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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RasGRP3
Full Name:
Ras guanyl-releasing protein 3
Alias:
Calcium and DAG-regulated guanine nucleotide exchange factor III; GRP3; Guanine nucleotide exchange factor for Rap1; KIAA0846; RAS guanyl releasing protein 3; RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
78332
Number AA:
690
UniProt ID:
Q8IV61
International Prot ID:
IPI00171874
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0046582
GO:0005509
GO:0019992
PhosphoSite+
KinaseNET
Biological Process:
GO:0000165
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
D
N
G
E
L
D
N
S
Y
L
P
R
I
V
L
Site 2
Y33
N
G
E
L
D
N
S
Y
L
P
R
I
V
L
L
Site 3
S47
L
M
H
R
W
Y
L
S
S
T
E
L
A
E
K
Site 4
S48
M
H
R
W
Y
L
S
S
T
E
L
A
E
K
L
Site 5
Y59
A
E
K
L
L
C
M
Y
R
N
A
T
G
E
S
Site 6
T63
L
C
M
Y
R
N
A
T
G
E
S
C
N
E
F
Site 7
T99
D
L
G
L
I
R
M
T
E
E
F
R
E
V
A
Site 8
Y111
E
V
A
S
Q
L
G
Y
E
K
H
V
S
L
I
Site 9
Y126
D
I
S
S
I
P
S
Y
D
W
M
R
R
V
T
Site 10
T133
Y
D
W
M
R
R
V
T
Q
R
K
K
V
S
K
Site 11
T161
I
E
L
A
E
H
L
T
F
L
E
H
K
S
F
Site 12
S167
L
T
F
L
E
H
K
S
F
R
R
I
S
F
T
Site 13
S172
H
K
S
F
R
R
I
S
F
T
D
Y
Q
S
Y
Site 14
T174
S
F
R
R
I
S
F
T
D
Y
Q
S
Y
V
I
Site 15
Y176
R
R
I
S
F
T
D
Y
Q
S
Y
V
I
H
G
Site 16
Y179
S
F
T
D
Y
Q
S
Y
V
I
H
G
C
L
E
Site 17
T190
G
C
L
E
N
N
P
T
L
E
R
S
I
A
L
Site 18
S194
N
N
P
T
L
E
R
S
I
A
L
F
N
G
I
Site 19
S211
W
V
Q
L
M
V
L
S
K
P
T
P
Q
Q
R
Site 20
T214
L
M
V
L
S
K
P
T
P
Q
Q
R
A
E
V
Site 21
S251
V
V
G
G
L
S
H
S
S
I
S
R
L
K
E
Site 22
S252
V
G
G
L
S
H
S
S
I
S
R
L
K
E
T
Site 23
S254
G
L
S
H
S
S
I
S
R
L
K
E
T
H
S
Site 24
T259
S
I
S
R
L
K
E
T
H
S
H
L
S
S
E
Site 25
S261
S
R
L
K
E
T
H
S
H
L
S
S
E
V
T
Site 26
S265
E
T
H
S
H
L
S
S
E
V
T
K
N
W
N
Site 27
T268
S
H
L
S
S
E
V
T
K
N
W
N
E
M
T
Site 28
T275
T
K
N
W
N
E
M
T
E
L
V
S
S
N
G
Site 29
Y284
L
V
S
S
N
G
N
Y
C
N
Y
R
K
A
F
Site 30
Y287
S
N
G
N
Y
C
N
Y
R
K
A
F
A
D
C
Site 31
S342
V
T
L
S
E
L
V
S
L
Q
N
A
S
H
H
Site 32
Y367
L
T
L
S
L
D
L
Y
H
T
E
D
D
I
Y
Site 33
Y374
Y
H
T
E
D
D
I
Y
K
L
S
L
V
L
E
Site 34
S377
E
D
D
I
Y
K
L
S
L
V
L
E
P
R
N
Site 35
S385
L
V
L
E
P
R
N
S
K
S
Q
P
T
S
P
Site 36
S387
L
E
P
R
N
S
K
S
Q
P
T
S
P
T
T
Site 37
S391
N
S
K
S
Q
P
T
S
P
T
T
P
N
K
P
Site 38
T393
K
S
Q
P
T
S
P
T
T
P
N
K
P
V
V
Site 39
T394
S
Q
P
T
S
P
T
T
P
N
K
P
V
V
P
Site 40
T415
V
M
P
K
P
D
P
T
V
I
N
K
H
I
R
Site 41
Y432
V
E
S
V
F
R
N
Y
D
H
D
H
D
G
Y
Site 42
Y439
Y
D
H
D
H
D
G
Y
I
S
Q
E
D
F
E
Site 43
S441
H
D
H
D
G
Y
I
S
Q
E
D
F
E
S
I
Site 44
S447
I
S
Q
E
D
F
E
S
I
A
A
N
F
P
F
Site 45
S470
K
D
Q
D
G
L
I
S
K
D
E
M
M
A
Y
Site 46
Y477
S
K
D
E
M
M
A
Y
F
L
R
A
K
S
Q
Site 47
S483
A
Y
F
L
R
A
K
S
Q
L
H
C
K
M
G
Site 48
Y502
H
N
F
Q
E
M
T
Y
L
K
P
T
F
C
E
Site 49
Y523
W
G
I
I
K
Q
G
Y
K
C
K
D
C
G
A
Site 50
S552
R
R
F
A
R
A
P
S
L
S
S
G
H
G
S
Site 51
S554
F
A
R
A
P
S
L
S
S
G
H
G
S
L
P
Site 52
S555
A
R
A
P
S
L
S
S
G
H
G
S
L
P
G
Site 53
S559
S
L
S
S
G
H
G
S
L
P
G
S
P
S
L
Site 54
S563
G
H
G
S
L
P
G
S
P
S
L
P
P
A
Q
Site 55
S565
G
S
L
P
G
S
P
S
L
P
P
A
Q
D
E
Site 56
S588
A
G
H
R
D
L
D
S
R
A
I
T
L
V
T
Site 57
T592
D
L
D
S
R
A
I
T
L
V
T
G
S
S
R
Site 58
S602
T
G
S
S
R
K
I
S
V
R
L
Q
R
A
T
Site 59
T609
S
V
R
L
Q
R
A
T
T
S
Q
A
T
Q
T
Site 60
T610
V
R
L
Q
R
A
T
T
S
Q
A
T
Q
T
E
Site 61
S611
R
L
Q
R
A
T
T
S
Q
A
T
Q
T
E
P
Site 62
S621
T
Q
T
E
P
V
W
S
E
A
G
W
G
D
S
Site 63
S628
S
E
A
G
W
G
D
S
G
S
H
T
F
P
K
Site 64
S630
A
G
W
G
D
S
G
S
H
T
F
P
K
M
K
Site 65
T632
W
G
D
S
G
S
H
T
F
P
K
M
K
S
K
Site 66
S638
H
T
F
P
K
M
K
S
K
F
H
D
K
A
A
Site 67
T671
V
D
V
V
D
R
G
T
E
F
E
L
D
Q
D
Site 68
T683
D
Q
D
E
G
E
E
T
R
Q
D
G
E
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation