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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF19
Full Name:
Rho guanine nucleotide exchange factor 19
Alias:
ARHGJ; FLJ33962; rho guanine nucleotide exchange factor (GEF) 19; WGEF
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
89179
Number AA:
802
UniProt ID:
Q8IW93
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
D
C
G
P
P
A
T
L
Q
P
H
L
T
G
Site 2
T14
A
T
L
Q
P
H
L
T
G
P
P
G
T
A
H
Site 3
S63
E
E
L
R
A
P
G
S
R
W
S
L
G
T
P
Site 4
S66
R
A
P
G
S
R
W
S
L
G
T
P
A
P
L
Site 5
T69
G
S
R
W
S
L
G
T
P
A
P
L
Q
G
L
Site 6
S81
Q
G
L
L
W
P
L
S
P
G
G
S
D
T
E
Site 7
S85
W
P
L
S
P
G
G
S
D
T
E
I
T
S
G
Site 8
T87
L
S
P
G
G
S
D
T
E
I
T
S
G
G
M
Site 9
S91
G
S
D
T
E
I
T
S
G
G
M
R
P
S
R
Site 10
S97
T
S
G
G
M
R
P
S
R
A
G
S
W
P
H
Site 11
S101
M
R
P
S
R
A
G
S
W
P
H
C
P
G
A
Site 12
S118
P
A
L
E
G
P
W
S
P
R
H
T
Q
P
Q
Site 13
T122
G
P
W
S
P
R
H
T
Q
P
Q
R
R
A
S
Site 14
S129
T
Q
P
Q
R
R
A
S
H
G
S
E
K
K
S
Site 15
S132
Q
R
R
A
S
H
G
S
E
K
K
S
A
W
R
Site 16
S136
S
H
G
S
E
K
K
S
A
W
R
K
M
R
V
Site 17
Y144
A
W
R
K
M
R
V
Y
Q
R
E
E
V
P
G
Site 18
S172
V
V
Q
E
Q
A
L
S
T
E
E
P
R
V
E
Site 19
S181
E
E
P
R
V
E
L
S
G
S
T
R
V
S
L
Site 20
S183
P
R
V
E
L
S
G
S
T
R
V
S
L
E
G
Site 21
S187
L
S
G
S
T
R
V
S
L
E
G
P
E
R
R
Site 22
S197
G
P
E
R
R
R
F
S
A
S
E
L
M
T
R
Site 23
S199
E
R
R
R
F
S
A
S
E
L
M
T
R
L
H
Site 24
T203
F
S
A
S
E
L
M
T
R
L
H
S
S
L
R
Site 25
S207
E
L
M
T
R
L
H
S
S
L
R
L
G
R
N
Site 26
S208
L
M
T
R
L
H
S
S
L
R
L
G
R
N
S
Site 27
S215
S
L
R
L
G
R
N
S
A
A
R
A
L
I
S
Site 28
T226
A
L
I
S
G
S
G
T
G
A
A
R
E
G
K
Site 29
S235
A
A
R
E
G
K
A
S
G
M
E
A
R
S
V
Site 30
S241
A
S
G
M
E
A
R
S
V
E
M
S
G
D
R
Site 31
S245
E
A
R
S
V
E
M
S
G
D
R
V
S
R
P
Site 32
S250
E
M
S
G
D
R
V
S
R
P
A
P
G
D
S
Site 33
S257
S
R
P
A
P
G
D
S
R
E
G
D
W
S
E
Site 34
S263
D
S
R
E
G
D
W
S
E
P
R
L
D
T
Q
Site 35
T269
W
S
E
P
R
L
D
T
Q
E
E
P
P
L
G
Site 36
T280
P
P
L
G
S
R
S
T
N
E
R
R
Q
S
R
Site 37
S286
S
T
N
E
R
R
Q
S
R
F
L
L
N
S
V
Site 38
S292
Q
S
R
F
L
L
N
S
V
L
Y
Q
E
Y
S
Site 39
S299
S
V
L
Y
Q
E
Y
S
D
V
A
S
A
R
E
Site 40
S303
Q
E
Y
S
D
V
A
S
A
R
E
L
R
R
Q
Site 41
S336
G
P
P
R
A
N
L
S
P
S
S
S
F
R
A
Site 42
S338
P
R
A
N
L
S
P
S
S
S
F
R
A
Q
R
Site 43
S339
R
A
N
L
S
P
S
S
S
F
R
A
Q
R
S
Site 44
S340
A
N
L
S
P
S
S
S
F
R
A
Q
R
S
A
Site 45
S346
S
S
F
R
A
Q
R
S
A
R
G
S
T
F
S
Site 46
S350
A
Q
R
S
A
R
G
S
T
F
S
L
W
Q
D
Site 47
T351
Q
R
S
A
R
G
S
T
F
S
L
W
Q
D
I
Site 48
S353
S
A
R
G
S
T
F
S
L
W
Q
D
I
P
D
Site 49
T369
R
G
S
G
V
L
A
T
L
S
L
R
D
C
K
Site 50
S387
A
K
F
E
L
I
T
S
E
A
S
Y
I
H
S
Site 51
S429
S
K
L
P
E
V
K
S
T
S
E
R
F
L
Q
Site 52
T430
K
L
P
E
V
K
S
T
S
E
R
F
L
Q
D
Site 53
S431
L
P
E
V
K
S
T
S
E
R
F
L
Q
D
L
Site 54
Y466
C
P
A
F
R
R
V
Y
L
P
Y
V
T
N
Q
Site 55
Y469
F
R
R
V
Y
L
P
Y
V
T
N
Q
A
Y
Q
Site 56
Y475
P
Y
V
T
N
Q
A
Y
Q
E
R
T
Y
Q
R
Site 57
Y480
Q
A
Y
Q
E
R
T
Y
Q
R
L
L
L
E
N
Site 58
S500
I
L
A
R
L
E
E
S
P
V
C
Q
R
L
P
Site 59
T533
V
E
N
I
L
K
R
T
A
Q
G
S
E
D
E
Site 60
S537
L
K
R
T
A
Q
G
S
E
D
E
D
M
A
T
Site 61
T544
S
E
D
E
D
M
A
T
K
A
F
N
A
L
K
Site 62
S560
L
V
Q
E
C
N
A
S
V
Q
S
M
K
R
T
Site 63
T567
S
V
Q
S
M
K
R
T
E
E
L
I
H
L
S
Site 64
Y621
K
L
S
S
K
A
V
Y
L
H
L
F
N
D
C
Site 65
S632
F
N
D
C
L
L
L
S
R
R
K
E
L
G
K
Site 66
S657
E
L
Q
V
R
D
L
S
L
K
L
Q
G
I
P
Site 67
T688
Q
F
L
L
R
A
R
T
E
S
E
K
Q
R
W
Site 68
S690
L
L
R
A
R
T
E
S
E
K
Q
R
W
I
S
Site 69
S697
S
E
K
Q
R
W
I
S
A
L
C
P
S
S
P
Site 70
S703
I
S
A
L
C
P
S
S
P
Q
E
D
K
E
V
Site 71
Y726
Q
V
Q
C
V
R
T
Y
K
A
L
H
P
D
E
Site 72
T735
A
L
H
P
D
E
L
T
L
E
K
T
D
I
L
Site 73
T739
D
E
L
T
L
E
K
T
D
I
L
S
V
R
T
Site 74
S743
L
E
K
T
D
I
L
S
V
R
T
W
T
S
D
Site 75
T748
I
L
S
V
R
T
W
T
S
D
G
W
L
E
G
Site 76
S749
L
S
V
R
T
W
T
S
D
G
W
L
E
G
V
Site 77
Y770
K
G
W
V
P
Q
A
Y
V
E
E
I
S
S
L
Site 78
S776
A
Y
V
E
E
I
S
S
L
S
A
R
L
R
N
Site 79
S778
V
E
E
I
S
S
L
S
A
R
L
R
N
L
R
Site 80
T791
L
R
E
N
K
R
V
T
S
A
T
S
K
L
G
Site 81
S792
R
E
N
K
R
V
T
S
A
T
S
K
L
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation