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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLD3
Full Name:
Phospholipase D3
Alias:
Choline phosphatase 3;HindIII K4L homolog;Hu-K4;Phosphatidylcholine-hydrolyzing phospholipase D3
Type:
Mass (Da):
54705
Number AA:
490
UniProt ID:
Q8IV08
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
K
P
K
L
M
Y
Q
E
L
K
V
P
A
Site 2
Y78
N
Q
R
P
A
P
C
Y
D
P
C
E
A
V
L
Site 3
T100
L
D
F
P
N
A
S
T
G
N
P
S
T
S
Q
Site 4
S106
S
T
G
N
P
S
T
S
Q
A
W
L
G
L
L
Site 5
Y126
S
L
D
I
A
S
F
Y
W
T
L
T
N
N
D
Site 6
T134
W
T
L
T
N
N
D
T
H
T
Q
E
P
S
A
Site 7
T136
L
T
N
N
D
T
H
T
Q
E
P
S
A
Q
Q
Site 8
T153
E
V
L
R
Q
L
Q
T
L
A
P
K
G
V
N
Site 9
S166
V
N
V
R
I
A
V
S
K
P
S
G
P
Q
P
Site 10
Y213
V
V
D
Q
T
H
F
Y
L
G
S
A
N
M
D
Site 11
S223
S
A
N
M
D
W
R
S
L
T
Q
V
K
E
L
Site 12
T225
N
M
D
W
R
S
L
T
Q
V
K
E
L
G
V
Site 13
S238
G
V
V
M
Y
N
C
S
C
L
A
R
D
L
T
Site 14
S259
W
F
L
G
Q
A
G
S
S
I
P
S
T
W
P
Site 15
S263
Q
A
G
S
S
I
P
S
T
W
P
R
F
Y
D
Site 16
T264
A
G
S
S
I
P
S
T
W
P
R
F
Y
D
T
Site 17
Y269
P
S
T
W
P
R
F
Y
D
T
R
Y
N
Q
E
Site 18
Y273
P
R
F
Y
D
T
R
Y
N
Q
E
T
P
M
E
Site 19
T277
D
T
R
Y
N
Q
E
T
P
M
E
I
C
L
N
Site 20
S302
A
P
P
P
L
C
P
S
G
R
T
P
D
L
K
Site 21
T305
P
L
C
P
S
G
R
T
P
D
L
K
A
L
L
Site 22
T332
A
V
M
N
Y
L
P
T
L
E
F
S
H
P
H
Site 23
T353
D
D
G
L
R
R
A
T
Y
E
R
G
V
K
V
Site 24
Y354
D
G
L
R
R
A
T
Y
E
R
G
V
K
V
R
Site 25
S373
C
W
G
H
S
E
P
S
M
R
A
F
L
L
S
Site 26
T389
A
A
L
R
D
N
H
T
H
S
D
I
Q
V
K
Site 27
S391
L
R
D
N
H
T
H
S
D
I
Q
V
K
L
F
Site 28
Y411
E
A
Q
A
R
I
P
Y
A
R
V
N
H
N
K
Site 29
Y419
A
R
V
N
H
N
K
Y
M
V
T
E
R
A
T
Site 30
T422
N
H
N
K
Y
M
V
T
E
R
A
T
Y
I
G
Site 31
Y427
M
V
T
E
R
A
T
Y
I
G
T
S
N
W
S
Site 32
T430
E
R
A
T
Y
I
G
T
S
N
W
S
G
N
Y
Site 33
Y437
T
S
N
W
S
G
N
Y
F
T
E
T
A
G
T
Site 34
S458
N
G
R
G
G
L
R
S
Q
L
E
A
I
F
L
Site 35
S470
I
F
L
R
D
W
D
S
P
Y
S
H
D
L
D
Site 36
Y472
L
R
D
W
D
S
P
Y
S
H
D
L
D
T
S
Site 37
S473
R
D
W
D
S
P
Y
S
H
D
L
D
T
S
A
Site 38
T478
P
Y
S
H
D
L
D
T
S
A
D
S
V
G
N
Site 39
S482
D
L
D
T
S
A
D
S
V
G
N
A
C
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation