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Updated November 2019
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Protein Info
Short Name:
Tiam2
Full Name:
T-lymphoma invasion and metastasis-inducing protein 2
Alias:
SIF and TIAM1-like exchange factor; STEF; T-cell lymphoma invasion and metastasis 2; TIAM-2
Type:
GTPase activating protein, misc.; Guanine nucleotide exchange factor, Rac/Rho; Apoptosis
Mass (Da):
193408
Number AA:
1730
UniProt ID:
Q8IVF5
International Prot ID:
IPI00018363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0030175
GO:0030426
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0005515
GO:0005057
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
N
S
D
S
Q
Y
T
L
Q
G
S
Site 2
Y8
M
G
N
S
D
S
Q
Y
T
L
Q
G
S
K
N
Site 3
T9
G
N
S
D
S
Q
Y
T
L
Q
G
S
K
N
H
Site 4
S17
L
Q
G
S
K
N
H
S
N
T
I
T
G
A
K
Site 5
T21
K
N
H
S
N
T
I
T
G
A
K
Q
I
P
C
Site 6
S29
G
A
K
Q
I
P
C
S
L
K
I
R
G
I
H
Site 7
S50
L
H
G
W
G
H
G
S
N
G
A
G
Y
K
S
Site 8
Y55
H
G
S
N
G
A
G
Y
K
S
R
S
L
A
R
Site 9
S57
S
N
G
A
G
Y
K
S
R
S
L
A
R
S
C
Site 10
S59
G
A
G
Y
K
S
R
S
L
A
R
S
C
L
S
Site 11
S63
K
S
R
S
L
A
R
S
C
L
S
H
F
K
S
Site 12
S66
S
L
A
R
S
C
L
S
H
F
K
S
N
Q
P
Site 13
S70
S
C
L
S
H
F
K
S
N
Q
P
Y
A
S
R
Site 14
Y74
H
F
K
S
N
Q
P
Y
A
S
R
L
G
G
P
Site 15
S76
K
S
N
Q
P
Y
A
S
R
L
G
G
P
T
C
Site 16
T82
A
S
R
L
G
G
P
T
C
K
V
S
R
G
V
Site 17
S86
G
G
P
T
C
K
V
S
R
G
V
A
Y
S
T
Site 18
S92
V
S
R
G
V
A
Y
S
T
H
R
T
N
A
P
Site 19
T93
S
R
G
V
A
Y
S
T
H
R
T
N
A
P
G
Site 20
T96
V
A
Y
S
T
H
R
T
N
A
P
G
K
D
F
Site 21
S107
G
K
D
F
Q
G
I
S
A
A
F
S
T
E
N
Site 22
S111
Q
G
I
S
A
A
F
S
T
E
N
G
F
H
S
Site 23
S118
S
T
E
N
G
F
H
S
V
G
H
E
L
A
D
Site 24
Y141
N
G
H
L
L
N
C
Y
G
R
N
E
S
I
A
Site 25
S146
N
C
Y
G
R
N
E
S
I
A
S
T
P
P
G
Site 26
S149
G
R
N
E
S
I
A
S
T
P
P
G
E
D
R
Site 27
T150
R
N
E
S
I
A
S
T
P
P
G
E
D
R
K
Site 28
S158
P
P
G
E
D
R
K
S
P
R
V
L
I
K
T
Site 29
S184
F
H
N
G
G
N
P
S
K
V
P
A
E
D
C
Site 30
S192
K
V
P
A
E
D
C
S
E
P
V
Q
L
L
R
Site 31
S201
P
V
Q
L
L
R
Y
S
P
T
L
A
S
E
T
Site 32
T203
Q
L
L
R
Y
S
P
T
L
A
S
E
T
S
P
Site 33
S206
R
Y
S
P
T
L
A
S
E
T
S
P
V
P
E
Site 34
S209
P
T
L
A
S
E
T
S
P
V
P
E
A
R
R
Site 35
S218
V
P
E
A
R
R
G
S
S
A
D
S
L
P
S
Site 36
S219
P
E
A
R
R
G
S
S
A
D
S
L
P
S
H
Site 37
S222
R
R
G
S
S
A
D
S
L
P
S
H
R
P
S
Site 38
S225
S
S
A
D
S
L
P
S
H
R
P
S
P
T
D
Site 39
S229
S
L
P
S
H
R
P
S
P
T
D
S
R
L
R
Site 40
T231
P
S
H
R
P
S
P
T
D
S
R
L
R
S
S
Site 41
S233
H
R
P
S
P
T
D
S
R
L
R
S
S
K
G
Site 42
S237
P
T
D
S
R
L
R
S
S
K
G
S
S
L
S
Site 43
S238
T
D
S
R
L
R
S
S
K
G
S
S
L
S
S
Site 44
S241
R
L
R
S
S
K
G
S
S
L
S
S
E
S
S
Site 45
S242
L
R
S
S
K
G
S
S
L
S
S
E
S
S
W
Site 46
S244
S
S
K
G
S
S
L
S
S
E
S
S
W
Y
D
Site 47
S245
S
K
G
S
S
L
S
S
E
S
S
W
Y
D
S
Site 48
S247
G
S
S
L
S
S
E
S
S
W
Y
D
S
P
W
Site 49
S248
S
S
L
S
S
E
S
S
W
Y
D
S
P
W
G
Site 50
Y250
L
S
S
E
S
S
W
Y
D
S
P
W
G
N
A
Site 51
S252
S
E
S
S
W
Y
D
S
P
W
G
N
A
G
E
Site 52
S261
W
G
N
A
G
E
L
S
E
A
E
G
S
F
L
Site 53
S266
E
L
S
E
A
E
G
S
F
L
A
P
G
M
P
Site 54
S276
A
P
G
M
P
D
P
S
L
H
A
S
F
P
P
Site 55
S280
P
D
P
S
L
H
A
S
F
P
P
G
D
A
K
Site 56
S293
A
K
K
P
F
N
Q
S
S
S
L
S
S
L
R
Site 57
S294
K
K
P
F
N
Q
S
S
S
L
S
S
L
R
E
Site 58
S295
K
P
F
N
Q
S
S
S
L
S
S
L
R
E
L
Site 59
S297
F
N
Q
S
S
S
L
S
S
L
R
E
L
Y
K
Site 60
S298
N
Q
S
S
S
L
S
S
L
R
E
L
Y
K
D
Site 61
Y303
L
S
S
L
R
E
L
Y
K
D
A
N
L
G
S
Site 62
S310
Y
K
D
A
N
L
G
S
L
S
P
S
G
I
R
Site 63
S312
D
A
N
L
G
S
L
S
P
S
G
I
R
L
S
Site 64
S314
N
L
G
S
L
S
P
S
G
I
R
L
S
D
E
Site 65
S319
S
P
S
G
I
R
L
S
D
E
Y
M
G
T
H
Site 66
Y322
G
I
R
L
S
D
E
Y
M
G
T
H
A
S
L
Site 67
T325
L
S
D
E
Y
M
G
T
H
A
S
L
S
N
R
Site 68
S328
E
Y
M
G
T
H
A
S
L
S
N
R
V
S
F
Site 69
S330
M
G
T
H
A
S
L
S
N
R
V
S
F
A
S
Site 70
S337
S
N
R
V
S
F
A
S
D
I
D
V
P
S
R
Site 71
S343
A
S
D
I
D
V
P
S
R
V
A
H
G
D
P
Site 72
Y353
A
H
G
D
P
I
Q
Y
S
S
F
T
L
P
C
Site 73
S354
H
G
D
P
I
Q
Y
S
S
F
T
L
P
C
R
Site 74
S355
G
D
P
I
Q
Y
S
S
F
T
L
P
C
R
K
Site 75
T370
P
K
A
F
V
E
D
T
A
K
K
D
S
L
K
Site 76
S384
K
A
R
M
R
R
I
S
D
W
T
G
S
L
S
Site 77
T387
M
R
R
I
S
D
W
T
G
S
L
S
R
K
K
Site 78
S389
R
I
S
D
W
T
G
S
L
S
R
K
K
R
K
Site 79
S391
S
D
W
T
G
S
L
S
R
K
K
R
K
L
Q
Site 80
S402
R
K
L
Q
E
P
R
S
K
E
G
S
D
Y
F
Site 81
S406
E
P
R
S
K
E
G
S
D
Y
F
D
S
R
S
Site 82
Y408
R
S
K
E
G
S
D
Y
F
D
S
R
S
D
G
Site 83
S411
E
G
S
D
Y
F
D
S
R
S
D
G
L
N
T
Site 84
S413
S
D
Y
F
D
S
R
S
D
G
L
N
T
D
V
Site 85
T418
S
R
S
D
G
L
N
T
D
V
Q
G
S
S
Q
Site 86
S424
N
T
D
V
Q
G
S
S
Q
A
S
A
F
L
W
Site 87
S427
V
Q
G
S
S
Q
A
S
A
F
L
W
S
G
G
Site 88
S435
A
F
L
W
S
G
G
S
T
Q
I
L
S
Q
R
Site 89
T436
F
L
W
S
G
G
S
T
Q
I
L
S
Q
R
S
Site 90
S440
G
G
S
T
Q
I
L
S
Q
R
S
E
S
T
H
Site 91
S445
I
L
S
Q
R
S
E
S
T
H
A
I
G
S
D
Site 92
Y459
D
P
L
R
Q
N
I
Y
E
N
F
M
R
E
L
Site 93
S469
F
M
R
E
L
E
M
S
R
T
N
T
E
N
I
Site 94
T471
R
E
L
E
M
S
R
T
N
T
E
N
I
E
T
Site 95
T473
L
E
M
S
R
T
N
T
E
N
I
E
T
S
T
Site 96
T482
N
I
E
T
S
T
E
T
A
E
S
S
S
E
S
Site 97
S485
T
S
T
E
T
A
E
S
S
S
E
S
L
S
S
Site 98
S486
S
T
E
T
A
E
S
S
S
E
S
L
S
S
L
Site 99
S487
T
E
T
A
E
S
S
S
E
S
L
S
S
L
E
Site 100
S489
T
A
E
S
S
S
E
S
L
S
S
L
E
Q
L
Site 101
S491
E
S
S
S
E
S
L
S
S
L
E
Q
L
D
L
Site 102
S492
S
S
S
E
S
L
S
S
L
E
Q
L
D
L
L
Site 103
Y538
A
R
R
K
W
K
Q
Y
W
V
T
L
K
G
C
Site 104
Y550
K
G
C
T
L
L
F
Y
E
T
Y
G
K
N
S
Site 105
Y553
T
L
L
F
Y
E
T
Y
G
K
N
S
M
D
Q
Site 106
S557
Y
E
T
Y
G
K
N
S
M
D
Q
S
S
A
P
Site 107
S561
G
K
N
S
M
D
Q
S
S
A
P
R
C
A
L
Site 108
S562
K
N
S
M
D
Q
S
S
A
P
R
C
A
L
F
Site 109
S577
A
E
D
S
I
V
Q
S
V
P
E
H
P
K
K
Site 110
Y598
S
N
S
F
G
D
V
Y
L
F
Q
A
T
S
Q
Site 111
S604
V
Y
L
F
Q
A
T
S
Q
T
D
L
E
N
W
Site 112
T632
K
K
H
G
K
E
D
T
L
R
L
L
K
N
Q
Site 113
S651
L
Q
K
I
D
M
D
S
K
M
K
K
M
A
E
Site 114
S662
K
M
A
E
L
Q
L
S
V
V
S
D
P
K
N
Site 115
S700
R
M
R
C
Y
L
A
S
L
Q
G
G
E
L
P
Site 116
S711
G
E
L
P
N
P
K
S
L
L
A
A
A
S
R
Site 117
S741
S
F
H
A
L
V
C
S
R
D
D
S
A
L
R
Site 118
S745
L
V
C
S
R
D
D
S
A
L
R
K
R
T
L
Site 119
T751
D
S
A
L
R
K
R
T
L
S
L
T
Q
R
G
Site 120
S753
A
L
R
K
R
T
L
S
L
T
Q
R
G
R
N
Site 121
T755
R
K
R
T
L
S
L
T
Q
R
G
R
N
K
K
Site 122
S767
N
K
K
G
I
F
S
S
L
K
G
L
D
T
L
Site 123
T773
S
S
L
K
G
L
D
T
L
A
R
K
G
K
E
Site 124
S784
K
G
K
E
K
R
P
S
I
T
Q
V
D
E
L
Site 125
S797
E
L
L
H
I
Y
G
S
T
V
D
G
V
P
R
Site 126
T798
L
L
H
I
Y
G
S
T
V
D
G
V
P
R
D
Site 127
T823
F
Q
D
N
H
G
V
T
V
G
I
K
P
E
H
Site 128
T837
H
R
V
E
D
I
L
T
L
A
C
K
M
R
Q
Site 129
S848
K
M
R
Q
L
E
P
S
H
Y
G
L
Q
L
R
Site 130
Y850
R
Q
L
E
P
S
H
Y
G
L
Q
L
R
K
L
Site 131
Y864
L
V
D
D
N
V
E
Y
C
I
P
A
P
Y
E
Site 132
Y878
E
Y
M
Q
Q
Q
V
Y
D
E
I
E
V
F
P
Site 133
T894
N
V
Y
D
V
Q
L
T
K
T
G
S
V
C
D
Site 134
T896
Y
D
V
Q
L
T
K
T
G
S
V
C
D
F
G
Site 135
S962
K
Q
M
E
A
L
F
S
E
K
S
V
G
L
T
Site 136
T969
S
E
K
S
V
G
L
T
L
I
A
R
P
P
D
Site 137
T977
L
I
A
R
P
P
D
T
K
A
T
L
C
T
S
Site 138
T980
R
P
P
D
T
K
A
T
L
C
T
S
W
S
D
Site 139
S984
T
K
A
T
L
C
T
S
W
S
D
S
D
L
F
Site 140
S986
A
T
L
C
T
S
W
S
D
S
D
L
F
S
R
Site 141
S988
L
C
T
S
W
S
D
S
D
L
F
S
R
D
Q
Site 142
S992
W
S
D
S
D
L
F
S
R
D
Q
K
S
L
L
Site 143
S997
L
F
S
R
D
Q
K
S
L
L
P
P
P
N
Q
Site 144
S1024
K
N
T
A
N
D
F
S
N
V
P
D
I
T
T
Site 145
T1031
S
N
V
P
D
I
T
T
G
L
K
R
S
Q
T
Site 146
S1036
I
T
T
G
L
K
R
S
Q
T
D
G
T
L
D
Site 147
T1038
T
G
L
K
R
S
Q
T
D
G
T
L
D
Q
V
Site 148
T1041
K
R
S
Q
T
D
G
T
L
D
Q
V
S
H
R
Site 149
S1046
D
G
T
L
D
Q
V
S
H
R
E
K
M
E
Q
Site 150
T1054
H
R
E
K
M
E
Q
T
F
R
S
A
E
Q
I
Site 151
S1067
Q
I
T
A
L
C
R
S
F
N
D
S
Q
A
N
Site 152
S1071
L
C
R
S
F
N
D
S
Q
A
N
G
M
E
G
Site 153
S1095
R
P
L
A
R
H
L
S
D
A
D
R
L
R
K
Site 154
T1110
V
I
Q
E
L
V
D
T
E
K
S
Y
V
K
D
Site 155
S1113
E
L
V
D
T
E
K
S
Y
V
K
D
L
S
C
Site 156
Y1114
L
V
D
T
E
K
S
Y
V
K
D
L
S
C
L
Site 157
T1136
L
Q
N
E
T
F
L
T
Q
D
E
M
E
S
L
Site 158
S1142
L
T
Q
D
E
M
E
S
L
F
G
S
L
P
E
Site 159
S1166
E
T
L
E
D
G
I
S
A
S
S
D
F
N
T
Site 160
S1169
E
D
G
I
S
A
S
S
D
F
N
T
L
E
T
Site 161
T1173
S
A
S
S
D
F
N
T
L
E
T
P
S
Q
F
Site 162
T1176
S
D
F
N
T
L
E
T
P
S
Q
F
R
K
L
Site 163
S1178
F
N
T
L
E
T
P
S
Q
F
R
K
L
L
F
Site 164
T1220
K
V
L
E
R
A
K
T
D
K
A
F
K
A
F
Site 165
T1234
F
L
D
A
R
N
P
T
K
Q
H
S
S
T
L
Site 166
S1238
R
N
P
T
K
Q
H
S
S
T
L
E
S
Y
L
Site 167
S1239
N
P
T
K
Q
H
S
S
T
L
E
S
Y
L
I
Site 168
T1240
P
T
K
Q
H
S
S
T
L
E
S
Y
L
I
K
Site 169
S1243
Q
H
S
S
T
L
E
S
Y
L
I
K
P
V
Q
Site 170
S1264
L
L
L
K
E
L
V
S
L
T
D
Q
E
S
E
Site 171
T1266
L
K
E
L
V
S
L
T
D
Q
E
S
E
E
H
Site 172
S1270
V
S
L
T
D
Q
E
S
E
E
H
Y
H
L
T
Site 173
Y1274
D
Q
E
S
E
E
H
Y
H
L
T
E
A
L
K
Site 174
S1288
K
A
M
E
K
V
A
S
H
I
N
E
M
Q
K
Site 175
Y1297
I
N
E
M
Q
K
I
Y
E
D
Y
G
T
V
F
Site 176
Y1300
M
Q
K
I
Y
E
D
Y
G
T
V
F
D
Q
L
Site 177
T1302
K
I
Y
E
D
Y
G
T
V
F
D
Q
L
V
A
Site 178
T1314
L
V
A
E
Q
S
G
T
E
K
E
V
T
E
L
Site 179
T1319
S
G
T
E
K
E
V
T
E
L
S
M
G
E
L
Site 180
S1322
E
K
E
V
T
E
L
S
M
G
E
L
L
M
H
Site 181
S1340
S
W
L
N
P
F
L
S
L
G
K
A
R
K
D
Site 182
S1375
K
L
K
K
K
L
P
S
N
S
R
P
A
H
N
Site 183
S1377
K
K
K
L
P
S
N
S
R
P
A
H
N
S
T
Site 184
S1383
N
S
R
P
A
H
N
S
T
D
L
D
P
F
K
Site 185
T1410
R
L
G
N
P
A
G
T
E
N
N
S
I
W
E
Site 186
S1414
P
A
G
T
E
N
N
S
I
W
E
L
I
H
T
Site 187
T1421
S
I
W
E
L
I
H
T
K
S
E
I
E
G
R
Site 188
S1423
W
E
L
I
H
T
K
S
E
I
E
G
R
P
E
Site 189
T1431
E
I
E
G
R
P
E
T
I
F
Q
L
C
C
S
Site 190
S1438
T
I
F
Q
L
C
C
S
D
S
E
S
K
T
N
Site 191
S1440
F
Q
L
C
C
S
D
S
E
S
K
T
N
I
V
Site 192
S1442
L
C
C
S
D
S
E
S
K
T
N
I
V
K
V
Site 193
T1444
C
S
D
S
E
S
K
T
N
I
V
K
V
I
R
Site 194
S1452
N
I
V
K
V
I
R
S
I
L
R
E
N
F
R
Site 195
T1471
C
E
L
P
L
E
K
T
C
K
D
R
L
V
P
Site 196
S1486
L
K
N
R
V
P
V
S
A
K
L
A
S
S
R
Site 197
S1494
A
K
L
A
S
S
R
S
L
K
V
L
K
N
S
Site 198
S1501
S
L
K
V
L
K
N
S
S
S
N
E
W
T
G
Site 199
S1503
K
V
L
K
N
S
S
S
N
E
W
T
G
E
T
Site 200
T1507
N
S
S
S
N
E
W
T
G
E
T
G
K
G
T
Site 201
T1514
T
G
E
T
G
K
G
T
L
L
D
S
D
E
G
Site 202
S1518
G
K
G
T
L
L
D
S
D
E
G
S
L
S
S
Site 203
S1522
L
L
D
S
D
E
G
S
L
S
S
G
T
Q
S
Site 204
S1524
D
S
D
E
G
S
L
S
S
G
T
Q
S
S
G
Site 205
S1525
S
D
E
G
S
L
S
S
G
T
Q
S
S
G
C
Site 206
T1527
E
G
S
L
S
S
G
T
Q
S
S
G
C
P
T
Site 207
S1529
S
L
S
S
G
T
Q
S
S
G
C
P
T
A
E
Site 208
S1530
L
S
S
G
T
Q
S
S
G
C
P
T
A
E
G
Site 209
T1534
T
Q
S
S
G
C
P
T
A
E
G
R
Q
D
S
Site 210
S1541
T
A
E
G
R
Q
D
S
K
S
T
S
P
G
K
Site 211
S1543
E
G
R
Q
D
S
K
S
T
S
P
G
K
Y
P
Site 212
S1545
R
Q
D
S
K
S
T
S
P
G
K
Y
P
H
P
Site 213
Y1549
K
S
T
S
P
G
K
Y
P
H
P
G
L
A
D
Site 214
S1565
A
D
N
L
I
K
E
S
D
I
L
S
D
E
D
Site 215
S1569
I
K
E
S
D
I
L
S
D
E
D
D
D
H
R
Site 216
T1578
E
D
D
D
H
R
Q
T
V
K
Q
G
S
P
T
Site 217
S1583
R
Q
T
V
K
Q
G
S
P
T
K
D
I
E
I
Site 218
S1598
Q
F
Q
R
L
R
I
S
E
D
P
D
V
H
P
Site 219
S1615
E
Q
Q
P
G
P
E
S
G
E
G
Q
K
G
G
Site 220
S1641
P
I
K
R
K
A
N
S
T
K
R
D
R
G
T
Site 221
T1642
I
K
R
K
A
N
S
T
K
R
D
R
G
T
L
Site 222
T1648
S
T
K
R
D
R
G
T
L
L
K
A
Q
I
R
Site 223
S1658
K
A
Q
I
R
H
Q
S
L
D
S
Q
S
E
N
Site 224
S1661
I
R
H
Q
S
L
D
S
Q
S
E
N
A
T
I
Site 225
S1663
H
Q
S
L
D
S
Q
S
E
N
A
T
I
D
L
Site 226
T1667
D
S
Q
S
E
N
A
T
I
D
L
N
S
V
L
Site 227
S1672
N
A
T
I
D
L
N
S
V
L
E
R
E
F
S
Site 228
S1682
E
R
E
F
S
V
Q
S
L
T
S
V
V
S
E
Site 229
S1688
Q
S
L
T
S
V
V
S
E
E
C
F
Y
E
T
Site 230
Y1693
V
V
S
E
E
C
F
Y
E
T
E
S
H
G
K
Site 231
T1695
S
E
E
C
F
Y
E
T
E
S
H
G
K
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation