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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APLF
Full Name:
Aprataxin and PNK-like factor
Alias:
APFL; Aprataxin and PNKP like factor; Apurinic-apyrimidinic endonuclease APLF; C2orf13; MGC47799; PNK and APTX-like FHA domain-containing protein; Xip1; XRCC1-interacting protein 1
Type:
DNA repair
Mass (Da):
56956
Number AA:
511
UniProt ID:
Q8IW19
International Prot ID:
IPI00217108
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008408
GO:0003906
GO:0004520
PhosphoSite+
KinaseNET
Biological Process:
GO:0006302
GO:0000012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T34
R
G
P
L
L
G
I
T
D
K
R
V
S
R
R
Site 2
S39
G
I
T
D
K
R
V
S
R
R
H
A
I
L
E
Site 3
Y64
I
H
T
N
P
C
F
Y
Q
S
S
E
K
S
Q
Site 4
S66
T
N
P
C
F
Y
Q
S
S
E
K
S
Q
L
L
Site 5
S67
N
P
C
F
Y
Q
S
S
E
K
S
Q
L
L
P
Site 6
S70
F
Y
Q
S
S
E
K
S
Q
L
L
P
L
K
P
Site 7
Y82
L
K
P
N
L
W
C
Y
L
N
P
G
D
S
F
Site 8
S88
C
Y
L
N
P
G
D
S
F
S
L
L
V
D
K
Site 9
T112
S
E
V
E
M
Q
C
T
L
R
N
S
Q
V
L
Site 10
S116
M
Q
C
T
L
R
N
S
Q
V
L
D
E
D
N
Site 11
T128
E
D
N
I
L
N
E
T
P
K
S
P
V
I
N
Site 12
S131
I
L
N
E
T
P
K
S
P
V
I
N
L
P
H
Site 13
S144
P
H
E
T
T
G
A
S
Q
L
E
G
S
T
E
Site 14
S149
G
A
S
Q
L
E
G
S
T
E
I
A
K
T
Q
Site 15
T155
G
S
T
E
I
A
K
T
Q
M
T
P
T
N
S
Site 16
T158
E
I
A
K
T
Q
M
T
P
T
N
S
V
S
F
Site 17
T160
A
K
T
Q
M
T
P
T
N
S
V
S
F
L
G
Site 18
S162
T
Q
M
T
P
T
N
S
V
S
F
L
G
E
N
Site 19
S164
M
T
P
T
N
S
V
S
F
L
G
E
N
R
D
Site 20
S196
W
M
L
A
E
H
L
S
D
Q
N
L
S
V
P
Site 21
S201
H
L
S
D
Q
N
L
S
V
P
A
I
S
G
G
Site 22
S214
G
G
N
V
I
Q
G
S
G
K
E
E
I
C
K
Site 23
S224
E
E
I
C
K
D
K
S
Q
L
N
T
T
Q
Q
Site 24
T228
K
D
K
S
Q
L
N
T
T
Q
Q
G
R
R
Q
Site 25
S238
Q
G
R
R
Q
L
I
S
S
G
S
S
E
N
T
Site 26
S239
G
R
R
Q
L
I
S
S
G
S
S
E
N
T
S
Site 27
S241
R
Q
L
I
S
S
G
S
S
E
N
T
S
A
E
Site 28
S242
Q
L
I
S
S
G
S
S
E
N
T
S
A
E
Q
Site 29
T245
S
S
G
S
S
E
N
T
S
A
E
Q
D
T
G
Site 30
S246
S
G
S
S
E
N
T
S
A
E
Q
D
T
G
E
Site 31
T258
T
G
E
E
C
K
N
T
D
Q
E
E
S
T
I
Site 32
S266
D
Q
E
E
S
T
I
S
S
K
E
M
P
Q
S
Site 33
S267
Q
E
E
S
T
I
S
S
K
E
M
P
Q
S
F
Site 34
S273
S
S
K
E
M
P
Q
S
F
S
A
I
T
L
S
Site 35
S275
K
E
M
P
Q
S
F
S
A
I
T
L
S
N
T
Site 36
S280
S
F
S
A
I
T
L
S
N
T
E
M
N
N
I
Site 37
T314
H
K
I
A
T
K
R
T
P
H
K
E
D
E
A
Site 38
S323
H
K
E
D
E
A
M
S
C
S
E
N
C
S
S
Site 39
S325
E
D
E
A
M
S
C
S
E
N
C
S
S
A
Q
Site 40
S329
M
S
C
S
E
N
C
S
S
A
Q
G
D
S
L
Site 41
S330
S
C
S
E
N
C
S
S
A
Q
G
D
S
L
Q
Site 42
S335
C
S
S
A
Q
G
D
S
L
Q
D
E
S
Q
G
Site 43
S340
G
D
S
L
Q
D
E
S
Q
G
S
H
S
E
S
Site 44
S343
L
Q
D
E
S
Q
G
S
H
S
E
S
S
S
N
Site 45
S345
D
E
S
Q
G
S
H
S
E
S
S
S
N
P
S
Site 46
S347
S
Q
G
S
H
S
E
S
S
S
N
P
S
N
P
Site 47
S348
Q
G
S
H
S
E
S
S
S
N
P
S
N
P
E
Site 48
S349
G
S
H
S
E
S
S
S
N
P
S
N
P
E
T
Site 49
S352
S
E
S
S
S
N
P
S
N
P
E
T
L
H
A
Site 50
T356
S
N
P
S
N
P
E
T
L
H
A
K
A
T
D
Site 51
T362
E
T
L
H
A
K
A
T
D
S
V
L
Q
G
S
Site 52
S364
L
H
A
K
A
T
D
S
V
L
Q
G
S
E
G
Site 53
T377
E
G
N
K
V
K
R
T
S
C
M
Y
G
A
N
Site 54
Y381
V
K
R
T
S
C
M
Y
G
A
N
C
Y
R
K
Site 55
S402
H
F
S
H
P
G
D
S
D
Y
G
G
V
Q
I
Site 56
Y404
S
H
P
G
D
S
D
Y
G
G
V
Q
I
V
G
Site 57
T415
Q
I
V
G
Q
D
E
T
D
D
R
P
E
C
P
Site 58
Y423
D
D
R
P
E
C
P
Y
G
P
S
C
Y
R
K
Site 59
T442
K
I
E
Y
R
H
N
T
L
P
V
R
N
V
L
Site 60
S467
N
E
Y
D
L
N
D
S
F
L
D
D
E
E
E
Site 61
Y476
L
D
D
E
E
E
D
Y
E
P
T
D
E
D
S
Site 62
S483
Y
E
P
T
D
E
D
S
D
W
E
P
G
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation