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Updated November 2019
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Protein Info
Short Name:
NAV2
Full Name:
Neuron navigator 2
Alias:
FLJ10633; FLJ11030; FLJ23707; HELAD1; Helicase APC down-regulated 1; Helicase, APC down-regulated 1; KIAA1419; Neuron navigator 2; POMFIL2; Pore membrane and/or filament interacting like protein 2; Pore membrane and/or filament-interacting-like protein 2; RAINB1; Retinoic acid inducible gene in neuroblastoma 1; Retinoic acid inducible in neuroblastoma 1; Steerin2; Steerin-2; Unc-53 homolog 2; Unc53H2
Type:
EC 3.6.1.-; Extracellular matrix; Helicase
Mass (Da):
268133
Number AA:
2488
UniProt ID:
Q8IVL1
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004386
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
L
V
A
S
K
M
K
S
G
L
P
K
P
V
H
Site 2
Y38
R
A
G
P
Q
P
C
Y
L
K
L
G
S
K
V
Site 3
S48
L
G
S
K
V
E
V
S
K
T
T
Y
P
S
Q
Site 4
T50
S
K
V
E
V
S
K
T
T
Y
P
S
Q
I
P
Site 5
Y52
V
E
V
S
K
T
T
Y
P
S
Q
I
P
L
K
Site 6
S54
V
S
K
T
T
Y
P
S
Q
I
P
L
K
S
Q
Site 7
S60
P
S
Q
I
P
L
K
S
Q
V
L
Q
G
L
Q
Site 8
S79
E
G
L
P
L
R
K
S
G
S
V
E
N
G
F
Site 9
S81
L
P
L
R
K
S
G
S
V
E
N
G
F
D
T
Site 10
Y98
Y
T
D
W
A
N
H
Y
L
T
K
S
G
H
K
Site 11
S102
A
N
H
Y
L
T
K
S
G
H
K
R
L
I
K
Site 12
T116
K
D
L
Q
Q
D
V
T
D
G
V
L
L
A
Q
Site 13
S168
G
I
N
I
Q
G
L
S
A
E
E
I
R
N
G
Site 14
S188
L
G
L
F
F
S
L
S
R
Y
K
Q
Q
Q
Q
Site 15
Y190
L
F
F
S
L
S
R
Y
K
Q
Q
Q
Q
Q
P
Site 16
S203
Q
P
Q
K
Q
H
L
S
S
P
L
P
P
A
V
Site 17
S204
P
Q
K
Q
H
L
S
S
P
L
P
P
A
V
S
Site 18
S218
S
Q
V
A
G
A
P
S
Q
C
Q
A
G
T
P
Site 19
T224
P
S
Q
C
Q
A
G
T
P
Q
Q
Q
V
P
V
Site 20
T232
P
Q
Q
Q
V
P
V
T
P
Q
A
P
C
Q
P
Site 21
S256
K
A
Q
A
E
M
Q
S
S
A
S
S
K
D
S
Site 22
S257
A
Q
A
E
M
Q
S
S
A
S
S
K
D
S
S
Site 23
S259
A
E
M
Q
S
S
A
S
S
K
D
S
S
Q
S
Site 24
S260
E
M
Q
S
S
A
S
S
K
D
S
S
Q
S
K
Site 25
S263
S
S
A
S
S
K
D
S
S
Q
S
K
I
I
R
Site 26
S264
S
A
S
S
K
D
S
S
Q
S
K
I
I
R
F
Site 27
S266
S
S
K
D
S
S
Q
S
K
I
I
R
F
T
L
Site 28
T272
Q
S
K
I
I
R
F
T
L
G
Q
K
K
I
S
Site 29
S282
Q
K
K
I
S
R
L
S
G
P
T
A
R
V
S
Site 30
S289
S
G
P
T
A
R
V
S
A
A
G
S
E
A
K
Site 31
S293
A
R
V
S
A
A
G
S
E
A
K
T
R
G
G
Site 32
T297
A
A
G
S
E
A
K
T
R
G
G
S
T
T
A
Site 33
S301
E
A
K
T
R
G
G
S
T
T
A
N
N
R
R
Site 34
T303
K
T
R
G
G
S
T
T
A
N
N
R
R
S
Q
Site 35
S309
T
T
A
N
N
R
R
S
Q
S
F
N
N
Y
D
Site 36
S311
A
N
N
R
R
S
Q
S
F
N
N
Y
D
K
S
Site 37
Y315
R
S
Q
S
F
N
N
Y
D
K
S
K
P
V
T
Site 38
S318
S
F
N
N
Y
D
K
S
K
P
V
T
S
P
P
Site 39
T322
Y
D
K
S
K
P
V
T
S
P
P
P
P
P
S
Site 40
S323
D
K
S
K
P
V
T
S
P
P
P
P
P
S
S
Site 41
S329
T
S
P
P
P
P
P
S
S
H
E
K
E
P
L
Site 42
S330
S
P
P
P
P
P
S
S
H
E
K
E
P
L
A
Site 43
S338
H
E
K
E
P
L
A
S
S
A
S
S
H
P
G
Site 44
S339
E
K
E
P
L
A
S
S
A
S
S
H
P
G
M
Site 45
S341
E
P
L
A
S
S
A
S
S
H
P
G
M
S
D
Site 46
S342
P
L
A
S
S
A
S
S
H
P
G
M
S
D
N
Site 47
S347
A
S
S
H
P
G
M
S
D
N
A
P
A
S
L
Site 48
S353
M
S
D
N
A
P
A
S
L
E
S
G
S
S
S
Site 49
S356
N
A
P
A
S
L
E
S
G
S
S
S
T
P
T
Site 50
S358
P
A
S
L
E
S
G
S
S
S
T
P
T
N
C
Site 51
S359
A
S
L
E
S
G
S
S
S
T
P
T
N
C
S
Site 52
S360
S
L
E
S
G
S
S
S
T
P
T
N
C
S
T
Site 53
T361
L
E
S
G
S
S
S
T
P
T
N
C
S
T
S
Site 54
T363
S
G
S
S
S
T
P
T
N
C
S
T
S
S
A
Site 55
S366
S
S
T
P
T
N
C
S
T
S
S
A
I
P
Q
Site 56
T367
S
T
P
T
N
C
S
T
S
S
A
I
P
Q
P
Site 57
S369
P
T
N
C
S
T
S
S
A
I
P
Q
P
G
A
Site 58
S383
A
A
T
K
P
W
R
S
K
S
L
S
V
K
H
Site 59
S385
T
K
P
W
R
S
K
S
L
S
V
K
H
S
A
Site 60
S387
P
W
R
S
K
S
L
S
V
K
H
S
A
T
V
Site 61
S391
K
S
L
S
V
K
H
S
A
T
V
S
M
L
S
Site 62
S395
V
K
H
S
A
T
V
S
M
L
S
V
K
P
P
Site 63
S398
S
A
T
V
S
M
L
S
V
K
P
P
G
P
E
Site 64
T410
G
P
E
A
P
R
P
T
P
E
A
M
K
P
A
Site 65
S423
P
A
P
N
N
Q
K
S
M
L
E
K
L
K
L
Site 66
S433
E
K
L
K
L
F
N
S
K
G
G
S
K
A
G
Site 67
S437
L
F
N
S
K
G
G
S
K
A
G
E
G
P
G
Site 68
S445
K
A
G
E
G
P
G
S
R
D
T
S
C
E
R
Site 69
T448
E
G
P
G
S
R
D
T
S
C
E
R
L
E
T
Site 70
S449
G
P
G
S
R
D
T
S
C
E
R
L
E
T
L
Site 71
T455
T
S
C
E
R
L
E
T
L
P
S
F
E
E
S
Site 72
S458
E
R
L
E
T
L
P
S
F
E
E
S
E
E
L
Site 73
S462
T
L
P
S
F
E
E
S
E
E
L
E
A
A
S
Site 74
T473
E
A
A
S
R
M
L
T
T
V
G
P
A
S
S
Site 75
S479
L
T
T
V
G
P
A
S
S
S
P
K
I
A
L
Site 76
S481
T
V
G
P
A
S
S
S
P
K
I
A
L
K
G
Site 77
T493
L
K
G
I
A
Q
R
T
F
S
R
A
L
T
N
Site 78
S495
G
I
A
Q
R
T
F
S
R
A
L
T
N
K
K
Site 79
T499
R
T
F
S
R
A
L
T
N
K
K
S
S
L
K
Site 80
S503
R
A
L
T
N
K
K
S
S
L
K
G
N
E
K
Site 81
S532
K
D
L
A
K
R
A
S
V
T
E
R
L
D
L
Site 82
S548
E
E
P
K
E
D
P
S
G
A
A
V
P
E
M
Site 83
S559
V
P
E
M
P
K
K
S
S
K
I
A
S
F
I
Site 84
S560
P
E
M
P
K
K
S
S
K
I
A
S
F
I
P
Site 85
S564
K
K
S
S
K
I
A
S
F
I
P
K
G
G
K
Site 86
S574
P
K
G
G
K
L
N
S
A
K
K
E
P
M
A
Site 87
S583
K
K
E
P
M
A
P
S
H
S
G
I
P
K
P
Site 88
S585
E
P
M
A
P
S
H
S
G
I
P
K
P
G
M
Site 89
S594
I
P
K
P
G
M
K
S
M
P
G
K
S
P
S
Site 90
S599
M
K
S
M
P
G
K
S
P
S
A
P
A
P
S
Site 91
S601
S
M
P
G
K
S
P
S
A
P
A
P
S
K
E
Site 92
S606
S
P
S
A
P
A
P
S
K
E
G
E
R
S
R
Site 93
S612
P
S
K
E
G
E
R
S
R
S
G
K
L
S
S
Site 94
S614
K
E
G
E
R
S
R
S
G
K
L
S
S
G
L
Site 95
S618
R
S
R
S
G
K
L
S
S
G
L
P
Q
Q
K
Site 96
S619
S
R
S
G
K
L
S
S
G
L
P
Q
Q
K
P
Site 97
S633
P
Q
L
D
G
R
H
S
S
S
S
S
S
L
A
Site 98
S634
Q
L
D
G
R
H
S
S
S
S
S
S
L
A
S
Site 99
S635
L
D
G
R
H
S
S
S
S
S
S
L
A
S
S
Site 100
S636
D
G
R
H
S
S
S
S
S
S
L
A
S
S
E
Site 101
S637
G
R
H
S
S
S
S
S
S
L
A
S
S
E
G
Site 102
S638
R
H
S
S
S
S
S
S
L
A
S
S
E
G
K
Site 103
S641
S
S
S
S
S
L
A
S
S
E
G
K
G
P
G
Site 104
S642
S
S
S
S
L
A
S
S
E
G
K
G
P
G
G
Site 105
T651
G
K
G
P
G
G
T
T
L
N
H
S
I
S
S
Site 106
S655
G
G
T
T
L
N
H
S
I
S
S
Q
T
V
S
Site 107
S657
T
T
L
N
H
S
I
S
S
Q
T
V
S
G
S
Site 108
S658
T
L
N
H
S
I
S
S
Q
T
V
S
G
S
V
Site 109
T660
N
H
S
I
S
S
Q
T
V
S
G
S
V
G
T
Site 110
S662
S
I
S
S
Q
T
V
S
G
S
V
G
T
T
Q
Site 111
T668
V
S
G
S
V
G
T
T
Q
T
T
G
S
N
T
Site 112
S673
G
T
T
Q
T
T
G
S
N
T
V
S
V
Q
L
Site 113
T675
T
Q
T
T
G
S
N
T
V
S
V
Q
L
P
Q
Site 114
S677
T
T
G
S
N
T
V
S
V
Q
L
P
Q
P
Q
Site 115
Y687
L
P
Q
P
Q
Q
Q
Y
N
H
P
N
T
A
T
Site 116
T692
Q
Q
Y
N
H
P
N
T
A
T
V
A
P
F
L
Site 117
T694
Y
N
H
P
N
T
A
T
V
A
P
F
L
Y
R
Site 118
S702
V
A
P
F
L
Y
R
S
Q
T
D
T
E
G
N
Site 119
T704
P
F
L
Y
R
S
Q
T
D
T
E
G
N
V
T
Site 120
T706
L
Y
R
S
Q
T
D
T
E
G
N
V
T
A
E
Site 121
T711
T
D
T
E
G
N
V
T
A
E
S
S
S
T
G
Site 122
S715
G
N
V
T
A
E
S
S
S
T
G
V
S
V
E
Site 123
S716
N
V
T
A
E
S
S
S
T
G
V
S
V
E
P
Site 124
T717
V
T
A
E
S
S
S
T
G
V
S
V
E
P
S
Site 125
S720
E
S
S
S
T
G
V
S
V
E
P
S
H
F
T
Site 126
S724
T
G
V
S
V
E
P
S
H
F
T
K
T
G
Q
Site 127
T729
E
P
S
H
F
T
K
T
G
Q
P
A
L
E
E
Site 128
T749
P
E
A
R
R
L
R
T
V
K
N
I
A
D
L
Site 129
S765
Q
N
L
E
E
T
M
S
S
L
R
G
T
Q
V
Site 130
S766
N
L
E
E
T
M
S
S
L
R
G
T
Q
V
T
Site 131
T770
T
M
S
S
L
R
G
T
Q
V
T
H
S
T
L
Site 132
T773
S
L
R
G
T
Q
V
T
H
S
T
L
E
T
T
Site 133
S775
R
G
T
Q
V
T
H
S
T
L
E
T
T
F
D
Site 134
T779
V
T
H
S
T
L
E
T
T
F
D
T
N
V
T
Site 135
T786
T
T
F
D
T
N
V
T
T
E
M
S
G
R
S
Site 136
S790
T
N
V
T
T
E
M
S
G
R
S
I
L
S
L
Site 137
S796
M
S
G
R
S
I
L
S
L
T
G
R
P
T
P
Site 138
T798
G
R
S
I
L
S
L
T
G
R
P
T
P
L
S
Site 139
T802
L
S
L
T
G
R
P
T
P
L
S
W
R
L
G
Site 140
S805
T
G
R
P
T
P
L
S
W
R
L
G
Q
S
S
Site 141
S811
L
S
W
R
L
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G
F
D
G
Y
S
M
P
R
E
G
S
T
Site 446
S2432
Y
S
M
P
R
E
G
S
T
S
K
Q
M
P
P
Site 447
T2433
S
M
P
R
E
G
S
T
S
K
Q
M
P
P
S
Site 448
S2434
M
P
R
E
G
S
T
S
K
Q
M
P
P
S
D
Site 449
S2440
T
S
K
Q
M
P
P
S
D
A
E
G
D
P
L
Site 450
Y2460
R
L
Q
E
A
A
N
Y
S
S
P
Q
S
Y
D
Site 451
S2461
L
Q
E
A
A
N
Y
S
S
P
Q
S
Y
D
S
Site 452
S2462
Q
E
A
A
N
Y
S
S
P
Q
S
Y
D
S
D
Site 453
S2465
A
N
Y
S
S
P
Q
S
Y
D
S
D
S
N
S
Site 454
Y2466
N
Y
S
S
P
Q
S
Y
D
S
D
S
N
S
N
Site 455
S2468
S
S
P
Q
S
Y
D
S
D
S
N
S
N
S
H
Site 456
S2470
P
Q
S
Y
D
S
D
S
N
S
N
S
H
H
D
Site 457
S2472
S
Y
D
S
D
S
N
S
N
S
H
H
D
D
I
Site 458
S2474
D
S
D
S
N
S
N
S
H
H
D
D
I
L
D
Site 459
S2482
H
H
D
D
I
L
D
S
S
L
E
S
T
L
_
Site 460
S2483
H
D
D
I
L
D
S
S
L
E
S
T
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation