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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WDFY1
Full Name:
WD repeat and FYVE domain-containing protein 1
Alias:
WD40- and FYVE domain-containing protein 1
Type:
Mass (Da):
46324
Number AA:
410
UniProt ID:
Q8IWB7
International Prot ID:
IPI00024283
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005769
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005545
GO:0008270
GO:0005545
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
A
E
I
H
S
R
P
Q
S
S
R
P
Site 2
S11
E
I
H
S
R
P
Q
S
S
R
P
V
L
L
S
Site 3
S12
I
H
S
R
P
Q
S
S
R
P
V
L
L
S
K
Site 4
S18
S
S
R
P
V
L
L
S
K
I
E
G
H
Q
D
Site 5
S43
E
D
G
V
I
T
A
S
E
D
R
T
I
R
V
Site 6
T47
I
T
A
S
E
D
R
T
I
R
V
W
L
K
R
Site 7
Y59
L
K
R
D
S
G
Q
Y
W
P
S
I
Y
H
T
Site 8
Y76
S
P
C
S
A
M
A
Y
H
H
D
S
R
R
I
Site 9
Y110
K
M
N
F
I
K
T
Y
P
A
H
Q
N
R
V
Site 10
Y163
S
W
A
S
C
L
Q
Y
D
F
D
T
Q
Y
A
Site 11
Y169
Q
Y
D
F
D
T
Q
Y
A
F
V
G
D
Y
S
Site 12
T180
G
D
Y
S
G
Q
I
T
L
L
K
L
E
Q
N
Site 13
S190
K
L
E
Q
N
T
C
S
V
I
T
T
L
K
G
Site 14
T194
N
T
C
S
V
I
T
T
L
K
G
H
E
G
S
Site 15
S216
P
I
Q
R
L
L
F
S
G
A
S
D
N
S
I
Site 16
T235
I
G
G
R
K
G
R
T
L
L
L
Q
G
H
H
Site 17
S259
Q
L
T
R
Q
L
V
S
C
S
S
D
G
G
I
Site 18
S284
E
A
P
Q
W
L
E
S
D
S
C
Q
K
C
E
Site 19
T306
K
Q
M
W
D
T
K
T
L
G
L
R
Q
H
H
Site 20
S326
Q
A
V
C
G
K
C
S
S
K
R
S
S
Y
P
Site 21
S327
A
V
C
G
K
C
S
S
K
R
S
S
Y
P
V
Site 22
S330
G
K
C
S
S
K
R
S
S
Y
P
V
M
G
F
Site 23
S331
K
C
S
S
K
R
S
S
Y
P
V
M
G
F
E
Site 24
Y332
C
S
S
K
R
S
S
Y
P
V
M
G
F
E
F
Site 25
Y348
V
R
V
C
D
S
C
Y
D
S
I
K
D
E
D
Site 26
S350
V
C
D
S
C
Y
D
S
I
K
D
E
D
R
T
Site 27
T357
S
I
K
D
E
D
R
T
S
L
A
T
F
H
E
Site 28
S358
I
K
D
E
D
R
T
S
L
A
T
F
H
E
G
Site 29
T361
E
D
R
T
S
L
A
T
F
H
E
G
K
H
N
Site 30
S408
C
S
L
A
T
G
F
S
P
H
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation