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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MFN1
Full Name:
Mitofusin-1
Alias:
Fzo homolog;Transmembrane GTPase MFN1
Type:
Mass (Da):
84100
Number AA:
741
UniProt ID:
Q8IWA4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y40
S
H
F
V
E
A
T
Y
K
N
P
E
L
D
R
Site 2
T50
P
E
L
D
R
I
A
T
E
D
D
L
V
E
M
Site 3
Y60
D
L
V
E
M
Q
G
Y
K
D
K
L
S
I
I
Site 4
S65
Q
G
Y
K
D
K
L
S
I
I
G
E
V
L
S
Site 5
T84
K
V
A
F
F
G
R
T
S
S
G
K
S
S
V
Site 6
S86
A
F
F
G
R
T
S
S
G
K
S
S
V
I
N
Site 7
S89
G
R
T
S
S
G
K
S
S
V
I
N
A
M
L
Site 8
S90
R
T
S
S
G
K
S
S
V
I
N
A
M
L
W
Site 9
S114
H
I
T
N
C
F
L
S
V
E
G
T
D
G
D
Site 10
T118
C
F
L
S
V
E
G
T
D
G
D
K
A
Y
L
Site 11
Y124
G
T
D
G
D
K
A
Y
L
M
T
E
G
S
D
Site 12
S130
A
Y
L
M
T
E
G
S
D
E
K
K
S
V
K
Site 13
S135
E
G
S
D
E
K
K
S
V
K
T
V
N
Q
L
Site 14
T138
D
E
K
K
S
V
K
T
V
N
Q
L
A
H
A
Site 15
S179
D
D
L
V
L
V
D
S
P
G
T
D
V
T
T
Site 16
T185
D
S
P
G
T
D
V
T
T
E
L
D
S
W
I
Site 17
T186
S
P
G
T
D
V
T
T
E
L
D
S
W
I
D
Site 18
T215
S
E
S
T
L
M
N
T
E
K
H
F
F
H
K
Site 19
S228
H
K
V
N
E
R
L
S
K
P
N
I
F
I
L
Site 20
S242
L
N
N
R
W
D
A
S
A
S
E
P
E
Y
M
Site 21
S244
N
R
W
D
A
S
A
S
E
P
E
Y
M
E
D
Site 22
Y248
A
S
A
S
E
P
E
Y
M
E
D
V
R
R
Q
Site 23
S290
V
S
A
K
E
V
L
S
A
R
K
Q
K
A
Q
Site 24
S302
K
A
Q
G
M
P
E
S
G
V
A
L
A
E
G
Site 25
S329
Q
I
F
E
E
C
I
S
Q
S
A
V
K
T
K
Site 26
T335
I
S
Q
S
A
V
K
T
K
F
E
Q
H
T
I
Site 27
Y368
A
A
E
D
K
R
H
Y
S
V
E
E
R
E
D
Site 28
S369
A
E
D
K
R
H
Y
S
V
E
E
R
E
D
Q
Site 29
T391
R
N
Q
M
N
L
L
T
L
D
V
K
K
K
I
Site 30
T414
N
K
V
S
C
A
M
T
D
E
I
C
R
L
S
Site 31
Y441
N
P
D
V
L
K
I
Y
K
S
E
L
N
K
H
Site 32
S443
D
V
L
K
I
Y
K
S
E
L
N
K
H
I
E
Site 33
T462
R
N
L
A
D
R
C
T
D
E
V
N
A
L
V
Site 34
T494
G
I
Q
D
K
L
H
T
L
I
P
C
K
K
F
Site 35
Y505
C
K
K
F
D
L
S
Y
N
L
N
Y
H
K
L
Site 36
T562
L
P
R
S
L
A
S
T
P
T
A
P
T
T
P
Site 37
T564
R
S
L
A
S
T
P
T
A
P
T
T
P
A
T
Site 38
T568
S
T
P
T
A
P
T
T
P
A
T
P
D
N
A
Site 39
T571
T
A
P
T
T
P
A
T
P
D
N
A
S
Q
E
Site 40
S576
P
A
T
P
D
N
A
S
Q
E
E
L
M
I
T
Site 41
Y628
M
Y
G
A
L
Y
L
Y
E
R
L
S
W
T
T
Site 42
S632
L
Y
L
Y
E
R
L
S
W
T
T
H
A
K
E
Site 43
S659
E
K
L
R
M
I
V
S
S
T
S
A
N
C
S
Site 44
S660
K
L
R
M
I
V
S
S
T
S
A
N
C
S
H
Site 45
T661
L
R
M
I
V
S
S
T
S
A
N
C
S
H
Q
Site 46
S662
R
M
I
V
S
S
T
S
A
N
C
S
H
Q
V
Site 47
S666
S
S
T
S
A
N
C
S
H
Q
V
K
Q
Q
I
Site 48
T676
V
K
Q
Q
I
A
T
T
F
A
R
L
C
Q
Q
Site 49
T687
L
C
Q
Q
V
D
I
T
Q
K
Q
L
E
E
E
Site 50
S736
F
T
K
Q
F
L
P
S
S
N
E
E
S
_
_
Site 51
S737
T
K
Q
F
L
P
S
S
N
E
E
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation