D
R
P
C
L
E
L
S
A
E
S
E
A
E
M
Site 111
S873
Q
H
L
C
Q
A
V
S
K
G
V
I
P
Q
G
Site 112
T907
T
C
H
E
D
C
Q
T
S
F
F
R
S
L
G
Site 113
S912
C
Q
T
S
F
F
R
S
L
G
T
A
K
L
G
Site 114
S925
L
G
D
I
S
A
V
S
T
E
P
G
K
E
Y
Site 115
T926
G
D
I
S
A
V
S
T
E
P
G
K
E
Y
C
Site 116
Y932
S
T
E
P
G
K
E
Y
C
V
L
E
F
S
Q
Site 117
S938
E
Y
C
V
L
E
F
S
Q
D
S
Q
Q
L
L
Site 118
S941
V
L
E
F
S
Q
D
S
Q
Q
L
L
P
P
W
Site 119
S953
P
P
W
V
I
Y
L
S
C
T
S
E
L
D
R
Site 120
S963
S
E
L
D
R
L
L
S
A
L
N
S
G
W
K
Site 121
S967
R
L
L
S
A
L
N
S
G
W
K
T
I
Y
Q
Site 122
T971
A
L
N
S
G
W
K
T
I
Y
Q
V
D
L
P
Site 123
Y973
N
S
G
W
K
T
I
Y
Q
V
D
L
P
H
T
Site 124
S996
K
K
F
E
D
A
L
S
L
I
H
S
A
W
Q
Site 125
S1000
D
A
L
S
L
I
H
S
A
W
Q
R
S
D
S
Site 126
S1007
S
A
W
Q
R
S
D
S
L
C
R
G
R
A
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation