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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HERC6
Full Name:
Probable E3 ubiquitin-protein ligase HERC6
Alias:
HECT domain and RCC1-like domain-containing protein 6
Type:
Mass (Da):
115126
Number AA:
1022
UniProt ID:
Q8IVU3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
R
E
L
Q
R
R
R
T
A
G
S
P
G
A
E
Site 2
S20
Q
R
R
R
T
A
G
S
P
G
A
E
L
L
Q
Site 3
S30
A
E
L
L
Q
A
A
S
G
E
R
H
S
L
L
Site 4
S35
A
A
S
G
E
R
H
S
L
L
L
L
T
N
H
Site 5
S46
L
T
N
H
R
V
L
S
C
G
D
N
S
R
G
Site 6
S87
V
S
C
G
K
E
H
S
L
A
V
C
H
K
G
Site 7
S116
I
G
E
F
K
E
I
S
F
T
P
K
K
I
M
Site 8
T118
E
F
K
E
I
S
F
T
P
K
K
I
M
T
L
Site 9
T124
F
T
P
K
K
I
M
T
L
N
D
I
K
I
I
Site 10
Y138
I
Q
V
S
C
G
H
Y
H
S
L
A
L
S
K
Site 11
S140
V
S
C
G
H
Y
H
S
L
A
L
S
K
D
S
Site 12
S144
H
Y
H
S
L
A
L
S
K
D
S
Q
V
F
S
Site 13
S147
S
L
A
L
S
K
D
S
Q
V
F
S
W
G
K
Site 14
S151
S
K
D
S
Q
V
F
S
W
G
K
N
S
H
G
Site 15
S156
V
F
S
W
G
K
N
S
H
G
Q
L
G
L
G
Site 16
S168
G
L
G
K
E
F
P
S
Q
A
S
P
Q
R
V
Site 17
S171
K
E
F
P
S
Q
A
S
P
Q
R
V
R
S
L
Site 18
S177
A
S
P
Q
R
V
R
S
L
E
G
I
P
L
A
Site 19
S207
G
T
S
F
G
W
G
S
N
S
A
G
Q
L
A
Site 20
S209
S
F
G
W
G
S
N
S
A
G
Q
L
A
L
S
Site 21
S216
S
A
G
Q
L
A
L
S
G
R
N
V
P
V
Q
Site 22
S224
G
R
N
V
P
V
Q
S
N
K
P
L
S
V
G
Site 23
S229
V
Q
S
N
K
P
L
S
V
G
A
L
K
N
L
Site 24
T259
T
Q
D
G
K
V
F
T
F
G
D
N
R
S
G
Site 25
S265
F
T
F
G
D
N
R
S
G
Q
L
G
Y
S
P
Site 26
S271
R
S
G
Q
L
G
Y
S
P
T
P
E
K
R
G
Site 27
T273
G
Q
L
G
Y
S
P
T
P
E
K
R
G
P
Q
Site 28
S290
E
R
I
D
G
L
V
S
Q
I
D
C
G
S
Y
Site 29
Y302
G
S
Y
H
T
L
A
Y
V
H
T
T
G
Q
V
Site 30
S311
H
T
T
G
Q
V
V
S
F
G
H
G
P
S
D
Site 31
S317
V
S
F
G
H
G
P
S
D
T
S
K
P
T
H
Site 32
T319
F
G
H
G
P
S
D
T
S
K
P
T
H
P
E
Site 33
T329
P
T
H
P
E
A
L
T
E
N
F
D
I
S
C
Site 34
S367
V
T
T
H
Q
D
T
S
S
T
R
A
P
G
K
Site 35
S368
T
T
H
Q
D
T
S
S
T
R
A
P
G
K
T
Site 36
T375
S
T
R
A
P
G
K
T
L
P
E
I
S
R
I
Site 37
S380
G
K
T
L
P
E
I
S
R
I
S
Q
S
M
A
Site 38
S383
L
P
E
I
S
R
I
S
Q
S
M
A
E
K
W
Site 39
S385
E
I
S
R
I
S
Q
S
M
A
E
K
W
I
A
Site 40
S397
W
I
A
V
K
R
R
S
T
E
H
E
M
A
K
Site 41
T398
I
A
V
K
R
R
S
T
E
H
E
M
A
K
S
Site 42
S405
T
E
H
E
M
A
K
S
E
I
R
M
I
F
S
Site 43
S420
S
P
A
C
L
T
A
S
F
L
K
K
R
G
T
Site 44
T427
S
F
L
K
K
R
G
T
G
E
T
T
S
I
D
Site 45
T430
K
K
R
G
T
G
E
T
T
S
I
D
V
D
L
Site 46
S432
R
G
T
G
E
T
T
S
I
D
V
D
L
E
M
Site 47
T443
D
L
E
M
A
R
D
T
F
K
K
L
T
K
K
Site 48
S473
L
R
A
L
P
C
H
S
P
H
Q
E
A
L
S
Site 49
S515
V
C
E
M
S
K
Q
S
L
Q
V
L
K
K
C
Site 50
T583
N
C
R
L
P
E
N
T
F
N
I
N
E
L
S
Site 51
Y596
L
S
N
L
L
N
F
Y
I
D
R
G
R
Q
L
Site 52
S640
I
K
L
L
Q
A
D
S
H
I
K
M
Q
M
S
Site 53
Y652
Q
M
S
E
K
K
A
Y
M
L
M
H
E
T
I
Site 54
S669
K
K
D
E
F
P
P
S
P
R
F
I
L
R
V
Site 55
S690
K
D
A
L
R
Q
L
S
Q
A
E
A
T
D
F
Site 56
S713
I
N
E
I
C
P
E
S
G
G
V
S
S
E
F
Site 57
Y733
E
E
M
T
K
P
E
Y
G
M
F
M
Y
P
E
Site 58
Y758
P
K
P
E
K
K
R
Y
F
L
F
G
M
L
C
Site 59
Y784
L
P
F
P
L
A
L
Y
K
K
L
L
D
Q
K
Site 60
S793
K
L
L
D
Q
K
P
S
L
E
D
L
K
E
L
Site 61
S801
L
E
D
L
K
E
L
S
P
R
L
G
K
S
L
Site 62
S807
L
S
P
R
L
G
K
S
L
Q
E
V
L
D
D
Site 63
Y855
D
Q
T
N
K
R
D
Y
V
S
K
Y
I
D
Y
Site 64
Y859
K
R
D
Y
V
S
K
Y
I
D
Y
I
F
N
V
Site 65
Y862
Y
V
S
K
Y
I
D
Y
I
F
N
V
S
V
K
Site 66
Y880
E
E
F
Q
R
G
F
Y
R
V
C
E
K
E
I
Site 67
Y892
K
E
I
L
R
H
F
Y
P
E
E
L
M
T
A
Site 68
Y906
A
I
I
G
N
T
D
Y
D
W
K
Q
F
E
Q
Site 69
Y917
Q
F
E
Q
N
S
K
Y
E
Q
G
Y
Q
K
S
Site 70
T951
K
K
F
L
F
F
L
T
G
R
D
R
L
H
A
Site 71
T973
I
V
F
R
C
P
E
T
F
S
E
R
D
H
P
Site 72
S975
F
R
C
P
E
T
F
S
E
R
D
H
P
T
S
Site 73
S982
S
E
R
D
H
P
T
S
I
T
C
H
N
I
L
Site 74
Y994
N
I
L
S
L
P
K
Y
S
T
M
E
R
M
E
Site 75
T996
L
S
L
P
K
Y
S
T
M
E
R
M
E
E
A
Site 76
S1016
N
N
N
R
G
F
V
S
P
M
L
T
Q
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation