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Updated November 2019
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Protein Info
Short Name:
PLEKHH2
Full Name:
Pleckstrin homology domain-containing family H member 2
Alias:
Type:
Mass (Da):
168229
Number AA:
1493
UniProt ID:
Q8IVE3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
E
L
S
E
P
E
G
P
V
D
Site 2
S22
E
R
C
V
A
L
E
S
Q
L
M
K
F
R
V
Site 3
S32
M
K
F
R
V
Q
A
S
K
I
R
E
L
L
A
Site 4
S78
K
A
A
N
I
Q
T
S
E
S
E
T
R
L
Y
Site 5
S80
A
N
I
Q
T
S
E
S
E
T
R
L
Y
N
K
Site 6
Y85
S
E
S
E
T
R
L
Y
N
K
C
Q
D
L
E
Site 7
S93
N
K
C
Q
D
L
E
S
L
I
Q
E
K
D
D
Site 8
T161
N
Q
T
E
E
I
R
T
M
Q
S
K
L
Q
E
Site 9
S174
Q
E
V
Q
G
K
K
S
S
T
V
S
T
L
K
Site 10
S175
E
V
Q
G
K
K
S
S
T
V
S
T
L
K
L
Site 11
T176
V
Q
G
K
K
S
S
T
V
S
T
L
K
L
S
Site 12
S178
G
K
K
S
S
T
V
S
T
L
K
L
S
E
G
Site 13
T179
K
K
S
S
T
V
S
T
L
K
L
S
E
G
Q
Site 14
S183
T
V
S
T
L
K
L
S
E
G
Q
R
L
S
S
Site 15
S198
L
T
F
G
C
F
L
S
R
A
R
S
P
P
Q
Site 16
S202
C
F
L
S
R
A
R
S
P
P
Q
V
V
K
S
Site 17
S209
S
P
P
Q
V
V
K
S
E
E
M
S
K
I
S
Site 18
S213
V
V
K
S
E
E
M
S
K
I
S
S
K
E
P
Site 19
S217
E
E
M
S
K
I
S
S
K
E
P
E
F
T
E
Site 20
T223
S
S
K
E
P
E
F
T
E
G
K
D
M
E
E
Site 21
S237
E
M
E
I
P
E
K
S
V
D
N
Q
V
L
E
Site 22
T251
E
N
N
R
G
Q
R
T
L
H
Q
T
P
C
G
Site 23
T255
G
Q
R
T
L
H
Q
T
P
C
G
S
E
Q
N
Site 24
T265
G
S
E
Q
N
R
K
T
R
T
S
F
A
T
D
Site 25
S268
Q
N
R
K
T
R
T
S
F
A
T
D
G
G
I
Site 26
T271
K
T
R
T
S
F
A
T
D
G
G
I
S
Q
N
Site 27
S279
D
G
G
I
S
Q
N
S
G
A
P
V
S
D
W
Site 28
S284
Q
N
S
G
A
P
V
S
D
W
S
S
D
E
E
Site 29
S287
G
A
P
V
S
D
W
S
S
D
E
E
D
G
S
Site 30
S288
A
P
V
S
D
W
S
S
D
E
E
D
G
S
K
Site 31
S294
S
S
D
E
E
D
G
S
K
G
R
S
K
S
R
Site 32
S298
E
D
G
S
K
G
R
S
K
S
R
C
T
S
T
Site 33
S300
G
S
K
G
R
S
K
S
R
C
T
S
T
L
S
Site 34
T303
G
R
S
K
S
R
C
T
S
T
L
S
S
H
T
Site 35
S304
R
S
K
S
R
C
T
S
T
L
S
S
H
T
S
Site 36
T305
S
K
S
R
C
T
S
T
L
S
S
H
T
S
E
Site 37
S307
S
R
C
T
S
T
L
S
S
H
T
S
E
E
G
Site 38
S308
R
C
T
S
T
L
S
S
H
T
S
E
E
G
V
Site 39
S311
S
T
L
S
S
H
T
S
E
E
G
V
Q
C
S
Site 40
S318
S
E
E
G
V
Q
C
S
R
M
G
S
E
M
Y
Site 41
S322
V
Q
C
S
R
M
G
S
E
M
Y
L
T
A
S
Site 42
Y325
S
R
M
G
S
E
M
Y
L
T
A
S
D
D
S
Site 43
T327
M
G
S
E
M
Y
L
T
A
S
D
D
S
S
S
Site 44
S329
S
E
M
Y
L
T
A
S
D
D
S
S
S
I
F
Site 45
S332
Y
L
T
A
S
D
D
S
S
S
I
F
E
E
E
Site 46
S333
L
T
A
S
D
D
S
S
S
I
F
E
E
E
T
Site 47
S334
T
A
S
D
D
S
S
S
I
F
E
E
E
T
F
Site 48
T340
S
S
I
F
E
E
E
T
F
G
I
K
R
P
E
Site 49
Y352
R
P
E
H
K
K
L
Y
S
W
Q
Q
E
A
Q
Site 50
S353
P
E
H
K
K
L
Y
S
W
Q
Q
E
A
Q
W
Site 51
S365
A
Q
W
K
A
L
N
S
P
L
G
K
G
N
S
Site 52
S372
S
P
L
G
K
G
N
S
E
L
S
K
K
E
Q
Site 53
S375
G
K
G
N
S
E
L
S
K
K
E
Q
D
S
S
Site 54
S381
L
S
K
K
E
Q
D
S
S
S
D
E
L
N
K
Site 55
S382
S
K
K
E
Q
D
S
S
S
D
E
L
N
K
K
Site 56
S383
K
K
E
Q
D
S
S
S
D
E
L
N
K
K
F
Site 57
S392
E
L
N
K
K
F
Q
S
Q
R
L
D
Y
S
S
Site 58
Y397
F
Q
S
Q
R
L
D
Y
S
S
S
S
S
E
A
Site 59
S398
Q
S
Q
R
L
D
Y
S
S
S
S
S
E
A
N
Site 60
S399
S
Q
R
L
D
Y
S
S
S
S
S
E
A
N
T
Site 61
S400
Q
R
L
D
Y
S
S
S
S
S
E
A
N
T
P
Site 62
S401
R
L
D
Y
S
S
S
S
S
E
A
N
T
P
S
Site 63
S402
L
D
Y
S
S
S
S
S
E
A
N
T
P
S
P
Site 64
T406
S
S
S
S
E
A
N
T
P
S
P
I
L
T
P
Site 65
S408
S
S
E
A
N
T
P
S
P
I
L
T
P
A
L
Site 66
T412
N
T
P
S
P
I
L
T
P
A
L
M
P
K
H
Site 67
S422
L
M
P
K
H
P
N
S
L
S
G
K
G
T
Q
Site 68
S424
P
K
H
P
N
S
L
S
G
K
G
T
Q
L
V
Site 69
T428
N
S
L
S
G
K
G
T
Q
L
V
P
S
S
H
Site 70
S433
K
G
T
Q
L
V
P
S
S
H
L
P
P
P
K
Site 71
S434
G
T
Q
L
V
P
S
S
H
L
P
P
P
K
L
Site 72
S459
A
L
A
K
R
H
L
S
Q
P
Q
L
S
S
D
Site 73
S464
H
L
S
Q
P
Q
L
S
S
D
R
M
F
G
T
Site 74
S465
L
S
Q
P
Q
L
S
S
D
R
M
F
G
T
N
Site 75
T471
S
S
D
R
M
F
G
T
N
R
N
A
I
S
M
Site 76
S496
L
D
L
V
D
G
D
S
T
E
V
L
E
N
M
Site 77
T497
D
L
V
D
G
D
S
T
E
V
L
E
N
M
D
Site 78
T505
E
V
L
E
N
M
D
T
S
C
D
D
G
L
F
Site 79
S506
V
L
E
N
M
D
T
S
C
D
D
G
L
F
S
Site 80
S513
S
C
D
D
G
L
F
S
Y
D
S
L
D
S
P
Site 81
Y514
C
D
D
G
L
F
S
Y
D
S
L
D
S
P
N
Site 82
S516
D
G
L
F
S
Y
D
S
L
D
S
P
N
S
D
Site 83
S519
F
S
Y
D
S
L
D
S
P
N
S
D
D
Q
E
Site 84
S522
D
S
L
D
S
P
N
S
D
D
Q
E
H
C
D
Site 85
S530
D
D
Q
E
H
C
D
S
A
K
K
V
A
Y
S
Site 86
Y536
D
S
A
K
K
V
A
Y
S
K
P
P
T
P
P
Site 87
S537
S
A
K
K
V
A
Y
S
K
P
P
T
P
P
L
Site 88
T541
V
A
Y
S
K
P
P
T
P
P
L
H
R
F
P
Site 89
S549
P
P
L
H
R
F
P
S
W
E
S
R
I
Y
A
Site 90
S552
H
R
F
P
S
W
E
S
R
I
Y
A
V
A
K
Site 91
Y555
P
S
W
E
S
R
I
Y
A
V
A
K
S
G
I
Site 92
S560
R
I
Y
A
V
A
K
S
G
I
R
M
S
E
A
Site 93
S565
A
K
S
G
I
R
M
S
E
A
F
N
M
E
S
Site 94
S572
S
E
A
F
N
M
E
S
V
N
K
N
S
A
A
Site 95
S582
K
N
S
A
A
T
L
S
Y
T
T
S
G
L
Y
Site 96
T584
S
A
A
T
L
S
Y
T
T
S
G
L
Y
T
S
Site 97
Y589
S
Y
T
T
S
G
L
Y
T
S
L
I
Y
K
N
Site 98
S591
T
T
S
G
L
Y
T
S
L
I
Y
K
N
M
T
Site 99
T599
L
I
Y
K
N
M
T
T
P
V
Y
T
T
L
K
Site 100
Y602
K
N
M
T
T
P
V
Y
T
T
L
K
G
K
A
Site 101
T610
T
T
L
K
G
K
A
T
Q
I
S
S
S
P
F
Site 102
S613
K
G
K
A
T
Q
I
S
S
S
P
F
L
D
D
Site 103
S615
K
A
T
Q
I
S
S
S
P
F
L
D
D
S
S
Site 104
S621
S
S
P
F
L
D
D
S
S
G
S
E
E
E
D
Site 105
S622
S
P
F
L
D
D
S
S
G
S
E
E
E
D
S
Site 106
S624
F
L
D
D
S
S
G
S
E
E
E
D
S
S
R
Site 107
S629
S
G
S
E
E
E
D
S
S
R
S
S
S
R
T
Site 108
S630
G
S
E
E
E
D
S
S
R
S
S
S
R
T
S
Site 109
S632
E
E
E
D
S
S
R
S
S
S
R
T
S
E
S
Site 110
S633
E
E
D
S
S
R
S
S
S
R
T
S
E
S
D
Site 111
S634
E
D
S
S
R
S
S
S
R
T
S
E
S
D
S
Site 112
T636
S
S
R
S
S
S
R
T
S
E
S
D
S
R
S
Site 113
S637
S
R
S
S
S
R
T
S
E
S
D
S
R
S
R
Site 114
S639
S
S
S
R
T
S
E
S
D
S
R
S
R
S
G
Site 115
S641
S
R
T
S
E
S
D
S
R
S
R
S
G
P
G
Site 116
S643
T
S
E
S
D
S
R
S
R
S
G
P
G
S
P
Site 117
S645
E
S
D
S
R
S
R
S
G
P
G
S
P
R
A
Site 118
S649
R
S
R
S
G
P
G
S
P
R
A
M
K
R
G
Site 119
S658
R
A
M
K
R
G
V
S
L
S
S
V
A
S
E
Site 120
S660
M
K
R
G
V
S
L
S
S
V
A
S
E
S
D
Site 121
S661
K
R
G
V
S
L
S
S
V
A
S
E
S
D
Y
Site 122
S666
L
S
S
V
A
S
E
S
D
Y
A
I
P
P
D
Site 123
Y668
S
V
A
S
E
S
D
Y
A
I
P
P
D
A
Y
Site 124
Y675
Y
A
I
P
P
D
A
Y
S
T
D
T
E
Y
S
Site 125
S676
A
I
P
P
D
A
Y
S
T
D
T
E
Y
S
Q
Site 126
T679
P
D
A
Y
S
T
D
T
E
Y
S
Q
P
E
Q
Site 127
Y681
A
Y
S
T
D
T
E
Y
S
Q
P
E
Q
K
L
Site 128
T691
P
E
Q
K
L
P
K
T
C
S
S
S
S
D
N
Site 129
S693
Q
K
L
P
K
T
C
S
S
S
S
D
N
G
K
Site 130
S694
K
L
P
K
T
C
S
S
S
S
D
N
G
K
N
Site 131
S696
P
K
T
C
S
S
S
S
D
N
G
K
N
E
P
Site 132
S707
K
N
E
P
L
E
K
S
G
Y
L
L
K
M
S
Site 133
Y709
E
P
L
E
K
S
G
Y
L
L
K
M
S
G
K
Site 134
S714
S
G
Y
L
L
K
M
S
G
K
V
K
S
W
K
Site 135
Y734
L
K
G
G
E
L
L
Y
Y
K
S
P
S
D
V
Site 136
Y735
K
G
G
E
L
L
Y
Y
K
S
P
S
D
V
I
Site 137
S737
G
E
L
L
Y
Y
K
S
P
S
D
V
I
R
K
Site 138
S752
P
Q
G
H
I
E
L
S
A
S
C
S
I
L
R
Site 139
S756
I
E
L
S
A
S
C
S
I
L
R
G
D
N
K
Site 140
T765
L
R
G
D
N
K
Q
T
V
Q
L
T
T
E
K
Site 141
T769
N
K
Q
T
V
Q
L
T
T
E
K
H
T
Y
Y
Site 142
Y775
L
T
T
E
K
H
T
Y
Y
L
T
A
D
S
P
Site 143
Y776
T
T
E
K
H
T
Y
Y
L
T
A
D
S
P
N
Site 144
S781
T
Y
Y
L
T
A
D
S
P
N
I
L
E
E
W
Site 145
S805
V
Q
A
A
N
P
L
S
L
Q
P
E
G
K
P
Site 146
T813
L
Q
P
E
G
K
P
T
M
K
G
L
L
T
K
Site 147
T819
P
T
M
K
G
L
L
T
K
V
K
H
G
Y
S
Site 148
Y839
T
L
I
G
K
T
L
Y
Y
F
R
S
Q
E
D
Site 149
Y840
L
I
G
K
T
L
Y
Y
F
R
S
Q
E
D
K
Site 150
S843
K
T
L
Y
Y
F
R
S
Q
E
D
K
F
P
L
Site 151
S866
K
V
E
E
V
D
R
S
C
D
S
D
E
D
Y
Site 152
S869
E
V
D
R
S
C
D
S
D
E
D
Y
E
A
S
Site 153
Y873
S
C
D
S
D
E
D
Y
E
A
S
G
R
S
L
Site 154
S876
S
D
E
D
Y
E
A
S
G
R
S
L
L
S
T
Site 155
S879
D
Y
E
A
S
G
R
S
L
L
S
T
H
Y
T
Site 156
Y885
R
S
L
L
S
T
H
Y
T
I
V
I
H
P
K
Site 157
T886
S
L
L
S
T
H
Y
T
I
V
I
H
P
K
D
Site 158
Y898
P
K
D
Q
G
P
T
Y
L
L
I
G
S
K
H
Site 159
T909
G
S
K
H
E
K
D
T
W
L
Y
H
L
T
V
Site 160
S945
N
I
D
G
E
P
S
S
Q
I
W
R
H
P
T
Site 161
T952
S
Q
I
W
R
H
P
T
L
C
H
S
K
E
G
Site 162
S956
R
H
P
T
L
C
H
S
K
E
G
I
I
S
P
Site 163
S962
H
S
K
E
G
I
I
S
P
L
T
T
L
P
S
Site 164
S969
S
P
L
T
T
L
P
S
E
A
L
Q
T
E
A
Site 165
T974
L
P
S
E
A
L
Q
T
E
A
I
K
L
F
K
Site 166
Y998
V
D
S
P
A
I
D
Y
H
I
S
L
A
Q
S
Site 167
T1012
S
A
L
Q
I
C
L
T
H
P
E
L
Q
N
E
Site 168
S1073
H
L
K
R
N
A
D
S
R
T
E
F
G
K
Y
Site 169
T1075
K
R
N
A
D
S
R
T
E
F
G
K
Y
A
I
Site 170
Y1080
S
R
T
E
F
G
K
Y
A
I
Y
C
Q
R
C
Site 171
Y1083
E
F
G
K
Y
A
I
Y
C
Q
R
C
V
E
R
Site 172
S1102
G
D
R
E
A
R
P
S
R
M
E
I
L
S
T
Site 173
S1108
P
S
R
M
E
I
L
S
T
L
L
R
N
P
Y
Site 174
T1109
S
R
M
E
I
L
S
T
L
L
R
N
P
Y
H
Site 175
Y1115
S
T
L
L
R
N
P
Y
H
H
S
L
P
F
S
Site 176
S1118
L
R
N
P
Y
H
H
S
L
P
F
S
I
P
V
Site 177
T1149
T
V
E
E
F
L
N
T
L
N
Q
D
T
G
M
Site 178
T1154
L
N
T
L
N
Q
D
T
G
M
R
K
P
A
Q
Site 179
S1162
G
M
R
K
P
A
Q
S
G
F
A
L
F
T
D
Site 180
T1168
Q
S
G
F
A
L
F
T
D
D
P
S
G
R
D
Site 181
S1172
A
L
F
T
D
D
P
S
G
R
D
L
E
H
C
Site 182
T1208
Q
P
G
K
C
E
G
T
R
T
V
R
L
T
Y
Site 183
T1210
G
K
C
E
G
T
R
T
V
R
L
T
Y
K
N
Site 184
T1214
G
T
R
T
V
R
L
T
Y
K
N
R
L
Y
F
Site 185
Y1215
T
R
T
V
R
L
T
Y
K
N
R
L
Y
F
S
Site 186
Y1220
L
T
Y
K
N
R
L
Y
F
S
V
Q
A
R
G
Site 187
S1222
Y
K
N
R
L
Y
F
S
V
Q
A
R
G
E
T
Site 188
T1229
S
V
Q
A
R
G
E
T
D
R
E
K
L
L
L
Site 189
Y1238
R
E
K
L
L
L
M
Y
Q
T
N
D
Q
I
I
Site 190
S1276
G
D
F
E
R
P
F
S
T
P
A
G
H
V
T
Site 191
T1277
D
F
E
R
P
F
S
T
P
A
G
H
V
T
N
Site 192
Y1300
K
Q
V
I
E
K
F
Y
P
K
R
Y
R
D
G
Site 193
S1309
K
R
Y
R
D
G
C
S
E
E
Q
L
R
Q
L
Site 194
S1321
R
Q
L
C
Q
R
L
S
T
R
W
M
A
L
R
Site 195
T1322
Q
L
C
Q
R
L
S
T
R
W
M
A
L
R
G
Site 196
S1379
A
V
H
E
D
G
L
S
L
L
E
Y
N
S
M
Site 197
T1399
Y
V
Y
K
S
L
M
T
F
G
G
Y
Q
D
D
Site 198
T1421
T
H
S
K
D
K
P
T
E
K
L
L
F
A
M
Site 199
S1464
L
S
A
P
A
L
L
S
A
Q
T
R
G
P
Q
Site 200
S1477
P
Q
A
R
M
M
G
S
Q
P
L
L
S
S
S
Site 201
S1482
M
G
S
Q
P
L
L
S
S
S
R
P
T
K
G
Site 202
S1483
G
S
Q
P
L
L
S
S
S
R
P
T
K
G
P
Site 203
S1484
S
Q
P
L
L
S
S
S
R
P
T
K
G
P
T
Site 204
T1487
L
L
S
S
S
R
P
T
K
G
P
T
L
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation